|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Visible Light-Induced 3D Bioprinting Technologies and Corresponding Bioink Materials for Tissue Engineering: A Review显示文摘Three-dimensional(3D)bioprinting based on traditional 3D printing is an emerging technology that is used to precisely assemble biocompatible materials and cells or bioactive factors into advanced tissue engineering solutions.Similar technology,particularly photo-cured bioprinting strategies,plays an important role in the field of tissue engineering research.The successful implementation of 3D bioprinting is based on the properties of photopolymerized materials.Photocrosslinkable hydrogel is an attractive biomaterial that is polymerized rapidly and enables process control in space and time.Photopolymerization is frequently initiated by ultraviolet(UV)or visible light.However,UV light may cause cell damage and thereby,affect cell viability.Thus,visible light is considered to be more biocompatible than UV light for bioprinting.In this review,we provide an overview of photo curing-based bioprinting technologies,and describe a visible light crosslinkable bioink,including its crosslinking mechanisms,types of visible light initiator,and biomedical applications.We also discuss existing challenges and prospects of visible light-induced 3D bioprinting devices and hydrogels in biomedical areas. | Zizhuo Zheng David Eglin Mauro Alini Geoff RRichards Ling Qin Yuxiao Lai | 2021 | Engineering2021，7，7： | 3 |
| 2 | A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration显示文摘The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined,which significantly limits the application of such bioactive materials.Here,the transcriptional landscapes of different osteogenic microenvironments,including three-dimensional(3D)hydroxyapatite(HA)scaffolds and osteogenic medium(OM),for mesenchymal stromal cells(MSCs)in vitro were mapped at single-cell resolution.Our findings suggested that an osteogenic process reminiscent of endochondral ossification occurred in HA scaffolds through sequential activation of osteogenic-related signaling pathways,along with inflammation and angiogenesis,but inhibition of adipogenesis and fibrosis.Moreover,we revealed the mechanism during OM-mediated osteogenesis involves the ZBTB16 and WNT signaling pathways.Heterogeneity of MSCs was also demonstrated.In vitro ossification of LRRC75A+MSCs was shown to have better utilization of WNT-related ossification process,and PCDH10+MSCs with superiority in hydroxyapatite-related osteogenic process.These findings provided further understanding of the cellular activity modulated by OM conditions and HA scaffolds,providing new insights for the improvement of osteogenic biomaterials.This atlas provides a blueprint for research on MSC heterogeneity and the osteogenic microenvironment of HA scaffolds and a database reference for the application of bioactive materials for bone regeneration. | Peng Guo Xizhe Liu Penghui Zhang Zhongyuan He Zhen Li Mauro Alini RGeoff Richards Sibylle Grad Martin J.Stoddart Guangqian Zhou Xuenong Zou Danny Chan Wei Tian Dafu Chen Manman Gao Zhiyu Zhou Shaoyu Liu | 2022 | Bioactive Materials2022，7，3： | 3 |
| 3 | Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc显示文摘The depletion of chondroitin sulfates(CSs)within the intervertebral disc(IVD)during degenerative disc disease(DDD)results in a decrease in tissue hydration,a loss of fluid movement,cell apoptosis,a loss of nerve growth inhibition and ultimately,the loss of disc function.To date,little is known with regards to the structure and content of chondroitin sulfates(CSs)during IVD ageing.The behavior of glycosaminoglycans(GAGs),specifically CSs,as well as xylosyltransferase I(XT-I)and glucuronyltransferase I(GT-I),two key enzymes involved in CS synthesis as a primer of glycosaminoglycan(GAG)chain elongation and GAG synthesis in the nucleus pulposus(NP),respectively,were evaluated in a bovine ageing IVD model.Here,we showed significant changes in the