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| 1 | A general-purpose machine learning framework for predicting properties of inorganic materials显示文摘A very active area of materials research is to devise methods that use machine learning to automatically extract predictive models from existing materials data.While prior examples have demonstrated successful models for some applications,many more applications exist where machine learning can make a strong impact.To enable faster development of machine-learning-based models for such applications,we have created a framework capable of being applied to a broad range of materials data.Our method works by using a chemically diverse list of attributes,which we demonstrate are suitable for describing a wide variety of properties,and a novel method for partitioning the data set into groups of similar materials to boost the predictive accuracy.In this manuscript,we demonstrate how this new method can be used to predict diverse properties of crystalline and amorphous materials,such as band gap energy and glass-forming ability. | Logan Ward Ankit Agrawal Alok Choudhary Christopher Wolverton | 2016 | npj Computational Materials2016，，1： | 83 |
| 2 | Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats显示文摘Aim:To investigate the effect of arsenic on spermatogenesis.Methods:Mature(4 months old)Wistar rats were intraperitoneally administered sodium arsenite at doses of 4,5 or 6mg·kg^-1·day^-1 for 26 days.Different varieties of germ cells at stage Ⅶ seminiferous epithelium cycle,namely,type A spermatogonia(ASg),preleptotene spermatocytes(pLSc),midpachytene spermatocytes(mPSc) and step 7 spermatids(7Sd) were quantitatively evaluated, along with radioimmunoassay of plasma follicle-stimulating hormone(FSH),lutuneizing hormone(LH),testosterone and assessment of the epididymal sperm count.Results:In the 5 and 6 mg/kg groups,there were significant dosedependent decreases in the accessory sex organ weights,epididymal sperm count and plasma concentrations of LH,FSH and testosterone with massive degeneration of all the germ cells at stage Ⅶ,The changes were insignificant in the 4 mg/kg group.Conclusion:Arsenite has a suppressive influence on spermatogenesis and gonadotrophin and testosterone release in rats. | Mahitosh Sarkar Gargi Ray Chaudhuri Aloke Chattopadhyay Narendra Mohan Biswas | 2003 | Asian Journal of Andrology2003，5，1： | 24 |
| 3 | Acclimation and Tolerance Strategies of Rice under Drought Stress显示文摘Rice(Oryza sativa L.) is an important food crop and requires larger amount of water throughout its life cycle as compared to other crops. Hence,water related stress cause severe threat to rice production. Drought is a major challenge limiting rice production. It affects rice at morphological(reduced germination,plant height,plant biomass,number of tillers,various root and leaf traits),physiological(reduced photosynthesis,transpiration,stomatal conductance,water use efficiency,relative water content,chlorophyll content,photosystem Ⅱ activity,membrane stability,carbon isotope discrimination and abscisic acid content),biochemical(accumulation of osmoprotectant like proline,sugars,polyamines and antioxidants) and molecular(altered expression of genes which encode transcription factors and defence related proteins) levels and thereby affects its yield. To facilitate the selection or development of drought tolerant rice varieties,a thorough understanding of the various mechanisms that govern the yield of rice under water stress condition is a prerequisite. Thus,this review is focused mainly on recent information about the effects of drought on rice,rice responses as well as adaptation mechanisms to drought stress. | Veena PANDEY Alok SHUKLA | 2015 | Rice science2015，22，4： | 23 |
