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| 1 | The role of dietary fibre in pig production,with a particular emphasis on reproduction显示文摘Fibres from a variety of sources are a common constituent of pig feeds. They provide a means to utilise locallyproduced plant materials which are often a by-product of the food or drink industry. The value of a high fibre diet in terms of producing satiety has long been recognised. However the addition of fibre can reduce feed intake, which is clearly detrimental during stages of the production cycle when nutrient needs are high, for example in growing piglets and during lactation. More recently, fibre has been found to promote novel benefits to pig production systems,particularly given the reduction in antimicrobial use world-wide, concern for the welfare of animals fed a restricted diet and the need to ensure that such systems are more environmentally friendly. For example, inclusion of dietary fibre can alter the gut microbiota in ways that could reduce the need for antibiotics, while controlled addition of certain fibre types may reduce nitrogen losses into the environment and so reduce the environmental cost of pig production.Of particular potential value is the opportunity to use crude fibre concentrates as 'functional' feed additives to improve young pig growth and welfare. Perhaps the greatest opportunity for the use of high fibre diets is to improve the reproductive efficiency of pigs. Increased dietary fibre before mating improves oocyte maturation, prenatal survival and litter size; providing a consumer-acceptable means of increasing the amount of saleable meat produced per sow. The mechanisms responsible for these beneficial effects remain to be elucidated. However, changes in plasma and follicular fluid concentrations of key hormones and metabolites, as well as effects of the hypothalamic satiety centre on gonadotrophin secretion and epigenetic effects are strong candidates. | Selene Jarrett Cheryl J.Ashworth | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 13 |
| 2 | Evaluation of dry eye disease in newly diagnosed anxiety and depression patients using anterior segment optical coherence tomography显示文摘Background:We aimed to evaluate dry eye diseases(DED)in patients with newly diagnosed depression and anxiety patients.Methods:Forty newly diagnosed depression,35 anxiety patients,and 37 controls without any history of taking psychiatric drugs(or before the beginning of psychiatric medication)and topical ophthalmic drop use,were included in the study.All depression and anxiety diagnoses were performed by an experienced psychiatrist.Beck depression and anxiety tests were used to measure disease severity.Tear film break up time(TBUT),Schirmer’s test,Oxford scores and ocular surface disease index(OSDI)were admiinistered to participants.Anterior segment optical coherence tomography was used to measure tear meniscus heights(TMH),tear meniscus depths(TMD)and tear meniscus areas(TMA).Results:In anxiety and depression groups,Schirmer’s test(mm)(7.24±6.02,6.58±4.9 and 18.79±4.9 respectively,p<0.05)and TBUT(s)(5.62±3.1,5.6±3.5 and 13.37±1.7 respectively,p<0.05)were significantly lower than control group.In addition,OSDI and Oxford scores were significantly higher than controls.OSDI scores were 28.01±19,30.43±18.49,14.38±8.14 respectively(p=0.002)and Oxford scores were 1.9±0.7,2.1±0.6 and 0.7±0.4 respectively(p=0.001).TMD,TMH and TMA values were significantly lower in anxiety and depression groups compared with control groups.Correlations between disease inventory scores and dry eye tests were detected.Conclusions:This study showed a relation between DED and newly diagnosed anxiety and depression patients with no history of psychiatric drug use.The presence of correlation between dry eye tests and disease inventory scores strengthens this association.This is an important knowledge that need to be evaluated in these patients before starting psychiatric medication. | Mahmut Oğuz Ulusoy Selen Işık-Ulusoy SertaçArgun Kıvanç | 2019 | Eye and Vision2019，6，1： | 3 |
