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| 1 | Hepatocytic differentiation of mesenchymal stem cells in cocultures with fetal liver cells显示文摘瞄准:为了与胎儿的肝细胞(FLC ) 和可能性在合作文化调查间充质的干细胞(MSC ) 的 hepatocytic 区别膨胀,区分了 hepatocytic 房间。方法:MSC 被制动火箭与绿荧光灯的蛋白质(GFP ) 标记病毒的基因转导变异。同种细胞的显著 MSC 在用与干细胞补充的fibronectin涂的培养皿和媒介刺激条件的肝下面是也有教养的因素( SCF ), hepatocyte 生长因素( HGF ),表皮的生长因素( EGF ),和成纤维细胞生长因素 4 ( FGF-4 )独自一个,或在刚孤立的 FLC 的存在。在合作文化的房间被收获,并且 GFP+ 或 GFP- 房间用荧光被分开激活的房间排序。为肝 specific 标记 cytokeratin-18 (CK-18 ) 的反向的抄写聚合酶链反应(RT-PCR )( 法新社) ,白朊,和 alpha-fetoprotein 在不同房间人口被执行。结果:在指定文化条件下面,与 FLC co 有教养的老鼠 MSC 超过二个星期表示了白朊, CK-18,和 AFP-RNA。在 wk 3, MSC 失去了 hepatocytic 基因表示,可能由于 cocultured FLC 的增生。FLC 也在合作文化和一个很高的生长潜力显示出稳定的肝 specific 基因表情。结论:从骨髓的老鼠 MSC 能面对 FLC 在试管内区分 hepatocytic 房间,在合作文化的 MSC 的存在也为 FLC 的扩大和区别提供有益的环境。 | Claudia Lange Helge Bruns Dietrich Kluth Axel R Zander Henning C Fiegel | 2006 | World Journal of Gastroenterology2006，12，15： | 23 |
| 2 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 3 | Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography 1 1 This study was performed without additional financial support.显示文摘 | Stephen Schroeder Andreas F Kopp Andreas Baumbach Christoph Meisner Axel Kuettner Christian Georg Bernd Ohnesorge Christian Herdeg Claus D Claussen Karl R Karsch | 2001 | Journal of the American College of Cardiology2001，，5： | 3 |
| 4 | Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury显示文摘 | Caudrillier Axelle Kessenbrock Kai Gilliss Brian M Nguyen John X Marques Marisa B Monestier Marc Toy Pearl Werb Zena Looney Mark R | 2012 | EN2012，，7： | 2 |
| 5 | Influence of heart rate on vessel visibility in noninvasive coronary angiography using new multislice computed tomography显示文摘 | Stephen Schroeder Andreas F Kopp Axel Kuettner Christof Burgstahler Christian Herdeg Martin Heuschmid Andreas Baumbach Claus D Claussen Karl R Karsch Ludger Seipel | 2002 | Clinical Imaging2002，，2： | 2 |
| 6 | A Novel Multigene Family May Encode Odorant Receptors: a Molecular Basis for Odor Recognition显示文摘 | Buck L Axel R | 1991 | Cell1991，65，： | 1 |
| 7 | Genetic ablation and restoration of the olfactory topographic map显示文摘 | Axel R | 2000 | Cell2000，103，4： | 1 |
| 8 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition显示文摘 | Buck L Axel R | 1991 | Cell1991，65，： | 1 |
| 9 | Accuracy of nuchal translucency measurement depends on equipmentused and its calibration 显示文摘 | Axell R G Gillett A Pasupathy D | 2014 | Ultrasound Obstet Gynecol2014，4，1： | 1 |
| 10 | Effects of cerivastatin on human arterial smooth muscle cell proliferation and migration in transfilter cocultures显示文摘 | AXEL D I RIESSEN R RUNGE H | 2000 | J Cardiovasc Pharmacol2000，35，： | 1 |
| 11 | Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia 显示文摘 | Axel MH Sandra H Sibylle R | 2005 | Am J Hum Genet2005，77，1： | 1 |
| 12 | 2-D and 3-D reconstuctions of spiral computed tomography in localization of the inferior alveolar canal for dental implants显示文摘 | Marcelo GP Axel R | 1999 | Oral Surg Oral Med Oral Pathol1999，87，： | 1 |
| 13 | HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘 | Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe | 2010 | Virchows Archiv2010，，3： | 1 |
| 14 | Brain natriuretic peptide:a potential marker for mortality in septic shock显示文摘 | Castillo Jose R Zagler Axel Carrillo-Jimenez Rodolfo | 2004 | International Journal of Infectious Diseases2004，8，5： | 1 |
| 15 | Phase I-II Trial of Cetuximab, Capecitabine, Oxaliplatin, and Radiotherapy as Preoperative Treatment in Rectal Cancer显示文摘 | Claus R?del Dirk Arnold Matthias Hipp Torsten Liersch Kathrin Dellas Igors Iesalnieks Robert Michael Hermann Florian Lordick Axel Hinke Werner Hohenberger Rolf Sauer | 2008 | International Journal of Radiation Oncology Biology Physics2008，，4： | 1 |
| 16 | Effect of Gamma Irradiation on Human Cortical Bone Transplants Contaminated with Enveloped and Non-enveloped Viruses显示文摘 | Axel Pruss Moujahed Kao Uwe Gohs Jürgen Koscielny Rüdiger von Versen Georg Pauli | 2002 | Biologicals2002，，： | 1 |
| 17 | Expression of candidate pheromone receptor genes in vomeronasal neurons显示文摘 | Dulac C Axel R | 1998 | Chem Senses1998，23，4： | 1 |
| 18 | A novel family of genes encoding putative pheromone receptors in mammals显示文摘 | Dulac C Axel R | 1995 | Cell1995，83，2： | 1 |
| 19 | Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine显示文摘 | Sklar P Axel R | 1995 | Nature1995，374，： | 1 |
| 20 | Effects of cerivastatin on human arterial smooth muscle cell proliferation and migration in transfilter cocultures显示文摘 | Axel DI Riessen R Runge H | 2000 | J Cardiovasc Pharmacol2000，35，： | 1 |
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