| 4 | Pathogenic mechanisms of pancreatitis显示文摘Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pan-creatitis characterized by marked stroma formation with a high number of infiltrating granulocytes(such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells(PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i.e., a major risk factor for pancreatic cancer. A number of inflammatory cytokines are known to involve in pro-moting pancreatic pathogenesis that lead pancreatic fibrosis. Pancreatic fibrosis is a dynamic phenomenon that requires an intricate network of several autocrine and paracrine signaling pathways. In this review, we have provided the details of various cytokines and molecular mechanistic pathways(i.e., Transforming growth factor-β/SMAD, mitogen--activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) that have a critical role in the activation of PSCs to promote chronic pancreatitis and trigger the phenomenon of pancreatic fibrogenesis. In this review of literature, we discuss the involvement of several pro-inflammatory and anti-inflammatory cytokines, such as in interleukin(IL)-1, IL-1β, IL-6, IL--8 IL-10, IL-18, IL--33 and tumor necrosis factor-α, in the pathogenesis of disease. Our review also highlights the significance of several experimental animal models that have an important role in dissecting the mechanistic pathways operating in the development of chronic pancreatitis, including pancreatic fibrosis. Additionally, we provided several intermediary molecules that are involved in major signaling pathways that might provide target molecules for future therapeutic treatment strategies for pancreatic pathogenesis. | Murli Manohar Alok Kumar Verma Sathisha Upparahalli Venkateshaiah Nathan L Sanders Anil Mishra | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 21 |
| 5 | Gastric polyps: Association with Helicobacter pylori status and the pathology of the surrounding mucosa, a cross sectional study显示文摘aim:To assess the endoscopic characteristics of gastric polyps and their association with Helicobacter pylori(H.pylori)status in a predominantly Hispanic population.m ETHODS:We conducted a retrospective study of all esophagogastroduodenoscopies performed at our institution.Demographic,endoscopic and histopathological data were reviewed.Categorization of patients into Hispanic and Non-Hispanic was based on selfidentification.Patients without resection/biopsy were not included in the analysis.Identification of polyps type was based on histological examination.One way analysis of variance was used to compare continuousvariables among different polyp types and Fisher’s exact test was used compare categorical variables among polyp types.Unadjusted and adjusted comparisons of demographic and clinical characteristics were performed according to the H.pylori status and polyp type using logistic regressions.RESULTS:Of 7090 patients who had upper endoscopy,335 patients had gastric polyps(4.7%).Resection or biopsy of gastric polyps was performed in 296 patients(88.4%)with a total of 442 polyps removed or biopsied.Of 296 patients,87(29%)had hyperplastic polyps,82(28%)had fundic gland polyps and 5(1.7%)had adenomatous polyps.Hyperplastic polyps were significantly associated with positive H.pylori status compared with fundic gland polyps(OR=4.621;95%CI:1.92-11.13,P=0.001).Hyperplastic polyps were also found to be significantly associated with portal hypertensive gastropathy compared with fundic gland polyps(OR=6.903;95%CI:1.41-33.93,P=0.0174).Out of 296 patients,30(10.1%)had a followup endoscopy with a mean duration of 26±16.3 mo.Interval development of cancer was not noted in any of the patients during follow up period.CONCLUSi ON:Gastric hyperplastic polyps were significantly associated with positive H.pylori status and portal hypertensive gastropathy as compared with fundic gland polyps. | Sherif Elhanafi Mohammed Saadi Wynee Lou Indika Mallawaarachchi Alok Dwivedi Marc Zuckerman Mohamed O Othman | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，10： | 18 |
