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| 1 | Indoleamine 2,3-dioxygenase: As a potential prognostic marker and immunotherapeutic target for hepatocellular carcinoma显示文摘Tumor cells induce an immunosuppressive microen-vironment which leads towards tumor immune escape. Understanding the intricacy of immunomodulation by tumor cells is essential for immunotherapy. Indoleamine 2,3-dioxygenase(IDO) is an immunosuppressive enzyme which mediates tumor immune escape in various cancers including hepatocellular carcinoma(HCC). IDO up-regulation in HCC may lead to recruitment of regulatory T-cells into tumor microenvironment and therefore inhibit local immune responses and promote metastasis. HCC associated fibroblasts stimulate natural killer cells dysfunction through prostaglandin E2 and subsequently IDO promotes favorable condition for tumor metastasis. IDO up-regulation induces immuno-suppression and may enhance the risk of hepatitis C virus and hepatitis B virus induced HCC. Therefore, IDO inhibitors as adjuvant therapeutic agents may have clinical implications in HCC. This review proposes future prospects of IDO not only as a therapeutic target but also as a prognostic marker for HCC. | Kashif Asghar Asim Farooq Bilal Zulfiqar Muhammad Usman Rashid | 2017 | World Journal of Gastroenterology2017，23，13： | 16 |
| 2 | 形状特征和置信传播在去除SIFT特征点错误匹配中的应用显示文摘针对SIFT特征点匹配错误问题,提出一种置信传播与特征点形状特征相结合去除SIFT特征点匹配错误的算法.该算法分为4步:1)根据每个特征点的尺度信息、主方向信息以及匹配邻居特征点信息确定每个特征点邻域窗口的大小和方向,并计算每个特征点在邻域窗口内匹配邻居构成的形状特征;2)连接每个特征点与其最近的3个邻居特征点,构成置信传播网的基本框架;3)利用每对待确定特征点对的特征描述符之间的距离与其形状特征之间的距离生成置信传播网的证据函数,利用每对待确定特征点对与其邻居之间的空间关系生成置信传播网的相容函数;4)迭代计算每个特征点的置信度以及传递给邻居的消息,直至整个网络收敛,并通过最后得到的置信度确定初始匹配特征点对是否为误配.利用真实拍摄的图像和牛津几何视觉组数据库中的图像进行仿真实验,并与RANSAC算法、GTM算法以及BP_SIFT算法进行了比较,仿真结果表明,在召回率、准确率、丢失率和效率上,文中算法总体上优于上述3种算法. | 翟凤文 党建武 王阳萍 罗维薇 Muhammad Azim Asim | 2016 | 计算机辅助设计与图形学学报2016，28，3： | 5 |
| 3 | Integration of time-reversal mirror technique in short baseline positioning显示文摘Short baseline(SBL) system is one of the most significant systems for underwater positioning.In shallow water or littoral environment the system faces problems of large error in delay estimation and system instability because of severe multi-path.To address those problems,this paper proposes a SBL system transmitting a wideband signal combined with time-reversal.The effect of multi-path propagation on response signal is compensated by time reversal focusing which is derived from the channel multi-path characteristics.Results of simulations and actual experiments in lake show that the proposed scheme reduces errors in delay estimation.It is proved that time reversal mirror improves the accuracy and precision of underwater vehicle navigation and positioning. | LI Zhuang QIAO Gang Muhammad Asim Ismail | 2013 | Chinese Journal of Acoustics2013，32，3： | 3 |
| 4 | Intensive care unit complications and outcomes of adult patients with hemophagocytic lymphohistiocytosis: A retrospective study of 16 cases显示文摘AIM To study the management, complications and outcomes of adult patients admitted with hemophagocytic lymphohistiocytosis(HLH) in the intensive care unit(ICU).METHODS We performed a retrospective observational study of adult patients with the diagnosis of 'HLH' admitted to the two academic medical ICUs of Baylor College of Medicine between 01/01/2013 to 06/30/2017. HLH was diagnosed using the HLH-2004 criteria proposed by the Histiocyte Society.RESULTS Sixteen adult cases of HLH were admitted to the medical ICUs over 4 years.Median age of presentation was 49 years and 10(63%) were males. Median Sequential Organ Failure Assessment(SOFA) score at the time of ICU admission was 10. Median ICU length of stay(LOS) was 11.5 d and median hospital LOS was 29 d. Septic shock and acute respiratory failure accounted for majority of diagnoses necessitating ICU admission. Septic shock was the most common ICU complication seen in(88%) patients, followed by acute kidney injury(81%) and acute respiratory failure requiring mechanical ventilation(75%). Nine patients(56%) developed disseminated intravascular coagulation and eight(50%) had acute liver failure. 