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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | The environmental fate of phthalate esters: a literature review显示文摘 | Stales C A Peterson D R Parkerton T F Adams W J | 1997 | Chemosphere1997，35，4： | 1 |
| 4 | Hepatic resection for noncolorectal nonendocrine liver metastases analysis of 1 452 patients and development of a prognostic model显示文摘 | Adam R Chiche L Aloia T | 2006 | Ann Surg2006，244，4： | 1 |
| 5 | The environmental fate of phthalate esters: a literature review 显示文摘 | Stales C A Peterson D R Parkerton T F Adams W J | 1997 | Chemosphere1997，35，4： | 1 |
| 6 | Evaluation of hemispherical photography for determining plant area index and geometry of a forest stand显示文摘 | Chen J M Black T A Adams R S | 1991 | Agricultural and Forest Meteorology1991，56，1： | 1 |
| 7 | Characterization of puff-by-puff resolved cigarette mainstream smoke by single photon ionization-time-of-flight mass spectrometry and principal component analysis显示文摘 | Adam T Baker R R Zimmermann R | 2007 | J Agric Food Chem2007，55，6： | 1 |
| 8 | 显示文摘 | Adams J J Weiland T L Stanley J R | 2005 | Proc of SPIE2005，5647，： | 1 |
| 9 | A novel Pd/MgAlOx catalyst for NOX storage-reduction显示文摘 | SILLETTI B A ADAMS R T SIGMON S M NIKOLOPOULOS A SPIVEY J J LAMB H H | 2006 | Catal Today2006，114，1： | 1 |
| 10 | Strain- dependent disruption of blood-cerebrospinal fluid barrier by Streptoccocus suis in vitro显示文摘 | Tenenbaum T Adam R Eggelnpohler I | 2005 | FEMS Immunol Med Microbiol2005，44，1： | 1 |
| 11 | Evaluation of hemispherical photography for determining plant area index and geometry of a forest stand显示文摘 | Chen J M Black T A Adams R S | 1991 | Agricultural and Forest Meteorology1991，56，： | 1 |
| 12 | Investigation, by singlephoton ionisation ( SPI )-time-of-flight mass spectrometry (TOFMS), of the effect of different cigarette-lighting devices on the chemical composition of the first cigarette puff显示文摘 | Adam T Baker R R Zimmermann R | 2007 | Analytical and Bioanalytical Chemistry2007，387，2： | 1 |
| 13 | A close to universal negative ion source显示文摘 | Middleton R Adams C T | 1974 | Nuclear Instruments and Methods1974，118，2： | 1 |
| 14 | Comparative ef-fectiveness of warfarin and new oral anticoagulants for themanagement of atrial fibrillation and venous thromboem-bolism:a systematic review显示文摘 | Adam S S McDuffie J R Ortel T L | 2012 | Ann Intern Med2012，157，11： | 1 |
| 15 | Use of preoperative three-dimensional computed tomography to quantify glenoid bone loss in shoulder instability显示文摘 | Chuang T Y Adams C R Burkhart S S | | 0，，04： | 1 |
| 16 | Heart disease and stroke statistics-2010 update:A report from the American Heart Association显示文摘 | Lloyd-Jones D Adams R J Brown T M | | 0，，7： | 1 |
| 17 | Boron in holocene illites of the Dovey estuary, wales, and its rel-ationship to palaeosa- Hnity in cyclothems显示文摘 | Adams T D Haynes J R Walker C T | 2006 | Sedimentology2006，4，3： | 1 |
| 18 | Novel high capacitance materials:BaTiO3:La and CaCu3Ti4O12显示文摘 | West A R Adams T B Morrison F D | 2004 | J Euro Cera Soci2004，24，： | 1 |
| 19 | Streamlining the Drug Discovery Process by Integrating Miniaturization, High Throughput Screening, High Content Screening, and Autination on the Cell ChipTM System显示文摘 | Kapur R Giuliano K A Adams T Campana M | 1999 | Biomedical Microdevices1999，2，2： | 1 |
| 20 | Executive summary:heart disease and stroke statistics:2010 update:a report from the American Heart Association显示文摘 | LLOYD-JONES D ADAMS R J BROWN T M | 2010 | Circulation2010，121，： | 1 |
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