| 6 | Post-Translational Derepression of Invertase Activity in Source Leaves via Down-Regulation of Invertase Inhibitor Expression Is Part of the Plant Defense Response显示文摘正在增加病原体做的证据不仅得到直接防卫回答,而且在主要糖类新陈代谢引起显著变化。Cell-wall-bound 转化酶属于糖类划分和来源水池关系的关键管理者。而研究到目前为止响应病原体感染仅仅集中了于转化酶基因的 transcriptional 正式就职,转化酶活动的 translational 以后规定的角色被忽视了并且是现在的学习的焦点。表示分析表明高 mRNA 在 Arabidopsis thaliana 的来源叶子从三个 proteinaceous 转化酶禁止者一个铺平被 Pseudomonas syringae pv 的剧毒的紧张强烈在感染之上镇压。西红柿 DC3000。这压抑是由在转化酶禁止者活动的减少的 paralleled。这规章的机制的生理的角色被发现那在由 P 的感染之上仅仅在 situ 转化酶活动是可检测的揭示。syringae。相反,一项高转化酶活动能在 vitro 被测量在粗略并且准备从的房间墙摘录感染并且非感染的叶子。差异在之间在里面 situ 并且在在 situ 的控制叶子和高度的 vitro 转化酶活动,在感染的叶子的转化酶活动能被转化酶禁止者表示和伴随物减小的病原体依赖者压抑在转化酶禁止者活动解释。从为防卫反应的 translational 以后抑制的转化酶的版本的功能的重要性被竞争化学转化酶禁止者 acarbose 的申请证实。由在叶子的 acarbose 的渗入的细胞外的转化酶活动的 translational 以后抑制被显示增加危险性到 P。syringae。光合作用的压抑和细菌的生长的提升的空间、时间的动力学上的转化酶抑制的影响在植物防卫为细胞外的转化酶在病原体感染期间支持一个角色。危险性的调停 acarbose 的增加在 sid2 和 cpr6 异种也是可检测的并且导致了水杨酸酸的稍微提高的层次,证明效果独立于水杨酸调整酸的防卫小径。这些调查结果为在来源叶子发现被使蛋白质被在转化酶和转化酶禁止者之间的 translational 以后相互作用在 situ 禁止了的高可引出的转化酶活动提供解释。在病原体感染之上,转化酶活动被转化酶禁止者表示的压抑释放,因此连接水池力量的本地正式就职到植物防卫反应。 | Katharina B. Bonfig Andrea Gabler Uwe K. Simon Nora Luschin-Ebengreuth Martina Hatz Susanne Berger Naseem Muhammad Jurgen Zeier Alok K. Sinha Thomas Roitsch | 2010 | Molecular Plant2010，3，6： | 14 |
| 7 | 用于固态照明的Mn^4+离子光谱学显示文摘Mn^4+离子激活的荧光粉在固态照明领域作为红光发射的热点载体正日益受到关注。我们针对当前研究热度撰写了Mn^4+离子光谱学的回顾,并在回顾中聚焦了许多对红色荧光粉商业研制有价值的重要基础研究点。这些研究点涵盖了如何理解自由和晶场状态下Mn^4+离子的能级结构以及Mn^4+发射波长对基质的依赖关系。此外,我们就如何实验调控Mn^4+离子掺杂型荧光粉的发射波长和发光强度给出了许多实际可行的建议。更为重要的是,我们收集并讨论了100多种荧光粉基质中Mn^4+离子光谱学参数,对它们的理解将会为未来Mn^4+掺杂型红色荧光粉的实验开发奠定基础。 | BRIK Mikhail G 马崇庚 SRIVASTAVA Alok M PIASECKI Michal | 2020 | 发光学报2020，41，9： | 11 |
| 8 | Recent advances and applications of deep learning methods in materials science显示文摘Deep learning(DL)is one of the fastest-growing topics in materials data science,with rapidly emerging applications spanning atomistic,image-based,spectral,and textual data modalities.DL allows analysis of unstructured data and automated identification of features.The recent development of large materials databases has fueled the application of DL methods in atomistic prediction in particular.In contrast,advances in image and spectral data have largely leveraged synthetic data enabled by high-quality forward models as well as by generative unsupervised DL methods.In this article,we present a high-level overview of deep learning methods followed by a detailed discussion of recent developments of deep learning in atomistic simulation,materials imaging,spectral analysis,and natural language processing.For each modality we discuss applications involving both theoretical and experimental data,typical modeling approaches with their strengths and limitations,and relevant publicly available software and datasets.We conclude the review with a discussion of recent cross-cutting work related to uncertainty quantification in this field and a brief perspective on limitations,challenges,and potential growth areas for DL methods in materials science. | Kamal Choudhary Brian DeCost Chi Chen Anubhav Jain Francesca Tavazza Ryan Cohn Cheol Woo Park Alok Choudhary Ankit Agrawal Simon J.L.Billinge Elizabeth Holm Shyue Ping Ong Chris Wolverton | 2022 | npj Computational Materials2022，，1： | 9 |
| 9 | Thermal decomposition and kinetics of plastic bonded explosives based on mixture of HMX and TATB with polymer matrices显示文摘This work describes thermal decomposition behaviour of plastic bonded explosives(PBXs) based on mixture of 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX) and 2,4,6-triamino-1,3,5-trinitrobenzene(TATB)with Viton A as polymer binder. Thermal decomposition of PBXs was undertaken by applying simultaneous thermal analysis(STA) and differential scanning calorimetry(DSC) to investigate influence of the HMX amount on thermal behavior and its kinetics. Thermogravimetric analysis(TGA) indicated that the thermal decomposition of PBXs based on mixture of HMX