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| 1 | Diagnosis and treatment of hepatocellular carcinoma: An update显示文摘Hepatocellular carcinoma(HCC) is one of the most common malignancies leading to high mortality rates in the general population; in cirrhotic patients, it is the primary cause of death. The diagnosis is usually delayed in spite of at-risk population screening recommendations, i.e., patients infected with hepatitis B or C virus. Hepatocarcinogenesis hinges on a great number of genetic and molecular abnormalities that lead to tumor angiogenesis and foster their dissemination potential. The diagnosis is mainly based on imaging studies such as computed tomography and magnetic resonance, in which lesions present a characteristic classical pattern of early arterial enhancement followed by contrast medium 'washout' in late venous phase. On occasion, when imaging studies are not conclusive, biopsy of the lesion must be performed to establish the diagnosis. The Barcelona Clinic Liver Cancer staging method is the most frequently used worldwide and recommended by the international guidelines of HCC management. Currently available treatments include tumor resection, liver transplant, sorafenib and locoregional therapies(alcoholization, radiofrequency ablation, chemoembolization). The prognosis of hepatocarcinoma is determined according to the lesion's stage and in cirrhotic patients, on residual liver function. Curative treatments, such as liver transplant, are sought in patients diagnosed in early stages; patients in more advanced stages, were not greatly benefitted by chemotherapy in terms of survival until the advent of target molecules such as sorafenib. | Javier Tejeda-Maldonado Ignacio García-Juárez Jonathan Aguirre-Valadez Adrián González-Aguirre Mario Vilatobá-Chapa Alejandra Armengol-Alonso Francisco Escobar-Penagos Aldo Torre Juan Francisco Sánchez-ávila Diego Luis Carrillo-Pérez | 2015 | World Journal of Hepatology2015，7，3： | 22 |
| 2 | Reduction of the closure time of postoperative enterocutaneous fistulas with fibrin sealant显示文摘AIM: To assess whether the use of fibrin sealantshortens the closure time of postoperative enterocutaneous fistulas (ECFs). METHODS: The prospective case-control study included 70 patients with postoperative ECFs with an output of < 500 mL/d, a fistulous tract of > 2 cm and without any local complication. They were divided into study (n = 23) and control groups (n = 47). Esophageal, gastric and colocutaneous fistulas were monitored under endoscopic visualization, which also allowed fibrin glue application directly through the external hole. Outcome variables included closure time, time to resume oral feeding and morbidity related to nutritional support. RESULTS: There were no differences in mean age, fistula output, and follow-up. Closure-time for all patients of the study group was 12.5 ± 14.2 d and 32.5 ± 17.9 d for the control group (P < 0.001), and morbidity related to nutritional support was 8.6% and 42.5%, respectively (P < 0.01). In patients with colonic fistulas, complete closure occurred 23.5 ± 19.5 d after the first application of fibrin glue, and spontaneous closure was observed after 36.2 ± 22.8 d in the control group (P = 0.36). Recurrences were observed in 2 patients because of residual disease. One patient of each group died during follow-up as a consequence of septic complications related to parenteral nutrition. CONCLUSION: Closure time was significantly reduced with the use of fibrin sealant, and oral feeding was resumed faster. We suggest the use of fibrin sealant for the management of stable enterocutaneous fistulas. | Jorge Avalos-González Eliseo Portilla-deBuen Caridad Aurea Leal-Cortés Abel Orozco-Mosqueda María del Carmen Estrada-Aguilar Gabriela Abigail Velázquez-Ramírez Gabriela Ambriz-González Clotilde Fuentes-Orozco Aldo Emmerson Guzmán-Gurrola Alejandro González-Ojeda | 2010 | World Journal of Gastroenterology2010，16，22： | 10 |
