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| 1 | Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial显示文摘AIM:To evaluate the effect of resistance training(RT)on non alcoholic liver disease(NAFLD)patients.METHODS:A randomized clinical trial enrolling NAFLD patients without secondary liver disease(e.g.,without hepatitis B virus,hepatitis C virus or excessive alcohol consumption).Patients were randomly allocated either to RT,three times weekly,for 3 mo or a control arm consisting of home stretching.The RT included leg press,chest press,seated rowing,latissimus pull down etc.with 8-12 repetitions,3 sets for each exercise,for a total duration of 40 min.Hepatic ultrasound,fasting blood tests,anthropometrics and body composition by dual energy X-ray absorptiometry were assessed.At baseline and follow-up,patients filled out a detailed semi-quantitative food frequency questionnaire reporting their habitual nutritional intake.Steatosis was quantified by the hepatorenal-ultrasound index(HRI)representing the ratio between the brightness level of the liver and the right kidney.The HRI has been previously demonstrated to be highly reproducible and was validated against liver biopsy and proton magnetic resonance spectroscopy.RESULTS:Eighty two patients with primary NAFLD were randomized to receive 3 mo of either RT or stretching.After dropout or exclusion from analysis because of protocol violation(weight change>3 kg),thirty three patients in the RT arm and 31 in the stretching arm completed the study per protocol.All baseline characteristics were similar for the two treatment groups with respect to demographics,anthropometrics and body composition,blood tests and liver steatosis on imaging.HRI score was reduced significantly in the RT arm as compared to the stretching arm(-0.25±0.37 vs-0.05±0.28,P=0.017).The RT arm had a significantly higher reduction in total,trunk and android fat with increase in lean body mass.There was no correlation between the reduction in HRI in the RT arm and weight change during the study,but it was positively correlated with the change in trunk fat(r=0.37,P=0.048).The RT arm had a significant reduction in serum ferritin and total cholesterol.There was no significant difference between arms in dietary changes and these did not correlate with HRI change.CONCLUSION:Three months RT improves hepatic fat content accompanied by favorable changes in body composition and ferritin.RT may serve as a complement to treatment of NAFLD. | Shira Zelber-Sagi Assaf Buch Hanny Yeshua Nahum Vaisman Muriel Webb Gil Harari Ofer Kis Naomi Fliss-Isakov Elena Izkhakov Zamir Halpern Erwin Santo Ran Oren Oren Shibolet | 2014 | World Journal of Gastroenterology2014，20，15： | 17 |
| 2 | Role of illness perception and self-efficacy in lifestyle modification among non-alcoholic fatty liver disease patients显示文摘AIM To describe the relationships between non-alcoholic fatty-liver disease(NAFLD) patient's disease consequences and treatment perceptions, self-efficacy, and healthy lifestyle maintenance. METHODS A cross-sectional study among 146 ultrasound diagnosed NAFLD patients who visited the fatty liver clinic at the TelAviv Medical Center. Eighty-seven of these individuals, participated in a clinical trial of physical activity and underwent fasting blood tests, analyzed at the same lab. Exclusion criteria included positivity for serum HBsA g or anti-HCV antibodies; fatty liver suspected to be secondary to hepatotoxic drugs; excessive alcohol consumption(≥ 30 g/d in men or ≥ 20 g/d in women) and positive markers of genetic or immune-mediated liver diseases. Patients were asked to complete a selfreport structured questionnaire, assembled by the Israeli Center for Disease Control. Nutrition habits were measured using six yes/no questions(0 = no, 1 = yes) adopted from the national survey questionnaire. Participants in the clinical trial completed a detailed semi-quantitative food frequency questionnaire(FFQ) reporting their habitual nutritional intake during the past year. Self-efficacy was assessed by the Self-Efficacy Scale questionnaire, emotional representation, degree of illness understanding, timeline perception, treatment perception and symptoms were measured by the Brief Illness Perception questionnaire. Illness consequences were measured by the Personal Models of Diabetes Interview questionnaire. A path analysis was performed to describe the interrelationships between the patients' illness perceptions, and assess the extent to which the data fit a prediction of nutritional habits.RESULTS The study sample included 54.1% men, with a mean age of 47.76 ± 11.68 years(range: 20-60) and mean body mass index of 31.56 ± 4.6. The average perceived nutrition habits score was 4.73 ± 1.45 on a scale between 0-6, where 6 represents the healthiest eating habits. Most of the study participants(57.2%) did not feel they fully understood what NAFLD is. Better nutritional habits