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| 1 | Cardiovascular autonomic neuropathy in diabetes:Pathophysiology,clinical assessment and implications显示文摘Cardiovascular autonomic neuropathy(CAN)is a debilitating condition that mainly occurs in long-standing type 2 diabetes patients but can manifest earlier,even before diabetes is diagnosed.CAN is a microvascular complication that results from lesions of the sympathetic and parasympathetic nerve fibers,which innervate the heart and blood vessels and promote alterations in cardiovascular autonomic control.The entire mechanism is still not elucidated,but several aspects of the pathophysiology of CAN have already been described,such as the production of advanced glycation end products,reactive oxygen species,nuclear factor kappa B,and pro-inflammatory cytokines.This microvascular complication is an important risk factor for silent myocardial ischemia,chronic kidney disease,myocardial dysfunction,major cardiovascular events,cardiac arrhythmias,and sudden death.It has also been suggested that,compared to other traditional cardiovascular risk factors,CAN progression may have a greater impact on cardiovascular disease development.However,CAN might be subclinical for several years,and a late diagnosis increases the mortality risk.The duration of the transition period from the subclinical to clinical stage remains unknown,but the progression of CAN is associated with a poor prognosis.Several tests can be used for CAN diagnosis,such as heart rate variability(HRV),cardiovascular autonomic reflex tests,and myocardial scintigraphy.Currently,it has already been described that CAN could be detected even during the subclinical stage through a reduction in HRV,which is a non-invasive test with a lower operating cost.Therefore,considering that diabetes mellitus is a global epidemic and that diabetic neuropathy is the most common chronic complication of diabetes,the early identification and treatment of CAN could be a key point to mitigate the morbidity and mortality associated with this long-lasting condition. | Alice Duque Mauro Felippe Felix Mediano Andrea De Lorenzo Luiz Fernando Rodrigues Jr | 2021 | World Journal of Diabetes2021，12，6： | 14 |
| 2 | Heart failure with preserved ejection fraction in the elderly: pathophysiology, diagnostic and therapeutic approach显示文摘Heart failure with preserved ejection fraction(HFpEF)is a clinical syndrome characterized by symptoms and sings of heart failure with elevated left ventricular filling pressures at rest or during exercise.It is the most common type of heart failure in the elderly and its prevalence increases with age and is higher in females at any given age.HFpEF is frequently accompanied of comorbid conditions such as diabetes mellitus,obesity,atrial fibrillation and renal dysfunction.The diagnosis relies in the integration of clinical information,laboratory data and interpretation of cardiac imaging and hemodynamic findings at rest and during exercise.Conditions that have a specific treatment such as coronary artery disease,valvular disease,cardiac amyloidosis and constrictive pericarditis should be considered and evaluated as appropriate.Aggressive management of comorbidities,optimization of blood pressure control and volume status using diuretics as needed are among the current treatment recommendations.There are no specific therapies that have shown to decrease mortality in HFpEF.In symptomatic patients with history of hospital admission for decompensated heart failure,the implantation of a wireless pulmonary artery pressure monitor should be considered.Finally,given the high mortality of this condition,goals of care discussion should be initiated early and involvement of palliative care medicine should be considered. | Ernesto Ruiz Duque Alexandros Briasoulis Paulino A Alvarez | 2019 | Journal of Geriatric Cardiology2019，16，5： | 13 |
| 3 | 由牙周探诊深度和探诊出血来看种植体周围炎的患病率:系统综述和Meta分析显示文摘目的:根据疾病定义和临界值.通过对亚组的meta分析和敏感度分析,比较分析患者水平和种植体水平种植体周围炎患病率的变化。牙周探诊深度(PPD)和探诊出血(BOP)是主要变量。材料和方法:对负重超过6个月的种植体的描述性研究进行电子和手动检索并评估研究质量。对可用研究进行描述性分析(定性分析)和meta分析(定量分析)。结果:该系统评价纳入55项研究.其中32项符合基于PPD和BOP指标评估该疾病的标准。共评估了2734名患者和7849颗种植体。当以患者水平为单位分析,PPD和BOP定义的种植体周围炎的患病率为17%,当以种植体水平为单位分析时.患病率为11%。如果临床标准为PPD≥4mm,则患者水平患病率为34%,种植体水平患病率为11%。如果PPD≥5ram,则患者水平的患病率为12%,种植体水平的患病率为10%。最后.如果临床标准为PPD≥6mm,则患者水平的患病率为18%.种植体水平的患病率为10%。结论:种植体周围炎的患病率受该疾病定义所用标准的影响,目前真实的患病率可能被误估。 | Viviana Munoz Giraldo Andres Duque Astrid Giraldo Aristizabal Ruben Dario Martrique Heenande 张瑞娟(译) 张珊珊(审) 郑树国(审) | 2018 | 中国口腔医学继续教育杂志2018，21，6： | 8 |
