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| 1 | Cardiac rehabilitation and exercise therapy in the elderly: Should we invest in the aged?显示文摘冠的心疾病(CHD ) 是世界范围的死亡的领先的原因并且在病人之中变得逐渐地流行 65 岁以上。老病人在为复杂并发症的更高的风险并且在一个心血管的事件以后加速物理 deconditioning,特别与他们的更年轻的对应物相比。最后几十年是到与 CHD 在病人之中在死亡,锻练能力,心理风险因素,发炎,和肥胖上表明了心脏的康复(CR ) 和锻练治疗的有益的效果的多重研究的厕所。不幸地,这个领域里的可得到的数据的重要部分与更年轻的病人相关。可行解释是更老的病人在为以病人开始并且延长到医生的多重原因的这些节目是非常未被充分代表的。在这篇文章,我们将考察 CR 节目的好处在之中老,以及一些妨碍他们的参予的障碍。 | Arthur R Menezes Carl J Lavie Richard V Milani Ross A Arena Timothy S Church | 2012 | Journal of Geriatric Cardiology2012，9，1： | 25 |
| 2 | 氧消耗和二氧化碳恢复期动力学对冠状动脉疾病严重性和结局的预测价值显示文摘血管重塑似乎只对高度缺血的患者有益。该研究调查了在心肺功能运动试验(eardiopulmonary exercisetest,CPET)恢复期中气体分析预测冠状动脉疾病(coronary artery disease,CAD)严重性和预后的价值。方法:研究者研究了40例白人患者(21.2%女性),平均年龄(63.5±7.6)岁,有显著冠状动脉损伤(≥50%)。 | 黄洁 叶鹏 Popovic D Martic D Djordjevic T Pesic V Guazzi M Myers J Mohebi R Arena R | 2017 | 中华高血压杂志2017，25，10： | 5 |
| 3 | Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis显示文摘BACKGROUND Anti-tumor necrosis factor α(TNFα) represents the best therapeutic option to induce mucosal healing and clinical remission in patients with moderate-severe ulcerative colitis. On the other side gut microbiota plays a crucial role in pathogenesis of ulcerative colitis but few information exists on how microbiota changes following anti-TNFα therapy and on microbiota role in mucosal healing.AIM To elucidate whether gut microbiota and immune system changes appear following anti TNFα therapy during dextran sulfate sodium(DSS) colitis.METHODS Eighty C57 BL/6 mice were divided into four groups: 'No DSS', 'No DSS + antiTNFα', 'DSS' and 'DSS + anti-TNFα'. 'DSS' and 'DSS + anti-TNFα' were treated for 5 d with 3% DSS. At day 3, mice whithin 'No DSS+anti-TNFα' and'DSS+anti-TNFα' group received 5 mg/kg of an anti-TNFα agent. Forty mice were sacrificed at day 5, forty at day 12, after one week of recovery post DSS. The severity of colitis was assessed by a clinical score(Disease Activity Index), colon length and histology. Bacteria such as Bacteroides, Clostridiaceae, Enterococcaceae and Fecalibacterium prausnitzii(F. prausnitzii) were evaluated by quantitative PCR.Type 1 helper T lymphocytes(Th1), type 17 helper T lymphocytes(Th17) and CD4+ regulatory T lymphocytes(Treg) distributions in the mesenteric lymph node(MLN) were studied by flow cytometry.RESULTS Bacteria associated with a healthy state(i.e., such as Bacteroides, Clostridiaceae and F. prausnitzii) decreased during colitis and increased in course of anti-TNFαtreatment. Conversely, microorganisms belonging to Enterococcaceae genera,which are linked to inflammatory processes, showed an opposite trend.Furthermore, in colitic mice treated with anti-TNFα microbial changes were associated with an initial increase(day 5 of the colitis) in Treg cells and a consequent decrease(day 12 post DSS) in Th1 and Th17 frequency cells. Healthy mice treated with anti-TNFα showed the same histological, microbial and immune features of untreated colitic mice. 'No DSS + anti-TNFα' group showed a lymphomononuclear infiltrate both at 5 th and 12 th d at hematoxylin and eosin staining, an increase of in Th1 and Th17 frequency at day 12, an increase of Enterococcaceae at day 5, a decrease of Bacteroides and Clostridiaceae at day 12.CONCLUSION Anti-TNFα treatment in experimental model of colitis improves disease activity but it is associated to an increase in Th17 pathway together with gut microbiota alteration. | Valentina Petito Cristina Graziani Loris R Lopetuso Marco Fossati Alessandra Battaglia Vincenzo Arena Domenico Scannone Gianluca Quaranta Andrea Quagliariello Federica Del Chierico Lorenza Putignani Luca Masucci Maurizio Sanguinetti Alessandro Sgambato Antonio Gasbarrini Franco Scaldaferri | 2019 | World Journal of Gastroenterology2019，25，12： | 2 |
