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| 1 | Comparative analysis of open and laparoscopic colectomy for malignancy in a developing country显示文摘AIM: To compare the short-term, including oncologic, outcomes of open vs laparoscopic colectomy for cancer in a developing country. METHODS: The records of patients who underwent elective open and laparoscopic colectomies for cancer at the University Hospital of the West Indies between January 2005 and December 2010 were retrospectively reviewed. Demographic(age, gender, Charlson comorbidity index score), peri-operative, post-operative and oncologic data were collected for each patient. Specific oncologic variables included lymph node yield, pathologic stage, grade, proximal, distal and circumferential margin involvement. Fisher's exact, Mann-Whitney, and binary logistic regression tests were used for analysis. Significance level was set atP < 0.05. RESULTS: There were 87 cases for open colectomy(OC) and 17 cases for laparoscopic colectomy(LC). Demographics did not significantly differ between OC and LC groups. Intra-operative blood loss and postoperative analgesic requirements did not significantly differ between groups. There was a trend towards longer operating times in OC group and shorter hospital stay in the LC group. Lymph node yield(14 vs 14, P = 0.619), proximal(10 cm vs 7 cm, P = 0.353) and distal(8 cm vs 8 cm, P = 0.57) resection margin distance and circumferential margin involvement(9 vs 0, P = 0.348) did not significantly differ between groups. Thirty-day morbidity was equivalent between groups(22 vs 6, P = 0.774). There were 6 deaths within 30 d of initial procedure, all in the OC group(6.9%). CONCLUSION: Laparoscopic colectomy in a developing country is oncologically safe and represents a option for colonic malignancies in these regions. Such data encourage the continued laparoscopic development. | Pierre-Anthony Leake Kristen Pitzul Patrick O Roberts Joseph M Plummer | 2013 | World Journal of Gastrointestinal Surgery2013，5，11： | 8 |
| 2 | Recent advances in the management of rectal cancer: No surgery, minimal surgery or minimally invasive surgery显示文摘Over the last decade,with the acceptance of the need for improvements in the outcome of patients affected with rectal cancer,there has been a significant increase in the literature regarding treatment options available to patients affected by this disease.That treatment related decisions should be made at a high volume multidisciplinary tumor board,after pre-operative rectal magnetic resonance imaging and the importance of total mesorectal excision(TME)are accepted standard of care.More controversial is the emerging role for watchful waiting rather than radical surgery in complete pathologic responders,which may be appropriate in 20%of patients.Patients with early T1 rectal cancers and favorable pathologic features can be cured with local excision only,with transanal minimal invasive surgery(TAMIS)because of its versatility and almost universal availability of the necessary equipment and skillset in the average laparoscopic surgeon,emerging as the leading option.Recent trials have raised concerns about the oncologic outcomes of the standard'top-down'TME hence transanal TME(Ta TME'bottom-up')approach has gained popularity as an alternative.The challenges are many,with a dearth of evidence of the oncologic superiority in the long-term for any given option.However,this review highlights recent advances in the role of chemoradiation only for complete pathologic responders,TAMIS for highly selected early rectal cancer patients and Ta TME as options to improve cure rates whilst maintaining quality of life in these patients,while we await the results of further definitive trials being currently conducted. | Joseph M Plummer Pierre-Anthony Leake Matthew R Albert | 2017 | World Journal of Gastrointestinal Surgery2017，9，6： | 6 |