| 3 | Clinical scenarios for the use of S100β as a marker of hepatic encephalopathy显示文摘AIM: To evaluate the association between serum concentrations of S100β in patients with cirrhosis and the presence of low grade hepatic encephalopathy(HE).METHODS: This was a cross-sectional study. The population was categorized into four groups healthy subjects, cirrhosis without HE, cirrhosis with covert hepatic encephalopathy(CHE) and cirrhosis with overt HE. Kruskal-Wallis, Mann Whitney's U with Bonferroni adjustment Spearman correlations and area under the ROC were used as appropriate.RESULTS: A total of 61 subjects were included, 46 cirrhotic patients and 15 healthy volunteers. S100β values were different among all groups, and differences remained significant between groups 1 and 2(P < 0.001), and also between groups 2 and 3(P = 0.016), but not between groups 3 and 4. In cirrhotic patients with HE S100β was higher than in patients without HE [0.18(0.14-0.28) ng/m L vs 0.11(0.06-0.14) ng/m L, P < 0.001]. There was a close correlation between serum concentrations of S100β and psychometric hepatic encephalopathy score in patients with cirrhosis without HE compared to the patients with cirrhosis with CHE(r =-0.413, P = 0.019). ROC curve analysis yielded > 0.13 ng/m L as the best cutoff value of S100β for the diagnosis of HE(sensitivity 83.3%, specificity 63.6%).CONCLUSION: Serum concentrations of S100β are higher in patients with cirrhosis than in healthy volunteers, and are further increased in the presence of hepatic encephalopathy. The results suggest that serum biomarkers such as S100β could help in the correct characterization of incipient stages of HE. | Andrés Duarte-Rojo Astrid Ruiz-Margáin Ricardo U Macias-Rodriguez Francisco Javier Cubero José Estradas-Trujillo Rosa Ma Munoz-Fuentes Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，17： | 4 |
| 4 | Factors that influence outcome in non-invasive and invasive treatment in polycystic liver disease patients显示文摘AIM: To evaluate the factors that influence outcome of both non-invasive and invasive treatment of polycystic liver disease. METHODS: Analysis of clinical files of patients with complete follow-up from July 1986 to June 2006. RESULTS: Forty-one patients (male, 7; female, 34), 47.8 ± 11.9 years age, and 5.7 ± 6.7 years follow-up, were studied. Alkaline phosphatase (AP) elevation (15% of patients) was associated with the requirement of invasive treatment (IT, P = 0.005). IT rate was higher in symptomatic than non-symptomatic patients (65.4% vs 14.3%, P = 0.002), and in women taking hormonal replacement therapy (HRT) (P = 0.001). Cysts complications (CC) were more frequent (22%) in the symptomatic patients group (P = 0.023). Patients with body mass index (BMI) > 25 (59%) had a trend to complications after IT (P = 0.075). Abdominal pain was the most common symptom (56%) and indication for IT (78%). Nineteen patients (46%) required a first IT: 12 open fenestration (OF), 4 laparoscopic fenestration (LF) and 3 fenestration with hepatic resection (FHR). Three required a second IT, and one required a third procedure. Complications due to first IT were found in 32% (OF 16.7%, LF 25%, FHR 66.7%), and in thesecond IT in 66.7% (OF 100%). Follow-up mortality rate was 0. CONCLUSION: Presence of symptoms, elevated AP, and CC are associated with IT requirement. HRT is associated with presence of symptoms and IT requirement. Patients with BMI > 25 have a trend be susceptible to IT complications. The proportions of complications are higher in FHR and second IT groups. RS is more frequent after OF. | Josué Barahona-Garrido Jesús Camacho-Escobedo Eduardo Cerda-Contreras Jorge Hernández-Calleros Jesús K Yamamoto-Furusho Aldo Torre Misael Uribe | 2008 | World Journal of Gastroenterology2008，14，20： | 4 |
| 5 | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis显示文摘AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. | Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，45： | 4 |
| 6 | Renal Failure in Patients With Cirrhosis and Sepsis Unrelated to Spontaneous Bacterial Peritonitis: Value of MELD Score显示文摘 | Carlos Terra Mónica Guevara Aldo Torre Rosa Gilabert Javier Fernández Marta Martín-Llahí Maria E. Baccaro Miquel Navasa Conxita Bru Vicente Arroyo Juan Rodés Pere Ginès | 2005 | Gastroenterology2005，，6： | 2 |