and TATB was occurred in a three-steps. The first step was mainly due to decomposition of HMX. The second step was ascribed due to decomposition of TATB, while the third step was occurred due to decomposition of the polymer matrices. The thermal decomposition % was increased with increasing HMX amount. The kinetics related to thermal decomposition were investigated under non-isothermal for a single heating rate measurement. The variation in the activation energy of PBXs based on mixture of HMX and TATB was observed with varying the HMX amount. The kinetics from the results of TGA data at various heating rates under non-isothermal conditions were also calculated by Flynn—Wall—Ozawa(FWO) and Kissinger-Akahira-Sunose(KAS)methods. The activation energies calculated by employing FWO method were very close to those obtained by KAS method. The mean activation energy calculated by FWO and KAS methods was also a good agreement with the activation energy obtained from single heating rate measurement in the first step decomposition. | Arjun Singh Tirupati C.Sharma Mahesh Kumar Jaspreet Kaur Narang Prateek Kishore Alok Srivastava | 2017 | Defence Technology(防务技术)2017，13，1： | 8 |
| 10 | ST-segment elevation: Distinguishing ST elevation myocardial infarction from ST elevation secondary to nonischemic etiologies显示文摘The benefits of early perfusion in ST elevation myocardial infarctions(STEMI) are established; howeverearly perfusion of non-ST elevation myocardial infarctions has not been shown to be beneficial. In additionST elevation(STE) caused by conditions other thanacute ischemia is common. Non-ischemic STE may beconfused as STEMI, but can also mask STEMI on electrocardiogram(ECG). As a result, activating the primarypercutaneous coronary intervention(pPCI) protocooften depends on determining which ST elevation patterns reflect transmural infarction due to acute coronary artery thrombosis. Coordination of interpreting theECG in its clinical context and appropriately activatingthe pPCI protocol has proved a difficult task in borderline cases. But its importance cannot be ignored, asreflected in the 2013 American College of CardiologyFoundation/American Heart Association guidelines concerning the treatment of ST elevation myocardial infarction. Multiples strategies have been tested and studiedand are currently being further perfected. No mattethe strategy, at the heart of delivering the best care lies rapid and accurate interpretation of the ECG. Here, we present the different patterns of non-ischemic STE and methods of distinguishing between them. In writing this paper, we hope for quicker and better stratification of patients with STE on ECG, which will lead to be bet-ter outcomes. | Alok Deshpande Yochai Birnbaum | 2014 | World Journal of Cardiology2014，6，10： | 7 |
| 11 | Computational Identification of Sweet Wormwood (Artemisia annua) microRNA and Their mRNA Targets显示文摘Despite its efficacy against malaria, the relatively low yield (0.01%-0.8%) of artemisinin in Artemisia annua is a serious limitation to the commercialization of the drug. A better understanding of the biosynthetic pathway of artemisinin and its regulation by both exogenous and endogenous factors is essential to improve artemisinin yield. Increasing evidence has shown that microRNAs (miRNAs) play multiple roles in various biological processes. In this study, we used previously known miRNAs from Arabidopsis and rice against expressed sequence tag (EST) database of A. annua to search for potential miRNAs and their targets in A. annua. A total of six potential miRNAs were predicted, which belong to the miR414 and miR1310 families. Furthermore, eight potential target genes were identified in this species. Among them, seven genes encode proteins that play important roles in ar- temisinin biosynthesis, including HMG-CoA reductase (HMGR), amorpha-4,11-diene synthase (ADS), farnesyl pyrophosphate synthase (FPS) and cytochrome P450. In addition, a gene coding for putative AINTEGUMENTA, which is involved in signal transduction and development, was also predicted as one of the targets. This is the first in silico study to indicate that miRNAs target genes encoding enzymes involved in artemisinin biosynthesis, which may help to understand the miRNA-mediated regulation of artemisinin biosynthesis in A. annua. | Alok Pani Rajani Kanta Mahapatra Niranjan Behera Pradeep Kumar Naik | 2011 | Genomics, Proteomics & Bioinformatics2011，9，6： | 7 |