| 3 | A systematic review of the accuracy and indications for diagnostic laparoscopy prior to curative-intent resection of gastric cancer显示文摘 | Pierre-Anthony Leake Roberta Cardoso Rajini Seevaratnam Laercio Lourenco Lucy Helyer Alyson Mahar Calvin Law Natalie G. Coburn | 2012 | Gastric Cancer2012，，1： | 5 |
| 4 | Neurotransmitter receptors on microglia显示文摘As the resident immune cells in the central nervous system,microglia have long been hypothesised to promote neuroinflammation and exacerbate neurotoxicity.However,this traditional view has undergone recent revision as evidence has accumulated that microglia exert beneficial and detrimental effects depending on activation status,polarisation phenotype and cellular context.A variety of neurotransmitter receptors are expressed on microglia and help mediate the bidirectional communication between neurons and microglia.Here we review data supporting the importance of neurotransmitter receptors on microglia,with a special emphasis on glutamate,γ-aminobutyric acid(GABA),norepinephrine,cannabinoid and acetylcholine receptors.We summarise evidence favouring a significant role for neurotransmitter receptors in modulating microglial activation,phagocytic clearance and phenotypic polarisation.Elucidating the effects of neurotransmitter receptors on microglia and dissecting the underlying mechanisms may help accelerate the discovery of novel drugs that tap the therapeutic potential of microglia. | Huan Liu Rehana K Leak Xiaoming Hu | 2016 | Stroke & Vascular Neurology2016，1，2： | 3 |
| 5 | 超越奇观:投影艺术的联想与参与显示文摘投影艺术表演化,作为一种吸引观众、宣传或娱乐的方式,也反映了社会和技术。本文首先分析了投影的发展,探究了当代投影艺术家、艺术活动家和商业设计师的作品。投影不仅是视觉传播的重要元素,也是视觉传达的有效工具,挑战了人与空间的关系。投影最有趣的特征是超越了图片和文字。它引导观众参与、反应、思考、质疑和学习,改变了曾经熟悉的事物。虽然这个艺术行为是短暂的,但却落入了眼帘。投影艺术具有改变我们环境的潜能,但不会产生任何物理后果;它可以影响我们对一个地方的感觉,还可以让人们从熟悉的事物里看到新事物。 | Jeff Leak 毛寒 | 2017 | 湖南包装2017，32，1： | 3 |
| 6 | Acute disseminated encephalomyelitis in childhood:epidemioiogic,clinical and laboratory features显示文摘 | Leake JAD Albani S Kao AS | 2004 | Pediatr Infect Dis J2004，23，8： | 1 |
| 7 | Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells:role of mitogen-activated protein kinases and Nrf2显示文摘 | Anwar AA Li FY Leake DS | 2005 | Free Radic Biol Med2005，39，2： | 1 |
| 8 | Rational siRNA design for RNA interference 显示文摘 | Reynolds A Leake D Boese Q | 2004 | Nature Biotechnology2004，22，3： | 1 |
| 9 | Rational Sirna Design for RNA Interference显示文摘 | ANGELA R LEAKE D BOESE Q | | 0，，03： | 1 |
| 10 | Pancreatic cancer: surprising role for fibrosis显示文摘 | LEAKE I | 2014 | Nat Rev Gastroenterol Hepatol2014，11，7： | 1 |
| 11 | Integrating diverse information resources in a case-based design environment 显示文摘 | Leake D B Birnbaum L Hammond K | 1999 | Engineering Applications of Artificial Intelligence1999，12，6： | 1 |
| 12 | chronic electrical stimulation by a cochlear implant promotes survival spiral ganglion neurons after neonatal deafness显示文摘 | Hradek GT Synder RL | 1999 | J CompNeurol1999，，： | 1 |
| 13 | The structure of lympillaries in lymph for ma- tion显示文摘 | Leak LV | 2006 | Fed Proeec2006，15，： | 1 |
| 14 | Identification of functionally variant MDR1 alleles among European Americans and African A- mericans显示文摘 | Kim RB Leake BF Choo EF | 2001 | Clin Pharmacol Ther2001，70，2： | 1 |
| 15 | Age distribution in virgin red spruce and northern hardwoods显示文摘 | Leak W B | | 0，，06： | 1 |
| 16 | Age distribution in virgin red spruce and northen hardwoods 显示文摘 | Leak W B | 1975 | Ecology1975，56，： | 1 |
| 17 | Zinc accumulation by Thlaspi caerulescens from soils with different Zn availability: a pot study 显示文摘 | Whiting S N Leake J R McGrath S P | 2001 | Plant Soil2001，236，： | 1 |
| 18 | Rational siRNA design for RNA interference显示文摘 | Reynolds A Leake D Boese Q | 2004 | Nat Biotechnol2004，22，3： | 1 |
| 19 | Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein显示文摘 | Kim RB Wandel C Leake B | 1999 | Pharm Res1999，16，： | 1 |
| 20 | Rational siRNA design for RNA interference显示文摘 | REYNOLDS A LEAKE D BOESEE Q | 2004 | Nat Biotechnol2004，22，3： | 1 |
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