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| 1 | Dynamic localization of hepatocellular transporters in health and disease显示文摘Vesicle-based traffi cking of hepatocellular transporters involves delivery of the newly-synthesized carriers from the rough endoplasmic reticulum to either the plasma membrane domain or to an endosomal,submembrane compartment,followed by exocytic targeting to the plasma membrane. Once delivered to the plasma membrane,the transporters usually undergo recycling between the plasma membrane and the endosomal compartment,which usually serves as a reservoir of pre-existing transporters available on demand. The balance between exocytic targeting and endocytic internalization from/to this recycling compartment is therefore a chief determinant of the overall capability of the liver epithelium to secrete bile and to detoxify endo and xenobiotics. Hence,it is a highly regulated process. Impaired regulation of this balance may lead to abnormal localization of these transporters,which results in bile secretory failure due to endocytic internalization of key transporters involved in bile formation. This occurs in several experimental models of hepatocellular cholestasis,and in most human cholestatic liver diseases. This review describes the molecular bases involved in the biology of the dynamic localization of hepatocellular transporters and its regulation,with a focus on the involvement of signaling pathways in this process. Their alterations in different experimental models of cholestasis and in human cholestatic liver disease are reviewed. In addition,the causes explaining the pathological condition (e.g. disorganization of actin or actin-transporter linkers) and the mediators involved (e.g. activation of cholestatic signaling transduction pathways) are also discussed. Finally,several experimental therapeutic approaches based upon the administration of compounds known to stimulate exocytic insertion of canalicular transporters (e.g. cAMP,tauroursodeoxycholate) are described. | Marcelo G Roma Fernando A Crocenzi Aldo D Mottino | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 2 | A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics显示文摘 | Alexander Hoppe Nusret S. Güldal Aldo R. Boccaccini | 2011 | Biomaterials2011，，11： | 2 |
| 3 | Classification of polyolefins from building and construction waste using NIR hyperspectral imaging system显示文摘 | Silvia S Aldo G Giuseppe B | 2012 | Resources Conservation andRecycling2012，61，： | 1 |
| 4 | Placental viral infection sensitizes to endotoxin-induced pre-term labor: a double hit hypothesis 显示文摘 | Cardenas I Mor G Aldo P | 2011 | Am J Reprod Immunol2011，65，： | 1 |
| 5 | The governance of university knowl- edge transfer: a critical review of the literature 显示文摘 | ALDO G ALESSANDRO M | 2009 | Minerva2009，，1： | 1 |
| 6 | JOE : A mobile, inverted pendulum显示文摘 | Felix G Aldo D A Silvio C | 2002 | IEEE Transaction on Industrial Electronics2002，49，1： | 1 |
| 7 | JOE: A mobile inverted Pendulum 显示文摘 | Felix G Aldo D A Silvio C | 2002 | IEEE Transactions on Industrial Electronics2002，49，1： | 1 |
| 8 | Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity显示文摘 | Aldo P Michele E Erri G | 2004 | Circulation2004，109，11： | 1 |
| 9 | Unscented Kalman Filtering for Nonlinear Structural Dynamics显示文摘 | Stefano M Aldo G | 2007 | Nonlinear Dyn2007，，49： | 1 |
| 10 | Human atherosclerotic plaques contain gamma-glutamy transpeptidase enzyme acticity 显示文摘 | Aldo P Michele E Erri G | 2004 | Circulation2004，109，： | 1 |
| 11 | Chemiluminescent high-throughput microassay applied to imidazothiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors显示文摘 | Aldo A Silvia B Massimiliano G | 2008 | Euro J of Med Chem2008，43，： | 1 |
| 12 | Antitumor activity of new substituted 3-(5-imidazothiazolylmethylene)-2-indolinones and study of their effect on the cell cycle1显示文摘 | Aldo A Massimiliano G Alberto L | 2005 | J Med Chem2005，48，： | 1 |
| 13 | A brain imaging study of the choice procedure显示文摘 | ALDO R JOHN D PAOLO G | 2005 | Games and Economic Behavior2005，52，： | 1 |
| 14 | Human ath- erosclerotic plaques contain gamma -- glutamyl transpeptidase enzyme activity显示文摘 | ALDO P MICHELE E ERRI G | 2004 | Circulation2004，，： | 1 |
| 15 | Neutrophil gelatinase - associat- ed lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences 显示文摘 | Aldo C Claudio G Antonio F | 2012 | Clin Chem Lab Med2012，50，9： | 1 |
| 16 | Semliki Forest virus as a vector: pros and cons for its use in biopharmaeeuticals production 显示文摘 | Nunez E G F Jorge S A C Aldo Tonso | 2013 | Brazilian Archives of Biology and Technology2013，56，： | 1 |
| 17 | Genetic profile of 22 pancreatic carcinoma cell lines显示文摘 | Patrick S. Moore Bence Sipos Simonetta Orlandini Claudio Sorio Francisco X. Real Nicholas R. Lemoine Thomas Gress Claudio Bassi Günter Kl?ppel Holger Kalthoff Hendrik Ungefroren Matthias L?hr Aldo Scarpa | 2001 | Virchows Archiv2001，，6： | 1 |
| 18 | A two-stage method for nonlinear inverse problems显示文摘 | MARIA G G ALESSANDRA P ALDO P | 2007 | Journal of Compu- tational and Applied Mathematics2007，198，： | 1 |
| 19 | Direct yaw moment control actuated through electric drivetrains and fric- tion brakes: Theoretical design and experimental assessment显示文摘 | LEONARDO D N ALDO S PATRICK G | 2015 | Mechatronics2015，26，： | 1 |
| 20 | JOE:A mobile,inverted pendulum显示文摘 | Felix G Aldo D A Silvio C | 2002 | IEEE Transaction on Industral Electronics2002，49，1： | 1 |
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