10 episodes of clinically significant bleeding were observed.Multi system organ failure was the most common cause of death seen in 12(75%)patients. The 30 d mortality was 37%(6 cases) and 90 d mortality was 81%(13 cases). There was no difference in mortality based on age(above or less than 50 years), SOFA score on ICU admission(more than or less than 10),immunosuppression, time to diagnose HLH or direct ICU admission versus floor transfer.CONCLUSION HLH is a devastating disease associated with poor outcomes in ICU. Intensivists need to have a high degree of clinical suspicion for HLH in patients with septic shock/multi system organ failure and progressive bi/pancytopenia who are not responding to standard management in ICU. | Sumit Kapoor Christopher K Morgan Muhammad Asim Siddique Kalpalatha K Guntupalli | 2018 | World Journal of Critical Care Medicine2018，7，6： | 3 |
| 5 | Zernike矩快速算法的修正显示文摘首先对Mukundan和Ramakrishnan提出的Zernike矩快速算法进行了修正,给出了更为完整、准确的坐标变换公式。然后给出了由伪极坐标系向笛卡尔坐标系转换的方法。最后,将每一幅图像在相同阶数和重复度下的4个方向Zernike矩模值的均方差与均值的比作为评价指标,对修正前和修正后的算法以及图像预处理对Zernike矩快速算法的影响进行了综合验证。针对5幅图片,两种算法分别有5×11个评价值,实验结果表明:改进后的算法有44个评价值好于原始算法,同时也通过实验验证了多种预处理对Zernike矩的影响。 | 翟凤文 Muhammad Asim Azim 王阳萍 党建武 | 2014 | 吉林大学学报(工学版)2014，44，6： | 3 |
| 6 | Ketamine Alleviates Fear Generalization Through GluN2B-BDNF Signaling in Mice显示文摘Fear memories are critical for survival.Nevertheless,over-generalization of these memories,depicted by a failure to distinguish threats from safe stimuli,is typical in stress-related disorders.Previous studies have supported a protective role of ketamine against stress-induced depressive behavior.However,the effect of ketamine on fear generalization remains unclear.In this study,we investigated the effects of ketamine on fear generalization in a fear-generalized mouse model.The mice were given a single sub-anesthetic dose of ketamine(30 mg/kg,i.p.)1 h before,1 week before,immediately after,or 22 h after fear conditioning.The behavioral measure of fear(indicated by freezing level)and synaptic protein expression in the basolateral amygdala(BLA)and inferior-limbic pre-frontal cortex(IL-PFC)of mice were examined.We found that only ketamine administered 22 h after fear conditioning significantly decreased the fear generalization,and the effect was dose-dependent and lasted for at least 2 weeks.The fear-generalized mice showed a lower level of brainderived neurotrophic factor(BDNF)and a higher level of GluN2B protein in the BLA and IL-PFC,and this was reversed by a single administration of ketamine.Moreover,the GluN2B antagonist ifenprodil decreased the fear generalization when infused into the IL-PFC,but had no effect when infused into the BLA.Infusion of ANA-12(an antagonist of the BDNF receptor TrkB)into the BLA or ILPFC blocked the effect of ketamine on fear generalization.These findings support the conclusion that a single dose of ketamine administered 22 h after fear conditioning alleviates the fear memory generalization in mice and the GluN2B-related BDNF signaling pathway plays an important role in the alleviation of fear generalization. | Muhammad Asim Bo Hao Yu-Han Yang Bu-Fang Fan Li Xue Yan-Wei Shi Xiao-Guang Wang Hu Zhao | 2020 | Neuroscience Bulletin2020，36，2： | 2 |