| 3 | Diagnostic and therapeutic potential of exosomal miRNAs in Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a primary cause of dementia.AD is a neurodegenerative disorder,characterized by synapses loss,extracellular amyloid plaques composed of the amyloid-βpeptide(Aβ)and intracellular aggregates of hyperphosphorylated tau protein.AD is a complex disease linked to multiple interacting factors,both environmental and genetic,which can contribute to the onset and severity of the disease.Longitudinal studies have highlighted several cardiovascular risk factors that can increase the risk of AD.The genetic landscape of AD has changed dramatically in recent decades.Early studies identified mutations in the amyloid precursor protein gene(APP)as well as proteins that are involved in the enzymatic cleavage of APP to toxicβ-amyloid(Aβ),namely presenilin-1 and presnilin-2.However,these mutations were found in familial cases of early-onset AD,while the causes of sporadic late-onset AD are still unknown.The latest advances in Genomewide Association Studies(GWAS),sequencing,and bioinformatics have begun to unravel the complex genetic architecture of the sporadic form of AD.GWAS were able to uncover common variants with high frequency in the population that individually carried low risk(Robinson et al.,2017).The advent of next-generation and thirdgeneration sequencing platforms shows great promise in further unravelling the genetics of AD. | Ida Manna Selene De Benedittis Enrico Iaccino Andrea Quattrone Aldo Quattrone | 2021 | Neural Regeneration Research2021，16，11： | 3 |
| 4 | Modeling aggregate size distribution of eroded sediment resulting from rain-splash and raindrop impacted flow processes显示文摘Soil susceptibility to detachment and transport sub-processes of erosion is generally controled by the aggregate breakdown mechanism. Measuring particle size and aggregation to the estimate erodibility potential of soils is important under erosive rainfall conditions. The Aggregate Size Distribution (ASD) is one of the most important determinants of soil structure along with soil organic matter content for describing the efficiency of applied, sustainable management strategies. This study aimed to compare the performances of three different aggregate size distribution models to predict the characteristic aggregate size parameter (median diameter, D50) for eroded sediment from interrill erosion processes of Rain- Splash Transport (RST) and Raindrop Impacted Flow Transport (RIFT). The ASDs of 1143 collected sediment samples from the RST and RIFT processes were measured and modeled by the Log-normal, Fractal, and Weibull approaches. The D50 value, as a characteristic parameter for aggregate size distributions, derived from the cumulative ASD curve was compared for soils from different land use types and different slope and rainfall intensity conditions. The performance of each model was evaluated using the Mean Square Error (MSE) and Coefficient of Determination (R^2). The Weibull approach was the most accurate model showing the best fit with the lowest MSE values (0.0002 ≤MSE≤ 0.0048) and having the greatest R2 values (0.936≤ R^2≤ 0.998) when compared with the Log-normal and Fractal models. Herewith, for semi-arid land use and soil, specific shape and scale parameters for the Weibull distribution, the respective ASDs were successfully re-generated for modeling the eroded sediment of the simulated RST and RIFT interill processes. | Selen Deviren Saygin Gunay Erpul | 2019 | International Journal of Sediment Research2019，34，2： | 3 |
