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| 1 | Epidemiology of electrical burns and its impact on quality of life-the developing world scenario显示文摘BACKGROUND Electrical burns are devastating injuries and can cause deep burns with significant morbidity and delayed sequelae.Epidemiological data regarding the etiology,socioeconomic differences and geographic variation are necessary to assess the disease burden and plan an effective preventive strategy.These severe injuries often lead to amputations and thus hamper quality of life in the long term AIM To identify the population at maximum risk of sustaining electrical burns.We also studied the impact of electrical burns on these patients in terms of quality of life as well as return to work.METHODS The study was conducted at a tertiary referral teaching hospital over a period of eighteen months.All patients with a history of sustaining electrical burns and satisfying the inclusion criteria were included in the study.All relevant epidemiological parameters and treatment details were recorded.The patients were subsequently followed up at 3 mo,6 mo and 9 mo.The standardized Brief Version of the Burn Specic Health Scale(BSHS-B)was adopted to assess quality of life.Statistical analysis was conducted using IBM SPSS statistics(version 22.0).A P value of<0.05 was considered statistically significant.RESULTS A total of 103 patients were included in the study.The mean age of the patients was 31.83 years(range 18-75 years).A significant majority(91.3%)of patients were male.The mean total body surface area(TBSA)in these patients was 21.1%.In most of the patients(67%),the injury was occupation-related.High voltage injuries were implicated in 72.8%of patients.Among the 75 high voltage burn patients,31(41%)required amputation.The mean number of surgeries the patients underwent in hospital was 2.03(range 1 to 4).The quality of life parameters amongst the patients sustaining high voltage electrical burns were poorer when compared to low voltage injuries at all follow-up intervals across nine domains.In eight of these domains,the difference was statistically significant.Similarly,the scores among the amputees were poorer when compared to non-amputees.The difference was statistically significant in six domains.CONCLUSION Electrical burns remain a problem in the developing world.Most injuries are occupation-related.The quality of life in patients with high voltage burns and amputees remains poor.Work resumption was almost impossible for amputees.These patients could not regain pre-injury status.Steps should be taken to create awareness and to implement an effective preventive strategy to safeguard against electrical injuries. | Giriraj Gandhi Atul Parashar Ramesh K Sharma | 2022 | World Journal of Critical Care Medicine2022，11，1： | 3 |
| 2 | Clinicopathological spectrum of snake bite-induced acute kidney injury from India显示文摘AIM To study the clinico-pathological spectrum of snake bite-induced acute kidney injury(AKI).METHODS A retrospective study of patients admitted at Indira Gandhi Medical College Hospital,Shimla with snake bite-induced AKI from July 2003 to June 2016.Medical records were evaluated for patient's information on demographic,clinical characteristics,complications and outcome.Outcomes of duration of hospital stay,requirement for intensive care unit support,treatment with dialysis,survival and mortality were analyzed.The survival and non survival groups were compared to see the difference in the demographic factors,clinical characteristics,laboratory results,and complications.In patients subjected to kidney biopsy,the findings of histopathological examination of the kidney biopsies were also analyzed.RESULTS One hundred and twenty-one patients were diagnosed with snake bite-induced AKI.Mean age was 42.2 ± 15.1 years and majority(58%) were women.Clinical details were available in 88 patients.The mean duration of arrival at