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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | PRSS1 and SPINK1 mutations in idiopathic chronic and recurrent acute pancreatitis显示文摘AIM: To identify gene mutations in PRSS1 and SPINK1 in individuals with early onset idiopathic chronic or recurrent acute pancreatitis.METHODS: The cationic trypsinogen gene(PRSS1; exons 2 and 3) and the serine protease inhibitor Kazal 1 gene(SPINK1; exon 3) were selectively amplified and sequenced from blood samples of 19 patients admitted to the Pancreas Clinic at our institution with chronic pancreatitis and/or idiopathic recurrent acute pancreatitis that were diagnosed or with onset before age 35. Fifty healthy volunteers served as controls. Whole blood samples were collected and gene specific sequences were amplified by polymerase chain reaction(PCR). All PCR products were subsequently sequenced in order to identify the presence of any mutations.RESULTS: Nineteen patients with pancreatitis(14 males; median age 24 years, range 15-48 years) were included in this study, of which five showed the presence of gene mutations. Direct sequencing results indicated the presence of two previously unidentified mutations in exon 2 of PRSS1(V39E and N42S) in two patients with recurrent acute pancreatitis. Two cases had the N34 S SPINK1 mutation. Analysis of the relatives of one patient homozygous for this mutation showed that five of the six family members carried the N34 S SPINK1 mutation. Of these members, three were healthy heterozygous carriers and two were homozygotes(one sibling had diabetes, the other was healthy). Another patient was heterozygous for a novel SPINK1 mutation located on exon 3(V46D). All members from this patient's family had normal genotypes, indicating that it was a de novo mutation. No mutations in either gene were present in the control subjects. CONCLUSION: Two novel PRSS1 mutations and one novel SPINK1 mutation were identified in Mexican patients with early onset idiopathic recurrent acute pancreatitis. | Mario Pelaez-Luna Guillermo Robles-Diaz Samuel Canizales-Quinteros Maria T Tusié-Luna | 2014 | World Journal of Gastroenterology2014，20，33： | 7 |
| 3 | 注册会计师和内部审计师在公司治理结构中的作用显示文摘 | Mario T·Mananghaya 刘国萍 章海贤 | 2001 | 中国注册会计师2001，，3： | 2 |
| 4 | Extraction of a monospecific Coombs-reagent from chicken eggs 显示文摘 | Gutierrez Calzado E Cruz Mario E Samon Chavez T | 2003 | ALTEX2003，20，1： | 1 |
| 5 | Software-in-the-loop development and validation of a cornering brake control logic显示文摘 | Riccardo R Mario T Francesco T | 2007 | Vehicle System Dynamics2007，45，2： | 1 |
| 6 | Blind Frequency-offset estimation for OFDM/OQAM systems显示文摘 | Tilde F Mario T | 2007 | IEEE Trans on Signal Pro- cessing2007，55，5： | 1 |
| 7 | Trib3 is regulated by IL-3 and affects bone marrow-derived mast cell survival and function显示文摘 | Tiit ?rd Daima ?rd Sulev Kuuse Mario Plaas T?nis ?rd | 2012 | Cellular Immunology2012，，1： | 1 |
| 8 | Clinical out come of submerged vs non-submerged implants placed infresh exactraction sockets 显示文摘 | Luca C Ferruccio T Mario R | 2009 | Clin Oral Implant Res2009，20，： | 1 |
| 9 | Transatrial approach of acquired posterior ventrieular septal rupture and double orifice technique in tricuspid valve repair 显示文摘 | MARIO Z ANNA M ERNESTO T | 2003 | The Annals of Thoracic Surgery2003，76，： | 1 |
| 10 | A sliding mode missile pitch autopilot synthesis for high angle of attack maneuvering显示文摘 | Mario I | 1998 | IEEE Transactions on Control Systems Technology1998，6，3： | 1 |
| 11 | Treatment of aqueous effluent for fluoride removal显示文摘 | John P B Marios T | 1987 | J Water Pollut Control Fed1987，59，： | 1 |
| 12 | Unsupervised Learning of Finite Mixture Models 显示文摘 | Mario A T Figueiredo Anil K Jain | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，3： | 1 |
| 13 | Three dimensional shape reconstruction and finite element models to be used in clinical studies显示文摘 | Marco V Mario D Fulvia T | 2004 | J Biomech2004，37，： | 1 |
| 14 | Removal of hazardous organic pollutants by biomass adsorption 显示文摘 | JOHN P B MARIOS T | 1987 | Journal Water Pollution Control Federation1987，59，4： | 1 |
| 15 | Thermal effect of the adsorption heat on an adsorbed natural gas storage and transportation systems显示文摘 | ALEJANDRO S MARIO T | 2009 | Appl Thermal Eng2009，29，13： | 1 |
| 16 | Clinical out come of submerged vs non-submerged implants placed in fresh exactraction sockets 显示文摘 | Luca C Ferruccio T Mario R | 2009 | Clin Oral Implant Res2009，20，： | 1 |
| 17 | A new TwIST: two-step iterative shrinkage/thresholding algorithms for image restoration显示文摘 | Jose M Bioucas-Dias Mario A T Figueiredo | 2007 | IEEE Transactions on Image Processing2007，16，12： | 1 |
| 18 | High-resolution CT in silicosis correlation with radiographic findings and functional impairment显示文摘 | VINICIUS C S A GERMANIA A P MARIO T F | 2005 | J Comput Assist Tomogr2005，29，： | 1 |
| 19 | Unsupervised learning of finite mixture models显示文摘 | Mario A T Figueiredo Anil K Jean | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，3： | 1 |
| 20 | Semantics and Knowledge Grids: Building the Next-generation Grid显示文摘 | Mario C Domenico T | 2004 | IEEE Intelligent Systems2004，19，1： | 1 |
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