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| 1 | 影响湖相沉积岩中有机碳分布的主要因素——以三水盆地为例显示文摘湖相沉积中的有机质含量随有机质堆积条件变化而发生波动。本文以三水盆地下第三系土布心组二段地层为例 ,对其作高分辨率岩芯取样并结合地球化学方法 ,分析生物学因素对有机碳分布的影响。在较干燥的气候条件下 ,水生浮游生物是有机质的主要来源 ,由于此时湖泊与海洋沟通 ,出现半咸水环境 ,硫酸盐还原作用显著 ,不利于有机质保存。所取岩芯段的中上部即是这种情况 ,以低TOC和高SRI值为特征。而当气候湿润时 ,植物繁荣 ,湖水淡化 ,陆源有机质丰富。缺氧条件下的有机质降解主要是效率极低的发酵作用。有利于有机质保存。这种情形出现于岩芯段的下部 。 | 刘春莲 杨建林 Hans-JoachimRhl Annette Schmid Rhl | 2001 | 沉积学报2001，19，1： | 37 |
| 2 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 3 | Cerebral processing of auditory stimuli in patients with irritable bowel syndrome显示文摘瞄准:用大脑决定功能的磁性的回声成像(fMRI ) 非内脏的刺激的服的处理是否在急躁的肠症候群(IBS ) 被改变病人与健康题目相比。围绕针的内脏躯体集中机制,并且识别心理因素的可能的影响,我们使用了听觉的刺激刺激在他们的感情的质量不同。方法:在 8 个 IBS 病人和 8 控制, fMRI 大小用不同感情的质量(钟声,讨厌的偷看(2000 Hz ) ,中立的词,和感情的词的愉快的声音) 的 4 听觉的刺激的一个块图案被执行。坡度回响 T2 * 加权的顺序被用于功能的扫描。统计地图用一般线性模型被构造。结果:到感情的听觉的刺激,,相对控制的 IBS 病人在感情的处理区域的一个更大的变化与更强壮的释放反应了反应模式,在控制不同,没在令人烦恼或愉快的声音之间区分。到中立听觉的刺激,由对比,仅仅 IBS 病人与大重要激活反应了。结论:到在感情的处理刺激的区域的听觉的刺激的改变的服的反应模式建议在 IBS 的改变的感觉处理不能为内脏的感觉是特定的,但是可能在感情的敏感和感情方面的反应反映概括变化,可能与经常在 IBS 病人发现的心理 comorbidity 联系了。 | Viola Andresen Alexander Poellinger Chedwa Tsrouya Dominik Bach Albrecht Stroh Annette Foerschler Petra Georgiewa Marco Schmidtmann Ivo R van der Voort Peter Kobelt Claus Zimmer Bertram Wiedenmann Burghard F Klapp Hubert Monnikes | 2006 | World Journal of Gastroenterology2006，12，11： | 8 |
| 4 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 5 | Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer’s disease: randomised, double-blind, placebo-controlled, first-in-human study显示文摘 | Bengt Winblad Niels Andreasen Lennart Minthon Annette Floesser Georges Imbert Thomas Dumortier R Paul Maguire Kaj Blennow Joens Lundmark Matthias Staufenbiel Jean-Marc Orgogozo Ana Graf | 2012 | Lancet Neurology2012，，7： | 3 |
| 6 | 无明显移位的髋臼骨折可以保守治疗吗?显示文摘对髋臼骨折保守治疗的长期随访结果研究甚少。作者对104例保守治疗的髋臼骨折患者进行平均随访12.1年(9-20年)的研究。结果发现,保守治疗髋臼骨折患者的10年生存率为94%,89%患者Harris评分优良,88%患者Merle-Postel评分优良,最主要的负面影响因素是闭孔斜位片上骨折台阶〉2mm。 | John C J Annette K B Olav R 李军 荆珏华 | 2017 | 临床骨科杂志2017，20，1： | 2 |
| 7 | Uncoupled eNOS annihilates neuregulin-1β-induced cardioprotection: a novel mechanism in pharmacological postconditioning in myocardial infarction显示文摘 | Bernd Ebner Stefan A. Lange Thomas Eckert Clementine Wischniowski Annette Ebner Rüdiger C. Braun-Dullaeus Christof Weinbrenner Carsten Wunderlich Gregor Simonis Ruth H. Strasser | 2013 | Molecular and Cellular Biochemistry2013，，1： | 2 |
| 8 | A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis显示文摘 | JONKER Johan W MYOUNG SUH Jae ATKINS Annette R | | 0，，7398： | 1 |
| 9 | Micro-Raman studies on DLC coatings 显示文摘 | Irmer G Annett D R | 2005 | Advanced Engineering Materials2005，8，： | 1 |
| 10 | Determinants of life quality in school-age children with cerebral palsy显示文摘 | Annette M Micbeal S Peter R etal | 2007 | Journal of Pediatrics2007，151，5： | 1 |
| 11 | Production of hepatic outflow block and ascites with an ameroid constrictor 显示文摘 | Sweat E R Musieant M E Annetts D L | 1966 | Surg Forum1966，17，： | 1 |
| 12 | A study on reducing substrates of manganese-oxidizing peroxidases from Pleurotus eryngii and Bjerkandera adusta 显示文摘 | Annette H Francisco J R D Maria J M | 1998 | FEBS Lett1998，428，3： | 1 |
| 13 | The effects of vapreotide, a somatostatin analogue, on gastric acidity, gallbladder emptying and hormone release after 1 week of continuous subcutaneous infusion in normal subjects显示文摘 | MARC A R JURGEN D ANNETTE Z | 1999 | Brit J Clin Pharmacol1999，47，： | 1 |
| 14 | Thermal denaturation and coagulation of whey proteins: effect of sugars显示文摘 | GARRETT J M STAIRS R A ANNETT R G | 1988 | Journal of Dairy Science1988，71，： | 1 |
| 15 | Position of horse- shoe crabs in estuarine food webs: N and C stable isotopic study of foraging ranges and diet composition 显示文摘 | Carmichael R H Rutecki D Annett B | 2004 | Journal of Experimental Marine Biology and Ecology2004，299，2： | 1 |
| 16 | Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer显示文摘 | Annette Eyking Birgit Ey Michael Rünzi Andres I. Roig Henning Reis Kurt W. Schmid Guido Gerken Daniel K. Podolsky Elke Cario | 2011 | Gastroenterology2011，，6： | 1 |
| 17 | Does acute stress disorder predict posttraumatic stress disorder in traffic accident victims? Analysis of a self-report inventory显示文摘 | Annette K J Fuglsang R Hanspeter Moergeli Li | 2004 | N J Psychiatry2004，58，： | 1 |
| 18 | Advanced drug delivery devices via self-assembly of amphiphilic block copolymers显示文摘 | Annette R?sler Guido W.M. Vandermeulen Harm-Anton Klok | 2012 | Advanced Drug Delivery Reviews2012，，： | 1 |
| 19 | Etiologic yield of subspecialists' evaluation of young children with global developmental delay显示文摘 | Michael IS Annette M Peter R et at | 2000 | Journal of Pediatrics2000，136，5： | 1 |
| 20 | Acute myoglobinuria and heroin snorting显示文摘 | ANNETT E N | 1979 | JAMA1979，241，： | 1 |
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