| 4 | More Transporters,More Substrates:The Arabidopsis Major Facilitator Superfamily Revisited显示文摘The Major Facilitator Superfamily(MFS)is ubiquitous in living organisms and represents the largest group of secondary active membrane transporters.In plants,significant research efforts have focused on the role of specific families within the MFS,particularly those transporting macronutrients(C,N,and P)that constitute the vast majority of the members of this superfamily.Other MFS families remain less explored,although a plethora of additional substrates and physiological functions have been uncovered.Nevertheless,the lack of a systematic approach to analyzing the MFS as a whole has obscured the high diversity and versatility of these transporters.Here,we present a phylogenetic analysis of all annotated MFS domaincontaining proteins encoded in the Arab/dops/s fA?a//ana genome and propose that this superfamily of transporters consists of 218 members,clustered in 22 families.In reviewing the available information regarding the diversity in biological functions and substrates of Arab/dops/s MFS members,we provide arguments for intensified research on these membrane transporters to unveil the breadth of their physiological relevance,disclose the molecular mechanisms underlying their mode of action,and explore their biotechnological potential. | Maria Nino-Gonzalez Esther Novo-Uzal Dale N.Richardson Pedro M.Barros Paula Duque | 2019 | Molecular Plant2019，12，9： | 5 |
| 5 | 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis显示文摘 | Jacqueline E Tate Anthony H Burton Cynthia Boschi-Pinto A Duncan Steele Jazmin Duque Umesh D Parashar | 2012 | The Lancet Infectious Diseases2012，，2： | 2 |
| 6 | A model for calculation of steam injector performance 显示文摘 | Deberne N Leone J F Duque A | 1999 | International J of Multiphase Flow1999，25，1： | 2 |
| 7 | 轨枕间距对钢轨波磨的影响显示文摘主要研究轨枕间距对钢轨波磨发展的影响。研究小半径曲线内轨的小矢跨比波磨。这些出现问题的曲线段属于西班牙毕尔巴鄂区域的地铁轨道,铺设着混凝土道床和两层STEDEF型支承垫层。当初始轨枕间距为1000mm时,仅有92万组轮对通过后所测得的波磨深度峰-峰值已经达到0.42mm。随后更换产生波磨的钢轨,比较列车通过时轨枕上方和轨间中部的内轨垂向、横向加速度。当轨枕间距为1000mm时,轨间中部出现频率为204和244Hz的强烈响应,在轨枕上方却未出现。在相邻轨枕中间铺设一个轨枕,使轨枕间距变为500mm,钢轨波磨停止发展。该结论是根据2年的观测结果得到的。 | Ernesto García Vadillo José A.Tárrago Gorka Garate Zubiaurre Carlos Angulo Duque 孙晓静 聂志理 | 2010 | 都市快轨交通2010，23，2： | 2 |
| 8 | A procedure to assess the spatial variability in the importance of abiotic factors affecting distributions: the case of world freshwater fishes显示文摘 | Ana M. MANJARRES-HERNANDEZ Castor GUISANDE Emilio GARCiA-ROSELLO Patricia PELAYO-VILLAMIL Jacinto GONZALEZ-DAcOSTA Juirgen HEINE Luis GONZALEZ VILAS Carlos GRANADO-LORENClO Santiago R. DUQUE Jorge M. LOBO | 2018 | Current Zoology2018，64，5： | 2 |
| 9 | Prevention and treatment of senile osteoporosis and hip fractures 显示文摘 | Duque G Demontiero O Troen BR | 2009 | Minerva Med2009，100，1： | 1 |
| 10 | Interactions of foot-and-mouth disease virus with soluble bovine ανβ3 and ανβ6 integrins显示文摘 | DUQUE H LAROCCO M WILLIAM T | 2004 | J Virol2004，78，18： | 1 |
| 11 | Age-related bone loss: Old bone, new facts 显示文摘 | Chan GK Duque G | 2002 | Gerontology2002，48，2： | 1 |
| 12 | Double attention bias for positive and emotional faces in clinical depression:Evidence from an eye-tracking study显示文摘 | Almudena Duque Carmelo Vazquez | 2015 | Journal of Behavior Therapy and Experimental Psychiatry2015，46，： | 1 |
| 13 | 2-Fluorophenol degradation by aerobic granular sludge in a sequencing batch reactor显示文摘 | Duque A F Bessa V S Carvalho M F | 2011 | Water Research2011，45，20： | 1 |
| 14 | Influence of interhemispheric interactions on motor function in chronic stroke显示文摘 | Murase N Duque J Mazzocchio R | 2004 | Ann Neurol2004，55，： | 1 |
| 15 | AFLP analysis of gene pools of wild bean core collection显示文摘 | TOHME J GONZALEZ D O BEEBE S DUQUE M C | 1996 | Crop Sciences1996，36，： | 1 |
| 16 | Report on the second Latin American consensus conference for flow cytometric immunophenotyping of hematological malignancies显示文摘 | Ruiz-Arguelles A Rivadeneyra-Espinoza L Duque RE | | 0，，： | 1 |
| 17 | High-resolution distribu- ted temperature sensing to detect seasonal groundwater discharge into Lake Vaeng,Denmark显示文摘 | Sebok E Duque C Kazmierczak J | 2013 | Water Resources Research2013，49，6： | 1 |
| 18 | Expression and function of the nuclear factor of activated T cells in colon carcinoma cells : involvemerit in the regulation of cyclooxygenasc-2 显示文摘 | Duque J Fresno M lniguez MA | 2005 | J Biol Chem2005，280，10： | 1 |
| 19 | Validation and comparison of advanced differential interferometry techniques: murcia metropolitan area case study显示文摘 | HERRERA G TOMAS R LOPEZ-SANCHEZ J M DELGADO J VICENTE F MULAS J COOKSLEY G SANCHEZ M DURO J ARNAUD A BLANCO P DUQUE S MALLORQUI J J DE la VEGA-PANIZO R MONSERRAT O | 2008 | ISPRS Journal of Photogrammetry and Remote Sensing2008，，： | 1 |
| 20 | Interaction of IgA with Fca receptors of human mesangial cells activates transcription factor nuclear factor-kB and induces expression and synthesis of monocyte chemoattractant protein-1, IL-8, and IFN-inducible protein 10 显示文摘 | Duque N Go' mez-Guerro C Egido J | 1997 | J Immunol1997，159，7： | 1 |
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