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| 1 | Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism显示文摘 | Fu YS Cheng YC Lin MY Cheng H Chu PM Chou SC Shih YH Ko MH Sung MS | 2006 | 中国生物学文摘2006，20，10： | 138 |
| 2 | 香港华人妇女产后抑郁危险因素的前瞻性研究显示文摘目的:产后抑郁是一种常见的精神障碍,对产妇、新生儿和其它家庭成员导致广泛的伤害。产后抑郁的病因学研究大多是基于西方样本,对其中的社会文化原因也缺乏实证研究。本研究从人口学、心理社会及种族文化因素等方面探讨中国妇女产后抑郁症状学的决定因素。方法:在大学附属综合医院产前门诊连续收集登记的中国孕妇959例,从她们第一次产前检查开始评估(基线),以后分别在孕期的最后3个月、产后即刻和产后3个月时评估。调查涉及的危险因素分6个方面:人口学和社会经济背景,躯体疾病及精神疾病病史, 产前抑郁情绪,围生期应激源,人际关系,和种族文化环境。采用等级回归进行分析。因变量是产后3个月时的抑郁评分。结果:决定产后抑郁症状学的因素有:目前的生活事件,缺乏社会支持,婚姻不满意,既往有故意自伤史,以及产前存在抑郁情绪。婆媳关系不好和没有陪月在产后阶段也与抑郁评分高有关联。结论:西方研究所确立的产后抑郁危险因素大体适用于中国妇女。产褥期的社会文化特点同样对产妇情绪有影响。 | Dominic TS Lee Alexander SK Yip Sandra SM Chan Fiona FY Lee Tony YS Leung Tony KH Chung | 2005 | 中国心理卫生杂志2005，19，9： | 50 |
| 3 | 南方4种草本植物对铝胁迫生理响应的研究显示文摘不同的植物对铝胁迫的生理响应不同, 因而对铝毒的耐性也不相同。设置5种铝浓度,进行砂培法处理,研究了4 种我国南方红壤广泛分布的草本植物———牵牛(Pharbitis nil )、望江南( Cassia occidentlis )、光头稗(Echinochloa colonum)和合萌(Aeschynomene indica)的种子萌发、光合色素、脯氨酸含量、丙二醛(MDA)含量、可溶性糖(SS)含量、质膜透性(MP)、过氧化氢酶(CAT) 活性以及过氧化物酶(POD)活性的变化。结果表明铝对4种植物的生理特性都有明显的影响。4种植物的种子在10 000 mg·L-1 Al3+处理条件下都不能萌发。2 000 mg·L-1 Al3+处理都不利于4种植物的生长,与对照相比,2 000 mg·L-1 Al3+处理时4种草本植物叶绿素和叶绿素总含量显著降低(p<0.05);MDA含量和MP显著增加(p<0.05);脯氨酸含量极显著增加(p<0.01);POD和CAT活性极显著降低(p<0.01)。中低铝(80和400 mg·L-1)处理时,牵牛和合萌与对照相比,MP和MDA含量降低,POD和CAT活性升高;望江南的反应与牵牛和合萌的反应相反;光头稗在80 mg·L-1 Al3+处理时,与牵牛和合萌的变化一致,在400 mg·L-1Al3+处理时,则相反。植物在中低铝处理条件下,通过维持较高的POD和CAT活性和脯氨酸、叶绿素含量,较低的MP和MDA含量来增加其对铝的耐性。 | 刘鹏 Yang YS 徐根娣 郭水良 汪敏 | 2005 | 植物生态学报2005，29，4： | 39 |
| 4 | Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation显示文摘The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in mice.In the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling mechanisms.IL-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and L-selectin.In addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and CCL2.We found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)pathways.Furthermore,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and IL-18.IL-1β,but not IL-18,markedly upregulated cell surface expression of ICAM-1.IL-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK pathways.Synergistic efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and IL-33.Taken together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation. | Joyce YS Chow Chun K Wong Phyllis FY Cheung Christopher WK Lam | 2010 | Cellular & Molecular Immunology2010，7，1： | 22 |
| 5 | Comparison of methods for total community DNA extraction and purification from compost显示文摘 | Yang ZH Xiao Y Zeng GM Xu ZY Liu YS | 2007 | 中国生物学文摘2007，21，8： | 18 |
