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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Does Helicobacter pylori infection eradication modify peptic ulcer prevalence? A 10 years' endoscopical survey显示文摘瞄准:为了在病人比较消化性溃疡流行,在根除治疗的进步散开以后在 pre-Helicobacter 时代和十年在二所意大利的医院里为上面的胃肠的内视镜检查法参考了。方法:我们检查了连续地在 1992 和 2002 期间在 1986-1987 和 1995-1996 期间在 Padova 的肠胃病学单位,并且在 Parma 的肠胃病学单位执行的所有内视镜的考试。迟平方测试被用于统计分析。结果:从两个的数据内视镜的中心在溃疡的流行显示出统计上重要的减少:从 12.7% ~ 6.3%(P<0.001 ) 在 Padova 并且从 15.6% ~ 12%(P<0.001 ) 在 Parma。减少两个都是重要的为十二指肠(从 8.8% ~ 4.8% , P<0.001 ) 并且胃溃疡(3.9% ~ 1.5% , P<0.001 ) 在 Padova,并且仅仅为在 Parma 的十二指肠溃疡(9.2% ~ 6.1% , P<0.001;胃溃疡:6.3% ~ 5.8% , NS ) 。结论:在征兆的病人的根除在消化性溃疡流行导致了重要减小的广泛的 Helicobacter pylori (H pylori ) 的十年。这减小在 Padova 是特别地明显的,在为在一般 practioners 之中的 H pylori 根除的致敏的一个工程在 1990 和 1992 之间被执行的地方。假如我们的假设应该是真的, H pylori 根除可能在未来导致是的消化性溃疡一稀罕内视镜的发现。 | Giorgio Nervi Stefania Liatopoulou Lucas Giovanni Cavallaro Alessandro Gnocchi Nadia Dal Bò Massimo Rugge Veronica Iori Giulia Martina Cavestro Marta Maino Giancarlo Colla Angelo Franzè Francesco Di Mario | 2006 | World Journal of Gastroenterology2006，12，15： | 5 |
| 3 | 在肝的 G6PT-H6PDH-11HSD1 三个一组和它在新陈代谢的症候群的 pathomechanism 的含意显示文摘 The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiometabolic risk determinants, including central obesity, glucose intolerance, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. Prevalence of the metabolic syndrome is rapidly increasing worldwide as a consequence of common overnutrition and consequent obesity. Although a unifying picture of the pathomechanism is still missing, the key role of the pre-receptor glucocorticoid activation has emerged recently. Local glucocorticoid activation is catalyzed by a triad composed of glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum. The elements of this system can be found in various cell types, including adipocytes and hepatocytes. While the contribution of glucocorticoid activation in adipose tissue to the pathomechanism of the metabolic syndrome has been well established, the relative importance of the hepatic process is less understood. This review summarizes the available data on the role of the hepatic triad and its role in the metabolic syndrome, by confronting experimental findings with clinical observations. | Ibolya Czegle Miklós Csala József Mandl Angelo Benedetti István Karádi Gábor Bánhegyi | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 4 | Relations of daily hassles with bothanxious and depressed mood in students 显示文摘 | D'ANGELO B WIERZBIEKI M | 2003 | Psychol Rep2003，9，2： | 1 |
| 5 | Thymosin alpha1: the regulator of regu-lators 显示文摘 | Pierluigi B D'Angelo C FallarinoF | 2010 | Ann N Y Acad Sci2010，1194，： | 1 |
| 6 | Clinical efficacy of cardiac resynchronization therapy using left ventricular pacing in heart failure patients stratified by severity of ventricular conduction delay显示文摘 | Angelo Auricchio Christoph Stellbrink Christian Butter Stefan Sack Jürgen Vogt Anand Ramdat Misier Dirk B?cker Michael Block Johannes H Kirkels Andrew Kramer Etienne Huvelle | 2003 | Journal of the American College of Cardiology2003，，12： | 1 |
| 7 | The internet of energy, a web-enabled smart grid system 显示文摘 | Nicola B Angelo P Michele Z | 2012 | IEEE Network2012，26，4： | 1 |
| 8 | 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy显示文摘 | Michele B Angelo A Gonzalo BE | 2013 | Eu- ropean Heart Journal2013，，34： | 1 |
| 9 | A comparison of remifentanil and morphine sulfate for acute postoperative analgesia after total intravenous anesthesia with remifentanil and propofol 显示文摘 | Yarmush J D'Angelo R Kirkhart B | 1997 | Anesthesiology1997，87，2： | 1 |
| 10 | The mechanism of stochastic resonance显示文摘 | Roberto B Alfonso S Angelo V | 1981 | J Phys A:Math Gen1981，14，： | 1 |
| 11 | Anticoagulant and aspirin prophylaxis for preventing thromboembolism after major gynecological surgery显示文摘 | Oates-Whitehead R M DAngelo A Mol B | 2004 | Br J Perioper Nurs2004，14，7： | 1 |
| 12 | Evaluation of Tempol Radioprotection in a Murine Tumor Model显示文摘 | Stephen M Hahn Francis J Sullivan Anne Marie DeLuca C.Murali Krishna Nancy Wersto David Venzon Angelo Russo James B Mitchell | 1996 | Free Radical Biology and Medicine1996，，7： | 1 |
| 13 | Moving beyond definitions: Implementing infor- mation literacy across the curriculum显示文摘 | Angelo B Maid B | 2004 | The Journal of Academic Librarianship2004，30，3： | 1 |
| 14 | Involvement of peroxisome proliferator-activated receptorβ/δ(PPARβ/δ)in BDNF signaling during aging and in Alzheimer disease:possible role of 4-hydroxynonenal(4-HNE)显示文摘 | Benedetti E D'Angelo B Cristiano L | 2014 | Cell Cycle2014，13，8： | 1 |
| 15 | Effects of nonsteroidal antiinflammatory drugs on inflammatory bowel disease: a case-control study显示文摘 | Joseph B Felder Burton I Korelitz Ramona Rajapakse Samuel Schwarz Angelo P Horatagis Gilbert Gleim | 2000 | The American Journal of Gastroenterology2000，，： | 1 |
| 16 | Thymosin alphal: the regulator of regulators 显示文摘 | Pierluigi B D'Angelo C Fallarino F | 2010 | Ann N Y Acad Sci2010，11，94： | 1 |
| 17 | Phase III trial comparing two dose levels of epirubicin combined with cyclophosphamide with cyclophosphamide,methotrexate,and fluorouracil in node-positive breast cancer显示文摘 | J PM Angelo DL Marc B | | 0，，12： | 1 |
| 18 | Incidence and risk factors for stroke in type2 diabetic patients: The DAl Study 显示文摘 | Carlo B G Angelo A Marina M | 2007 | Stroke2007，38，4： | 1 |
| 19 | Monte Carlo procedure for investigating light propagation and imaging of highly scattering media 显示文摘 | Angelo S Costantino B Fabrizio M | 1998 | Applied Optics1998，37，31： | 1 |
| 20 | PPAR @ a me-diates the effects of the pesticide methyl thiophanateon liver of the lizard Podarcis sicula 显示文摘 | Buono S Cristiano L D'angelo B | 2007 | ComparativeBiochemistry and Physiology Part C: Toxicology &Pharmacology2007，145，30： | 1 |
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