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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 3 | MODELING OF RIVER MORPHOLOGIC CHANGES显示文摘MODELINGOFRIVERMORPHOLOGICCHANGESCharlesC.S.SONG;YifanZHENG;andChihTedYANG(Professor,St.AnthonyFallsHydraulicLaboratory,Depar... | Charles C. S. SONG Yifan ZHENG and Chih Ted YANG( , St. Anthony Falls Hydraulic Laboratory, Department of Civil Engineering, University of Minnesota, Minneapolis MN 55414, U. S. A.)( Bechtel Corporation, formerly Reseaxch Assistant, St. Anthony Falls H | 1995 | International Journal of Sediment Research1995，10，2： | 2 |
| 4 | 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis显示文摘 | Jacqueline E Tate Anthony H Burton Cynthia Boschi-Pinto A Duncan Steele Jazmin Duque Umesh D Parashar | 2012 | The Lancet Infectious Diseases2012，，2： | 2 |
| 5 | Levobupivacaine A Review of its pharmacology and use as a local Anaesthetic 显示文摘 | Rachel H Foster Anthony Markham | 2000 | Drugs2000，59，3： | 2 |
| 6 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，1： | 2 |
| 7 | Acute myeloid leukemia 显示文摘 | Francis J Keating A Anthony H | 2002 | Hematology2002，，： | 2 |
| 8 | 用PDE-5抑制剂治疗勃起功能障碍的男性患者中前列腺癌的发生率:回顾性研究显示文摘本研究比较了用PDE-5抑制剂治疗勃起功能障碍(ED)7年的男性患者和与这些患者年龄及各种风险因素相似的7年内不使用PDE一5抑制剂治疗ED的男性患者中前列腺癌发生率的情况。通过分析2000年到2006年的电子病例和数据库,以年龄在50至69岁,2000年前无前列腺癌病史的ED患者作为研究对象。这些患者被分为两组:2362名曾用PDE-5抑制剂治疗的男性和2612名不曾使用过该药物的男性。比较每组的人口数据。在研究期内:97名(4.1%)接受过PDE-5抑制剂治疗的ED患者被诊断出患了前列腺癌,在非PDE-5抑制剂治疗组中,258名(9.9%)被诊断出患了前列腺癌(P〈O.0001)。在非洲裔美国人中,接受PDE-5抑制剂治疗的比例比不用的比例高(10.5%VS.7.1%,P〈0.0001)。接受过PDE-5治疗的患者,其前列腺特异性抗原增高的比例比较低(10.0%vs.13.1%,P=0.0008),但良性前列腺增生的比例比较高(38.4%vs.35.1%,P=0.0149)。接受PDE-5抑制剂治疗ED的男性不易患前列腺癌(调整后的优势比为0.4,95%CI:0.3—0.5,P〈0.0001)。我们的研究数据表明:用PDE-5抑制剂治疗ED的男性倾向于不易患前列腺癌。还需要进行更多的研究。 | Anthony H Chavez K Scott Coffield M Hasan Rajab Chanhee Joe | 2013 | Asian Journal of Andrology2013，15，2： | 2 |
| 9 | Multivariable sliding-mode control for autonomous diving and steering of unmanned underwater vehicles显示文摘 | ANTHONY J H | 1993 | TEEE Journal of Oceanic Engineering1993，18，3： | 1 |
| 10 | Rate constrained coder control and comparison of video coding standards显示文摘 | WIEGAND T SCHWARZ H ANTHONY J | 2003 | IEEE Transaction on Circuits and Systems for Video Technology2003，13，7： | 1 |
| 11 | Powder inhaler delivery of an antitubercular drug显示文摘 | VASU V S ANTHONY J H | 2002 | AAPS Pharm Scitech2002，3，4： | 1 |
| 12 | Logistics Outsourcing by Manufacturers in China:A Survey of the Industry显示文摘 | Junjie Hong Anthony T H Chin Binglian Liu | 2004 | Transportation Journal2004，43，1： | 1 |
| 13 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 14 | Direct electron transfer of gluc - ose oxidase on carbon nanotubes 显示文摘 | Anthony Guiseppi - Elie Chenghong Lei Ray H Baugh man | 2002 | Nanotechnology2002，13，： | 1 |
| 15 | Electrospinning and dtabilization of gfully hydrolrzed poly(viny alcohol)fibers显示文摘 | YAO LI THOMAS W H ANTHONY G E | 2003 | Chem Mater2003，15，： | 1 |
| 16 | Perovskite anode electrocatalysts for direct methanol fuel cells显示文摘 | White J Sammells H Anthony F | 1993 | Electrochem Soc1993，140，8： | 1 |
| 17 | Carbon and water vapor exchange of an open-canopied ponderosa pine ecosystem显示文摘 | Anthoni P M Law B E Unsworth M H | 1999 | Agricultural and Forest Meteorology1999，95，3： | 1 |
| 18 | A duplex RT-PCR assay for detection of genome segment 7 (VP7 gene) from 24 BTV serotypes 显示文摘 | Anthony S Jones H Darpel K E | 2007 | J Virol Methods2007，141，： | 1 |
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