| 6 | 术前肌电图和脑干听觉诱发电位与面肌痉挛微血管减压术后迟发性面瘫发生的关系(英文)显示文摘Background Delayed facial palsy ( DFP) after microvascular decompression ( MVD) in patients with hemifacial spasm ( HFS) is not uncommon,but the cause remains unknown. Objectives To assess whether intraoperative electromyography ( EMG) and brainstem auditory evoked potential ( BAEP) can predict DFP after MVD. Methods Between September 2009 and February 2011 we examined 86 patients,9 of whom ( 10. 4% ) developed DFP after MVD on the same side. All patients underwent MVD and were followed - up for a median period of 13 months ( range 6-22) . We retrospectively examined intraoperative facial EMG and BAEP findings using our MVD patients' registry. We excluded secondary HFS and immediate postoperative facial palsy after MVD in this study. We assessed the prevalence and clinical characteristics of DFP and compared EMG and BAEP findings between DFP and non-DFP groups. Results: All pa- tients recovered completely,with a mean time to recovery of 37. 8 days ( range 22-57) . There were no significant differences between DFP and non - DFP patients in terms of the amplitude and latency of intraoperative EMG and BAEP. Conclusion The usefulness of intraoperative facial EMG and BAEP is limited and cannot predict DFP after MVD for HFS. We speculate that DFP after MVD is not associated with permanent nerve damage according to the EMG findings. | Kim HJ Park YS Ryu JS Huh R Han I Shin DA Kim TG Cho KG Chung SS | 2012 | 中华神经外科疾病研究杂志2012，11，4： | 13 |
| 7 | 替诺福韦相比恩替卡韦可显著改善HBV相关肝细胞癌患者肝切除术后复发显示文摘【据Hepatology 2020年4月报道】题:替诺福韦与恩替卡韦对HBV相关肝细胞癌肝切除术后复发的影响(作者Choi J等)替诺福韦(TDF)和恩替卡韦(ETV)均为目前慢性乙型肝炎(CHB)临床指南中的一线治疗药物,有较高的抗病毒疗效和较低的耐药性。韩国蔚山大学医学院峨山医学中心研究团队的既往研究表明,使用TDF治疗的CHB患者相比于ETV治疗能显著降低肝细胞癌(HCC)的发生风险。该团队进行了一项回顾性队列分析,探讨了TDF与ETV治疗对HBV相关HCC根治性肝切除术后肿瘤复发及总生存率的影响。 | 江梦捷 赵婧菲 CHOI J JO C LIM YS | 2020 | 临床肝胆病杂志2020，36，9： | 12 |
| 8 | 溴代阻燃剂环境污染及毒性研究进展显示文摘溴代阻燃剂是普遍存在的一类环境污染物,包括多溴联苯醚、四溴双酚A、六溴环十二烷和十溴二苯乙烷等,在环境与生物体中均有检出。由于其具有环境持久性、长距离迁移性及生物富集性,对溴代阻燃剂的环境影响研究已经成为环境领域的热点之一。该文对溴代阻燃剂的来源、环境污染水平、毒理学效应进行综述,并提出了建议采取的溴代阻燃剂控制措施。 | 黄铸颖 李海燕 吴启航 Fu Jie Leung YS 朱立斌 骆展炜 陈俊 陆雅茵 黄雪夏 李淑更 耿新华 | 2014 | 环境与健康杂志2014，31，11： | 11 |
| 9 | Relationship between obesity and cardiovascular risk factors in elderly Chinese subjects显示文摘Objective To investigate the relative effects of degree and distribution of body fat with several cardiovascular disease (CVD) risk factors in elderly Chinese subjects.Methods One-hundred and thirty-five elderly Chinese individuals (age range, 60-65 y) without any history of significant renal, hepatic or cardiac disease were recruited. Seated