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| 1 | Liver Transplantation Criteria For Hepatocellular Carcinoma Should Be Expanded: A 22-Year Experience With 467 Patients at UCLA显示文摘 | John P. Duffy Andrew Vardanian Elizabeth Benjamin Melissa Watson Douglas G. Farmer Rafik M. Ghobrial Gerald Lipshutz Hasan Yersiz David S. K. Lu Charles Lassman Myron J. Tong Jonathan R. Hiatt Ronald W. Busuttil | 2007 | Annals of Surgery2007，，3： | 3 |
| 2 | Vascular Complications of Orthotopic Liver Transplantation: Experience in More than 4,200 Patients显示文摘 | John P. Duffy Johnny C. Hong Douglas G. Farmer Rafik M. Ghobrial Hasan Yersiz Jonathan R. Hiatt Ronald W. Busuttil | 2009 | Journal of the American College of Surgeons2009，，5： | 3 |
| 3 | Correlation between rpoB gene mutation in Mycobacterium avium subspecies paratuberculosis and clinical rifabutin and rifampicin resistance for treatment of Crohn’s disease显示文摘AIM: To investigate overlapping regions of the rpoB gene previously involved with rifamycin resistance in M. tuberculosis and seek correlation between rpoB mutations in clinical MAP strains with susceptibility to RIF and RFB. METHODS: We designed a molecular-based PCR method for the evaluation of rifabutin (RFB) and rifampicin (RIF) resistance based on probable determinant regions within the rpoB gene of MAP, including the 81 bp variable site located between nucleotides 1363 and 1443. The minimum inhibitory concentration (MIC) for RIF was also determined against 11 MAP isolates in attempt to seek correlation with rpoB sequences. RESULTS: We determined that MAP strain 18 had an MIC of > 30 mg/L and ≤ 5 mg/L for RIF and RFB respectively, and a significant and novel rpoB mutation C1367T, compared to an MIC of ≤ 1.0 mg/L for both drugs in the wild type MAP. The 30-fold increase in the MIC was a direct result of the rpoB mutation C1367T, which caused an amino acid change Thr456 to Ile456 in the drug’s binding site. In addition, MAP strain 185 contained five silent rpoB mutations and exhibited an MIC comparable to the wild-type. Moreover, our in vitroselected mutation in MAP strain UCF5 resulted in the generation of a new resistant strain (UCF5-RIF16r) that possessed T1442C rpoB mutation and an MIC > 30 mg/L and > 10 mg/L for RIF and RFB respectively. Sequencing of the entire rpoB gene in MAP strains UCF4, 18, and UCF5-RIF16r revealed an rpoB mutation A2284C further downstream of the 81 bp variable region in UCF4, accounting for observed slight increase in MIC. In addition, no other significant mutations were found in strains 18 and UCF-RIF16r. CONCLUSION: The data clearly illustrates that clinical and in vitro-selected MAP mutants with rpoB mutations result in resistance to RIF and RFB, and that a single amino acid change in the beta subunit may have a significant impact on RIF resistance. Unconventional drug susceptibility testing such as our molecular approach will be beneficial for evaluation of antibiotic effectiveness. This molecular approach may also serve as a model for other drugs used for treatment of MAP infections. | Daniel R Beckler Sammer Elwasila George Ghobrial John F Valentine Saleh A Naser | 2008 | World Journal of Gastroenterology2008，14，17： | 2 |
| 4 | Pretransplant Model to Predict Posttransplant Survival in Liver Transplant Patients显示文摘 | Rafik M. Ghobrial Jeffery Gornbein Randy Steadman Natale Danino James F. Markmann Curtis Holt Dean Anselmo Farin Amersi Pauline Chen Douglas G. Farmer Steve Han Francisco Derazo Sammy Saab Leonard I. Goldstein Sue V. McDiarmid Ronald W. Busuttil | 2002 | Annals of Surgery2002，，3： | 2 |
| 5 | Hepatocellular carcinoma screening in patients waiting for liver transplantation: A decision analytic model显示文摘 | Sammy Saab David Ly Jose Nieto Fasiha Kanwal David Lu Steven Raman Rafael Amado Barbara Nuesse Francisco Durazo Steven Han Douglas G. Farmer Rafik M. Ghobrial Hasan Yersiz Pauline Chen Kathy Schwegel Leonard I. Goldstein Myron Tong Ronald W. Busuttil | 2003 | Liver Transplantation2003，，7： | 2 |
