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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Association between Helicobacterpylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas显示文摘AIM To correlate Helicobacter pylori(H. pylori), Epstein-Barr virus(EBV) and human papillomavirus(HPV) with gastric cancer(GC) cases in Pará State, Brazil.METHODS Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eber1 RNA was used to detect the presence of EBV in the samples, and the L1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for E6 and E7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the patients.RESULTS The majority of the 302 samples analyzed were obtained from men(65%) aged 55 years or older(67%) and were classified as the intestinal subtype(55%). All three pathogens were found in the samples analyzed in the present study(H. pylori : 87%, EBV: 20%, HPV: 3%). Overall, 78% of the H. pylori-positive(H. pylori+) samples were cag A +(H. pylori-cag A+), and there was an association between the cytotoxic product of this gene and EBV. Coinfections of H. pylori-cagA+ and EBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for EBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the E6 and E7 oncoproteins was detected. The fundus of the stomach was the region least affected by the pathogens.CONCLUSION HPV was not involved in gastric tumorigenesis. Prophylactic and therapeutic measures against H. pylori and EBV may prevent the development of GC, especially the more aggressive forms. | Carolina Rosal Teixeira de Souza Marcelli Carolini Alves Almeida Andre Salim Khayat Emerson Lucena da Silva Paulo Cardoso Soares Luiz Claudio Chaves Rommel Mario Rodriguez Burbano | 2018 | World Journal of Gastroenterology2018，24，43： | 6 |
| 3 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 4 | Eltrombopag Increases Platelet Numbers in Thrombocytopenic Patients With HCV Infection and Cirrhosis, Allowing for Effective Antiviral Therapy显示文摘 | Nezam H. Afdhal Geoffrey M. Dusheiko Edoardo G. Giannini Pei–Jer Chen Kwang–Hyub Han Aftab Mohsin Maribel Rodriguez–Torres Sorin Rugina Igor Bakulin Eric Lawitz Mitchell L. Shiffman Ghias–Un–Nabi Tayyab Fred Poordad Yasser Mostafa Kamel Andres Brainsky Ja | 2014 | Gastroenterology2014，，2： | 2 |
| 5 | Phytohormone contents in Corylus avellana and their relationship to age and other developmental processes 显示文摘 | Andres H Fernandez B Rodriguez R | 2002 | Plant Cell Tiss Organ Culture2002，70，： | 1 |
| 6 | An im- proved control system for a split winding bearingless induction motor 显示文摘 | ELKIN Ferney Rodriguez JOSE Andres Santisteban | 2011 | IEEE Transactions on Industrial Electronics2011，58，8： | 1 |
| 7 | Characterization of clonal complexity in tuberculosis by Mycobacterial interspersed repeti- tive unit-variable-number tandem repeat typing 显示文摘 | Garcia de Viedma D Alonso Rodriguez N Andres S | 2005 | J Clin Microbiol2005，43，11： | 1 |
| 8 | Real-time Dynamic Control of a Stewart Platform显示文摘 | Nicolas Andres Ordoez Carlos Francisco Rodriguez | 2013 | Applied Mechanics and Materials2013，390，8： | 1 |
| 9 | Phylogeographic characteristics of vesicular stomatitis New Jersey viruses circulating in Mexico from 2005 to 2011 and their relationship to epidemics in the United States显示文摘 | Lauro Velazquez-Salinas Steven J. Pauszek Selene Zarate Francisco J. Basurto-Alcantara Antonio Verdugo-Rodriguez Andres M. Perez Luis L. Rodriguez | 2014 | Virology2014，，： | 1 |
| 10 | Tissue activity and cel- lular localization of human ve amine oxidase 显示文摘 | Andres N Lizcano JM Rodriguez M J | 2001 | J Histochem Cytochem2001，49，2： | 1 |
| 11 | Pharmacokinetic hehaviour of enrofloxacin and its metaholite ciprofloxacin after subcutaneous administration in cattle 显示文摘 | De Lucas J J San Andres M I Gonzalez F Froyman R Rodriguez C | 2008 | Veterinary Research Communications2008，32，4： | 1 |
| 12 | Air-steam gasification of sewage sludge in a bubbling bed reactor:Effect of alumina as a primary catalyst显示文摘 | Andres J M Narros A Rodriguez M E | 2011 | Fuel Processing Technology2011，92，3： | 1 |
| 13 | Air-steamgasification of sewage sludge in a bubbling bed reactor:Effect of alumina as a primary catalyst显示文摘 | Andres J M d Narros A Rodriguez M E | 2011 | Fuel ProcessingTechnology2011，，92： | 1 |
| 14 | Prospective Evaluation of Single‐Operator Peroral Cholangioscopy in Liver Transplant Recipients Requiring an Evaluation of the Biliary Tract显示文摘 | Domingo Balderramo Oriol Sendino Rosa Miquel Cristina Rodriguez de Miguel Josep M. Bordas Graciela Martinez‐Palli Maria L. Leoz Antoni Rimola Miguel Navasa Josep Llach Andrés Cardenas | 2013 | Liver Transpl2013，，2： | 1 |