| 7 | Statin Treatment Is Associated with Reduction in Serum Levels of Receptor Activator of NF- κ B Ligand and Neutrophil Activation in Patients with Severe Carotid Stenosis显示文摘 | Sébastien Lenglet Alessandra Quercioli Mathias Fabre Katia Galan Graziano Pelli Alessio Nencioni Inga Bauer Aldo Pende Magaly Python Maria Bertolotto Giovanni Spinella Bianca Pane Domenico Palombo Franco Dallegri Fran?ois Mach Nicolas Vuilleumier Fabrizio | 2014 | Mediators of Inflammation2014，，： | 2 |
| 8 | Microwave accelerated wittig reaction of stabilized phosphorus ylides with ketones under solvent-free conditions 显示文摘 | ALDO S TANCRED F ANNUNZIATA S | 1997 | Synlett1997，，1： | 1 |
| 9 | Classification of polyolefins from building and construction waste using NIR hyperspectral imaging system显示文摘 | Silvia S Aldo G Giuseppe B | 2012 | Resources Conservation andRecycling2012，61，： | 1 |
| 10 | Alteration of the E-cadherin /β-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids显示文摘 | Giuseppe P Aldo S Giacomo P | 2005 | Cancer2005，103，6： | 1 |
| 11 | A video camera system with enhanced zoom tracking and auto white balance显示文摘 | Yoon K K June S L Aldo W M | 2002 | IEEE Transactions on Consumer Electronics2002，48，3： | 1 |
| 12 | Stromal haze after combined riboflavin-UVA corneal colla- gen cross-linking in keratoconus:in vivo confocal microscopic evaluation显示文摘 | Mazzotta C Balestrazzi A Baiocchi S Traversi C Aldo Caporos- si A | 2007 | Clin Exp Ophthalmo12007，35，6： | 1 |
| 13 | Phylogeography and population genetic structure of the Talas tuco-tuco (Ctenomys talarum): integrating demographic and habitat histories显示文摘 | Mora Mat?as S Cutrera Ana P Lessa Enrique P Vassallo Aldo I D’Anatro Alejandro Mapelli Fernando J | 2013 | Journal of Mammalogy2013，，2： | 1 |
| 14 | Semliki Forest virus as a vector: pros and cons for its use in biopharmaeeuticals production 显示文摘 | Nunez E G F Jorge S A C Aldo Tonso | 2013 | Brazilian Archives of Biology and Technology2013，56，： | 1 |
| 15 | Determonation of free and amidated bile acids by high-performance liquid chromatography with evaporative light-scattering mass detection显示文摘 | Carolina C Patrizia S | 1992 | J Lipid Res1992，33，： | 1 |
| 16 | Direct yaw moment control actuated through electric drivetrains and fric- tion brakes: Theoretical design and experimental assessment显示文摘 | LEONARDO D N ALDO S PATRICK G | 2015 | Mechatronics2015，26，： | 1 |
| 17 | Free-surface turbulence and mass transfer in a channel flow显示文摘 | Gulliver J S | 2002 | AICHE Journal2002，48，12： | 1 |
| 18 | Thermodynamic features of bile salt-human serum albumin interaction显示文摘 | Franeesco S Aldo R Adamo F | 1984 | Biochimica et BioPhysica acta (BBA)-Prorein Structure and Molecular enzymology1984，791，2： | 1 |
| 19 | 雷米普利、替米沙坦或二者联用对心血管病高危人群肾脏结局的影响(ONTARGET研究):一项多中心、随机、双盲、对照试验显示文摘背景血管紧张素受体阻断剂(ARB)和血管紧张素转换酶抑制剂(ACEI)都可以减少蛋白尿,二者联用可能比单一用药更有效。目前还没有长期临床试验比较两者对肾功能的影响。本研究比较了雷米普利(一种ACEI)、替米沙坦(一种ARB)或二者联用对患有动脉粥样硬化性血管病或糖尿病合并终末器官损害的人群(年龄≥55岁)肾脏结局的影响。方法临床试验从2001年开始,到2007年结束。经过3周的导入期,25620例受试者被随机分配至10mg/d雷米普利组(n=8576)、80mg/d替米沙坦组(n=8542)或10mg/d雷米普利+80mg/d替米沙坦组(n=8502;中位随访期为56个月),同时检测肾功能和尿蛋白。主要肾脏结局为透析、血清肌酐加倍和死亡的复合终点。采用意向性治疗分析。本研究已在ClinicalTrials.gov注册,编号为NCT00153101。结果试验期间,784例患者因低血压症状提前终止随机治疗(联合用药组406例,雷米普利组149例,替米沙坦组229例)。替米沙坦组和雷米普利组发生复合终点事件的例数相近[替米沙坦组1147例(13.4%),雷米普利组1150例(13.5%);HR1.00(95%C10.92~1.09)],但在联合用药组有所增加[1233例(14.5%);HR1.09(95%CI1.01-1.18),P=0.037]。次要肾脏结局(透析或血清肌酐加倍)的发生例数在替米沙坦组(189例,2.21%)和雷米普利组(174例,2.03%)相近(HR1.09,95%C10.89~1.34),但在联合用药组显著增加(212例,2.49%:HR1.24,95%CI1.01~1.51.P=0.038)。肾小球滤过率估计值在雷米普利组下降最少,为-2.82ml/(min·1.73m^2)(s=17.2),而在替米沙坦组为-4.12ml/(min·1.73m^2)(S=17.4,P〈0.0001),在联合治疗组为-6.11ml/(min·1.73m^2)(S=17.9,P〈0.0001)。与雷米普利组相比,替米沙坦组(P=0.004)和联合用药组(P=0.001)较少发生尿蛋白排泄增加。结论在心血管病高危人群中,替米沙坦和雷米普利对肾脏结局的影响相同。尽管联合用药比单一治疗能更大程度减少蛋白尿,但总体上其增加了肾脏结局事件。基金 勃林格殷格翰公司。 | Johannes F E Mann, Roland E Schmieder Matthew McQueen Leanne Dyal Helmut Schumacher Janice Pogue Xingyu Wang Aldo Maggioni Andrzej Budaj Suphachai Chaithiraphan Kenneth Dickstein Matyas Keltai Kaj Metsarinne Ali Oto Alexander Parkhomenko Leopoldo S Piegas Tage L Svendsen Koon KTeo Salim Yusuf 刘欣(译) 王兴宇(审) | 2009 | 世界临床医学2009，，4： | 1 |
| 20 | Classification of polyolefins from building and construction waste using NIR hyperspectral imaging system显示文摘 | SILVIA S ALDO G GIUSEPPE B | 2012 | Resources Conservation Recycling2012，61，： | 1 |
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