hospital was 3.4 ± 3.7 d with a range of 1 to30 d.Eighty percent had oliguria and 55% had history of having passed red or brown colored urine.Coagulation defect was seen in 89% patients.The hematological and biochemical laboratory abnormalities were:Anemia(80.7%),leukocytosis(75%),thrombocytopenia(47.7%),hyperkalemia(25%),severe metabolic acidosis(39.8%),hepatic dysfunction(40.9%),hemolysis(85.2%) and rhabdomyolysis(68.2%).Main complications were:Gastrointestinal bleed(12.5%),seizure/encephalopathy(10.2%),hypertension,pneumonia/acute respiratory distress syndrome(ARDS) and disseminated intravascular coagulation(9.1% each),hypotension and multi organ failure(MOF)(4.5% each).Eighty-two percent patients required renal replacement therapy.One hundred and ten(90.9%) patient survived and 11(9.1%) patients died.As compared to the survival group,the white blood cell count(P = 0.023) and bilirubin levels(P = 0.006) were significant higher and albumin levels were significantly lower(0.005) in patients who died.The proportion of patients with pneumonia/ARDS(P = 0.001),seizure/encephalopathy(P = 0.005),MOF(P = 0.05) and need for intensive care unit support(0.001) was significantly higher and duration of hospital stay was significantly shorter(P = 0.012) in patients who died.Kidney biopsy was done in total of 22 patients.Predominant lesion on kidney biopsy was acute tubular necrosis(ATN) in 20(91%) cases.In 11 cases had severe ATN and in other nine(41%) cases kidney biopsy showed features of ATN associated with mild to moderate acute interstitial nephritis(AIN).One patient only had moderate AIN and one had patchy renal cortical necrosis(RCN).CONCLUSION AKI due to snake bite is severe and a high proportion requires renal replacement therapy.On renal histology ATN and AIN are common,RCN is rare. | Sanjay Vikrant Ajay Jaryal Anupam Parashar | 2017 | World Journal of Nephrology2017，6，3： | 2 |
| 3 | Ultrasound elastography as an adjuvant to conventional ultrasound in the preoperative assessment of axillary lymph nodes in suspected breast cancer: A pilot study显示文摘 | K. Taylor S. O’Keeffe P.D. Britton M.G. Wallis G.M. Treece J. Housden D. Parashar S. Bond R. Sinnatamby | 2011 | Clinical Radiology2011，，11： | 2 |
| 4 | Cloud federation in a layered service model显示文摘 | David Villegas Norman Bobroff Ivan Rodero Javier Delgado Yanbin Liu Aditya Devarakonda Liana Fong S. Masoud Sadjadi Manish Parashar | 2012 | Journal of Computer and System Sciences2012，，5： | 2 |
| 5 | 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis显示文摘 | Jacqueline E Tate Anthony H Burton Cynthia Boschi-Pinto A Duncan Steele Jazmin Duque Umesh D Parashar | 2012 | The Lancet Infectious Diseases2012，，2： | 2 |
| 6 | Electrical properties of bulk and nano Li_(2)TiO_(3) ceramics:A comparative study显示文摘Nanocrystalline and bulk Li_(2)TiO_(3) having monoclinic structure were prepared by mechanical alloying as well as conventional ceramic route.Complex impedance analysis in the frequency range of 100 Hz-1 MHz over a wide range of temperature(50-500℃)indicates the presence of grain boundary effect along with the bulk contribution.The frequency-dependent conductivity plots exhibit power law dependence,suggesting three types of conduction in the material:low-frequency(100 Hz-1 kHz)conductivity showing long-range translational motion of electrons(frequency independent),mid-frequency(1-10 kHz)conductivity showing short-range hopping of charge carriers and high-frequency(10 kHz-1 MHz)conductivity showing conduction due to localized orientation of hopping mechanism.The electrical conductivity measurement of nanocrystalline and bulk Li_(2)TiO_(3) with temperature shows the negative temperature coefficient of resistance(NTCR)behavior.The activation energy(0.77 eV for nano sample and 0.88 eV for bulk sample)study shows the conduction mechanism in both samples.The low activation energies of the samples suggest the presence of singly ionized oxygen vacancies in the conduction process. | Umasankar DASH Subhanarayan SAHOO Paritosh CHAUDHURI S.K.S.PARASHAR Kajal PARASHAR | 2014 | Journal of Advanced Ceramics2014，3，2： | 2 |