| 12 | Machining of circular micro holes by electrochemical micro-machining process显示文摘Machining of micro holes with micro electrochemical machining(micro ECM) process has been carried out with an indigenously developed set up.This paper describes relevant problems and solutions for the circular micro holes machining process on 304 stainless steel sheets with 60 μm thickness using high speed steel cylindrical tool of diameter 500 μm and using dilute H_2SO_4 as electrolyte.The taper angle variation of the machined hole is analyzed and reported for different experimental setting parameters.The minimum value of the taper angle of machined holes is achieved at the parameter setting of0.4 mol/L H_2SO_4,700 kHz,600 ns and 21 V,for stainless steel sheets and HSS tool. | Alok Kumar Das P. Saha AlokKumarDas·ParthaSaha | 2013 | Advances in Manufacturing2013，1，4： | 6 |
| 13 | A Molecular Framework for the Control of Adventitious Rooting by TIR1/AFB2-Aux/IAADependent Auxin Signaling in Arabidopsis显示文摘In Arabidopsis thaliana,canonical auxin-dependent gene regulation is mediated by 23 transcription factors from the AUXIN RESPONSE FACTOR(ARF)family that interact with auxin/indole acetic acid repressors(Aux/IAAs),which themselves form co-receptor complexes with one of six TRANSPORT INHIBITOR*!/AUXIN-SIGNALLING F-BOX(TIR1/AFB)proteins.Different combinations of co-receptors drive specific sensing outputs,allowing auxin to control a myriad of processes.ARF6 and ARF8 are positive regulators of adventitious root initiation upstream of jasmonate,but the exact auxin co-receptor complexes controlling the transcriptional activity of these proteins has remained unknown.Here,using loss-of-function mutants we show that three Aux/IAA genes,IAA6,IAA9,and IAA17,act additively in the control of adventitious root(AR)initiation.These three IAA proteins interact with ARF6 and/or ARF8 and likely repress their activity in AR development.We show that TIR1 and AFB2 are positive regulators of AR formation and TIR1 plays a dual role in the control of jasmonic acid(JA)biosynthesis and conjugation,as several JA biosynthesis genes are up-regulated in the tir1-1 mutant.These results lead us to propose that in the presence of auxin,TIR1 and AFB2 form specific sensing complexes with IAA6,IAA9,and/or IAA17 to modulate JA homeostasis and control AR initiation. | Abdellah Lakehal Salma Chaabouni Emilie Cavel Rozenn Le Hir Alok Ranjan Zahra Raneshan Ondrej Novak Daniel IPacurar Irene Perrone Frangois Jobert Laurent Gutierrez Laszlo Bako Catherine Bellini | 2019 | Molecular Plant2019，12，11： | 5 |
| 14 | The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation显示文摘 | Vidisha Tripathi Jonathan D. Ellis Zhen Shen David Y. Song Qun Pan Andrew T. Watt Susan M. Freier C. Frank Bennett Alok Sharma Paula A. Bubulya Benjamin J. Blencowe Supriya G. Prasanth Kannanganattu V. Prasanth | 2010 | Molecular Cell2010，，6： | 4 |
