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| 1 | Hypertriglyceridemia-induced pancreatitis: A case-based review显示文摘Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemia and how it can cause pancreatitis. We outline how to investigate and manage such patients. A 35 year old man presented to the emergency department with abdominal pain and biochemical evidence of acute pancreatitis. There was no history of alcohol consumption and biliary imaging was normal. The only relevant past medical history was that of mild hyperlipidemia, treated with diet alone. Physical exam revealed epigastric tenderness, right lateral rectus palsy, lipemia retinalis, bitemporal hemianopsia and a delay in the relaxation phase of his ankle reflexes. Subsequent laboratory investigation revealed marked hypertriglyceridemia and panhypopituarism. An enhanced CT scan of the head revealed a large suprasellar mass impinging on the optic chiasm and hypothalamus. The patient was treated supportively; thyroid replacement and lipid lowering agents were started. He underwent a successful resection of a craniopharyngioma. Post- operatively, the patient did well on hormone replacement therapy. He has had no further attacks of pancreatitis. This case highlights many of the factors involved in the regulation of triglyceride metabolism. We review the common causes of hypertriglyceridemia and the proposed mechanisms resulting in pancreatitis. The incidence and management of hypertriglyceridemia- induced pancreatitis are also discussed. | S Ian Gan Alun L Edwards Christopher J Symonds Paul L Beck | 2006 | World Journal of Gastroenterology2006，12，44： | 35 |
| 2 | 我国青少年公共体育服务供给机制的地方实践与创新显示文摘聚焦于“供给侧改革”背景下,讨论我国青少年公共体育服务复合供给机制概念模型的构建,分析如何选择供给主体和可能存在的供给运行模式。基于实地调研与相关资料,深入剖析我国部分地方实践青少年公共体育服务供给模式创新的多个案例,提出在青少年公共体育服务的实际供给过程中,必须结合青少年公共体育服务类型和特点,考虑青少年体育需求表达,在复合机制理论模型建构基础上,通过供给模式组合的不同选择,形成由政府、市场、社会等多元主体采取多种方式供给青少年公共体育服务复合供给的局面,实现青少年公共体育服务供给机制的创新。 | 郭玲玲 HARDMAN Alun | 2019 | 沈阳体育学院学报2019，38，6： | 13 |
| 3 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 4 | Review of High Voltage Direct Current Cables显示文摘Increased renewable energy integration and international power trades have led to the construction and development of new HVDC transmission systems.HVDC cables,in particular,play an important role in undersea power transmission and offshore renewable energy integration having lower losses and higher reliability.In this paper,the current commercial feasibility of HVDC cables and the development of different types of HVDC cables and accessories are reviewed.The non-uniform electric field distribution caused by the applied voltage,temperature dependent conductivity,and space charge accumulation is briefly discussed.Current research in HVDC cable for higher operation voltage level and larger power capacity is also reviewed with specific focus on the methodologies of space charge suppression for XLPE extruded cables. | George Chen Miao Hao Zhiqiang Xu Alun Vaughan Junzheng Cao Haitian Wang | 2015 | CSEE Journal of Power and Energy Systems2015，1，2： | 5 |
| 5 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 6 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 7 | Towards carbon neutrality:A study on China's long-term low-carbon transition pathways and strategies显示文摘As the world's biggest carbon dioxide(CO_(2))emitter and the largest developing country,China faces daunting challenges to peak its emissions before 2030 and achieve carbon neutrality within 40 years.This study fully considered the carbon-neutrality goal and the temperature rise constraints required by the Paris Agreement,by developing six long-term development scenarios,and conducting a quantitative evaluation on the carbon emissions pathways,energy transformation,technology,policy and investment demand for each scenario.This study combined both bottom-up and top-down methodologies,including simulations and analyses of energy consumption of end-use and power sectors(bottom-up),as well as scenario analysis,investment demand and technology evaluation at the macro level(top-down).This study demonstrates that achieving carbon neutrality before 2060 translates to significant efforts and overwhelming challenges for China.To comply with the target,a high rate of an average annual reduction of CO_(2) emissions by 9.3%from 2030 to 2050 is a necessity,which requires a huge investment demand.For example,in the 1.5℃ scenario,an investment in energy infrastructure alone equivalent to 2.6%of that year's GDP will be necessary.The technological pathway towards carbon neutrality will rely highly on both conventional emission reduction technologies and breakthrough technologies.China needs to balance a long-term development strategy of lower greenhouse gas emissions that meets both the Paris Agreement and the long-term goals for domestic economic and social development,with a phased implementation for both its five-year and long-term plans. | Jiankun He Zheng Li Xiliang Zhang Hailin Wang Wenjuan Dong Ershun Du Shiyan Chang Xunmin Ou Siyue Guo Zhiyu Tian Alun Gu Fei Teng Bin Hu Xiu Yang Siyuan Chen Mingtao Yao Zhiyi Yuan Li Zhou Xiaofan Zhao Ying Li Danwei Zhang | 2022 | Environmental Science and Ecotechnology2022，，1： | 2 |
| 8 | Differential involvement of dendritic cell subsets during acute Salmonella infeetionl 显示文摘 | Alun C Kirby U Mattias S | 2001 | J Immunol2001，166，： | 1 |
| 9 | Microglia kill amyloid-β1-42 damaged neurons by a CD14-dependent process显示文摘 | Clive Bate Robert Veerhuis Piet Eikelenboom Alun Williams | 2004 | NeuroReport2004，，9： | 1 |
| 10 | Perspective of polyamine metabolism显示文摘 | Heather MW Alison VF Alun HA | 2003 | Biochem J2003，376，1： | 1 |
| 11 | In Situ Neutralization in Boc-chemistry Solid Phase Peptide Synthesis显示文摘 | Martina Schn?lzer Paul Alewood Alun Jones Dianne Alewood Stephen B. H. Kent | 2007 | International Journal of Peptide Research and Therapeutics (-)2007，，1： | 1 |
| 12 | Recycling former psychiatric hospitals in New Zealand: Echoes of deinstitutionalisation and restructuring显示文摘 | Alun E. Joseph Robin A. Kearns Graham Moon | 2008 | Health and Place2008，，1： | 1 |
| 13 | Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and incient coronary heart disease:The PRIME study显示文摘 | Gerald LU AB Dominique AC Alun ED | 2003 | Atherosclerosis2003，170，1： | 1 |
| 14 | Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations显示文摘 | Kari Kuulasmaa Hugh Tunstall-Pedoe Annette Dobson Stephen Fortmann Susana Sans Hanna Tolonen Alun Evans Marco Ferrario | 2000 | 2000 (9205)2000，，9205： | 1 |
| 15 | Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42显示文摘 | Clive Bate Mario Salmona Alun Williams | 2004 | J Neuroinflammation2004，1，5： | 1 |
| 16 | Better knowledge management through knowledge engineering显示文摘 | Alun Preece Alan Flett Derek Sleeman | 2001 | IEEE Intelligent Systems2001，16，1： | 1 |
| 17 | A homogenous linear programming algorithm for the security constrained economic dispatch problem显示文摘 | RABIN A J ALUN H C BRIAN J C | 2000 | IEEE Transactions on Power Systems2000，15，3： | 1 |
| 18 | Voluntary emission reduction market in China: development, management status and future supply显示文摘The voluntary emission reduction (VER) trading mechanism has played an important role in China’s seven pilot carbon markets. From a comprehensive review of the VER trading and offsetting mechanisms since 2013, this study analyses the quality management of the Chinese Certified Emission Reduction (CCER) in the pilot carbon markets, conducts a comparative analysis of the geographical and field distributions of proposed and registered projects and emission reductions and provides the CCER supply outlook for 2020 in the aspects of on record, project registration, emission reduction registration and emission reduction issuance. Results show that the potential number of CCER projects by 2020 will be 2,864, 1,047, 818, and 286 with the corresponding emission reductions amounting to 493, 212, 133, and 49 million tCO2e, respectively. Although considerable progress has been made, China remains confronted with many challenges in developing the VER trading system. Accordingly, policy stability and continuity and guarding against market risks should be maintained to enable the system to play a substantial role in promoting ecological progress and green low-carbon development in China. | Yi Zhou Alun Gu Maozhi Deng | 2019 | Chinese Journal of Population,Resources and Environment2019，17，1： | 1 |
| 19 | Large-scale dispersant leaching and effectiveness ex- periments with oils on calm water 显示文摘 | Alun Lewis A B Ken Trudel Randy C Belore | 2010 | Marine Pollution Bulletin2010，60，2： | 1 |
| 20 | Perspective of polyamine metabolish显示文摘 | Heather MW Alison VF Alun HA | 2003 | Biochem J2003，376，1： | 1 |
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