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| 1 | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease显示文摘Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease.Alzheimer’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus bilaterally.Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration.Afterwards,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies.Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem cells.These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease.All procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval No.CICUAL 2016-011)on April 25,2016. | Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre | 2019 | Neural Regeneration Research2019，14，9： | 19 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Escherichia coli AspP activity is enhanced by macromolecular crowding and by both glucose-1, 6-bisphosphate and nucleotide-sugars 显示文摘 | Maria T M Z Alejandro M V Francisco J M | 2007 | FEBS Lett2007，581，5： | 1 |
| 4 | A validated solid - liquid extraction method for the HPLC determination of polyphenols in apple tissues Comparison with pressurised liquid extraction显示文摘 | ROSA M ALEJANDRO B EDURNE C LUIS A BLANCA G FRANCISCA V | 2005 | Talanta2005，，65： | 1 |
| 5 | Performance evaluation of MAC transmission power control in wireless sensor networks 显示文摘 | Javier V A Esteban E L Alejandro M S | 2007 | Computer Networks2007，51，6： | 1 |
| 6 | Regional geologic and tectonic setting of the Maracaibo supergiant basin,western Venezuela显示文摘 | Paul M Alejandro E María V C | 2006 | AAPG2006，90，4： | 1 |
| 7 | Cloning and sequencing of the genes involved in glyphosate utilization by pseudomonas pseudomoallei 显示文摘 | ALEJANDRO P V GILDAL M LUIS H E | 1995 | Applied and Environmental Microbiology1995，61，2： | 1 |
| 8 | Cloning and sequencing of the genes involved in glyphosate utilization by pseudomonas pseudomallei显示文摘 | Alejandro P V Gildal M Luis H E | 1995 | Applied and Environmental Microbiology1995，61，2： | 1 |
| 9 | Mechanisms involved in the formation of phosphosilicate glass from a phosphoric acid dopant ource 显示文摘 | Vais V Mrcariea M Alejandro F B | 2011 | Progress in Potovolatics2011，19，3： | 1 |
| 10 | Natural bile acids and synthetic analogues modulate large conductance Ca2 +-activated K + (BKCa)Channel activity in smooth muscle cells显示文摘 | Alejandro M Dopico John V | 2002 | J General Physiol2002，119，3： | 1 |
| 11 | Regional geologic and tectonic setting of the Maracaibo supergiant basin, western Venezuela显示文摘 | Paul M Alejandro E Maria V C | 2006 | AAPG2006，90，4： | 1 |
| 12 | Using genetic algorithms for com- pensating the local magnetic perturbation of a ship in the earth's magnetic field 显示文摘 | Antonio V M Alejandro A M | 2005 | Microwave and Optical Technology Letters2005，47，3： | 1 |
| 13 | Supporting dimension updates in an OLAP server显示文摘 | ALEJANDRO A V ALBERTO O M WALTER R | 2004 | Information Systems2004，29，2： | 1 |
| 14 | Simulation scalability issues in wireless sensor networks 显示文摘 | Esteban E L Javier V A Alejandro M S | 2006 | IEEE Communications Magazine2006，44，7： | 1 |
| 15 | Stratigraphic inversion of poststack PS converted waves data显示文摘 | Alejandro A V Reinaldo J M | 2000 | Expanded Abstracts of 70^th Annual Internat SEG Mtg2000，，： | 1 |
| 16 | Using ge- netic algorithms for compensating the local mag- netic perturbation of a ship in the earth's magnetic field 显示文摘 | ANTONIO V M ALEJANDRO A M | 2005 | Microwave and Optical Technology Let- ters2005，47，3： | 1 |
| 17 | Cloning and sequencing of the genes involved in glyphosate utilization by pseudomonas pseudomallei显示文摘 | Alejandro P V Gildal M Luis H E | 1995 | Applied and Environmental Microbiology1995，61，2： | 1 |
| 18 | Mechanism of granulosa cell death during follicular atresia depends on follicular size 显示文摘 | Israel A Ana M Alejandro V | 2003 | Theriogenology2003，60，： | 1 |
| 19 | Stratigraphic inversion of poststack PS converted waves date 显示文摘 | Alejandro A V Reinaldo J M | 2000 | Expand Abstracts of 70th Annual Internat SEG Mtg2000，，： | 1 |
| 20 | Performanee evaluation of MAC transmission power control in wireless sensor networks显示文摘 | Javier V Esteban E Alejandro M | 2007 | Computer Networks2007，51，： | 1 |
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