| 7 | Text Sentiment Analysis Using Frequency-Based Vigorous Features显示文摘Sentiment Analysis, an un-abating research area in text mining, requires a computational method for extracting useful information from text. In recent days, social media has become a really rich source to get information about the behavioral state of people(opinion) through reviews and comments. Numerous techniques have been aimed to analyze the sentiment of the text, however, they were unable to come up to the complexity of the sentiments. The complexity requires novel approach for deep analysis of sentiments for more accurate prediction. This research presents a three-step Sentiment Analysis and Prediction(SAP) solution of Text Trend through K-Nearest Neighbor(KNN). At first, sentences are transformed into tokens and stop words are removed. Secondly, polarity of the sentence, paragraph and text is calculated through contributing weighted words, intensity clauses and sentiment shifters. The resulting features extracted in this step played significant role to improve the results. Finally, the trend of the input text has been predicted using KNN classifier based on extracted features. The training and testing of the model has been performed on publically available datasets of twitter and movie reviews. Experiments results illustrated the satisfactory improvement as compared to existing solutions. In addition, GUI(Hello World) based text analysis framework has been designed to perform the text analytics. | Abdul Razzaq Muhammad Asim Zulqrnain Ali Salman Qadri Imran Mumtaz Dost Muhammad Khan Qasim Niaz | 2019 | China Communications2019，16，12： | 2 |
| 8 | Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases显示文摘Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer’s disease. The growing aging population is a significant healthcare problem globally that researchers must investigate to better understand the underlying aging processes. Advances in microarrays and sequencing techniques have resulted in deeper analyses of diverse essential genomes(e.g., mouse, human, and rat) and their corresponding cell types, their organ-specific transcriptomes, and the tissue involved in aging. Traditional gene controllers such as DNA-and RNA-binding proteins significantly influence such programs, causing the need to sort out long non-coding RNAs, a new class of powerful gene regulatory elements. However, their functional significance in the aging process and senescence has yet to be investigated and identified. Several recent researchers have associated the initiation and development of senescence and aging in mammals with several well-reported and novel long non-coding RNAs. In this review article, we identified and analyzed the evolving functions of long non-coding RNAs in cellular processes, including cellular senescence, aging, and age-related pathogenesis, which are the major hallmarks of long non-coding RNAs in aging. | Syed Aoun Mehmood Sherazi Asim Abbasi Abdullah Jamil Mohammad Uzair Ayesha Ikram Shanzay Qamar Adediji Ayomide Olamide Muhammad Arshad Peter J.Fried Milos Ljubisavljevic Ran Wang Shahid Bashir | 2023 | Neural Regeneration Research2023，18，5： | 2 |
| 9 | The importance of visualization of appendix on abdominal ultrasound for the diagnosis of appendicitis in children: A quality assessment review显示文摘BACKGROUND:Ultrasound has the first line investigation role in the diagnosis of acute appendicitis in children.The purpose of this study was to perform a quality assessment review on the visualization rate of appendix on ultrasound in children in the community hospital setting.METHODS:A retrospective chart review of the abdominal ultrasound findings for the visualization of the appendix was performed on paediatric patients ranging from 5 to 18 years.Data were collected from the two community hospitals of Toronto by using hospital electronic medical record for the ultrasound findings in patients presented with abdominal pain.RESULTS:Data from two community hospitals indicated visualization rate of the appendix as 11.0%and 23.2%for site 1 and site 2 respectively.In cases where the ultrasound was repeated the visualization rate remains the same.A two-proportion z-test was performed to find whether the visualization of appendix increases