|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sarcopenia and non-alcoholic fatty liver disease:Is there a relationship?A systematic review显示文摘AIM To perform a systematic review to evaluate the incidence and prevalence of non-alcoholic fatty liver disease(NAFLD) in adult patients with sarcopenia.METHODS Randomized clinical trials,cross-sectional or cohort studies including adult patients(over 18 years) with sarcopenia were selected.The primary outcomes of interest were the prevalence or incidence of NAFLD in sarcopenic patients.In the screening process,44 fulltext articles were included in the review and 41 studies were excluded.RESULTS Three cross-sectional studies were included.The authors attempted to perform a systematic review,but due to the differences between the studies,a qualitative synthesis was provided.The diagnosis of NAFLD was made by non-invasive methods(image methods or any surrogate markers) in all three evaluated studies.All the studies suggested that there was an independent association between sarcopenia and NAFLD.CONCLUSION Sarcopenia is independently associated with NAFLD and possibly to an advanced fibrosis. | Cristiane V Tovo Sabrina A Fernandes Caroline Buss Angelo A de Mattos | 2017 | World Journal of Hepatology2017，9，6： | 9 |
| 2 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 3 | Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis显示文摘AIM To investigate whether the use of proton pump inhibitors(PPIs) increases the incidence of spontaneous bacterial peritonitis(SBP) in patients with cirrhosis and ascites.METHODS An historical cohort study was carried out in cirrhotic outpatients with ascites followed in a specialized clinic at a tertiary hospital in Southern Brazil. Patient charts were reviewed to collect information on the variables of interest as the use of PPIs. Primary outcome was defined as development of SBP during the study period. SBP was diagnosed based on ascitic fluid polymorphonuclear cell count ≥ 250 cells/mm3 without evidence of an intraabdominal, surgically treatable source of infection.RESULTS Of 738 cirrhotic patients, 582(58.2% male) were enrolled, with mean age of 53.6 ± 12 years. Hepatitis C virus infection(36.2%) and alcohol abuse(25.6%) were the main etiologies of cirrhosis. The presence of ascites was detected in 299(51.4%) patients during the development of the study. Nineteen patients with previous diagnosis of SBP undergoing secondary prophylaxis and 22 patients with insufficient PPI data were further excluded. Of 258 patients with ascites, 151 used PPIs, and 34 developed SBP(22.5%). Among 107 non-users of PPIs, 23 developed SBP(21.5%)(HR = 1.44, 95%CI: 0.85-2.47, P = 0.176). The median follow-up time of patients using PPI was 27 mo vs 32 mo for non-users. Univariate analysis of the risk factors associated with the development of SBP revealed a significant association of SPB with the severity of liver disease according to the Child-Turcotte-Pugh(CTP) score. Multivariate analysis confirmed that CTP score was the only independent variable influencing the occurrence of SBP. Survival at 60 mo(Kaplan-Meier analysis) was similar in users and non-users of PPI, independently of the presence of SBP(58.4% vs 62.7% respectively, P = 0.66). For patients with SBP, survival at 60 mo was 55.1%, vs 61.7% in patients without SBP(P = 0.34). CONCLUSION In conclusion, the rate of SBP was not significantly different in users or non-users of PPIs in this cohort of cirrhotic with ascites. | Suelen A S Miozzo Jorge A John Marcelo C Appel-da-Silva Isabella A Dossin Cristiane V Tovo Angelo A Mattos | 2017 | World Journal of Hepatology2017，9，35： | 5 |
| 4 | P-glyeoprotein 170 expression and function as an adverse independent prognostic factor in childhood acute lymphoblastic leukemia显示文摘 | Casal F D angelo V Addeo R | 2004 | Oncol Rep2004，12，： | 1 |
| 5 | Striatal modulation of cAMP-response-element-binding protein (CREB) after excitotoxic lesions:implications with neuronal vulnerability in Huntington's disease显示文摘 | Giampà C DeMarch Z D'Angelo V | 2006 | Eur J Neurosci2006，23，8： | 1 |
| 6 | Sequential therapy versus standard triple-drug therapy for helicobacter pylori eradication显示文摘 | Dino V Angelo ZH NimishSH | 2007 | Annals of internal Medicine2007，146，8： | 1 |
| 7 | Treatment of landfill leachate by reverse osmosis显示文摘 | Angelo C Rolando R Nicola V | 1999 | Water Research1999，33，3： | 1 |
| 8 | Scheduling real-time mixed-criticality jobs 显示文摘 | BARUAH S K BONIFACI V D' ANGELO G | 2012 | IEEE Transactions on Computers2012，61，8： | 1 |
| 9 | Treatment of symptomatic intracranial arachnoid cysts by stereotactic cyst-ventricular shunting显示文摘 | Gorgoglione L Catapano G | 1999 | Stereotact Funct Neurosurg1999，72，1： | 1 |
| 10 | The mechanism of stochastic resonance显示文摘 | Roberto B Alfonso S Angelo V | 1981 | J Phys A:Math Gen1981，14，： | 1 |
| 11 | Two-Photon Deffraction and Quantum Lithography 显示文摘 | D' Angelo M Chekhova M V Shih Y | 2001 | Phys Rev Lett2001，87，01： | 1 |
| 12 | P-glycoprotein 170 expression and function as an adverse independent prognostic factor in childhood acute lymphoblastic leukemia 显示文摘 | Casale F D'Angelo V Addeo R | 2004 | Oncol Rep2004，12，6： | 1 |
| 13 | Striatal modulation of cAMP-response element-binding protein (CREB) after excitotoxic lesions: implications with neuronal vulnerability in Huntington's disease显示文摘 | Giampa C DeMarch Z D'Angelo V | 2006 | Eur J Neurosci2006，23，1： | 1 |
| 14 | Treatment of symptomatic intracranial arachnoid cysts by stereotatic cystventricular shunting显示文摘 | D'Angelo V Gorgoglione L Catapano G | 1999 | Stereotact Funct Neurosurg1999，72，1： | 1 |
| 15 | Surgical treatment of anterior callosal tumors 显示文摘 | D Angelo V Napolitano M Gorgoglione L | 1997 | J Neurosurg Sci1997，41，1： | 1 |
| 16 | Synthesis of ferrocenyl oxindole compounds with potential anticaneer activity 显示文摘 | Silva Bdrbara V Ribeiro Nfbia M Pinto Angelo C | 2008 | J Braz Chem Soc2008，19，7： | 1 |
| 17 | Amyloid beta- peptide inhibition of the PKA/CREB pathway and long- term potentiation: reversibility by drugs that enhance cAMP signaling显示文摘 | Vitolo O V Sant'Angelo A Costanzo V | 2002 | Proc Natl Acad Sci USA2002，99，13： | 1 |
| 18 | Methotrexate toxicity and efficacy during the consolidation phase in paediatric acute lymphoblastic leukaemia and MTHFR polymorphisms as pharmacogenetie determinants 显示文摘 | D'Angelo V Ramaglia M Iannotta A | 2011 | Cancer Chernother Pharmacol2011，68，： | 1 |
| 19 | Exergetic analysis of the refrigeration system in ethylene and propylene production process显示文摘 | Fabrega F M Rossi J S d'Angelo J V H | 2010 | Energy2010，35，3： | 1 |
| 20 | Mir-23b and miR- 130b expression is downregulated in pituitary adenomas显示文摘 | Leone V Langella C Angelo DD | 2014 | Mol Cell Endocrinol2014，390，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员