blood pressure, anthropometric and fasting plasma biochemical parameters were measured. Student’s t-test was used to compare the differences in biochemical and anthropometric markers between cohorts.Results Males were heavier (64.6±8.6, 57.2±8.2?kg, P<0.001), taller (1.65±0.06, 1.51± 0.05 m, P<0.001) and their greater body fat was predominantly deposited centrally (Waist-to-hip ratio, 0.91±0.06, 0.88±0.07, P<0.05). Females were more generally obese with increased body mass index (BMI, 23.8±4.6, 25.0±3.5 kg/m 2, P<0.05) and percentage body fat [26.3% (24.5%-28.1%) vs 37.2% (36.0%-38.9%), P<0.001] than the males. However, despite an 11% higher proportion of body fat in females, no significant differences were identified in blood pressure, lipid profile, indices of insulin resistance or albumin-to-creatinine ratios.Conclusion It is likely that central adiposity contributes disproportionately to these metabolic disorders in males even though they are much leaner than elderly Chinese females. | G Neil THOMAS 赵海潞 马艳青 Wilson YS LEUNG Juliana CN CHAN Brian TOMLINSON Julian AJH CRITCHLEY 梁润成 陈重娥 汤宁信 郭志良 | 2002 | Chinese Medical Journal2002，，6： | 11 |
| 10 | 用RT—PCR检测犬外周血液单核细胞中犬瘟热病毒核衣壳蛋…显示文摘为了迅捷地诊断犬瘟热病毒(CDV)感染,本研究采用及转录-聚合酶链反应(RT-PCR)技术,检测犬外周血液核细胞(PBMC)中CDV核衣壳蛋白(NP)基因。以两套引物针对CDVOnderstepoort毒株NP基因的两个片段。应用RT-PCR〉以6株CDV毒株感染Vero细胞,用CDV人工感犬染的的PBMC,在这两处细胞的提的RNA中,手增NP基因片段,取得了较好的结果。 | Shim.,YS 缪勤 | 1997 | 国外兽医学(畜禽传染病)1997，17，1： | 9 |
| 11 | PLoS Negl Trop Dis:中国科学家成功绘制出全国性的肝吸虫病风险地图显示文摘华支睾吸虫病(Clonorchiasis,肝吸虫病)是一种摄入未煮熟的鱼类而被感染的热带疾病。这种疾病常常会被忽视,有超过85%的病例都集中在中国。 | Lai YS | 2017 | 现代生物医学进展2017，17，11： | 9 |
| 12 | 体外冲击波治疗烧伤瘢痕增生的前瞻性随机双盲研究显示文摘该研究旨在探讨体外冲击波治疗对增生性瘢痕再生的影响作者将48例移植中厚皮片修复创面的烧伤患者随机分为治疗组(25例)和对照组(23例)2组患者创面愈合后均接受常规康复治疗,其中治疗组另加以0.05~03O mJ/mm^(2)的低能流密度冲击波治疗,每周1次。 | 茹天峰(编译) 谢卫国(审校) Lee SY Joo SY Cho YS | 2021 | 中华烧伤杂志2021，37，4： | 8 |
| 13 | Effect of alloying elements on valence electron structure (VES) of Fe-3Al intermetallic compounds显示文摘The hybridized state of each atom changes with various changes of alloying elements and different alloying degrees. It is shown that during the course of alloying, the changes in the microsolid_state reflection such as atomic hybridized state make the corresponding VES parameters change, and that affects the mechanical properties of Fe-3Al alloys. | Sun, KN Zhang, JD Yin, YS | 1998 | Chinese Science Bulletin1998，43，2： | 7 |
| 14 | 用TableCurve3D软件预测连续油管的直径增长显示文摘生产作业过程中, 连续油管直径增长会引起与设备的不相容, 进而导致连续油管的严重机械损坏。根据试验数据和运用TableCurve3D 软件建立的连续油管直径增长预测模型, 不仅可以预测连续油管在各种压力和几何弯曲形状下的直径增长, 而且还可以评价当连续油管的外径、壁厚、材料品质、内压和弯曲半径发生相对小的变化时对直径增长的影响。这些分析将帮助用户在连续油管发生严重损坏之前, 提前诊断连续油管的直径增长, 并排除或减少引起直径增长的因素。 | 钟守炎 Yang.,YS | 1999 | 石油机械1999，27，10： | 6 |
