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| 1 | Experimental study on hydration damage mechanism of shale from the Longmaxi Formation in southern Sichuan Basin, China显示文摘As a serious problem in drilling operation,wellbore instability restricts efficient development of shale gas.The interaction between the drilling fluid and shale with hydration swelling property would have impact on the generation and propagation mechanism of cracks in shale formation,leading to wellbore instability.In order to investigate the influence of the hydration swelling on the crack propagation,mineral components and physicochemical properties of shale from the Lower Silurian Longmaxi Formation(LF)were investigated by using the XRD analysis,cation exchange capabilities(CEC)analysis,and SEM observation,and we researched the hydration mechanism of LF shale.Results show that quartz and clay mineral are dominated in mineral composition,and illite content averaged 67%in clay mineral.Meanwhile,CEC of the LF shale are 94.4 mmol/kg.The process of water intruding inside shale along microcracks was able to be observed through high power microscope,meanwhile,the hydration swelling stress would concentrate at the crack tip.The microcracks would propagate,bifurcate and connect with each other,with increase of water immersing time,and it would ultimately develop into macro-fracture.Moreover,the macrocracks extend and coalesce along the bedding,resulting in the rock failure into blocks.Hydration swelling is one of the major causes that lead to wellbore instability of the LF shale,and therefore improving sealing capacity and inhibition of drilling fluid system is an effective measure to stabilize a borehole. | Xiangjun Liu Wei Zeng Lixi Liang Jian Xiong | 2016 | Petroleum2016，2，1： | 14 |
| 2 | Optimal Dispatch for Battery Energy Storage Station in Distribution Network Considering Voltage Distribution Improvement and Peak Load Shifting显示文摘Distribution networks are commonly used to demonstrate low-voltage problems.A new method to improve voltage quality is using battery energy storage stations(BESSs),which has a four-quadrant regulating capacity.In this paper,an optimal dispatching model of a distributed BESS considering peak load shifting is proposed to improve the voltage distribution in a distribution network.The objective function is to minimize the power exchange cost between the distribution network and the transmission network and the penalty cost of the voltage deviation.In the process,various constraints are considered,including the node power balance,single/two-way power flow,peak load shifting,line capacity,voltage deviation,photovoltaic station operation,main transformer capacity,and power factor of the distribution network.The big M method is used to linearize the nonlinear variables in the objective function and constraints,and the model is transformed into a mixed-integer linear programming problem,which significantly improves the model accuracy.Simulations are performed using the modified IEEE 33-node system.A typical time period is selected to analyze the node voltage variation,and the results show that the maximum voltage deviation can be reduced from 14.06%to 4.54%.The maximum peak-valley difference of the system can be reduced from 8.83 to 4.23 MW,and the voltage qualification rate can be significantly improved.Moreover,the validity of the proposed model is verified through simulations. | Xiangjun Li Rui Ma Wei Gan Shijie Yan | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，1： | 8 |
| 3 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 4 | Machine learning-based estimates of aboveground biomass of subalpine forests using Landsat 8 OLI and Sentinel-2B images in the Jiuzhaigou National Nature Reserve,Eastern Tibet Plateau显示文摘Accurate estimates of forest aboveground biomass(AGB)are critical for supporting strategies of ecosystem conservation and climate change mitigation.The Jiuzhaigou National Nature Reserve,located in Eastern Tibet Plateau,has rich forest resources on steep slopes and is very sensitive to climate change but plays an important role in the regulation of regional carbon cycles.However,an estimation of AGB of subalpine forests in the Nature Reserve has not been carried out and whether a global biomass model is available has not been determined.To provide this information,Landsat 8 OLI and Sentinel-2B data were combined to estimate subalpine forest AGB using linear regression,and two machine learning approaches–random forest and extreme gradient boosting,with 54 inventory