were positively predicted by the degree of illness understanding(β = 0.26; P = 0.002) and selfefficacy(β = 0.25; P = 0.003). Perceptions of more severe illness consequences were related with higher emotional representation(β = 0.55; P < 0.001), which was related with lower self-efficacy(β =-0.17; P = 0.034). The perception of treatment effectiveness was positively related with self-efficacy(β = 0.32; P < 0.001). In accordance with the correlation between self-efficacy and the perceived nutrition habits score, self-efficacy was also correlated with nutrient intake evaluated by the FFQ; negatively with saturated fat(percent of saturated fat calories from total calories)(r =-0.28, P = 0.010) and positively with fiber(r = 0.22, P = 0.047) and vitamin C intake(r = 0.34, P = 0.002). In a sub analysis of the clinical trial participants, objectively measured compliance to physical activity regimen was positively correlated with the self-efficacy level(r = 0.34, P = 0.046). CONCLUSION Self-efficacy and illness understanding are major determinants of lifestyle-modification among NAFLD patients. This information can assist clinicians in improving compliance with lifestyle changes among these patients. | Shira Zelber-Sagi Shiran Bord Gali Dror-Lavi Matthew Lee Smith Samuel D Towne Jr Assaf Buch Muriel Webb Hanny Yeshua Assy Nimer Oren Shibolet | 2017 | World Journal of Gastroenterology2017，23，10： | 6 |
| 3 | Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up显示文摘 | Shira Zelber-Sagi Roni Lotan Amir Shlomai Muriel Webb Gil Harrari Assaf Buch Dorit Nitzan Kaluski Zamir Halpern Ran Oren | 2012 | Journal of Hepatology2012，，5： | 4 |
| 4 | Direct and relaxation methods for soil-structure interaction due to tunneling显示文摘This paper deals with the problem of tunneling effects on existing buildings. The direct solution,using the condensation method,is presented. This method allows the structural and geotechnical engineers to treat the problem separately and then assemble a relatively small matrix that can be solved directly,even within a spreadsheet. There are certain concerns that the resultant matrix may be ill-conditioned when the structure is very stiff. This paper suggests an alternative method that essentially relaxes the system from an infinitely rigid structure solution. As such,it does not encounter the problems associated with stiff systems. The two methods are evaluated for an example problem of tunneling below a framed structure. It is found that while the direct method may fail to predict reasonable values when the structure is extremely rigid,the alternative method is stable. The relaxation method can therefore be used in cases where there are concerns about the reliability of a direct solution. | Assaf KLAR Itai ELKAYAM | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，1： | 3 |
| 5 | Colon mucosal neoplasia referred for endoscopic mucosal resection:Recurrence of adenomas and prediction of submucosal invasion显示文摘BACKGROUND Endoscopic mucosal resection(EMR)is an effective and minimally invasive alternative to surgery for large polyps and laterally spreading lesions.Gross morphology and surface characteristics may help predict submucosal invasion of the lesion(SMIL)during endoscopic evaluation.This is one of the largest singlecenter studies reporting endoscopic mucosal resection for larger(≥20 mm)colorectal lesions in the United States.AIM To determine the recurrence rate of adenomas and endoscopic features that may predict submucosal invasion of colonic mucosal neoplasia.METHODS This is a retrospective cohort study of all the patients referred for endoscopic mucosal resection for lesions≥20 mm,spanning a period from January 2013 to February 2017.The main outcome measure was identifying features that may predict submucosal invasion of mucosal lesions and predict recurrence of adenomas on follow-up surveillance colonoscopy performed at 4-6 mo.RESULTS A total of 480 patients with 500 lesions were included in the study.The median age was 68(Inter quantile range:14)with 52%males.The most common lesion location was ascending colon(161;32%).Paris classification 0-IIa(Flat elevation of mucosa-316;63.2%);Kudo Pit Pattern IIIs(192;38%)and Granular surface morphology(260;52%)were most prevalent.Submucosal invasion was present in 23(4.6%)out of 500 lesions.The independent risk factors for SMIL were Kudo Pit Pattern IIIL+IV and V(Odds ratio:4.5;P value<0.004)and Paris classification 0-IIc(Odds ratio:18.2;P value<0.01).Out of 500,354 post-endoscopic mucosal resection scars were examined at surveillance colonoscopy.Recurrence was noted in 21.8%(77 cases).CONCLUSION There was overall low prevalence of SMIL in our study.Kudo pit pattern(IIIL+IV and V)and Paris classification 0-IIc were the only factors identified as an independent risk factor for submucosal invasion.The independent risk factor for recurrence was adenoma size(>40 mm).Almost all recurrences(98.8%)were treated endoscopically. | Mamoon Ur Rashid Neelam Khetpal Hammad Zafar Saeed Ali Evgeny Idrisov Yuan Du Assaf Stein Deepanshu Jain Muhammad Khalid Hasan | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，7： | 3 |