| 15 | Mechanism of frost heave by film water migration under temperature gradient显示文摘IT is well known that there exists unfrozen film water in frozen soils due to the action of sur-face energy among soil particles and frost heave occurs by water migration under the tempera-ture gradient. The problem is how to determine the amount of frost heave quantitatively. The amount of frost heave induced by ice segregation can be calculated by the following e-quations: | Xu, XZ Wang, JC Zhang, LX Deng, YS Chuvilin, EM Yershov, ED Ishizaki, T Fukuda, M | 1997 | Chinese Science Bulletin1997，42，15： | 6 |
| 16 | 电针激活迷走神经-肾上腺轴的神经解剖学基础显示文摘电针刺激 (ES) 通过躯体感觉自主神经反射来调控机体的生理功能(如抑制严重的炎症)。二十世纪七十年代有学者认为针刺反射具有身体区域特异性(穴位特异性)。例如,低强度 (0.5 mA,10 Hz) ES 小鼠后肢穴位足三里 (ST36) 可激活迷走神经-肾上腺抗炎通路,而 ES 腹部天枢穴 (ST25) 无效,这种现象的神经解剖学基础尚不清楚。最近,在一项新的研究中,来自哈佛大学医学院、中国中医科学院和复旦大学的研究人员阐明了 ES 激活迷走神经-肾上腺轴抗炎通路的神经解剖学机制,并发现了由 PROKR2^(Cre)标记的感觉神经元对激活迷走神经-肾上腺轴至关重要。特异性敲除小鼠表达 PROKR2^(Cre)标记的 DRG 神经元,低强度电针 (0.5 mA) 刺激后肢 ST36 穴位不产生任何反应,不能使肾上腺释放儿茶酚胺类神经递质,也无法抑制细菌内毒素脂多糖 (LPS) 所诱发的全身炎症;而高强度电针 (3.0 mA)刺激后肢穴位 ST36 和腹部穴位 ST25 可激活交感神经抗炎通路。该研究还发现,进一步运用交叉遗传的方法特异性诱导光敏感通道蛋白 CatCh 表达于 PROKR2^(Cre)标记的神经末梢,可以激活迷走神经-肾上腺抗炎通路,但不能激活交感神经-肾上腺抗炎通路。此外,PROKR2^(Cre)神经纤维的分布可以预测低强度 ES 产生抗炎作用的身体区域(穴位特异性)。该研究为穴位选择和特异性激活自主神经通路提供了神经解剖学基础。尽管现代解剖学没有文献支持经络的物理存在,但针灸确实可以通过躯体神经反射来达到治疗效果。这些反射始于背根神经节 (DRG) 和/或三叉神经节周围神经的激活,然后从脊髓向大脑传递感觉信息,进而激活外周自主神经通路,最终对机体进行调控。该研究解读了为什么 ES 足三里 (ST36) 可激活迷走-肾上腺轴,而刺激腹部天枢穴 (ST25) 无任何效果,ES 刺激 ST25反而激活了脊髓交感神经通路。该研究认为迷走神经-肾上腺抗炎通道是由感觉神经介导,是后肢特有的 PROKR2^(Cre)标记的 DRG 神经元(一种 Cre 介导的重组标记神经元具有 PROKR2 持续或瞬时表达的作用)激活的,这些神经纤维密集分布在后肢深层筋膜组织。 | 陈紫悦(译) 韩清见(校) Liu SB Wang ZF Su YS | 2022 | 中国疼痛医学杂志2022，28，4： | 6 |
| 17 | Two limit theorems for NA random variables显示文摘THE NA (negatively associated) random variables are of considerable uses in system reliability and multivariate statistical analysis. Many authors have studied the limit properties for them. Definition 1. Random variables X1,…,Xn(n≥2) are called NA if for every two distinct nonempty subsets T1 and T2 of {1,…,n} and every pair of coordinatewise nondecreasing (or nonincreasing) functions f1 and f2, there | Su, C Qin, YS | 1997 | Chinese Science Bulletin1997，42，5： | 6 |