the likelihood of diagnosing appendicitis.The results revealed that the visualization of an appendix(P=0.52),significantly improved the diagnosis of appendicitis(z=34,P<0.001).CONCLUSION:Visualization of an appendix on ultrasound increases the likelihood of correctly diagnosing appendicitis.In our study,we found low visualization rate of appendix on ultrasound that could be the result of many factors that contribute towards the low visualization rate of an appendix on ultrasound.Hence,the challenges in identifying appendix should be minimized to improve the visualization and diagnosis of appendicitis on ultrasound. | Muhammad Akhter Hamid Ruqiya Afroz Uqba Nawaz Ahmed Aneela Bawani Dilnasheen Khan Rabia Shahab Asim Salim | 2020 | World Journal of Emergency Medicine2020，11，3： | 2 |
| 10 | 5,10,15,20-四(4-羧基苯基)卟啉(TCPP)检测水体痕量Hg2+的研究显示文摘由于羧基卟啉在水中良好的溶解性及对Hg^2+的高亲和性,利用5,10,15,20-四(4-羧基苯基)卟啉与Hg^2+反应前后的荧光特性变化,实现水体Hg^2+的痕量检测。结果显示,该探针与Hg^2+具有良好的配位性,且检测前后体系出现的颜色变化具有可视性。在中性条件下,四羧基卟啉荧光被Hg^2+猝灭,荧光强度与汞离子浓度之间存在良好的指数函数关系,相关系数为0.998。因此,5,10,15,20-四(4-羧基苯基)卟啉可作为一种高效、可靠的探针用于水体中Hg^2+的痕量检测。 | 吕向菲 吕东 Muhammad Asim Shahzad 王家宏 常江峰 李婷 | 2019 | 应用化工2019，48，12： | 2 |
| 11 | Highly active sites of NiVB nanoparticles dispersed onto graphene nanosheets towards efficient and pH-universal overall water splitting显示文摘Production of hydrogen(H2) and oxygen(O2) through electrocatalytic water splitting is one of the sustainable,green and pivotal ways to accomplish the ever-increasing demands for renewable energy sources,but remains a big challenge because of the uphill reaction during overall water splitting.Herein,we develop high-performance non-noble metal electrocatalysts for pH-universal water splitting,based on nickel/vanadium boride(NiVB) nanoparticles/reduced graphene oxide(rGO) hybrid(NiVB/rGO)through a facile chemical reduction approach under ambient condition.By virtue of more exposure to surface active sites,superior electron transfer capability and strong electronic coupling,the asprepared NiVB/rGO heterostructure needs pretty low overpotentials of 267 and 151 mV to deliver a current density of 10 mA cm^(-2) for oxygen evolution reaction(OER) and hydrogen evolution reaction(HER)respectively,with the corresponding Tafel slope of 44 and 88 mV dec^(-1) in 1.0 M KOH.Moreover,the NiVB/rGO electrocatalysts display a promising performance in a wide-pH conditions that require low overpotential of 310,353 and 489 mV to drive a current density of 10 mA cm^(-2) for OER under 0.5 M KOH,0.05 M H2SO4 and 1.0 M phosphate buffer solution(PBS) respectively,confirming the excellent electrocata lytic performance among state-of-the-art Ni-based electrocatalysts for overall water splitting.Therefore,the interfacial tuning based on incorporation of active heterostructure may pave a new route to develop bifunctional,cost-effective and efficient electrocatalyst systems for water splitting and H2 production. | Muhammad Arif Ghulam Yasin Muhammad Shakeel Muhammad Asim Mushtaq Wen Ye Xiaoyu Fang Shengfu Ji Dongpeng Yan | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 12 | 林烟草NsylCBL10互作蛋白激酶NsylCIPK的鉴定与分析显示文摘植物中的类钙调神经素B亚基蛋白CBL (calcineurin B-like protein)家族成员与其互作蛋白激酶CIPK (CBL-interacting kinase protein)家族成员形成了复杂精细的CBL-CIPK信号调控网络,在解码生物和非生物胁迫激发的钙信号及信号的进一步传导中发挥重要作用。CBL家族成员CBL10参与植物抵抗高盐胁迫、应对病菌侵染、参与分生组织和花器官发育、调节离子平衡等多个过程,对其下游互作CIPK家族成员的筛选与鉴定对于明确上述调节机制至关重要。为了鉴定林烟草(Nicotiana sylvestris) NsylCBL10下游互作NsylCIPK家族成员,本研究首先以拟南芥(Arabidopsis thaliana) AtCIPK家族成员和水稻(Oryza sativa) OsCIPK家族成员基因的CDS序列为检索序列,利用NCBI和中国烟草基因组数据库对林烟草中可能存在的NsylCIPK家族成员进行了预测;然后通过RT-PCR方法对预测到的NsylCIPK家族成员进行了克隆并利用生物学分析软件对其基因结构和蛋白保守结构域进行了分析;最后通过酵母双杂交实验鉴定了与Nsyl CBL10互作的NsylCIPK家族成员。结果表明,在林烟草中可能存在28个NsylCIPK家族成员,实际克隆获得了20个NsylCIPK家族成员,在酵母双杂交体系中与NsylCBL10互作的只有1个NsylCIPK家族成员Nsyl CIPK14a。本研究为解析林烟草及其他物种中CBL-CIPK信号通路的调节功能提供了试验数据。 | 许迪之 史素娟 毛静静 张鸽 李书贵 Muhammad Asim Zia Ullah 刘好宝 王倩 | 2018 | 分子植物育种2018，16，19： | 1 |