| 5 | Comparisons between glucose analogue 2-deoxy-2-(^(18)F)fluoro-D-glucose and ^(18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions显示文摘AIM: To compare 2-deoxy-2-(^(18)F)fluoro-D-glucose(^(18)FFDG) and ^(18)F-sodium(^(18)F-NaF) positron emission tomography/computed tomography(PET/CT) accuracy in breast cancer patients with clinically/radiologically suspected or known bone metastases.METHODS: A total of 45 consecutive patients with breast cancer and the presence or clinical/biochemical or radiological suspicion of bone metastatic disease underwent ^(18)F-FDG and ^(18)F-fluoride PET/CT. Imaging results were compared with histopathology when available, or clinical and radiological follow-up of at least 1 year. For each technique we calculated: Sensitivity(Se), specificity(Sp), overall accuracy, positive and negative predictive values, error rate, and Youden's index. Mc Nemar's χ~2 test was used to test the difference in sensitivity and specificity between the two diagnostic methods. All analyses were computed on a patient basis, and then on a lesion basis, with consideration ofthe density of independent lesions on the coregistered CT(sclerotic, lytic, mixed, no-lesions) and the divergent site of disease(skull, spine, ribs, extremities, pelvis). The impact of adding ^(18)F-Na F PET/CT to the work-up of patients was also measured in terms of change in their management due to ^(18)F-Na F PET/CT findings. RESULTS: The two imaging methods of ^(18)F-FDG and ^(18)F-fluoride PET/CT were significantly different at the patient-based analysis: Accuracy was 86.7% and 84.4%, respectively(Mc Nemar's χ~2 = 6.23, df = 1, P = 0.01). Overall, 244 bone lesions were detected in our analysis. The overall accuracy of the two methods was significantly different at lesion-based analysis(Mc Nemar's χ~2 = 93.4, df = 1, P < 0.0001). In the lesion density-based and site-based analysis, ^(18)F-FDG PET/CT provided more accurate results in the detection of CT-negative metastasis(P < 0.002) and vertebral localizations(P < 0.002); ^(18)F-Na F PET/CT was more accurate in detecting sclerotic(P < 0.005) and rib lesions(P < 0.04). ^(18)F-Na F PET/CT led to a change of management in 3 of the 45 patients(6.6%) by revealing findings that were not detected at ^(18)F-FDG PET/CT. CONCLUSION: ^(18)F-FDG PET/CT is a reliable imaging tool in the detection of bone metastasis in most cases, with a diagnostic accuracy that is slightly, but significantly, superior to that of ^(18)F-Na F PET/CT in the general population of breast cancer patients. However, the extremely high sensitivity of ^(18)F-fluoride PET/CT can exploit its diagnostic potential in specific clinical settings(i.e., small CT-evident sclerotic lesions, high clinical suspicious of relapse, and negative ^(18)F-FDG PET and conventional imaging). | Selene Capitanio Francesca Bongioanni Arnoldo Piccardo Claudio Campus Roberta Gonella Lucia Tixi Mehrdad Naseri Michele Pennone Vania Altrinetti Ambra Buschiazzo Irene Bossert Francesco Fiz Andrea Bruno Andrea DeCensi Gianmario Sambuceti Silvia Morbelli | 2016 | World Journal of Radiology2016，8，2： | 3 |
| 6 | 日粮纤维在繁殖母猪生产中的重要作用显示文摘各种来源的纤维是猪日粮中的一种常见成分。纤维可以为养猪生产者提供一种利用本地生产的植物性原料(来自食品行业或饮料行业的副产品)的方法。含高水平纤维的日粮能够使动物产生饱腹感的价值早已得到公认。然而,向日粮中添加纤维可能会降低猪的采食量,对正处于对营养需求有较高要求的生产阶段(如仔猪的生长期和母猪的哺乳期)的猪而言这显然是不利的。最近,人们发现纤维能给养猪生产带来鲜为人知的益处,特别是考虑到世界各地要求养猪业减少抗生素的使用量、对采用限饲的猪的福利关注以及需要确保此类生产系统对环境友好。例如,在日粮中添加纤维能够以一种可能会降低抗生素需求量的方式改变动物肠道中微生物菌群组成,受控制地添加某些种类的纤维可以减少在养猪生产过程中向环境排放的氮的数量,从而降低环境成本。具有特殊潜在价值的粗纤维浓缩物(crude fibre concentrates)有可能会被用作提高仔猪生长速度或改善其福利的“功能性”饲料添加剂。也许使用含高水平纤维的日粮最有可能提高母猪繁殖率。配种前提高日粮中纤维的含量可提高卵母细胞的成熟度、胚胎存活率和窝产仔数,为养猪生产者创造一种消费者可以接受的能够提高每头母猪可销售猪肉产量的方法,但产生这些益处的机制尚不明确。然而,血浆和卵泡液中关键激素和代谢产物的浓度的改变以及下丘脑饱腹感中枢对促性腺激素的分泌和表观遗传学的影响是主要影响因素。 | 刘文峰(译) 潘雪男(审) Selene Jarrett Cheryl J.Ashworth | 2020 | 国外畜牧学(猪与禽)2020，40，8： | 2 |
| 7 | 玻璃体腔抗VEGF治疗糖尿病性黄斑水肿的疗效分析(英文)显示文摘目的:评估玻璃体腔内抗VEGF治疗糖尿病黄斑水肿(DME)24mo后的现实生活剖析和视觉效果。方法:本研究包括了2012-06/2016-12接受玻璃体腔内注射的视网膜内和/或视网膜下液体和基线中心黄斑厚度(CMT)超过300μm的DME患者。在基线处3,6,12,18和24mo评估视力(VA)和CMT的变化,以及患者就诊和玻璃体腔内注射总数。结果:研究包含40例患者(54眼)。基线处3mo LogMAR视力从0.67±0.47提高到0.59±0.43并在12mo内保持3.5±2.19次注射。12mo和24mo时平均就诊次数分别为9±2.39和15.48±4.84。基线处平均CMT为450±153μm,12mo和24mo时分别降至385±141μm和305±111μm(P<0.001)。结论:PRN方法在治疗DME中可以保持视力稳定并改善黄斑水肿,但在主动疗法中,较低的就诊负担可能会获得类似的或更好的治疗效果。 | Cemal ?avdarli Firat Selen Pinar Topcu Yilmaz Mehmet Numan Alp | 2019 | 国际眼科杂志2019，19，8： | 2 |