| 15 | HYDRAULIC ANALYSES FOR A NEW BRIDGE OVER THE PARANA RIVER, ARGENTINA显示文摘This paper summarizes hydraulic studies carried out as part of the feasibility study for a new bridge over the Parana River in Argentina. The bridge will physically connect the provinces of Santa Fe and Corrientes, currently separated over the length a 200-km river reach. In addition to the hydraulic studies summarized here, the feasibility study includes analyses of the geology and geomorphology of the sites, land surveying, geophysical and hydrologic studies, studies of the navigation channel and fluvial transportation, transportation studies, and environmental impact studies. The main components of the present study were a geomorphologic analysis of the middle reach of the Parana River, and a quantitative hydraulic study. Qualitative and quantitative analyses provided a description of the hydraulic system, and served as a basis for a comparison of alternative bridge locations and the analysis of their vulnerability. The quantitative hydraulic study included the construction, calibration, and operation of one-dimensional (1D) and depth-averaged two-dimensional (2D) flow models. In order to tie the models to the most reliable data the 1D models covered a 450-km long reach, and included the main channel (about 2 km wide) and the flood plain (about 30 km wide). The results of the 1D models played a major role in the selection of the bridge location, and were subsequently used as boundary conditions for 2D modeling. The 2D models were constructed for a 70 km x 30 km modeling domain. This paper presents results of 1D modeling for large floods, both in the natural state and with the proposed bridge, and results of 2D modeling in the natural state. Modeling at this scale requires sound judgment to strike a balance between the desirable level of model detail and the cost of acquiring data for model construction and calibration. | André RODRIGUEZ Daniel BREA Daniel Farís Hétor R. BRAVO Edgar Castelló Gerardo HILLMAN Juan WEBER Mariana PAGOT Pablo SPALLETTI | 2003 | International Journal of Sediment Research2003，18，2： | 1 |
| 16 | Recreational atmospheric pollution episodes: Inhalable metalliferous particles from firework displays显示文摘 | Teresa Moreno Xavier Querol Andrés Alastuey Mari Cruz Minguillón Jorge Pey Sergio Rodriguez José Vicente Miró Carles Felis Wes Gibbons | 2006 | Atmospheric Environment2006，，5： | 1 |
| 17 | Tissue activity and cellular localization of human semicarbazidesensitive amine oxidase显示文摘 | Andres N Lizcano JM Rodriguez MJ | 2001 | J Histochem Cytochem2001，49，： | 1 |
| 18 | Tissue activity and cellular localization of human semicarbazidesensitive amine oxidase显示文摘 | Andres N Lizcano JM Rodriguez MJ | 2001 | J Histochem Cytochem2001，49，： | 1 |
| 19 | Increase in AMPA receptors in aged memory-impaired rats is not associated with increase in monoamine oxidase B levels显示文摘 | Andres N Rodriguez M J Andrade C | | 0，，： | 1 |
| 20 | First-line cisplatin,docetaxel,and cetuximab for patients with recurrent or metastatic head and neck cancer:A multicenter cohort study显示文摘BACKGROUND The targeted therapy cetuximab[directed at the epidermal growth factor receptor(EGFR)]in combination with 5-fluorouracil and platinum-based chemotherapy(the EXTREME regimen)has shown substantial efficacy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck(R/M SCCHN).Thus,this scheme has been established as the preferred first-line option for these patients.However,more recently,a new strategy combining platinum,taxanes,and cetuximab(the TPEx regimen)has demonstrated similar efficacy with a more favorable toxicity profile in clinical trials.AIM To evaluate the safety and efficacy of the TPEx scheme as first-line therapy in advanced SCCHN in a multicenter cohort study.METHODS This retrospective multicenter cohort study included patients with histologically confirmed recurrent or metastatic SCCHN treated with first-line TPEx at five medical centers in Argentina between January 1,2017 and April 31,2020.Chemotherapy consisted of four cycles of docetaxel,cisplatin,and cetuximab followed by cetuximab maintenance therapy.Clinical outcomes and toxicity profiles were collected from medical charts.Treatment response was assessed by the investigator in accordance with Response Evaluation Criteria in Solid Tumors(version 1.1).Adverse events were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 4.0).RESULTS Twenty-four patients were included.The median age at diagnosis was 58 years(range:36-77 years).The majority of patients(83.3%)received at least four chemotherapy cycles in the initial phase.In the included group,the overall response rate was 62.5%,and 3 patients achieved a complete response(12.5%).The median time to response was 2.4 mo[95% confidence interval(CI):1.3-3.5].With a median follow-up of 12.7 mo(95%CI:8.8-16.6),the median progression-free survival(PFS)was 6.9 mo(95%CI:6.5-7.3),and the overall survival rate at 12 mo was 82.4%.Patients with documented tumor response showed a better PFS than those with disease stabilization or progression[8.5 mo(95%CI:5.5-11.5)and 4.5 mo(95%CI:2.5-6.6),respectively;P=0.042].Regarding the safety analysis,two-thirds of patients reported at least one treatment-related adverse event,and 25% presented grade 3 toxicities.Of note,no patient experienced grade 4 adverse events.CONCLUSION TPEx was an adequately tolerated regimen in our population,with low incidence of grade 3-4 adverse events.The median PFS were consistent with those in recent reports of clinical trials evaluating this treatment combination.This regimen may be considered an attractive therapeutic strategy due to its simplified administration,decreased total number of chemotherapy cycles,and treatment tolerability. | Agustin Falco Mariano Leiva Albano Blanco Guido Cefarelli Andres Rodriguez Juan Melo Federico Cayol Manglio Miguel Rizzo Alejandro Sola Hernan Rodriguez Montani Matias Chacon Diego Enrico Federico Waisberg | 2022 | World Journal of Clinical Oncology2022，13，2： | 1 |
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