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| 1 | Serum adipokines might predict liver histology findings in non-alcoholic fatty liver disease显示文摘AIM: To assess significance of serum adipokines to determine the histological severity of non-alcoholic fatty liver disease.METHODS: Patients with persistent elevation in serum aminotransferase levels and well-defined characteristics of fatty liver at ultrasound were enrolled. Individuals with a history of alcohol consumption, hepatotoxic medication, viral hepatitis or known liver disease were excluded. Liver biopsy was performed to confirm nonalcoholic liver disease(NAFLD). The degrees of liver steatosis, lobular inflammation and fibrosis were determined based on the non-alcoholic fatty liver activity score(NAS) by a single expert pathologist. Patients with a NAS of five or higher were considered to have steatohepatitis. Those with a NAS of two or lower were defined as simple fatty liver. Binary logistic regression was used to determine the independent association of adipokines with histological findings. Receiver operating characteristic(ROC) analysis was employed to determine cut-off values of serum adipokines to discriminate the grades of liver steatosis,lobular inflammation and fibrosis. RESULTS: Fifty-four participants aged 37.02 ± 9.82 were enrolled in the study. Higher serum levels of visfatin, IL-8, TNF-α levels were associated independently with steatosis grade of more than 33% [β = 1.08(95%CI: 1.03-1.14), 1.04(95%CI: 1.008-1.07), 1.04(95%CI: 1.004-1.08), P < 0.05]. Elevated serum IL-6 and IL-8 levels were associated independently with advanced lobular inflammation [β = 1.4(95%CI: 1.09-1.8), 1.07(95%CI: 1.003-1.15), P < 0.05]. Similarly, higher TNF-α, resistin, and hepcidin levels were associated independently with advanced fibrosis stage [β = 1.06(95%CI: 1.002-1.12), 19.86(95%CI: 2.79-141.19), 560.72(95%CI: 5.98-5255.33), P < 0.05]. Serum IL-8 and TNF-α values were associated independently with the NAS score, considering a NAS score of 5 as the reference value [β = 1.05(95%CI: 1.01-1.1), 1.13(95%CI: 1.04-1.22), P < 0.05]. CONCLUSION: Certain adipokines may determine the severity of NAFLD histology accurately. | Raika Jamali Mohsen Razavizade Abbas Arj Mohammad Hossein Aarabi | 2016 | World Journal of Gastroenterology2016，22，21： | 7 |
| 2 | Serum parameters predict the severity of ultrasonographic findings in non-alcoholic fatty liver disease显示文摘BACKGROUND: Controversy exists about the correlation between liver ultrasonography and serum parameters for evaluating the severity of liver involvement in non-alcoholic fatty liver disease (NAFLD). This study was designed to determine the association between liver ultrasonography staging in NAFLD and serum parameters correlated with disease severity in previous studies; and set optimal cut-off points for those serum parameters correlated with NAFLD staging at ultrasonography, in order to differentiate ultrasonographic groups (USGs). METHODS: This cross-sectional study evaluated outpatients with evidence of NAFLD in ultrasonography referred to a general hospital. Those with positive viral markers, abnormal serum ceruloplasmin or gamma-globulin concentrations were excluded. A radiologist performed the ultrasonography staging and stratified the patients into mild, moderate, and severe groups. Fasting serum alanine aminotransferase (ALT), aspartate aminotransferase, alkaline phosphatase, triglyceride (TG), high and low density lipoprotein (HDL, LDL), and cholesterol were checked. RESULTS: Two hundred and forty-five patients with a mean age (±standard deviation) of 41.63(±11.46) years were included. There were no significant differences when mean laboratory concentrations were compared between moderate and severe USGs. Therefore, these groups were combined to create revised USGs ('mild' versus 'moderate or severe'). There were associations between the revised USGs, and ALT, TG, HDL levels, and diabetes mellitus [odds ratios=2.81 (95% confidence interval (CI): 1.37-5.76), 2.48 (95% CI: 1.29- 4.78), 0.36 (95% CI: 0.18-0.74), and 5.65 (95% CI: 2.86-11.16)respectively; all P values <0.01]. A cut-off value of 32.5 mg/dL for ALT gave a sensitivity of 70% and a specificity of 62%, for differentiating between the revised USGs. CONCLUSIONS: Serum ALT, TG, and HDL concentrations seem to be associated with the staging by liver ultrasonography in NAFLD. They might be used to predict the staging of liver ultrasonography in these patients. | Mohsen Razavizade Raika Jamali Abbas Arj Hamidreza Talari | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 4 |