plots.Regardless of forest type,Observed AGB of the Reserve varied from 61.7 to 475.1 Mg hawith an average of 180.6 Mg ha.Results indicate that integrating the Landsat 8 OLI and Sentinel-2B imagery significantly improved model efficiency regardless of modelling approaches.The results highlight a potential way to improve the prediction of forest AGB in mountainous regions.Modelled AGB indicated a strong spatial variability.However,the modelled biomass varied greatly with global biomass products,indicating that global biomass products should be evaluated in regional AGB estimates and more field observations are required,particularly for areas with complex terrain to improve model accuracy. | Ke Luo Yufeng Wei Jie Du Liang Liu Xinrui Luo Yuehong Shi Xiangjun Pei Ningfei Lei Ci Song Jingji Li Xiaolu Tang | 2022 | Journal of Forestry Research2022，33，4： | 2 |
| 5 | Ant colony optimization based load balancing routing and wavelength assignment for optical satellite networks显示文摘An ant colony optimization(ACO) based load balancing routing and wavelength assignment(RWA) algorithm(ALRWA) was put forward for the sake of achieving a fairy load balancing over the entire optical satellite networks. A multi-objective optimization model is established considering the characteristic of global traffic distribution. This not only employs the traffic intensity to modify the light path cost, but also monitors the wavelength utilization of optical inter-satellite links(ISLs). Then an ACO algorithm is utilized to solve this model, leading to finding an optimal light path for every connection request. The optimal light path has the minimum light path cost under satisfying the constraints of wavelength utilization, transmission delay and wavelength-continuity. Simulation results show that ALRWA performs well in blocking probability and realizes efficient load balancing. Meanwhile, the average transmission delay can meet the basic requirement of real-time business transmission. | Wen Guoli Zhang Qi Wang Houtian Tian Qinghua Zhang Wei Xin Xiangjun | 2017 | The Journal of China Universities of Posts and Telecommunications2017，24，5： | 2 |
| 6 | Cloning and expression analysis of the nuclear factor erythroid 2-related factor 2(Nrf2)gene of grass carp(Ctenopharyngodon idellus)and the dietary effect of Eucommia ulmoides on gene expression显示文摘Nuclear factor erythroid 2-related factor 2(Nrf2)is an important transcription factor in the regulation of redox homeostasis,which plays a vital role in metabolism,the cell cycle,and cell protection.In this study,the complete cDNA sequence of Nrf2 gene of grass carp was obtained by rapid amplification of cDNA ends-polymerase chain reaction(RACE-PCR),and the characteristics of Nrf2 proteins predicted from gene sequencing were analyzed by bioinformatics methods.Tissue differential expression patterns were also detected by Real-time Fluorescence quantitative PCR(qRT-PCR).Then,Eucommia ulmoides(EU),a traditional Chinese medicine,was added into diet with an inclusion of 2%to feed grass carp for 3 months to investigate the effects on the expression of Nrf2 gene in tissues.The results showed that the full-length of Nrf2 gene of grass carp is 2760 bp,encoding 593 amino acids,and the predicted Nrf2 protein is a hydrophilic and non-secretory protein.Grass carp Nrf2 gene showed higher expression in kidney,gill,liver,spleen,and blood tissues than in other tissues.In the feeding trial,dietary EU significantly promoted the Nrf2 mRNA expression in kidney,gill,and liver tissues after three months feeding.The results suggest that Nrf2 plays an important role in the anti-oxidative capacity of grass carp and its expression is enhanced by dietary EU. | Junpeng Wang Jun Xie Zhihan Tu Jing Wei Wenqian Pan Jing Hu Yi Zhang Xiangjun Leng Xiaoqin Li | 2018 | Aquaculture and Fisheries2018，3，5： | 2 |
| 7 | Frontier research of ultra-high-speed ultra-large-capacity and ultra-long-haul optical transmission显示文摘极端高速度, ultra-large-capacity 和 ultra-long-haul (3U ) 是光通讯的永久追求。作为光通讯的一个新模式, 3U 传播能极大地支持下一代光因特网和宽带活动通讯网络开发和工艺的进步,因此,它变得国际高技术知识产权竞争的焦点扎根。这篇论文在 3U 传播研究引入科学问题,关键技术和重要成就。 | Daojun XUE Shaohua YU Qi YANG Nan CHI Lan RAO Xiangjun XIN Wei LI Songnian FU Sheng CUI Demin LIU Zhuo LI Aijun WEN Chongxiu YU Xinmei WANG | 2016 | Frontiers of Optoelectronics2016，9，2： | 2 |