| 7 | Early debridement and delayed primary vascularized cover in forearm electrical burns: A prospective study显示文摘AIM To look into the management options of early debridement of the wound, followed by vascularized cover to bring in fresh blood supply to remaining tissue in electrical burns. METHODS A total of 16 consecutive patients sustaining full thickness forearm burns over a period of one year were included in the study group. Debridement was undertaken within 48 h in 13 patients. Three patients were taken for debridement after 48 h. Debridement was repeated within 2-4 d after daily wound assessment and need for further debridement. RESULTS On an average two debridements(range 1-4) was required in our patients for the wound to be ready for definitive cover. Interval between each debridement ranged from 2-18 d. Fourteen patients were provided vascularized cover after final debridement(6 free flaps, 8 pedicled flaps). Functional assessment of gross hand function done at 6 wk, 2 mo, 3 mo and 6 mo follow-up. CONCLUSION High-tension electrical burns lead to significant morbi-dity. These injuries are best managed by early decompression followed by multiple serial debridements. The ideal timing of free flap coverage needs further investigation. | Aniruddh Mene Gautam Biswas Atul Parashar Anish Bhattacharya | 2016 | World Journal of Critical Care Medicine2016，5，4： | 2 |
| 8 | 抑郁治疗和急性心肌梗死后1年死亡率的相关性:TRIUMPH注册研究显示文摘在急性心肌梗死(acute myocardial infarction,AMI)患者中,抑郁症是很普遍的,并且与不良的生活质量和预后相关。尽管一些国家组织提出了筛选抑郁症的建议,但尚不清楚AMI患者的抗抑郁治疗是否与更好的预后相关。该研究的目的是确定接受抗抑郁治疗是否对患者的预后有影响。方法: | 刘莉 叶鹏 Smolderen KG Buchanan DM Gosch K Whooley MA Chan PS Vaccarino V Parashar S Shah AJ Ho PM Spertus JA | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 9 | 显示文摘 | Parashar S Raju A R Rao C N R | 2003 | J Phys D: Appl Phys2003，36，17： | 1 |
| 10 | Rotavirus epidemiology:the asian rotavirus surveillance network显示文摘 | Nelson EA Bresee JS Parashar UD | 2008 | Vaccine2008，26，26： | 1 |
| 11 | Global illness and deaths caused by rotavirus disease in children显示文摘 | Parashar U D Hummelman E G Bresee J S | 2003 | Emerg Infect Dis2003，9，5： | 1 |
| 12 | Liver irradiation: a potential pre-paration regimen for hepatocyte transplantation显示文摘 | Guha C Parashar B Deb N J | 2001 | Int J Radiation Oncol Biol Phys2001，49，： | 1 |
| 13 | Global illness and deaths caused by rotavirus disease in children 显示文摘 | Parashar UD Hummelman EG Bresee JS | 2003 | Emerg Infect Dis2003，9，5： | 1 |
| 14 | Ethyl Silicate Binders for High Performance Coatings 显示文摘 | Geeta Parashar Deepak Srivastava Pramod Kumara | 2001 | Progress in Organic Coatings2001，，42： | 1 |
| 15 | Gastroenteritis hospitalizations in older children and adults in the United States before and after implementation of infant rotavirus vaccination显示文摘 | Gastanaduy PA Curns AT Parashar UD | 2013 | JAMA2013，310，8： | 1 |
| 16 | Rotavirus and severe child- hood diarrhea 显示文摘 | Parashar UD Gibson C J Bresee js | 2006 | Emerg Infect Dis2006，12，： | 1 |
| 17 | Rotavirus and severe childhood diarrhea 显示文摘 | Parashar UD Gibson CJ Bresee JS | 2006 | Emerg Infect Dis2006，12，2： | 1 |
| 18 | Value of post-licensure data on benefits and risks of vaccination to inform vaccine policy: The example of rotavirus vaccines显示文摘 | Umesh D Parashar Margaret M Cortese Daniel C Payne Benjamin Lopman Catherine Yen Jacqueline E Tate | 2015 | Vaccine2015，，： | 1 |
| 19 | Global illness and deaths caused by rotavirus disease in children 显示文摘 | Parashar UD Hummelman EG Bresee JS | 2003 | Emerg Infect Dis2003，9，： | 1 |
| 20 | Global mortality associated with rotavirus disease among children in 2004 显示文摘 | Parashar UD Burton A Lanata C | 2009 | Journal of Infec- tious Diseases2009，200，： | 1 |
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