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| 1 | Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis显示文摘AIM:To assess the nourishment status and lifestyle of non-hospitalized patients with compensated cirrhosis by using noninvasive methods.METHODS:The subjects for this study consisted of 27 healthy volunteers,59 patients with chronic viral hepatitis,and 74 patients with viral cirrhosis,from urban areas.We assessed the biochemical blood tests,anthropometric parameters,diet,lifestyle and physical activity of the patients.A homeostasis model assessment-insulin resistance(HOMA-IR) value of ≥ 2.5 was considered to indicate insulin resistance.We measured height,weight,waist circumference,arm circumference,triceps skin-fold thickness,and handgrip strength,and calculated body mass index,arm muscle circumference(AMC),and arm muscle area(AMA).We interviewed the subjects about their dietary habits and lifestyle using health assessment computer software.We surveyed daily physical activity using a pedometer.Univariate and multivariate logistic regression modeling were used to identify the relevant factors for insulin resistance.RESULTS:The rate of patients with HOMA-IR ≥ 2.5(which was considered to indicate insulin resistance) was 14(35.9%) in the chronic hepatitis and 17(37.8%) in the cirrhotic patients.AMC(%)(control vs chronic hepatitis,111.9% ± 10.5% vs 104.9% ± 10.7%,P = 0.021;control vs cirrhosis,111.9% ± 10.5% vs 102.7% ± 10.8%,P = 0.001) and AMA(%)(control vs chronic hepatitis,128.2% ± 25.1% vs 112.2% ± 22.9%,P = 0.013;control vs cirrhosis,128.2% ± 25.1% vs 107.5% ± 22.5%,P = 0.001) in patients with chronic hepatitis and liver cirrhosis were significantly lower than in the control subjects.Handgrip strength(%) in the cirrhosis group was significantly lower than in the controls(control vs cirrhosis,92.1% ± 16.2% vs 66.9% ± 17.6%,P < 0.001).The results might reflect a decrease in muscle mass.The total nutrition intake and amounts of carbohydrates,protein and fat were not significantly different amongst the groups.Physical activity levels(kcal/d)(control vs cirrhosis,210 ± 113 kcal/d vs 125 ± 74 kcal/d,P = 0.001),number of steps(step/d)(control vs cirrhosis,8070 ±3027 step/d vs 5789 ± 3368 step/d,P = 0.011),and exercise(Ex)(Ex/wk)(control vs cirrhosis,12.4 ± 9.3 Ex/wk vs 7.0 ± 7.7 Ex/wk,P = 0.013) in the cirrhosis group was significantly lower than the control group.The results indicate that the physical activity level of the chronic hepatitis and cirrhosis groups were low.Univariate and multivariate logistic regression modeling suggested that Ex was associated with insulin resistance(odds ratio,6.809;95% CI,1.288-36.001;P = 0.024).The results seem to point towards decreased physical activity being a relevant factor for insulin resistance.CONCLUSION:Non-hospitalized cirrhotic patients may need to maintain an adequate dietary intake and receive lifestyle guidance to increase their physical activity levels. | Fumikazu Hayashi Chika Momoki Miho Yuikawa Yuko Simotani Etsushi Kawamura Atsushi Hagihara Hideki Fujii Sawako Kobayashi Shuji Iwai Hiroyasu Morikawa Masaru Enomoto Akihiro Tamori Norifumi Kawada Satoko Ohfuji Wakaba Fukusima Daiki Habu | 2012 | World Journal of Gastroenterology2012，18，40： | 11 |
| 2 | Gene Body CG and CHG Methylation and Suppression of Centromeric CHH Methylation are Mediated by DECREASE IN DNA METHYLATION1 in Rice显示文摘Dear Editor, DECREASE IN DNA METHYLATION1 (DDM1) is a chromatin remodeling protein required for maintenance of cytosine and histone H3K9 methylation in heterochromatin regions in the genome of Arabidopsis thaliana (Gendrel et al.,2002).A ddm 1 mutant also increases the rate of meiotic recombination in euchromatic but not heterochromatic regions of A.thaliana (Melamed-Bessudo and Levy,2012),and changes the state of cytosine methylation of agene flanked by a LINE element located in a region of euchromatin (Saze and Kakutani,2007). | Hisataka Numa Katsushi Yamaguchi Shuji Shigenobu Yoshiki Habu | 2015 | Molecular Plant2015，8，10： | 2 |
