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| 1 | Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism显示文摘BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase rate.GICA-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer therapies.AIM To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active GICA-VTE.METHODS A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was performed.Inclusion criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or LMWH.The Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB events.Odds ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk factor.RESULTS A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were excluded.Patients median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active chemotherapy.Sixty-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a primary or secondary outcome for all anticoagulation therapies included:Active systemic treatment(OR=5.1,95%CI:1.3-19.3),high Khorana Score[≥3 points](OR=5.5,95%CI:1.7-17.1),active smoker(OR=6.7,95%CI:2.1-21.0),pancreatic cancer(OR=6.8,95%CI:1.9-23.2),and stage IV disease(OR=9.9,95%CI:1.2-79.1).CONCLUSION Rivaroxaban compared to apixaban and enoxaparin had a significantly higher risk of MB on GICA-VTE patients with equivocal efficacy. | Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker Aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 3 |
| 2 | Marine pharmacology in 1999 : compounds with antibacterial, anticoagulant, anti fungal, anthelmintic, anti-inflammatory, antiplatelet, anti protozoal and antiviral activities affecting the cardiovascular, endocrine, immune and nervors systems, and other miscella- neous mechanisms of action 显示文摘 | Alejandro M Mayer S Hamann M T | 2002 | Cornp Biochem Physiol Part C2002，132，： | 1 |
| 3 | Escherichia coli AspP activity is enhanced by macromolecular crowding and by both glucose-1, 6-bisphosphate and nucleotide-sugars 显示文摘 | Maria T M Z Alejandro M V Francisco J M | 2007 | FEBS Lett2007，581，5： | 1 |
| 4 | Application ofdensity functional theory to the study of the reaction of NOwith char-bound nitrogen during combustion显示文摘 | Alejandro M Truong T N Sarofim A F | 2000 | Journal of Physical Chemistry2000，104，： | 1 |
| 5 | Kinetics of nitric oxide desorption from carbonaceous surfaces显示文摘 | Alejandro M Fanor M Truong N T | 2002 | Fuel Processing Technology2002，7778，： | 1 |
| 6 | Oral treatment of chickens with Lactobacillus reuteri LM1 reduces Brachyspira pilosicoli-induced pathology显示文摘 | Luke J M Monika A T Alejandro N | 2013 | Journal of Medical Microbiolo- gy2013，62，2： | 1 |
| 7 | Thermal effect of the adsorption heat on an adsorbed natural gas storage and transportation systems显示文摘 | ALEJANDRO S MARIO T | 2009 | Appl Thermal Eng2009，29，13： | 1 |
| 8 | A major secreted elastase It essential for pathogenicity of Aeromonas hydrophila 显示文摘 | Alberto C Javier Y Alejandro T | 2000 | Infection and Im- munity2000，68，6： | 1 |
| 9 | Regulation of nonsymbiotic and truncated hemoglobin genes of Lotus japonicus in plant organs and in response to nitric oxide and hormones 显示文摘 | Pilar B S Alejandro T M Martin C | 2011 | New Phytologist2011，189，： | 1 |
| 10 | Minimally Invasive Liver Resection for Metastatic Colorectal Cancer: A Multi-Institutional, International Report of Safety, Feasibility, and Early Outcomes显示文摘 | Kevin Tri Nguyen Alexis Laurent Ibrahim Dagher David A. Geller Jennifer Steel Mark T. Thomas Michael Marvin Kadiyala V. Ravindra Alejandro Mejia Panagiotis Lainas Dominique Franco Daniel Cherqui Joseph F. Buell T Clark Gamblin | 2009 | Annals of Surgery2009，，5： | 1 |
| 11 | Management of HCC显示文摘 | Carlos RL Silvia T Alejandro F | 2012 | J Hepatology2012，56，1： | 1 |
| 12 | Minimally Invasive Liver Resection for Metastatic Colorectal Cancer: A Multi-Institutional, International Report of Safety, Feasibility, and Early Outcomes显示文摘 | Kevin Tri Nguyen Alexis Laurent Ibrahim Dagher David A. Geller Jennifer Steel Mark T. Thomas Michael Marvin Kadiyala V. Ravindra Alejandro Mejia Panagiotis Lainas Dominique Franco Daniel Cherqui Joseph F. Buell T Clark Gamblin | 2009 | Annals of Surgery2009，，5： | 1 |
| 13 | The outcome of company and account manager relationship quality on loyalty,relationship value and perfor-mance显示文摘 | Alejandro T B | 2011 | Industrial Marketing Management2011，40，1： | 1 |
| 14 | Caregiver unmet needs, burden, and satisfaction in symptomatic advanced cancer patients at a Veterans Affairs (VA) medical center 显示文摘 | Hwang S S Chang V T Alejandro Y | 2003 | Palliat Support Care2003，1，4： | 1 |
| 15 | Achievement of insulin independence via pancreatic islet transplantation using a remote isolation center: a first-year review显示文摘 | N.R Barshes T Lee S Goodpasture F.C Brunicardi R Alejandro C Ricordi G Soltes M Barth D Hamilton J.A Goss | 2004 | Transplantation Proceedings2004，，4： | 1 |
| 16 | Thermal decomposition of RDX from reactive molecular dy- namics显示文摘 | Alejandro Strachan Edward M Kober Adri C T van Duin | 2005 | Journal of Chemical Physics2005，122，5： | 1 |
| 17 | Maternal diet-induced micrornas and mtor underlie beta cell dysfunction in offspring 显示文摘 | Alejandro E U Gregg B Wallen T | 2014 | J Clin Invest2014，124，10： | 1 |
| 18 | A majorsecreted elastase is essential for pathogenicity of Aeromonas hydrophila显示文摘 | Alberto C Javier Y Alejandro T | 2000 | Infect Immun2000，68，： | 1 |
| 19 | Se- rvice infusion as agile incrementalism in action显示文摘 | Kowalkowski C Kindstr6m D Alejandro T B | 2012 | Jou- rnal of Business Research2012，65，6： | 1 |
| 20 | 显示文摘 | Alejandro R S Alfredo A E Luis de L T S | 2001 | Carbon2001，39，9： | 1 |
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