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| 1 | Cardiac rehabilitation and exercise therapy in the elderly: Should we invest in the aged?显示文摘冠的心疾病(CHD ) 是世界范围的死亡的领先的原因并且在病人之中变得逐渐地流行 65 岁以上。老病人在为复杂并发症的更高的风险并且在一个心血管的事件以后加速物理 deconditioning,特别与他们的更年轻的对应物相比。最后几十年是到与 CHD 在病人之中在死亡,锻练能力,心理风险因素,发炎,和肥胖上表明了心脏的康复(CR ) 和锻练治疗的有益的效果的多重研究的厕所。不幸地,这个领域里的可得到的数据的重要部分与更年轻的病人相关。可行解释是更老的病人在为以病人开始并且延长到医生的多重原因的这些节目是非常未被充分代表的。在这篇文章,我们将考察 CR 节目的好处在之中老,以及一些妨碍他们的参予的障碍。 | Arthur R Menezes Carl J Lavie Richard V Milani Ross A Arena Timothy S Church | 2012 | Journal of Geriatric Cardiology2012，9，1： | 25 |
| 2 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 3 | Translational pancreatic cancer research:a comparative study on patient-derived xenograft models显示文摘AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice.METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical characteristics.CONCLUSION In our experience, the faster development andgreatest number of viable xenografts could make the subcutaneous model the best option for experimentation in pancreatic cancer. | Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz | 2018 | World Journal of Gastroenterology2018，24，7： | 2 |
| 4 | Enterohepatie bacterial infections dysregulate the FGF15-FGFR4 endocrine axis 显示文摘 | Romain G Tremblay S Arena ET | 2013 | BMC Mierobiol2013，13，： | 1 |
| 5 | Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons显示文摘 | Trupp M Ryden M Jomvall H Funakoshi H Timmusk T Arena S | 1995 | J Cell Biol1995，130，1： | 1 |
| 6 | Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency显示文摘 | Marinaki AM Arenas M | 2002 | Hum Genet2002，111，45： | 1 |
| 7 | Fetal risks related to thead- ministration of anti - arrhythmia drugs during pregnancy 显示文摘 | Ferrero S Colombo BM Arena E | 2002 | Ital Heart Jsupp12002，3，10： | 1 |
| 8 | Comparison of odour active compounds detected by gas-chromatography-olfactometry between hand-squeezed juices from different orange varieties显示文摘 | ARENA E GUARRERA N CAMPIS1 S | 2006 | Food Chemistry2006，98，1： | 1 |
| 9 | Comparison of odour active compounds detected by gas-chromatography- olfactometry between hand-squeezed juices from different orange varieties 显示文摘 | Arena E Guarrera N Campisi S | 2006 | Food Chemistry2006，98，： | 1 |
| 10 | Exercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing显示文摘 | Chaudhry S Arena R Wasserman K | 2009 | Am J Cardiol2009，103，5： | 1 |
| 11 | Elastography, spleen size, and platelet count identify portal hypertension in patients with compensated cirrhosis 显示文摘 | BERZIGOTrI A SEIJO S ARENA U | 2013 | Gastroenterology2013，144，1： | 1 |
| 12 | Comparison of odour active compounds detected by gas-cbromatography-olfactometry between hand-squeezed juices from different orange varieties显示文摘 | ARENA E GUARRERA N CAMPISI S | 2006 | Food Chemistry2006，98，： | 1 |
| 13 | Expression of a glutamate-activatedchloride current in Xenopus oocytes injected with Caenorhabditiselegans RNA:evidence for modulation by avermectin显示文摘 | ARENA J P LIU K K PARESS P S | 1992 | Molecular Brain Research1992，15，34： | 1 |
| 14 | The Vila de Cruces Ophiolite:a remnant of the early Rheic Ocean in the Variscan suture of Galicia (Northwest Iberian Massif)显示文摘 | Arenas R Martínez Catalán J.R Sánchez Martínez S Fernández-Suárez J Andonaegui P Pearce J.A Coffu F | | 0，，： | 1 |
| 15 | Exploring thechicken egg white proteome with combinatorial peptide ligandlibraries显示文摘 | D′Ambrosio C Arena S Scaloni A | 2008 | Journal of Proteome Research2008，7，8： | 1 |
| 16 | Two different Em-like genes are expressed in Arabidopsis thaliana seeds during maturation显示文摘 | Pascale Gaubier Monique Raynal Gillian Hull Gordon M. Huestis Fran?oise Grellet César Arenas Montserrat Pagès Michel Delseny | 1993 | MGG Molecular & General Genetics1993，，3： | 1 |
| 17 | In vitro characterization of a calcium sulfate/PLLA composite for use as a bone graft material 显示文摘 | Mamidwar SS Arena C Kelly S | 2007 | J Biomed Mater Res B Appl Biomater2007，81，： | 1 |
| 18 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 19 | Chemically deposited copper oxide thin films: structural,optical and electrical characteristics显示文摘 | Nair M T S Guerrero L Arenas O L | 1999 | Applied Surface Science1999，150，： | 1 |
| 20 | Mineralization of collagen may occur on fibril surfaces: Evidence from conventional and high-voltage electron microscopy and three-dimensional imaging 显示文摘 | Landis W J Hodgens K J Song M J Arena J Kiyonaga S Marko M Owen C Mcewen B F | 1996 | Journal of Structural Biology1996，117，1： | 1 |
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