| 3 | Decrease of CD56 + T Cells and Natural Killer Cells in Cirrhotic Livers With Hepatitis C May Be Involved in Their Susceptibility to Hepatocellular Carcinoma显示文摘 | Nobuaki Kawarabayashi Shuhji Seki Kazuo Hatsuse Takashi Ohkawa Yuji Koike Tsukasa Aihara Yoshiko Habu Ryusuke Nakagawa Katsunori Ami Hoshio Hiraide Hidetaka Mochizuki | 2000 | Hepatology2000，，5： | 2 |
| 4 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 2 |
| 5 | Revaluation of clinical features of ischemic colitis:analysis of 68 concecutive cases diagnosis by early colonoscopy显示文摘 | Habu Y Tahashi Y Kiyota K | 1996 | Scand J Gastroenterol1996，31，： | 1 |
| 6 | The mechanism of a defective lFN-gamma response to bacterial toxins in an atopic dermatitismodel,NC/Nga mice, and the therapeutic effect of IFN-gamma, IL-12, or IL-I 8 on dermatitis显示文摘 | Habu Y Seki S Takayama E | 2001 | J Immuno12001，166，9： | 1 |
| 7 | Inhibition of HIV-1 gene expression by retroviral vector-mediated small-guide RNAs that direct specific RNA cleavage by tRNase ZL显示文摘 | Yuichiro Habu Naoko Miyano-Kurosaki Michiko Kitanol | | 0，，01： | 1 |
| 8 | Effect of different proton pump inhibitors, differences in CYP2C19 genotype and antibiotic resistance on the eradication rate of Helicobacter pylori infection by a 1-week regimen of proton inhibitor, amoxicilin and clarithromycin 显示文摘 | Kawabata H Habu Y Tomioka H | 2003 | Aliment Pharmacol Ther2003，17，： | 1 |
| 9 | Natural course of portal hemodynamics in patients with chronic liver diseases, evaluated by per-rectal portal scintigraphy with Tc-99m pertechnetate显示文摘 | Susumu Shiomi Nobumitsu Sasaki Daiki Habu Tadashi Takeda Shuhei Nishiguchi Tetsuo Kuroki Takashi Tanaka Hironobu Ochi | 1998 | Journal of Gastroenterology1998，，4： | 1 |
| 10 | In vitro antioxidant capacity and free radical scavenging evaluation of active metabolite constituents of Newbouldia laevis ethanolic leaf extract显示文摘 | Josiah Bitrus Habu Ban:holomew Okechukwu Ibeh | 2015 | Biol Res2015，48，1： | 1 |
| 11 | Amplified re-striction fragment length polymorphism-based mRNA finger-printing using a single restriction enzyme that recognizes a 4-bp sequence显示文摘 | Habu Y Fukada-Tanaka S Hisatomi Y | 1997 | Biochemical and Biophysical Research Com-munications1997，234，： | 1 |
| 12 | Decreased activity of baso- lateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2 显示文摘 | Habu Y Yano I Takeuchi A | 2003 | Biochem Pharmacol2003，66，6： | 1 |
| 13 | The mechanism of a defective IFN-gamma response to bacterial toxins in an atopic dermatitis model, NC/Nga mice, and the therapeutic effect of IFN-gamma, IL-12, or IL-18 on dermatitis显示文摘 | Habu Y Seki S Takayama E Ohkawa T Koike Y Ami K | 2001 | J Immunol2001，166，9： | 1 |
| 14 | Initial steroid hormonedose in the treatment of idiopathic sudden deafness显示文摘 | Mineda R Masuyama K Habu K | 2000 | Am J Otol2000，21，6： | 1 |
| 15 | Gastric cancer in elderly patients-results of sur- gical treatment 显示文摘 | Habu H Endo M | 1989 | Hepatogastroenterology1989，36，2： | 1 |
| 16 | Restored expression and activity of organic ion transporters rOATI, rOAT3 and rOCT2 after hyperuricemia in the rat kidney显示文摘 | Habu Y Yano I Okuda M | 2005 | Biochem Pharmacol2005，69，6： | 1 |
| 17 | Test of B/ Ti muhilayer reactive igniters for a micro solid rocket ar- ray thruster 显示文摘 | TANAKA S KONDO K HABU H etal | 2008 | Sensors and Actuators A: Physical2008，144，2： | 1 |
| 18 | Solid propulsion for space applications: An updated roadmap显示文摘 | Jean-Francois Guery I-Shih Chang Toru Shimada Marilyn Glick Didier Boury Eric Robert John Napior Robert Wardle Christian Pérut Max Calabro Robert Glick Hiroto Habu Nobuhiro Sekino Gilles Vigier Bruno d’Andrea | 2009 | Acta Astronautica2009，，1： | 1 |
| 19 | Suppression of human immunodeflciency virus type 1(HIV-1)replication by an HIV-1-dependent double locked vector with the Cre/loxP system显示文摘 | Habu Y Nagawa T Matsumoto N | 2005 | Nucleosides Nucleotides Nucleic Acids2005，24，1012： | 1 |
| 20 | Epigenetic regula- tion of transcription in intermediate heterochromatin 显示文摘 | Habu Y Mathieu O Tariq M | 2006 | EMBO Rep2006，7，12： | 1 |
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