| 8 | Arylhydrazones Derivatives Containing a Benzothiazole Moiety, Efficient Ligands in the Palladium-Catalyzed Mizoroki-Heck and Suzuki-Miyaura Cross-coupling Reactions under IR Irradiation显示文摘包含可以在催化钯的 Mizoroki 被用作有效 ligand 的 benzothiazole 一半的简单 arylhydrazone -- 哎呀并且 Suzuki-Miyaura 跨 coupling 反应,在是的红外线的照耀下面精力的其他的来源,被介绍。反应在温和条件下面继续了极其高的效率并且生产了很好的收益。 | Fernando Ortega-Jiménez José Guillermo Penieres-Carrillo José Guadalupe López-Cortés M. Carmen Ortega-Alfaro Selene Lagunas-Rivera | 2017 | Chinese Journal of Chemistry2017，35，12： | 2 |
| 9 | Adipose-derived stem cells in the treatment of hepatobiliary diseases and sepsis显示文摘Determination of the mesenchymal stem cells is one of the greatest and most exciting achievements that tissue engineering and regenerative medicine have achieved.Adipose-derived mesenchymal stem cells(AD-MSC)are easily isolated and cultured for a long time before losing their stem cell characteristics,which are self-renewal and pluripotency.AD-MSC are mesenchymal stem cells that have pluripotent lineage characteristics.They are easily accessible,and the fraction of stem cells in the adipose tissue lysates is highest among all other sources of mesenchymal stem cells.It is also HLA-DR negative and can be transplanted allogenically without the need for immunosuppression.These advantages have popularized its use in many fields including plastic reconstructive surgery.However,in the field of hepatology and liver transplantation,the progress is slower.AD-MSC have the potential to modulate inflammation,ameliorate ischemia-reperfusion injury,and support liver and biliary tract regeneration.These are very important for the treatment of various hepatobiliary diseases.Furthermore,the anti-inflammatory potential of these cells has paramount importance in the treatment of sepsis.We need alternative therapeutic approaches to treat end-stage liver failure.AD-MSC can provide a means of therapy to bridge to definitive therapeutic alternatives such as liver transplantation.Here we propose to review theoretic applications of AD-MSC in the treatment of hepatobiliary diseases and sepsis. | Basri Satilmis Gizem Selen Cicek Egemen Cicek Sami Akbulut Tevfik Tolga Sahin Sezai Yilmaz | 2022 | World Journal of Clinical Cases2022，10，14： | 1 |
| 10 | Effect of storage on nonenzymatic browning of apple juice concentrates显示文摘 | SELEN BURDURLU H KARADENIZ F | | 0，，1： | 1 |
| 11 | The Needfor Comparison in Intercultural Education 显示文摘 | GuntherDietz & Laura Selene Mateos Cort 6 s | 2012 | InterculturalEducation2012，，5： | 1 |
| 12 | Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains 显示文摘 | ALBERTS P NILSSON C SELEN G | 2003 | Endocrinolo- gy2003，144，11： | 1 |
| 13 | Automatic ro- bust adaptive beamforming via ridge regression 显示文摘 | SELEN Y ABRAHAMSSON R STOICA P | 2008 | Signal Processing2008，88，1： | 1 |
| 14 | Model-order selection: a review of information criterion rules显示文摘 | Stoica P Selen Y | 2004 | IEEE Signal Process Mag2004，21，4： | 1 |
| 15 | Impact structures and events - a Nordic perspective显示文摘 | Henning Dypvik Jueri Plado Claus Heinberg Eckart Hakansson Lauri J. Pesonen Birger Schmitz Selen Raiskila | 2008 | Episodes2008，31，1： | 1 |
| 16 | Pharmacokinetics of probenecid following oral doses to human volunteers显示文摘 | Selen A Amidon GL Welling PG | 1982 | J Pharm Sci1982，71，： | 1 |
| 17 | Phylogeographic characteristics of vesicular stomatitis New Jersey viruses circulating in Mexico from 2005 to 2011 and their relationship to epidemics in the United States显示文摘 | Lauro Velazquez-Salinas Steven J. Pauszek Selene Zarate Francisco J. Basurto-Alcantara Antonio Verdugo-Rodriguez Andres M. Perez Luis L. Rodriguez | 2014 | Virology2014，，： | 1 |
| 18 | Dynamic capability building in serv ice value networks for achieving service innovation显示文摘 | Agarwal R and Selen W | | Deci sion Sciences0，，3： | 1 |
| 19 | The Impact of Internal Integration and Relationship Commitment on External Integration显示文摘 | ZHAO X D HUO B F SELEN W | 2011 | Journal of Operations Management2011，29，12： | 1 |
| 20 | The impact of internal integration and relationship commitment on external integration显示文摘 | Zhao X Huo B Selen W | 2011 | Journal of Operations Management2011，29，1： | 1 |
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