composition of GAGs during the disc ageing process(6-month-old,2-year-old and 8-year-old IVDs representing the immature to mature skeleton).The CS quantity and composition of annulus fibrosus(AF)and NP were determined.The expression of both XT-I and GT-I was detected using immunohistochemistry.A significant decrease in GAGs was observed during the ageing process.CSs are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity,which correlated with a decrease in the expression of both XT-I and GT-I.A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 years.These changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair. | Estelle C Collin Oliver Carroll Michelle Kilcoyne Marianna Peroglio Eugene See Doris Hendig Mauro Alini Sibylle Grad Abhay Pandit | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 4 | Chondrogenesis of human bone marrow mesenchymal stem celis in fibrin-polyurethane composites is modulated by frequency and amplitude of dynamic compression and shear stress 显示文摘 | Li Z Yao SJ Alini M | 2010 | Tissue Eng PartA2010，16，2： | 1 |
| 5 | Chondrogenesis of mesenchymal stem cells for cartilage tissue engineering显示文摘 | Gardner OF Archer CW Alini M | | 0，，01： | 1 |
| 6 | Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression 显示文摘 | Maclean JJ Lee CR Alini M | 2004 | J Orthop Res2004，22，6： | 1 |
| 7 | Cells and biomaterials for inter-vertebral disc regeneration显示文摘 | Grad S Alini M Eg^in D | 2010 | Synth Lect Tissue Eng2010，2，1： | 1 |
| 8 | The potential and limitations of a cell-seeded collagen/hyaluronan scaffold to engineer an intervertebral disc-like matrix显示文摘 | Alini M Li W Markovic P | 2003 | Spine2003，28，5： | 1 |
| 9 | Sucrose metabolism and accumulation in developing fruit of Cucumis显示文摘 | SCHAFFER A A ALINI B FOGELMAN E | 1987 | Phytochem1987，26，： | 1 |
| 10 | Ef ect of reduced oxygen tension and long-term mechanical stimulation on chondrocyte-polymer constructs显示文摘 | Wernike E Li Z Alini M | | 0，，02： | 1 |
| 11 | The effect of dexamethasone and triiodothyronine on terminal differentiation of primary bovine chondrocytes and chondrogenically differentiated mesenchymal stem cells显示文摘 | Randau TM Schildberg FA Alini M | 2013 | PLoS One2013，8，72： | 1 |
| 12 | Are animal models useful for studying human disc disorders/degeneration?显示文摘 | Mauro Alini Stephen M. Eisenstein Keita Ito Christopher Little A. Annette Kettler Koichi Masuda James Melrose Jim Ralphs Ian Stokes Hans Joachim Wilke | 2008 | European Spine Journal2008，，1： | 1 |
| 13 | Effectiveness of intermediate-fi-delity simulation training technology in undergraduate nursing educa-tion显示文摘 | Alinier G Hunt B Gordon R | 2006 | J Adv Nurs2006，54，3： | 1 |
| 14 | Sucrose metabolism and accumulation in developing fruit of Cucumis显示文摘 | SCHAFFER A A ALINI B FOGELMAN E | 1987 | Phytochem1987，26，： | 1 |
| 15 | Are animal models useful for studying human disc disorders/degeneration?显示文摘 | ALINI M EISENISTIN S M ITO K | 2008 | Eur Spine J2008，17，： | 1 |
| 16 | Chondrogenesis of human bone marrow mesenchymal stem cells in fibrin-polyurethane composites is modulated by frequency and amplitude of dynamic compression and shear stress显示文摘 | Li Z Yao S J Alini M | 2009 | Tissue Engineering Part A2009，16，2： | 1 |
| 17 | 2004 Young Investigator Award Winner:vertebral endplate marrow contact channel occlusions and intervertebral disc degeuemtion显示文摘 | Benneker LM Heini PF Alini M | 2005 | Spine2005，30，2： | 1 |
| 18 | The potential and limitation of a cellseeeded collagen/hyaluronan scaffold to engineer an intervertebral disc-like matrix显示文摘 | Alini M Li W Markovic P | 2003 | Spine2003，28，： | 1 |
| 19 | Tissue engineering for articular cartilage repair-the state of the art显示文摘 | Johnstone B Alini M Cucchiarini M | 2013 | Eur Cells Mater2013，25，： | 1 |
| 20 | The potential and limitations of a cell-seeded collagen/hyaluronan scaffold to engineer an intervertebral disc-like matrix显示文摘 | Alini M Li W Markovic P | 2003 | Spine2003，28，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员