| 18 | Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy显示文摘我们与优先的主要雄激素剥夺治疗(ADT ) 在变形前列腺癌症在前进木头(PSAVAP ) 以后调查了前列腺特定的抗原天底(TTPN ) 和前列腺特定的抗原速度的对数的时间的协会。从 2000 ~ 2009 与主要 ADT 对待的所有变形前列腺癌症病人被考察。开发了疾病前进的病人在随后的分析被包括。病人们根据他们的 TTPN 被分成三个组:< 的 TTPN; 3 个月, 3-17 月,和 > 17 个月。我们用 Mann-Whitney U-test 和 Kruskal-Wallis 测试比较了在不同 TTPN 组之间的木头(PSAVAP ) 。木头(PSAVAP ) 上的进一步多重的线性回归分析被执行为使因素惊讶的另外的潜力调整。在与主要 ADT 被对待的 419 个病人之中, 306 个病人与 28 个月的中部的后续开发了疾病前进。更长的 TTPN 与更低的木头(PSAVAP ) 被联系(P = 0.008 ) 在所有亚群分析以内(< 的 TTPN; 3 对 3-17 月, P = 0.020;3-17 对 > 的 TTPN; 17 个月, P = 0.009;并且 < 的 TTPN; 3 对 > 17 个月, P = 0.001 ) 。在多重线性回归分析之上,基线 PSA (回归系数 0.001 , P = 0.045 ), PSA 天底(回归系数 0.002 , P = 0.040 ),并且 TTPN (回归系数 − ; 0.030 , P = 0.001 )是显著地与木头( PSAVAP )被联系的三个因素。在结论,更长的 TTPN 在跟随主要 ADT 的变形前列腺癌症病人与更低的木头(PSAVAP ) 被联系。在 3 个月和 17 个月的 TTPN cut-offs 看起来在预言木头(PSAVAP ) 有预示的意义。TTPN 可以在与疾病前进在病人决定治疗策略用作好预示的指示物。 | Jeremy YC Teoh James HL Tsu Steffi KK Yuen Peter KF Chiu Samson YS Chan Ka-Wing Wong Kwan-Lun Ho Simon SM Hou Chi-Fai Ng Ming-Kwong Yiu | 2017 | Asian Journal of Andrology2017，19，1： | 6 |
| 19 | Elderly healthcare service at the community health centers in the Pearl River Delta region,China显示文摘Objective:The recent population census showed China had officially become a graying society.In the meantime,China also faces a growing burden of non-communicable diseases.Since 2009,a series of policies have been implemented to enhance primary care at the community level.This study describes the elderly care services provided in the differently organized community health centers(CHCs).Methods:It covered 13 CHCs of six cities located within the Pearl River Delta(PRD)region.In-depth interviews were conducted with a total of 59 health administrators,CHC managers,and CHC doctors regarding elderly care.Results:The study found that accessibility of healthcare for elders has been improved due to the development of health insurance schemes as well as preferential policy to encourage the CHC utilization by the elderly.All the CHCs provide health examinations and chronic disease management to the permanent elderly within their catchment district.However,some preventative care such as fall prevention,immunization and mental health management are not provided.Conclusion:Key barriers include low capacity of health service providers in the CHCs,and a lack of government investment in CHCs.Our report provides an empirical evidence for the health care reform in China. | NAN YANG XIAOLIN WEI HAITAO LI ZHENZHEN ZHANG JAMIE RODAS SAMUEL YS WONG MARTIN CS WONG YANG GAO JIAJI WANG DONALD KT LI JINLING TANG SIAN GRIFFITHS | 2013 | Family Medicine and Community Health2013，1，1： | 5 |
| 20 | Black and green tea consumption and the risk of coronary artery disease, a meta-analysis显示文摘 | Wang ZM Zhou, B Wang, YS Gong, QY Wang, QM Yan, JJ Gao, W Wang, LS | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 5 |
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