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| 1 | NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS显示文摘AIM: To evaluate the efficacy and mechanism of action of NCB-02, a standardized Curcumin preparation, against 2, 4-dinitrochlorobenzene (DNCB)-induced ulcerative colitis in rats. METHODS: Ulcerative colitis was induced in male rats by sensitizing with topical application of DNCB in acetone for 14 d and intra-colonol challenge with DNCB on day 15. A separate group of animals with vehicle treatment in similar fashion served as control group. Colitis rats were divided into different groups and treated with NCB-02 at doses of 25, 50 and 100 mg/kg b.wt p.o. for 10 d. Sulfasalazine at a dose of 100 mg/kg b.wt for 10 d served as a reference group. On day 10 after respective assigned treatment, all the animals were euthanized and the length of the colon, weight of entire colon and distal 8 cm of the colon were recorded. The distal part of the colon was immediately observed under a stereomicroscope and the degree of damage was scored. Further distal 8 cm of the colon was subject to the determination of colonic myeloperoxidase (MPO), lipid peroxidation (LPO) and alkaline phosphatase (ALP) activities. A small piece of the sample from distal colon of each animal was fixed in 10% neutral buffered formalin and embedded in paraffin wax and sectioned for immunohistochemical examination of NFκ-B and iNOS expression. RESULTS: NCB-02 showed a dose dependent protection against DNCB-induced alteration in colon length and weight. NCB-02 treatment also showed a dose dependent protection against the elevated levels of MPO, LPO and ALP, induced by DNCB. NCB-02 demonstrated a significant effect at a dose of 100 mg/kg b.wt., which was almost equipotent to 100 mg/kg b.wt. of sulfasalazine. Treatment with sulfasalazine and curcuminat a dose of 100 mg/kg b.wt. inhibited the DNCB-induced overexpression of NFκ-B and iNOS in the colon. CONCLUSION: Curcumin treatment ameliorates colonic damage in DNCB-induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and downregulation of colonic NFκ-B and iNOS expression. | MV Venkataranganna Md Rafiq S Gopumadhavan Ghouse Peer UV Babu SK Mitra | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 2 | Application of Response Surface Methodolody to Prediction of Dilution in Plasma Transferred Arc Hardfacing of Stainless Steel on Carbon Steel显示文摘The application of response surface methodology was highlighted to predict and optimize the percentage of dilution of iron-based hardfaced surface produced by the PTA (plasma transferred arc welding) process.The experi- ments were conducted based on five-factor five-level central composite rotatable design with full replication technique and a mathematical model was developed using response surface methodology.Furthermore,the response surface methodology was also used to optimize the process parameters that yielded the lowest percentage of dilution. | V Balasubramanian A K Lakshminarayanan R Varahamoorthy S Babu | 2009 | Journal of Iron and Steel Research(International)2009，16，1： | 8 |
| 3 | 不同激光表面纹理对轴承材料AISI52100摩擦性能的影响显示文摘铬钢因具有高强度和耐磨性而用于轴承。然而,在实际使用中,因滑动摩擦导致的故障而使寿命缩短。为了提高AISI52100铬钢材料的耐久性,本文分析了激光表面纹理(LST)化的效果。利用圆盘摩擦,对不同形状,如椭圆和圆,与未纹理化处理试样的磨损行为进行了对比研究。用于磨损分析的润滑剂是SKFNLGI-3半固体锂基润滑脂。在10、30和50 N的不同载荷下,用750 r/min和1400 r/min 2种滑动速度进行滑动磨损分析。用扫描电子显微镜(SEM)对磨损形貌进行了分析。样品的粗糙度用白光干涉仪测量。与未纹理化处理试样相比,观察到不同形状如圆和椭圆对铬合金摩擦磨损性能的影响。由于磨损碎片和润滑剂被捕获,激光表面纹理显示椭圆的摩擦和磨损与圆形图案相比,明显减少。 | PAUL JOSHUA S DINESH BABU P | 2020 | Journal of Central South University2020，27，8： | 6 |
| 4 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 5 | Alkaline unfolding and saltinduced folding of bovine liver eatalase at high pH显示文摘 | Prajapati S Bhakuni V Babu K R | 1998 | Eur J Biochem1998，255，1： | 1 |
| 6 | Effect of thermal cycling on friction stir welds of 2195 aluminum alloy显示文摘 | S S Babu S A David E A Kenik | 2001 | Welding journal2001，80，3： | 1 |
| 7 | Development of macro-and mierostnictures of carbon-manganese low alloy steel welds: inclusion formation 显示文摘 | Babu S S David S A | 1995 | Mater Sci Technol1995，11，2： | 1 |
| 8 | Tumour reducing and anticarcino genic activity of Acanthus ilicifolius in mice显示文摘 | Babu B H Shylesh B S Padikkala J | 2002 | J Ethnopharmacol2002，79，1： | 1 |
| 9 | Immediate primary skin elosure in type - iii A and B open fractures : results after a minimum of five years 显示文摘 | Rajasekaran S Dheenadhayalan J Babu JN | 2009 | J Bone Joint Surg Br2009，91，： | 1 |
| 10 | A crit- ical study of selected classification algorithms for Liver Disease Diagnosis 显示文摘 | Bendi V R Pmsad Babu M S Venkateswarlu N B | 2011 | International Journal of Database Management Systems(UDMS)2011，3，2： | 1 |
| 11 | Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation显示文摘 | Bhardwaj S Roy H Babu M | 2011 | Atherosclerosis2011，219，1： | 1 |
| 12 | Modeling,simulation,and estimation of optimum parameters in pyrolysis of biomass显示文摘 | Babu B V Chaurasia A S | | 0，，13： | 1 |
| 13 | A review on nanomaterials for environmental remediation显示文摘 | Khin M.M Nair S Babu V.J | | 0，，8： | 1 |
| 14 | Serum albumin levels in ischemic stroke and its subtypes: correlation with Clinical outcome显示文摘 | Babu MS Kaul S Dadheech S | 2013 | Nutrition2013，29，87： | 1 |
| 15 | Integrating marker-assis- ted selection in crop breeding-prospects and challenges 显示文摘 | Babu R Nair S K Prasanna B M | 2004 | Cur- int Sci2004，87，： | 1 |
| 16 | Intensification of nicotinic acid separation using organophosphorous solvating extractants by reactive extraction 显示文摘 | KUMAR S WASEWAR K L BABU B V | 2008 | Chem Eng Technol2008，31，11： | 1 |
| 17 | Liquid-liquid extraction of brornelain and polyphenol oxidase using aqueous two-phase system显示文摘 | RAV1NDRA BABU B RASTOGI N K RAGHAVARAO K S M S | 2008 | Chemical Engineering and Processing2008，47，1： | 1 |
| 18 | Mechanism of the Transition From Kainite to Acicular Ferrite 显示文摘 | BABU S S BHADESHIA H D | 1991 | Materials Transaction JIM1991，32，2： | 1 |
| 19 | Parametric study of thermal and thermodynamic properties on pyrolysis of biomass in thermally thick regime 显示文摘 | Babu B V Chaurasia A S | 2004 | Energy Conversion and Management2004，45，1： | 1 |
| 20 | Induction of systemic resistance in rice against sheath blight disease by Pseudomonas fluorescens显示文摘 | Nandakumar R Babu S Viswanathan R et a1 | 2001 | Soil Biology and Biochemistry2001，33，45： | 1 |
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