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| 1 | Use of rifaximin in gastrointestinal and liver diseases显示文摘Rifaximin is a broad spectrum oral antibiotic with antimicrobial activity against Gram-positive and Gramnegative aerobic and anaerobic bacteria. It is poorly absorbed and thus has a highly favorable safety profile. Rifaximin has been shown to be effective in the treatment of traveler's diarrhea, functional bloating and irritable bowel syndrome, small bowel bacterial overgrowth and in the prevention of recurrent overt hepatic encephalopathy. In addition, there is emerging evidence for a possible beneficial effect of rifaximin in the treatment of uncomplicated diverticular disease and in the prevention of recurrent diverticulitis. The use of rifaximin is associated with a low incidence of development, or persistence of spontaneous bacterial mutants. Moreover, the development of important drug resistance among extra-intestinal flora during rifaximin therapy is unlikely because of minimal systemic absorption and limited cross-resistance of rifaximin with other antimicrobials. This review addresses the current and emerging role of rifaximin in the treatment of gastrointestinal and liver disorders. | Rani H Shayto Rachel Abou Mrad Ala I Sharara | 2016 | World Journal of Gastroenterology2016，22，29： | 10 |
| 2 | Tissue differential expression of lycopene β-cyclase gene in papaya显示文摘Carotene pigments in flowers and fruits are distinct features related to fitness advantages such as attracting insects forpollination and birds for seed dispersal.In papaya,the flesh color of the fruit is considered a quality trait that correlateswith nutritional value and is linked to shelf-life of the fruit.To elucidate the carotenoid biosynthesis pathway in papaya,we took a candidate gene approach to clone the lycopene β-cyclase gene,LCY-B.A papaya LCY-B ortholog,cpLCY-B,was successfully identified from both cDNA and bacterial artificial chromosome(BAC)libraries and complete genomicsequence was obtained from the positive BAC including the promoter region.This cpLCY-B shared 80% amino acididentity with citrus LCY-B.However,full genomic sequences from both yellow- and red-fleshed papaya were identical.Quantitative real-time PCR(qPCR)revealed similar levels of expression at six different maturing stages of fruits forboth yellow-and red-fleshed genotypes.Further expression analyses of cpLCY-B showed that its expression levels wereseven- and three-fold higher in leaves and,respectively,flowers than in fruits,suggesting that cpLCY-B is down-regulatedduring the fruit ripening process. | Rachel L Skelton Qingyi Yu Rajeswari Srinivasan Richard Manshardt Paul H Moore Ray Ming | 2006 | Cell Research2006，16，8： | 8 |
| 3 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 4 | Liver disease in pregnancy显示文摘 | Deepak Joshi Andra James Alberto Quaglia Rachel H Westbrook Michael A Heneghan | 2010 | The Lancet2010，，9714： | 2 |
| 5 | Levobupivacaine A Review of its pharmacology and use as a local Anaesthetic 显示文摘 | Rachel H Foster Anthony Markham | 2000 | Drugs2000，59，3： | 2 |
| 6 | Stock optionsand managerial incentives for risk taking: Evidencefrom FAS 123R显示文摘 | RACHEL M H | 2012 | Journal of Financial Economics2012，105，1： | 1 |
| 7 | Exercise Training in Patients With Severe Congestive Heart Failure: Enhancing Peak Aerobic Capacity While Minimizing the Increase in Ventricular Wall Stress显示文摘 | Laura Demopoulos Rachel Bijou Icilma Fergus Margaret Jones Joel Strom Thierry H LeJemtel | 1997 | Journal of the American College of Cardiology1997，，3： | 1 |
| 8 | Viruses and thyroidi- tis: an update显示文摘 | Rachel D Didier H | 2009 | Virology Journal2009，6，5： | 1 |
| 9 | A study of amber and copal samples using FT-Ramanspeetroscopy显示文摘 | Rachel H Brody Howell G M Edwards | 2001 | Spectrochimica Acta Part A2001，，57： | 1 |
| 10 | Emission analysis of alternative diesel fuels using a compression ignition benchtop engine generator显示文摘 | GREGORY S B RACHEL L M MICHAEL P H | 2011 | Energy & Fuels2011，25，： | 1 |
| 11 | How much are differences in managerial ability worth显示文摘 | Rachel M H Scott S | 1999 | Journal of Accounting and Economics1999，27，： | 1 |
| 12 | A known SOST gene mutation causes sclerosteosis in a familial and an iso- lated case from Brazilian origin 显示文摘 | Chong AK Rachel H Debora B | 2008 | Gentic Tes2008，，： | 1 |
| 13 | A new phylum ofar- chaea represented by a nanosized hyperthermophilic sym- biont显示文摘 | Huber H Hohn M J Rachel R | 2002 | Nature2002，417，6884： | 1 |
| 14 | Levobupivacaine A Review of its pharmacology and use as a local anaesthetic 显示文摘 | Rachel H Foster Anthony Markham | 2000 | Drugs2000，59，3： | 1 |
| 15 | Telomere shortening in atherosclerosis显示文摘 | Nilesh J Samani Rachel Boultby Robert Butler John R Thompson Alison H Goodall | 2001 | The Lancet2001，，9280： | 1 |
| 16 | Antisense inhibition of the NR Gene restores norml ripening to the tomato Never- ripe mutant consistent with the ethylene receptor- inhibition model 显示文摘 | Rachel M H Chin - Wen Ho Zhefeng L | 2000 | Plant Physiol2000，，10： | 1 |
| 17 | On the Issue of Functional Form Choice in Hedonic Price Functions:Further Evidence显示文摘 | Rachel A B Bruce E H | 1997 | Environmental Management1997，21，5： | 1 |
| 18 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate 显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 19 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 20 | Control of pollen tube tip growth by a Rop GTPase dependent pathway that leads to tip localized calcium influx显示文摘 | Hal L Yakang L Rachel H Michael Z | 1999 | Plant Cell1999，11，： | 1 |
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