| 13 | MPLS Unleashed:Remedy Using IPSEC over MPLS VPN显示文摘 | Syed Noor-ul-Hassan Shirazi Muhammad Asim Muhammad Irfan and Nassar Ikram | 2010 | Communications in Computer and Information Science2010，76，： | 1 |
| 14 | Concentration-Dependent Solar Thermochemical CO_(2)/H_(2)O Splitting Performance by Vanadia-Ceria Multiphase Metal Oxide Systems显示文摘The effects of V and Ce concentrations(each varying in the 0-100%range)in vanadia-ceria multiphase systems are investigated for synthesis gas production via thermochemical redox cycles of CO_(2) and H_(2)O splitting coupled to methane partial oxidation reactions.The oxidation of prepared oxygen carriers is performed by separate and sequential CO_(2) and H_(2)O splitting reactions.Structural and chemical analyses of the mixed-metal oxides revealed important information about the Ce and V interactions affecting their crystal phases and redox characteristics.Pure CeO_(2) and pure V_(2)O_(5) are found to offer the lowest and highest oxygen exchange capacities and syngas production performance,respectively.The mixed-oxide systems provide a balanced performance:their oxygen exchange capacity is up to 5 times higher than that of pure CeO_(2) while decreasing the extent of methane cracking.The addition of 25%V to CeO_(2) results in an optimum mixture of CeO_(2) and CeVO4 for enhanced CO_(2) and H_(2)O splitting.At higher V concentrations,cyclic carbide formation and oxidation result in a syngas yield higher than that for pure CeO_(2). | Asim Riaz Muhammad Umair Ali T.Gabriel Enge Takuya Tsuzuki Adrian Lowe Wojciech Lipinski | 2020 | Research2020，，1： | 1 |
| 15 | A study on mul- ti-path channel response of acoustic propagation in northwestern Arabian Sea显示文摘 | Gang Qiao Asim Ismail Muhammad Aatiq | 2013 | Research Journal of Applied Sciences Engineering and Technology2013，5，19： | 1 |
| 16 | 基于互信息和类电磁机制优化算法的医学图像配准研究显示文摘采用互信息来描述图像配准的效果,应用类电磁机制优化算法搜索配准所对应的空间变换参数,并借鉴POWELL优化算法,在局部搜索过程中采用了黄金分割点一维搜索方法进行搜索,实验结果表明提出的算法可以很好的脱离局部最优解,同时可以达到较好的配准精度,并具有较好的时效性. | 翟凤文 Muhammad Asim Azim 王阳萍 党建武 | 2013 | 兰州交通大学学报2013，32，4： | 1 |
| 17 | Zingiber officinale ameliorates allergic asthma via suppression of Th2-mediated immune response显示文摘 | Asad Mahmood Khan Muhammad Shahzad M. B. Raza Asim Muhammad Imran Arham Shabbir | 2014 | Pharmaceutical Biology2014，，： | 1 |
| 18 | Fahr' s syndrome: literature re- view of current evidence 显示文摘 | SHAFAQ SALEEM HAFIZ MUHAMMAD ASLAM MUHAM- MAD ASIM KHAN REHMANI | 2013 | Orphanet Journal of Rare Disease2013，8，： | 1 |
| 19 | On the security defects of an image encryption scheme显示文摘 | LI Chengqing LI Shujun ASIM Muhammad | 2009 | Image and Vision Computing2009，27，9： | 1 |
| 20 | Numerical Simulation and Experimental Verification of CMOD in SENT Specimen: Application on FCGR of Welded Tool Steel显示文摘Single-edged notched tension (SENT) specimen is used to study the fatigue crack growth rate (FCGR) behavior of AISI 50100 steel using MTS 810. Calibration tests are run to get plots of crack mouth opening displacement (CMOD) vs. load and CMOD vs. crack length-to-width ratio with the known crack lengths. Numerical simulation is also done to try to establish a relation between crack length and CMOD. FCGR of welded and un-welded specimens are plotted against stress intensity factor range to show the effect of welding on fatigue crack growth rate of AISI 50100 steel. The experimentally obtained CMOD values are compared with values obtained by numerical simulation using ABAQUS/StandardTM software package. Results show that numerical values are in good agreement with experimental data for small crack lengths and lower values of applied load. | Amir SULTAN Riffat Asim PASHA Mifrah ALI Muhammad Zubair KHAN Muhammad Afzal KHAN Naeem Ullah DAR Masood SHAH | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，1： | 1 |
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