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| 1 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 2 | DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination显示文摘 | Weihua Qin Patricia Wolf Nan Liu Stephanie Link Martha Smets Federica La Mastra Ignasi Forne Garwin Pichler David Horl Karin Fellinger Fabio Spada Ian Marc Bonapace Axel Imhof Hartmann Harz Heinrich Leonhardt | 2015 | Cell Research2015，25，8： | 5 |
| 3 | Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial显示文摘 | Ralf-Dieter Hofheinz Frederik Wenz Stefan Post Axel Matzdorff Stephan Laechelt J?rg T Hartmann Lothar Müller Hartmut Link Markus Moehler Erika Kettner Elisabeth Fritz Udo Hieber Hans Walter Lindemann Martina Grunewald Stephan Kremers Christian Constantin | 2012 | Lancet Oncology2012，，6： | 1 |
| 4 | High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling — Results from a randomized, double-blind, and placebo-controlled study显示文摘 | Sandra Erbs Ephraim B. Beck Axel Linke Volker Adams Stephan Gielen Nicolle Kr?nkel Sven M?bius-Winkler Robert H?llriegel Holger Thiele Rainer Hambrecht Gerhard Schuler | 2010 | International Journal of Cardiology2010，，1： | 1 |
| 5 | Exercise training in patients with advanced chronic heart failure(NYHA IIIb)promotes restoration of peripheral vasomotor function,induction of endogenous regeneration,and improvement of left ventricular function显示文摘 | Sandra Erbs Robert Hllriegel Axel Linke | 2010 | Circ Heart Fail2010，3，： | 1 |
| 6 | Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure 显示文摘 | Schulze PC Kratzsch J Linke Axel Schoene N Adams V Gielen S | 2003 | Eur J Heart Fail2003，，5： | 1 |
| 7 | Regular Exercise Training Prevents Aortic Valve Disease in Low-Density Lipoprotein–Receptor–Deficient Mice显示文摘 | Yasuharu Matsumoto Volker Adams Saskia Jacob Norman Mangner Gerhard Schuler Axel Linke | 2010 | Circulation2010，，6： | 1 |
| 8 | Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial显示文摘 | Ralf-Dieter Hofheinz Frederik Wenz Stefan Post Axel Matzdorff Stephan Laechelt J?rg T Hartmann Lothar Müller Hartmut Link Markus Moehler Erika Kettner Elisabeth Fritz Udo Hieber Hans Walter Lindemann Martina Grunewald Stephan Kremers Christian Constantin | 2012 | Lancet Oncology2012，，6： | 1 |
| 9 | In-crease of circulating endothelial progenitor cells in patients withcoronary artery disease after exercise-induced ischemia显示文摘 | VOLKER ADAMS KARSTEN LENK AXEL LINKE | 2004 | Arte-riosclerosis Thrombosis and Vascular Biology2004，24，： | 1 |
| 10 | Intracoronary Compared With Intravenous Bolus Abciximab Application in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: The Randomized Leipzig Immediate Percutaneous Coronary Intervention Abciximab IV显示文摘 | Holger Thiele Kathrin Schindler Josef Friedenberger Ingo Eitel Georg Fürnau Eigk Grebe Sandra Erbs Axel Linke Sven M?bius-Winkler Dietmar Kivelitz Gerhard Schuler | 2008 | Circulation2008，，1： | 1 |
| 11 | 生物可降解多聚体biolimus洗脱支架与不可降解多聚体西罗莫司洗脱支架用于冠状动脉血运乖建(LEADERS):一项随机非劣效性试验显示文摘背景初步研究表明,从生物可降解多聚体中释出biolimus(西罗莫司类似物)的一种新型洗脱支架有望获得良好的临床效果。本研究比较了biolimus洗脱支架(具有生物可降解多聚体)和西罗莫司洗脱支架(具有不可降解多聚体)的安全性和疗效。方法作者在欧洲的10个研究中心进行了一项多中心、评估音设盲的非劣效性研究。1707例年龄≥18岁、患有慢性稳定性冠心病或急性冠状动脉综合征的患者经计算机产生的一组随机分配序列进行集中随机分组,分别接受biolimus,先脱支架(n=857)或西罗莫司洗脱支架(n=850)植入主要终点是在9个月内心脏性死亡、心肌梗死或具有临床指征的靶血管血运重建(TVR)的复合事件、采用意向治疗分析法对结果进行分析、随机抽取427例患者接受血管造影随访,主要结果指标为9个月时史巢内直径狭窄的百分比。本临床试验在ClinicalTrials.gov网站上注册,注册号为NCT00389220。结果对研究中所有随机分组的患者进行了分析。9个月时biolimus洗脱支架组在主要终点指标上并不劣于西罗莫司洗脱支架组[79例(9%)vs89例(11%),RR0.88,95%CI0.64~1.19,非劣效P=0.003,优势P=0.39]。心脏性死亡发生率[14例(1.6%)vs21例(2.5%),优势P=0.22]、心肌梗死发生率[49例(5.7%)vs39例(4.6%),P=0.30]以及具有临床指征的TVR实施率[38例(4.4%)vs547例(5.5%),P=0.29]在两组中相似.Biolimus洗脱支架组有168例(79%)患者的资料可用于血管造影随访,西罗莫司洗脱支架组有167例(78%)Biolimus洗脱支架组在支架内直径狭窄百分比上不劣于西罗莫司洗脱支架组(20.9%vs 23.3%,差值-2.2%.95%CI-6.0%~1.6%,非劣效P=0.001,优势P=0.26)、结论研究结果表明,从生物可降解多聚体中释出biolimus的洗脱支架安全有效,在对慢性稳定性冠心病或急性冠状动脉综合征患者进行治疗时,它可以取代从不可降解多聚体中释出西罗莫司的洗脱支架。 | Stephan Windecker Patrick W Serruys Simon Wandel Pawel Buszman Stanislaw Trznadel Axel Linke Karsten Lenk Thomas Ischinger Volker Klauss Franz Eberli Roberto Corti William Wijns Marie-Claude Morice Carlo di Mario Simon Davies Robert-Jan van Geuns Pedro Eerdmans Gerrit- Anne van Es Bernhard Meier Peter Jüni 刘少伟(译) | 2009 | 世界临床医学2009，3，3： | 0 |
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