| 4 | 心肺运动测试期间的血压反应峰值显示文摘该研究的目的是建立美国平板心肺运动测试中达最大运动量时的血压水平的规范标准。美国4家成熟的、具有完善质量控制的实验室提供了1986年9月1日至2015年2月1日期间的数据。研究人员开展FRIEND(fitness registry and the importance of exercise:a national database)研究,纳入健康、无心血管病的男性和女性总计2917个最大运动量(峰值呼吸交换率≥1.00)平板心肺运动试验的研究数据,计算每10年峰值收缩压和舒张压数据的百分比。 | 叶超毅 叶鹏 Sabbahi A Arena R Kaminsky LA Myers J Phillips SA | 2018 | 中华高血压杂志2018，26，1： | 1 |
| 5 | TiC-VC-Co: a study on its sintering and microstructure 显示文摘 | Sepulveda R Arenas F | 2001 | Refractory Metals & Hard Materials2001，19，： | 1 |
| 6 | Activity and resistance to leaching of Cu-based catalysts in the wet oxidation of phenol 显示文摘 | Arena F Giovenco R Torre T | 2003 | Appl Catal B2003，45，1： | 1 |
| 7 | The impact of pharmacotherapy on the cardiopulmonary exercise test response in patients with heart failure:a mini review显示文摘 | Guazzi M Arena R | 2009 | Curr Vasc Pharmacol2009，7，4： | 1 |
| 8 | Thyroid ma: prevalence, prognosis, and management 显示文摘 | Arena R Pedayatty SJ Saliby AH | 1999 | Endocr Pratt1999，5，3： | 1 |
| 9 | Comparison of ventilatory expired gas parameters used to predict hospitalization in patients with heart failure显示文摘 | Arena R Humphrey R | 2002 | Am Heart 12002，143，3： | 1 |
| 10 | Impact of exercise training on adverse event risk and quality of life in patients with heart failure 显示文摘 | CAHALIN L P ARENA R | 2012 | Phys Ther2012，92，11： | 1 |
| 11 | Exercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing显示文摘 | Chaudhry S Arena R Wasserman K | 2009 | Am J Cardiol2009，103，5： | 1 |
| 12 | The minute ventilation/ carbon dioxide production slope is prognostically superior to the oxygen uptake efficiency slope显示文摘 | Arena R Myers 1 Hsu L | 2007 | J Card Fail2007，13，6： | 1 |
| 13 | The Vila de Cruces Ophiolite:a remnant of the early Rheic Ocean in the Variscan suture of Galicia (Northwest Iberian Massif)显示文摘 | Arenas R Martínez Catalán J.R Sánchez Martínez S Fernández-Suárez J Andonaegui P Pearce J.A Coffu F | | 0，，： | 1 |
| 14 | Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific state- ment from the American Heart Association显示文摘 | Balady GJ Arena R Sietsema K | 2010 | Circulation2010，122，2： | 1 |
| 15 | Activity and resistance to leaching of Cu-based catalysts in the wet oxidation of phenol显示文摘 | Arena F Giovenco R Torte T | 2003 | Applied Catalysis B: Environmental2003，45，1： | 1 |
| 16 | Pulmonary hypertension with left-sided heart disease显示文摘 | Ouazzi M Arena R | 2010 | Nat RevCardiol2010，7，11： | 1 |
| 17 | Pulmonary hypertension with left-sided heartdisease显示文摘 | Guazzi M Arena R | 2010 | Nat Rev Cardiol2010，7，11： | 1 |
| 18 | Cardiopulmonary exercise testing in the clinical evaluation of patients with heart and lung disease显示文摘 | Arena R Sietsema KE | 2011 | Circulation2011，123，6： | 1 |
| 19 | Prognostic usefulness of the functional aerobic reserve in patients with heart failure显示文摘 | CHASE P ARENA R GUAZZI M | 2010 | Am Heart J2010，160，5： | 1 |
| 20 | Cardiopulmonary exercise testing in patients with pulmonary arterial hypertension:an evidencebased review显示文摘 | Arena R Lavie C J Milani RV | 2010 | J Heart Lung Transplant2010，29，2： | 1 |
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