| 6 | Non‐alcoholic fatty liver disease independently predicts prediabetes during a 7‐year prospective follow‐up显示文摘 | Shira Zelber‐Sagi Roni Lotan Oren Shibolet Muriel Webb Assaf Buch Dorit Nitzan‐Kaluski Zamir Halpern Erwin Santo Ran Oren | 2013 | Liver Int2013，，9： | 3 |
| 7 | Simpli?ed point-of-care ultrasound protocol to con?rm central venous catheter placement:A prospective study显示文摘BACKGROUND: The current standard for con? rmation of correct supra-diaphragmatic central venous catheter(CVC) placement is with plain ? lm chest radiography(CXR). We hypothesized that a simple point-of-care ultrasound(POCUS) protocol could effectively con? rm placement and reduce time to con? rmation.METHODS: We prospectively enrolled a convenience sample of patients in the emergency department and intensive care unit who required CVC placement. Correct positioning was considered if turbulent flow was visualized in the right atrium on sub-xiphoid, parasternal or apical cardiac ultrasound after injecting 5 cc of sterile, non-agitated, normal saline through the CVC.RESULTS: Seventy-eight patients were enrolled. POCUS had a sensitivity of 86.8%(95%CI 77.1%–93.5%) and speci? city of 100%(95%CI 15.8%–100.0%) for identifying correct central venous catheter placement. Median POCUS and CXR completion were 16 minutes(IQR 10–29) and 32 minutes(IQR 19–45), respectively.CONCLUSION: Ultrasound may be an effective tool to confirm central venous catheter placement in instances where there is a delay in obtaining a con? rmatory CXR. | Scan P.Wilson Samer Assaf Shadi Lahham Mohammad Subeh Alan Chiem Craig Anderson Samantha Shwe Ryan Nguyen John C.Fox | 2017 | World Journal of Emergency Medicine2017，8，1： | 2 |
| 8 | Anal carcinoma in giant anal condyloma, multidisciplinary approach necessary for optimal outcome:Two case reports and review of literature显示文摘BACKGROUND Anal cancers are caused by human papilloma virus(HPV). Buschke-Lowenstein tumor also known as giant anal condyloma(GCA) is a variant of giant neglected anal tumors arising from warts caused by HPV infection. HPV are a family of double-stranded DNA viruses and primarily cause sexually transmitted disease of the genitalia and oropharyngeal mucosa. These tumors are slow growing;locally destructive large verrucous masses.CASE SUMMARY We present a series of two cases with large anal tumors harboring invasive cancers and highlight their presentation and management. Tumors with high risk HPV subtypes(HPV 16, 18, 31, 33) may progress into invasive squamous cell carcinoma(SCC). Untreated GCA can attain enormous size and extend into the pelvic organs and bony structures. Some tumors show malignant degeneration into SCC and are often difficult to diagnose given the large size of the tumors.Complete surgical excision with negative margins is the treatment of choice and necessary to prevent recurrence. This is often not feasible and leaves large surgical wounds with tissue defects with delay in healing and increases postoperative morbidity. Pelvic reconstructive techniques including muscle flaps and grafts are often necessary to close the defects. Human immunodeficiency virus and immunocompromised patients generally do poorly with standard treatments.CONCLUSION A multidisciplinary team of colorectal and plastic surgeons, medical and radiation oncologists along with combination treatment modalities are necessary when malignant transformation occurs in GCA, for optimal outcomes. | Santosh Shenoy Murali Nittala Yazen Assaf | 2019 | World Journal of Gastrointestinal Oncology2019，11，2： | 2 |
| 9 | Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development显示文摘 | Assaf C. Bester Maayan Roniger Yifat S. Oren Michael M. Im Dan Sarni Malka Chaoat Aaron Bensimon Gideon Zamir Donna S. Shewach Batsheva Kerem | 2011 | Cell2011，，3： | 2 |
| 10 | Effect of different lens status on intraocular pressure elevation in patients treated with anti-vascular endothelial growth factor injections显示文摘AIM: To assess the effect of lens status on sustained intraocular pressure(IOP) elevation in patients treated intravitreally with anti-vascular endothelial growth factor(VEGF) agents. METHODS: Data were retrospectively collected for all patients treated with intravitreal injections of anti-VEGF medication at a tertiary medical center in July 2015. Findings were analyzed by lens status during 6 months' follow-up. The main outcome measure was a sustained increase in IOP(≥21 mm Hg or change of ≥6 mm Hg from baseline on ≥2 consecutive visits, or addition of a new IOPlowering medication during follow-up). RESULTS: A total of 119 eyes of 100 patients met the study criteria: 40 phakic, 40 pseudophakic, and 39 pseudophakic after Nd:YAG capsulotomy. The rate of