| 6 | Histopathological changes in the oesophageal mucosa in Egyptian children with corrosive strictures: A single-centre vast experience显示文摘BACKGROUND The caustic ingestion continues to be a major problem worldwide especially in developing countries. The long-term complications include stricture and increased life time risk of oesophageal carcinoma. Patients suffered from corrosive induced oesophageal strictures have more than a 1000-fold risk of developing carcinoma of the oesophagus.AIM To determine the possibility of oesophageal mucosal dysplasia after prolonged dilatation in post corrosive stricture.METHODS This observational study was conducted at the Paediatric Endoscopy Unit in Cairo University Children's Hospital. It included children of both sexes older than 2 years of age who had an established diagnosis of post-corrosive oesophageal stricture and repeated endoscopic dilatation sessions for more than 6 mo. All patients were biopsied at the stricture site after 6 mo of endoscopic dilatation. A histopathological examination of an oesophageal mucosal biopsy was performed for the detection of chronic oesophagitis, inflammatory cellular infiltration and dysplasia.RESULTS The mean age of the enrolled children was 5.9 ± 2.6 years; 90% of the patients had ingested an alkaline corrosive substance(potash). The total number of endoscopic dilatation sessions were ranging from 16 to 100 with mean number of sessionswas 37.2 ± 14.9. Histopathological examination of the specimens showed that 85%of patients had evidence of chronic oesophagitis(group A) in the form of basal cell hyperplasia, hyperkeratosis and subepithelial fibrosis. Thirteen percent of the patients had evidence of reactive atypia(group B) in the form of severe neutrophilic intraepithelial inflammatory cellular infiltration, and 2 patients(2%)had mild squamous dysplasia(group C); we rebiopsied these two patients 6 mo after the initial pathological assessment, guided by chromoendoscopy by Lugol's iodine.CONCLUSION The histopathology of oesophageal mucosal biopsies in post-corrosive patients demonstrates evidence of chronic oesophagitis, intraepithelial inflammatory cellular infiltration and dysplasia. Dysplasia is one of the complications of postcorrosive oesophageal stricture. | Ayman EskANDer Carolyne Ghobrial Nabil A Mohsen Bahaa Mounir Dalia Abd EL-Kareem Sara Tarek Mortada HF El-Shabrawi | 2019 | World Journal of Gastroenterology2019，25，7： | 2 |
| 7 | A model to predict the development of mental status changes of unclear cause after liver transplantation显示文摘 | Fasiha Kanwal David Chen Lena Ting Jeffrey Gornbein Sammy Saab Francisco Durazo Hasan Yersiz Douglas Farmer R. Mark Ghobrial Ronald W. Busuttil Steven-Huy Han | 2003 | Liver Transplantation2003，，12： | 2 |
| 8 | Predictors of survival after liver transplantation for hepatocellular carcinoma associated with hepatitis C显示文摘 | Shimoda M Ghobrial R Carmody I | 2004 | Liver Transpl2004，10，2： | 1 |
| 9 | Immune thrombocytopenia:a rare presenting manifestation of tuberculosis显示文摘 | Ghobrial MW Albornoz MA | 2001 | Am J Hematol2001，67，2： | 1 |
| 10 | New Era of Liver Transplantation for Hepatitis B: A 17-Year Single-Center Experience显示文摘 | Dean M. Anselmo Rafik M. Ghobrial Lee Chan Jung Michael Weaver Carlos Cao Sammy Saab Greg Kunder Pauline W. Chen Douglas G. Farmer Hasan Yersiz Angeles Baquerizo Sunil Geevarghese Steven H. Han Leonard Goldstein Curtis D. Holt Jeffrey A. Gornbein Ronald W | 2002 | Annals of Surgery2002，，5： | 1 |
| 11 | Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma显示文摘 | Witzig TE Geyer SM Ghobrial I | 2005 | J Clin Oncol2005，23，23： | 1 |
| 12 | Clinical profile of single-agent modified-release oprozomib tablets in patienls ( Pls ) with hematologic malignancies: 显示文摘 | Ghobrial ]M | 2013 | Blood (ASH annual meeting Abstracts )2013，123，： | 1 |
| 13 | Th1 and Th2 cytokines in organ transplantation : paradigm lost? 显示文摘 | ZHAI Y GHOBRIAL R M BUSUTTIL R W | 1999 | Crit Rev Immunol1999，19，： | 1 |
| 14 | Technical challenges of hepatic venous outflow reconstruction in right lobe adult living donor liver transplantation显示文摘 | Ghobrial RM Hsieh CB Lerner S | 2001 | Liver Transpl2001，7，6： | 1 |
| 15 | Advances in pediatric liver and intestinal transplantation 显示文摘 | Ghobrial RM Farmer DG Amersi F | 2000 | Am J Surg2000，180，5： | 1 |
| 16 | Phase 1] trial of single - agent temsirolimus( CC! - 779 ) for relapsed mantle cell lymphoma显示文摘 | Witzig TE Geyer SM Ghobrial I | 2005 | J Clin Oncol2005，23，： | 1 |
| 17 | Predictors of survival after In vivo split liver transplantation:analysis of 110 consecutive patients显示文摘 | Ghobrial RM Yersiz H Farmer DG | | 0，，03： | 1 |
| 18 | Residual SYNTAX score after PCI for triple vessel coronary artery disease; quantify- ing the adverse effect of incomplete revascularisation显示文摘 | Malkin CJ George V Ghobrial MS | 2013 | EuroInt- ervention2013，8，11： | 1 |
| 19 | Liver transplantation for fulminant hepatic failure: experience with more than 200 patients over a 17 - year period显示文摘 | Farmer DG Anselmo DM Ghobrial RM | 2003 | Ann Surg2003，237，5： | 1 |
| 20 | Advances in pediatric liver and intestingal transplantation 显示文摘 | Ghobrial RM Farmer DG | 2000 | Am J Surgery2000，180，： | 1 |
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