| 15 | Carcinogenic Helicobacter pylori in gastric pre-cancer and cancer lesions: Association with tobacco-chewing显示文摘AIM:To investigate the low gastric cancer incidence rate relative to the highly prevalent Helicobacter pylori(H.pylori)infection;data relevant to H.pylori infection during gastric carcinogenesis in Indian patients is currently lacking.METHODS:The present study examines the prevalence of H.pylori infection in DNA derived from 156endoscopic gastric biopsies of different disease groups that represent gastric pre-cancer[intestinal metaplasia(n=15),dysplasia(n=15)],cancer[diffuse adenocarcinoma(n=44),intestinal adenocarcinoma(n=21)],and symptomatic but histopathologically-normal controls(n=61).This was done by generic ureC polymerase chain reaction(PCR)and cagA-specific PCR that could specifically identify the carcinogenic H.pylori strain.RESULTS:Our analysis showed the presence of H.pylori infection in 61%of symptomatic histopathologically-normal individuals,however only 34%of control tissues were harboring the cagA+H.pylori strain.A similar proportion of H.pylori infection(52%)and cagA(26%)positivity was observed in the tumor tissue of the gastric cancer group.In comparison,H.pylori infection(90%)and cagA positivity(73%)were the highest in gastric pre-cancer lesions.In relation to tobacco and alcohol abuse,H.pylori infection showed an association with tobacco chewing,whereas we did not observe any association between tobacco smoking or alcohol abuse with prevalence of H.pylori infection in the tissue of any of the patient groups studied.CONCLUSION:High incidence of H.pylori infection and carcinogenic cagA positive strain in pre-cancer lesions during gastric carcinogenesis may be | Arvind Pandey Satyendra Chandra Tripathi Sutapa Mahata Kanchan Vishnoi Shirish Shukla Sri Prakash Misra Vatsala Misra Suresh Hedau Ravi Mehrotra Manisha DwivediZ Alok C Bharti | 2014 | World Journal of Gastroenterology2014，20，22： | 4 |
| 16 | And-hyperglycemic activity of leaves extract of Hyptis suavcolens L.Poit in streptozotocin induced diabetic rats显示文摘Objective:To evaluate the antihyperglycemic activity of leaves of Hyptis suaveolens using streptozotocin model.Mothods:Hyptis suaveolens extract(HSE) 250 and 500 mg/kg body weight was administered orally to streptozotocin induced diabetes,once daily for 21 days.Results:A significant reduction in blood glucose was observed in diabetic animals treated with HSE at different doses when compared with diabetic rats.Levels of triglyceride,total cholesterol,low density lipoprolein.very low density lipoprotein were decreased while administering HSE at different doses,compared with their control values in diabetic animals.Conclusions:Our results show that HSE possesses significant antihyperglycemic activity which might be attributed to stimulating effects on glucose utilization and antioxidant enzyme. | Shanti Bhushan Mishra Amita Verma Alok Mukerjee Vijayakumar M | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 4 |
| 17 | Herbal antioxidant in clinical practice:A review显示文摘Antioxidant-the word itself is magic.Using the antioxidant concept as a spearhead in proposed mechanisms for staving off so-called'free-radical'reactions,the rush is on to mine claims for the latest and most effective combination of free-radical scavenging compounds.We must acknowledge that such'radicals'have definitively been shown to damage all biochemical components such as DNA/HNA,carbohydrates,unsaturated lipids,proteins,and micronutrients such as carotenoids(alpha and beta carotene,lycopene),vitamins A,B_6,B_(12),and folate.Defense strategies against such aggressive radical species include enzymes,antioxidants that occur naturally in the body(glutathione,uric acid,ubiquinol-10,and others)and radical scavenging nutrients,such as vitamins A,C,and E,and carotenoids.This paper will present a brief discussion of some well-and little-known herbs that may add to the optimization of antioxidant status and therefore offer added preventive values for overall health.It is important to state at the outset that antioxidants vary widely in their free-radical quenching effects and each may be individually attracted to specific cell sites.Further evidence of the specialized nature of the carotenoids is demonstrated by the appearance of two carotenoids in the macula region of the retina where beta-carotene is totally | Shashi Alok Sanjay Kumar Jain Amita Verma Mayank Kumar Alok Mahor Monika Sabharwal | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 4 |