sustained IOP elevation was significantly higher in the postcapsulotomy group(23.1%) than in the phakic/pseudophakic groups(8.1%;P=0.032), with no statistically significant differences among the 3 groups in mean number of injections, either total(P=0.82) or by type of anti-VEGF mediation(bevacizumab: P=0.19;ranibizumab: P=0.13), or mean follow-up time(P=0.70). CONCLUSION: Nd:YAG capsulotomy appears to be a risk factor for sustained IOP elevation in patients receiving intravitreal anti-VEGF injections. This finding has important implications given the growing use of anti-VEGF treatment and the irreversible effects of elevated IOP. | Amir Sternfeld Rita Ehrlich Dov Weinberger Assaf Dotan | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 2 |
| 11 | A hardening load transfer function for rock bolts and its calibration using distributed fiber optic sensing显示文摘Confinement of rock bolts by the surrounding rock formation has long been recognized as a positive contributor to the pull-out behavior,yet only a few experimental works and analytical models have been reported,most of which are based on the global rock bolt response evaluated in pull-out tests.This paper presents a laboratory experimental setup aiming to capture the rock formation effect,while using distributed fiber optic sensing to quantify the effect of the confinement and the reinforcement pull-out behavior on a more local level.It is shown that the behavior along the sample itself varies,with certain points exhibiting stress drops with crack formation.Some edge effects related to the kinematic freedom of the grout to dilate are also observed.Regardless,it was found that the mid-level response is quite similar to the average response along the sample.The ability to characterize the variation of the response along the sample is one of the many advantages high-resolution fiber optic sensing allows in such investigations.The paper also offers a plasticity-based hardening load transfer function,representing a'slice'of the anchor.The paper describes in detail the development of the model and the calibration/determination of its parameters.The suggested model captures well the coupled behavior in which the pull-out process leads to an increase in the confining stress due to dilative behavior. | Assaf Klar Ori Nissim Itai Elkayam | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，11： | 2 |
| 12 | Antidiabetic activity and toxicity of Zizyphus spina-christi leaves显示文摘 | Ahmed O. Abdel-Zaher Safa Y. Salim Mahmoud H. Assaf Randa H. Abdel-Hady | 2005 | Journal of Ethnopharmacology2005，，1： | 2 |
| 13 | Overcoming multidrug resistance with nanomedicines显示文摘 | Assaf Ganoth Keren Cohen Merimi Dan Peer | 2015 | Expert Opinion on Drug Delivery2015，，2： | 2 |
| 14 | Migration and pension with international capital mobility显示文摘 | Assaf Razin Efraim Sadka | 1999 | Journal of Public Economics1999，，1： | 2 |
| 15 | La_(2-x)CexCu_(1-y)Zn_yO_4 perovskites for high temperature water-gas shift reaction显示文摘The performance of La2-xCexCu1-yZnyO4 perovskites as catalysts for the high temperature water-gas shift reaction (HT-WGSR) was investigated. The catalysts were characterized by EDS, XRD, BET surface area, TPR, and XANES. The results showed that all the perovskites exhibited the La2CuO4 orthorhombic structure, so the Pechini method is suitable for the preparation of pure perovskite. However, the La1.90Ce0.10CuO4 perovskite alone, when calcined at 350/700℃, also showed a (La0.935Ce0.065)2CuO4 perovskite with tetragonal structure, which produced a surface area higher than the other perovskites. The perovskites that exhibited the best catalytic performance were those calcined at 350/700 ℃ and, among these, La1.90Ce0.10CuO4 was outstanding, probably because of the high surface area associated with the presence of the (La0.935Ce0.065)2CuO4 perovskite with tetragonal structure and orthorhombic La2CuO4 phase. | S. S. Maluf E. M. Assaf | 2009 | Journal of Natural Gas Chemistry2009，18，2： | 2 |
| 16 | Consecutive versus separate sessions of endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) for symptomatic choledocholithiasis显示文摘 | Fabiana Benjaminov Assaf Stein George Lichtman Itamar Pomeranz Fred M. Konikoff | 2013 | Surgical Endoscopy2013，，6： | 2 |
| 17 | Minimizing adverse sideeffects of oral bexarotene in cutaneous T - cell lymphoma : an expert opinion 显示文摘 | Assaf C Bagol M Dummer R et al | 2006 | BrJ Dermatol2006，155，2： | 1 |
| 18 | Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions 显示文摘 | Tsenter J Beni-Adani L Assaf Y | 2008 | J Neurotrauma2008，25，4： | 1 |
| 19 | FIE and CURLY LEAF polycomb proteins inte ract in the regulation of homeobox gene expression during sporophyte development显示文摘 | AVIVA K MORAN O ASSAF M | 2004 | The Plant Journal2004，37，5： | 1 |
| 20 | High b value q-space-an-显示文摘 | Assaf Y Mayzel-Oreg 0 Gigi A | 2002 | J Neurol Sci2002，，15： | 1 |
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