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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 3 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 4 | Intravitreal triamcinolone for refractory diabetic macular edema显示文摘 | Adam Martidis Jay S Duker Paul B Greenberg Adam H Rogers Carmen A Puliafito Elias Reichel Caroline Baumal | 2002 | Ophthalmology2002，，5： | 2 |
| 5 | Bee Parasitic Mite Syndrome(II):The Role of Varroa Mite and Virues 显示文摘 | Hung A C F Adams J R Shimanuki H | 1995 | American Bee Journal1995，12，： | 2 |
| 6 | A theory for the ablation of glassy materials显示文摘 | BETHE H A ADAMS M C | 1959 | Journal of the Aero/Space Sciences1959，26，6： | 1 |
| 7 | The energy spectra of heavy nuclei measured by the ATIC experi- ment显示文摘 | PANOV A D ADAMS J H AHN H S | 2006 | Advances in Space Research2006，37，10： | 1 |
| 8 | Sensitive de- tection of occult breast cancer by the reverse - transcriptase poly- merase chain reaction显示文摘 | DATI?A Y H ADAMS P T DROBYKI W R_ | 1994 | J Clin Oncol1994，12，6： | 1 |
| 9 | Diffuse axonal in- jury and traumatic coma in the primate 显示文摘 | Gennarelli T A Thibault L E Adams J H | 1982 | Ann Neurol1982，12，6： | 1 |
| 10 | Effects of a reduced calcium,phosphorus and protein intake and of benzoic acid on calcium and phosphorus metabolism of growing pigs显示文摘 | GUTZWILLER A HESS H D ADAM A | 2011 | Animal Feed Science and Technology2011，168，1： | 1 |
| 11 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 12 | Postoperative pain management in orthopaedic patients: no differences in pain score,but improved stress control by epidural anaesthesia显示文摘 | Adams H A Saatweber P Schmitz C S | 2002 | Eur J Anaesthesiol2002，19，9： | 1 |
| 13 | The Effects and Limitations of Automated Text Condensing on Reading Comprehension Performance显示文摘 | Morris A H Kaspcr G M Adams D A | 1992 | Information Systems Research1992，，1： | 1 |
| 14 | A novel direct torque control algorithm for IPMSM with minimum harmonics and torque Ripples 显示文摘 | Gulez K Adam A A Pastaei H | 2007 | IEEE/ASME Transactions on Mechatronics2007，12，2： | 1 |
| 15 | A novel Pd/MgAlOx catalyst for NOX storage-reduction显示文摘 | SILLETTI B A ADAMS R T SIGMON S M NIKOLOPOULOS A SPIVEY J J LAMB H H | 2006 | Catal Today2006，114，1： | 1 |
| 16 | Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate显示文摘 | de Oliveira A Adams S D Lee L H | | 0，，： | 1 |
| 17 | The Effects and Limitations of Automated Text Condensing on Reading Comprehension Performance显示文摘 | Morris A H Kaspcr G M Adams D A | 1992 | Information Systems Research1992，3，1： | 1 |
| 18 | Using chlorophyll fluorescence to assess the fraction of absorbed light allocated to thermal dissipation to of excess excitation 显示文摘 | DEMMIG A B ADAMS W W BARKER D H | 1996 | Physiol Plant1996，98，： | 1 |
| 19 | Effects of varying forage types on milk production responses to whole cotton- seed, tallow, and yeast 显示文摘 | Adams A L Harrjs B Van H | 1995 | Dairy Sci1995，78，： | 1 |
| 20 | Developing sustainability criteria for urban infrastructure systems 显示文摘 | Sahely H R Kennedy C A Adams B I | 2005 | Canadian Journal of Civil Engineering2005，32，1： | 1 |
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