| 3 | Acute Morphine Administration Reduces Cell-Mediated Immunity and Induces Reactivation of Latent Herpes Simplex Virus Type 1 in BALB/c Mice显示文摘Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte (CTL) activity in the inhibition of herpes simplex virus type 1 (HSV-1) reactivation, the effect of acute morphine administration on CTL responses was also evaluated. Furthermore, lymphocyte proliferation and IFN-γ production were evaluated for their roles in the induction of the CTL response. The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-γ production. Furthermore, acute morphine administration has been shown to reactivate latent HSV-1. Previous studies have shown that cellular immune responses have important roles in the inhibition of HSV reactivation. These findings suggest that suppression of a portion of the cellular immune response after acute morphine administration may constitute one part of the mechanism that induces HSV reactivation. | Shafi Mojadadi Abbas Jamali Behzad Khansarine jad Hoorieh Soleimanjahi Taravat Bamdad | 2009 | Cellular & Molecular Immunology2009，6，2： | 3 |
| 4 | 以硅胶键合N-丙基哌嗪基丙酸钠为可循环催化剂合成3,4-二氢吡喃[c]苯并吡喃衍生物和香豆素(英文)显示文摘A simple and efficient procedure for the preparation of silica-bonded N-propylpiperazine sodium n-propionate(SBPPSP) by the hydrolysis of silica-bonded N-propylpiperazine methyl n-propionate(SBPPMP) in hydrochloric acid(0.5 mol/L) followed by treatment with saturated sodium bicarbonate is described.The SBPPMP was obtained by the reaction of 3-silica-bonded N-propylpiperazine and methyl acrylate in methanol.SBPPSP was used as a recyclable basic catalyst for the synthesis of 3,4-dihydropyrano[c]chromenes by the reaction of aromatic aldehydes,malononitrile,and 4-hydroxycoumarin in aqueous ethanol(1:1 v/v) under reflux conditions.Biscoumarins were also obtained via condensation of aldehydes and 4-hydroxycoumarin in aqueous ethanol(1:1 v/v) under reflux conditions.The catalyst could be recycled several times without any additional treatment. | Khodabakhsh NIKNAM Abbas JAMALI | 2012 | 催化学报2012，33，11： | 3 |
| 5 | 硅胶键合N-丙基哌嗪n-丙酸钠作为可循环使用催化剂催化4H-吡喃衍生物合成(英文)显示文摘Silica‐bonded N‐propylpiperazine sodium n‐propionate(SBPPSP) was found to act as an efficient solid base for the preparation of a series of 4H‐benzo[b]pyran derivatives. SBPPSP was used as a recyclable heterogeneous solid base catalyst for the synthesis of 3,4‐dihydropyrano[c]chromenes, 2‐amino‐4H‐pyrans, 1,4‐dihydropyrano[2,3‐c]pyrazoles, and 2‐amino‐4H‐benzo[e]‐chromenes via the condensation reaction of dimedone, ethyl acetoacetate, 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5(4H)‐ one, and α‐naphthol, respectively, with aromatic aldehydes and malononitrile in refluxing aqueous ethanol. The heterogeneous solid base showed similar efficiency when reused in consecutive reactions. | Khodabakhsh Niknam Nassim Borazjani Reza Rashidian Abbas Jamali | 2013 | 催化学报2013，34，12： | 2 |
| 6 | Determination of Copper and Iron in Biological Samples of Viral Hepatitis (A–E) Female Patients显示文摘 | Hassan Imran Afridi Tasneem Gul Kazi Naveed Gul Kazi Mohammad Khan Jamali Raja Adil Sarfaraz Mohammad Balal Arain Ghulam Abbas Kandhro Abdul Qadir Shah Jamil Ahmed Baig Nusrat Jalbani Rehana Ansari | 2009 | Biological Trace Element Research2009，，1： | 1 |
| 7 | Arsenic fractionation in sediments of different origins using BCR sequential and single extraction methods显示文摘 | Jameel Ahmed Baig Tasneem Gul Kazi Muhammad Balal Arain Abdul Qadir Shah Raja Adil Sarfraz Hassan Imran Afridi Ghulam Abbas Kandhro Muhammad Khan Jamali Sumaira Khan | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 8 | Evaluation of humoral and cellular immune responses against HSV-1 using genetic immunization by filamentous phage particles: A comparative approach to conventional DNA vaccine显示文摘 | Hamidreza Hashemi Taravat Bamdad Abbas Jamali Somayeh Pouyanfard Masoumeh Gorgian Mohammadi | 2009 | Journal of Virological Methods2009，，2： | 1 |
| 9 | 硅胶键合的N-丙基三亚乙基四胺氨基磺酸作为可回收固体酸催化剂催化合成2-氨基-4,6-二芳基烟腈(英文)显示文摘A simple and efficient procedure for the preparation of silica-bound N-propyl triethylenetetramine sulfamic acid(SBPTETSA) by the reaction of silica-bound N-propyl triethylenetetramine(SBPTET) with chlorosulfonic acid in chloroform is described.Silica-bound N-propyl triethylenetetramine sulfamic acid was employed as a recyclable catalyst for the synthesis of 2-amino-4,6-diarylnicotinonitriles from the multi-component reaction of an acetophenone derivative,an aromatic aldehyde,malononitrile,and ammonium acetate under solvent-free conditions at 100 °C.The heterogeneous catalyst was recycled for five consecutive runs in the optimized multi-component reaction of 4-chloroacetophenone,4-chloroenzaldehyde,malononitrile,and ammonium acetate without significant loses to its catalytic activity. | Khodabakhsh NIKNAM Abbas JAMALI Marzieh TAJADDOD Abdollah DERIS | 2012 | 催化学报2012，33，8： | 1 |
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