| 18 | Transplantation of engineered exosomes derived from bone marrow mesenchymal stromal cells ameliorate diabetic peripheral neuropathy under electrical stimulation显示文摘Diabetic peripheral neuropathy(DPN)is a long-term complication associated with nerve dysfunction and uncontrolled hyperglycemia.In spite of new drug discoveries,development of effective therapy is much needed to cure DPN.Here,we have developed a combinatorial approach to provide biochemical and electrical cues,considered to be important for nerve regeneration.Exosomes derived from bone marrow mesenchymal stromal cells(BMSCs)were fused with polypyrrole nanoparticles(PpyNps)containing liposomes to deliver both the cues in a single delivery vehicle.We developed DPN rat model and injected intramuscularly the fused exosomal system to understand its long-term therapeutic effect.We found that the fused system along with electrical stimulation normalized the nerve conduction velocity(57.60±0.45 m/s)and compound muscle action potential(16.96±0.73 mV)similar to healthy control(58.53±1.10 m/s;18.19±1.45 mV).Gastrocnemius muscle morphology,muscle mass,and integrity were recovered after treatment.Interestingly,we also observed paracrine effect of delivered exosomes in controlling hyperglycemia and loss in body weight and also showed attenuation of damage to the tissues such as the pancreas,kidney,and liver.This work provides a promising effective treatment and also contribute cutting edge therapeutic approach for the treatment of DPN. | Anamika Singh Alok Raghav Parvaiz Ahmad Shiekh Ashok Kumar | 2021 | Bioactive Materials2021，6，8： | 4 |
| 19 | 西印度醋栗对四氯化碳引起的大鼠和小鼠急性过氧化肝损伤的保护作用(英文)显示文摘目的:证实西印度醋栗(Phyllanthus acidus(L.)Skeels)的果实在传统医学中作为保肝药使用的药用用途。方法:连续5d分别给予各组大鼠西印度醋栗果实的70%乙醇提取物(100,200和400mg/kg口服)及对照药水飞蓟素(100mg/kg口服)并于第2天及第3天皮下注射四氯化碳(2mL/kg)。测定血清天冬氨酸氨基转移酶(aspartate transaminase,AST)、丙氨酸氨基转移酶(alanine transaminase,ALT)、碱性磷酸酶(alkaline phosphatase,ALP)、总胆红素以及总蛋白并进行肝脏组织病理学检测。检测大鼠肝组织匀浆中的氧化应激标记物如脂质过氧化反应(lipid peroxidation,LPO)、还原型谷胱甘肽(reduced glutathione,GSH)、超氧化物歧化酶(superoxide dismutase,SOD)、过氧化氢酶(catalase,CAT)以及谷胱甘肽过氧化物酶(glutathione peroxidase,GPx)以衡量西印度醋栗的体外抗氧化作用。此外,本实验还记录了伊维巴诱导的给药后小鼠睡眠时间,使用2,2-二苯基-1-苦基肼(2,2-diphenyl-1-picrylhydrazil,DPPH)法测定小鼠服药后的自由基清除率。结果:与对照组相比,西印度醋栗果实的乙醇提取物及水飞蓟素均显著降低了模型大鼠血清AST、ALT和ALP水平及LPO并升高了TP、GSH、SOD、CAT和GPx的水平(P<0.01或P<0.05)。大鼠肝脏组织的组织病理学切片结果也证实了以上实验结果。在小鼠实验中,与对照组相比,西印度醋栗果实的乙醇提取物显著缩短了伊维巴诱导的小鼠睡眠时间(P<0.01),并具有较高的DPPH清除率。结论:本研究的实验结果证实了西印度醋栗果实对四氯化碳引起的大鼠急性过氧化肝损伤的保护作用,机制可能与其抗氧化作用及自由基清除功能有关。 | Nilesh Kumar Jain Santram Lodhi Avijeet Jain Alok Nahata Abhay K.Singhai | 2011 | 中西医结合学报2011，9，1： | 3 |
| 20 | Two-warehouse inventory model for deteriorating items with demand influenced by innovation criterion in growing technology market显示文摘One of the major concerns for the technology market is the demand volatility andits impact on inventory policies. Demand volatility in the technology sector mayarise due to many factors namely customer choices, competition, growingmarket size, and so on. Often companies use rented warehouses to absorb anyfluctuations in demand. Unfortunately, warehouse and inventory researchesignore the phenomenon of growing market size to formulate policy decisions. Inthis paper, we proposed a two-warehouse inventory model with deterioration fortechnology products with linearly increasing market size where demand followsinnovation diffusion criterion. The model is based on the assumption that theholding costs in the rented warehouse are more than the own warehouse. Asimple solution procedure also discussed to solve nonlinear cost function.Numerical example and sensitivity analysis are also used to describe the utilityof the model. | Alok Kumar Udayan Chandab | 2018 | Journal of Management Analytics2018，5，3： | 3 |
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