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| 1 | Carcinogenic Helicobacter pylori in gastric pre-cancer and cancer lesions: Association with tobacco-chewing显示文摘AIM:To investigate the low gastric cancer incidence rate relative to the highly prevalent Helicobacter pylori(H.pylori)infection;data relevant to H.pylori infection during gastric carcinogenesis in Indian patients is currently lacking.METHODS:The present study examines the prevalence of H.pylori infection in DNA derived from 156endoscopic gastric biopsies of different disease groups that represent gastric pre-cancer[intestinal metaplasia(n=15),dysplasia(n=15)],cancer[diffuse adenocarcinoma(n=44),intestinal adenocarcinoma(n=21)],and symptomatic but histopathologically-normal controls(n=61).This was done by generic ureC polymerase chain reaction(PCR)and cagA-specific PCR that could specifically identify the carcinogenic H.pylori strain.RESULTS:Our analysis showed the presence of H.pylori infection in 61%of symptomatic histopathologically-normal individuals,however only 34%of control tissues were harboring the cagA+H.pylori strain.A similar proportion of H.pylori infection(52%)and cagA(26%)positivity was observed in the tumor tissue of the gastric cancer group.In comparison,H.pylori infection(90%)and cagA positivity(73%)were the highest in gastric pre-cancer lesions.In relation to tobacco and alcohol abuse,H.pylori infection showed an association with tobacco chewing,whereas we did not observe any association between tobacco smoking or alcohol abuse with prevalence of H.pylori infection in the tissue of any of the patient groups studied.CONCLUSION:High incidence of H.pylori infection and carcinogenic cagA positive strain in pre-cancer lesions during gastric carcinogenesis may be | Arvind Pandey Satyendra Chandra Tripathi Sutapa Mahata Kanchan Vishnoi Shirish Shukla Sri Prakash Misra Vatsala Misra Suresh Hedau Ravi Mehrotra Manisha DwivediZ Alok C Bharti | 2014 | World Journal of Gastroenterology2014，20，22： | 4 |
| 2 | Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil显示文摘 | Arvind Pandey Kanchan Vishnoi Sutapa Mahata Satyendra Chandra Tripathi Sri Prakash Misra Vatsala Misra Ravi Mehrotra Manisha Dwivedi Alok C. Bharti | 2015 | Nutrition and Cancer2015，，8： | 2 |
| 3 | Assessment of surface and subsurface waterlogging, water level fluctuations, and lithological variations for evaluating groundwater resources in Ganga Plains显示文摘In the present study,the multi-temporal satellite images of IRS P6 LISS III were used to map waterlogging dynamics over different seasons.An area of 594.36 km2(6.75%)and 4.17 km^(2)(0.04%)was affected by surface waterlogging during pre and postmonsoon season,respectively.The average annual groundwater level fluctuations were calculated using 18 years(1990-2007)pre and postmonsoon groundwater level data to identify the areas which are under groundwater induced waterlogging conditions.The soil map clearly indicates that salinity and sodicity exhibit the highest severity and occur in areas with shallow groundwater levels.The hydrogeomorphical units mapped using IRS P6 LISS III satellite images are flood plain,alluvial plain,paleochannels,and oxbow lakes.The study revealed that 44.65%areas have very good to excellent groundwater resources.The litholog data clearly indicate an alternating sequence of clay and sand in which deep aquifers made up of coarse sand would be best suited for adequate water supply and good groundwater quality.The integrated study utilizing digital spatial data pertaining to waterlogging,soil salinity,water level fluctuation,and lithological variation proved that planning of any surface and subsurface water resources development activity should be taken up after assessments of said parameters. | Arvind Chandra Pandey Suraj Kumar Singh M.S.Nathawat Dipankar Saha | 2013 | International Journal of Digital Earth2013，6，3： | 1 |
| 4 | Effect of SBS content on low temperature impact strength,morphology and rheology of PP-cp/SBS blends显示文摘 | Vishal Das Saurabh Singh Gautam Arvind Kumar Pandey | 2011 | Polymer-Plastics Technology and Engineering2011，50，8： | 1 |
| 5 | Insulin-like growth factor-1 regulates glutathione peroxidase expression and activity in vascular endothelial cells: Implications for atheroprotective actions of insulin-like growth factor-1显示文摘 | Yusuke Higashi Arvind Pandey Brett Goodwin Patrice Delafontaine | 2012 | BBA - Molecular Basis of Disease2012，，： | 1 |
| 6 | Remote Sensing approach to evaluate anthropogenic influences on Forest Cover of Palamau Tiger Reserve,Eastern India显示文摘Background:Tropical forests have been experiencing remarkable rates of transformation over the past century as they are getting degraded or decimated to a great extent by anthropogenic activities.This study aims at investigating the long-term forest cover transformation in Palamau Tiger Reserve(PTR),Jharkhand,India,using Landsat TM,ETM+,and OLI satellite images during 1975-2015.The forest cover was delineated utilizing various keys of visual interpretation techniques.Results:The forest cover was primarily decreased in the north-eastern and north-western parts in PTR.In order to identify the anthropogenic disturbance in the forest reserve,human settlement density was mapped using highresolution Google Earth imagery.The results showed a positive correlation between human population density and settlement density.Five major affected sites with an outer buffer of 2 km were demarcated in order to deduce the anthropogenic influences in major non-forested sites in PTR.It was observed that the forest change was maximum at site 3(Ranidah,area 61.06 km^(2),−6.47%change)followed by site 2(Saidup,area 124.38 km^(2),−7.65%change),where settlement units were also high(2638 and 2621 settlement units,respectively).At site 1(Barkheta,area 81.59 km^(2)),−1.99%change was observed,and at site 4(Samadh Tola,area 9.15 km^(2)),1.03% change was observed having moderate settlement units(2422 and 1892 settlement units,respectively).Areas with the low level of human settlements(1038 settlement units)observed the least change,i.e.,at site 5(Netarhat,area 48.52 km^(2)),0.58%change was observed mainly during the years.Conclusions:The forest cover exhibited an overall decrease of 14.55 km^(2)(−1.34%change)with episodic variation during 1975-2015 in PTR,Eastern India.A significant forest disturbance occurred primarily in the north-eastern and north-western parts of PTR along the forest fringe due to the high population and settlement density.The study highlighted the potential use of freely available multi-temporal satellite observations in forest management. | Binita Kumari Arvind Chandra Pandey Amit Kumar | 2020 | Ecological Processes2020，9，1： | 0 |
| 7 | Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics显示文摘Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions of deaths every year.With the new understanding of the molecular mechanism(s)of disease progression,our knowledge about the disease is snowballing,leading to the evolution of many new therapeutic regimes and their successive trials.In the past few decades,various combinations of therapies have been pro-posed and are presently employed in the treatment of diverse cancers.Targeted drug therapy,immunotherapy,and personalized medicines are now largely being employed,which were not common a few years back.The field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies,extending patients’disease-free survival thereafter.Although growing evidence shows that a systematic and targeted approach could be the future of cancer medicine,chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological health.Chemother-apeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific reasons.The present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals;it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients. | Uttpal Anand Abhijit Dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra Devendra Kumar Pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu José M.Pérez de la Lastra | 2023 | Genes & Diseases2023，10，4： | 0 |
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