|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。 | Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 13 |
| 2 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 3 | Autoregulation of human optic nerve head circulation in response to increased intraocular pressure 显示文摘 | Pillunat LE Anderson DR Knighton RW | 1997 | Exp Eye Res1997，64，： | 2 |
| 4 | Calcitonin gene-related peptide regulates gene transcription in primary afferent neurons显示文摘 | Anderson LE Seybold VS | 2004 | J Neurochem2004，91，6： | 1 |
| 5 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 6 | Divergence in fitness and evolution of drug resistance in experimental populations of Candida albicans显示文摘 | Cowen LE Kohn LM Anderson JB | 2001 | J Bacteriol2001，183，10： | 1 |
| 7 | T cell activation is regulated by voltage-dependent and calcium-activated potassium channels显示文摘 | Rader RK Kahn LE Anderson GD | 1996 | J Immunol1996，156，4： | 1 |
| 8 | The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain 显示文摘 | Meyer MD Decker MW Rueter LE Anderson DJ Dart M J Kim KH | 2000 | Eur J Pharmacol2000，93，： | 1 |
| 9 | Regulation of progesterone and prostaglandin F2 alpha production in the CL 显示文摘 | Diaz FJ Anderson LE Wu YL | 2002 | Mol Cell Endocrinol2002，191，1： | 1 |
| 10 | Alkalemia-associated morbidity and mortality in medical and surgical patients显示文摘 | Anderson LE Henrich WL | 1987 | South Med J1987，80，6： | 1 |
| 11 | Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in bead and neck cancer显示文摘 | Keysar SB Le PN Anderson RT | 2013 | Cancer Res2013，73，11： | 1 |
| 12 | Rats Exposed to Intermittent 60 Hz Magnetic Fields 显示文摘 | Anderson LE Morris JE Miller DL | 2001 | Bioelectromagnetics2001，22，： | 1 |
| 13 | Effect sizes for inter preting changes in health status显示文摘 | Kazis LE Anderson JJ Meenan RF | 1989 | MedCare1989，27，3： | 1 |
| 14 | Hydrogen peroxide production and bactericidal activity in pronephros phagocyte sub-populations from fundulus heteroclitus following exposure to pentachloropheno显示文摘 | Roszell LE Anderson RS | 1997 | Pollution and Environmental Issues1997，44，1： | 1 |
| 15 | Personal computer versus workstation display : observer performance in detection of wrist fractures on digital radiographs显示文摘 | Doyle A J Le Fevre J Anderson G D | 2005 | Radiology2005，237，3： | 1 |
| 16 | Calcitonin gene-related peptide regu- lates gene transcription in primary afferent neurons 显示文摘 | Anderson LE Seybold VS | 2004 | J Neuro- chem2004，91，： | 1 |
| 17 | Evaluation of Fatigue Criteria for Bituminous Binder Binder 显示文摘 | Anderson D A Le Hir M Y Marasteanu M | 2001 | Transportation Research Record2001，1766，： | 1 |
| 18 | Effect sizes for interpreting changes in health status显示文摘 | Kazis LE Anderson JJ Meenan RF | 1989 | Med Care1989，27，： | 1 |
| 19 | The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain 显示文摘 | Decker MW Rueter LE Anderson DJ Dart M J Kim KH | 2000 | Eur J Pharmacol2000，393，13： | 1 |
| 20 | Effecting changes in high-molecular-weight glutenin subunit levels and composition using genetic transformation to creat new loci显示文摘 | Blechl A E Le H Q Anderson O A | 1997 | Cereal Foods World1997，42，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员