| 8 | Optomechanical soft metamaterials显示文摘We present a new type of optomechanical soft metamaterials, which is different from conventional mechanical metamaterials, in that they are simple isotropic and homogenous materials without resorting to any complex nano/microstructures. This metamaterial is unique in the sense that its responses to uniaxial forcing can be tailored by programmed laser inputs to manifest different nonlinear constitutive behaviors, such as monotonic, S-shape, plateau, and non-monotonic snapping performance. To demonstrate the novel metamaterial, a thin sheet of soft material impinged by two counterpropagating lasers along its thickness direction and stretched by an in-plane tensile mechanical force is considered. A theoretical model is formulated to characterize the resulting optomechanical behavior of the thin sheet by combining the nonlinear elasticity theory of soft materials and the optical radiation stress theory. The optical radiation stresses predicted by the proposed model are validated by simulations based on the method of finite elements. Programmed optomechanical behaviors are subsequently explored using the validated model under different initial sheet thicknesses and different optical inputs, and the first-and second-order tangential stiffness of the metamaterial are used to plot the phase diagram of its nonlinear constitutive behaviors.The proposed optomechanical soft metamaterial shows great potential in biological medicine, microfluidic manipulation,and other fields. | Xiangjun Peng Wei He Yifan Liu Fengxian Xin Tian Jian Lu | 2017 | Acta Mechanica Sinica2017，33，3： | 1 |
| 9 | A low-energy ion spectrometer with half-space entrance for three-axis stabilized spacecraft显示文摘A low-energy ion spectrometer(LEIS) for use aboard three-axis stabilized spacecraft has been developed to measure ion energy per charge distribution in three-dimensional space with good energy-, angular-and temporal-resolutions. For the standard top-hat electrostatic analyzer used widely in space plasma detection, three-axis stabilized spacecraft makes it difficult to obtain complete coverage of all possible ion arrival directions. We have designed angular scanning deflectors supplementing to a cylindrically symmetric top-hat electrostatic analyzer to provide a half-space field of view as 360°×90°(–45°–+45°), and fabricated the LEIS flight model for detecting magnetospheric ions in geosynchronous orbit. The performance of this payload has been evaluated in detail by a series of simulation and environmental tests, and the payload has also been calibrated through laboratory experiments using a low-energy ion source. The results show that capabilities of the LEIS payload are in accordance with the requirements of a magnetospheric mission. | HU RenXiang SHAN Xu YUAN GuangYuan WANG ShuWen ZHANG WeiHang QI Wei CAO Zhe LI YiRen CHEN ManMing YANG XiaoPing WANG Bo SHAO SiPei LI Feng ZHONG XiaoQing FAN Dan HAO XinJun FENG ChangQing SU ZhenPeng SHEN ChengLong LI Xin DAI GuYue QIU BingLin PAN ZongHao LIU Kai XU ChunKai LIU ShuBin AN Qi ZHANG TieLong WANG YuMing CHEN XiangJun | 2019 | Science China(Technological Sciences)2019，62，6： | 1 |
| 10 | Spectrophotometric Determination of Palladium by the Colouration with 2-( 2- Quinolylazo)-5-diethylaminobenzoic Acid 显示文摘 | Huang Zhangjie Wei Qunyan Yang Xiangjun | 2005 | Bull Korean Chem Soc2005，26，10： | 1 |
| 11 | Effects of Copper-based Nutritional Foliar Fertilizers on Photosynthetic Characteristics,Yield and Disease Control Efficiency of Cotton显示文摘[Objectives] The effects of copper-based nutrient foliar fertilizer on photosynthetic characteristics,yield,accumulation and distribution of trace elements in various organs,disease prevention effect and soil enzyme activity were studied,so as to provide a theoretical basis for the application of foliar fertilizers in cotton production. [Methods]Through two years of field experiments,six treatments were set in total,namely spraying water( CK),traditional Bordeaux mixture( BDM),Kocide 2000( KCD),copper-based nutrient foliar fertilizer( CF),iron-copper-based nutrient foliar fertilizer( CFFe),and zinc-boron-copper-based nutrient foliar fertilizer( CFZnB). Randomized block arrangement was adopted. Chlorophyll content in leaves was measured at each growth stage of the cotton. Photosynthetic characteristics of leaves were measured at the peak bolling stage. Plants were sampled at initial boll opening stage. The whole plant was divided into root,stem,leaf and cotton boll parts,in which the total copper,total zinc,total iron contents and accumulations were determined. Soil samples were collected from each plot,followed by the determination of soil enzyme activity. Disease index was investigated at bud,flowering and boll-forming and boll opening stage. [Results]( 1) Spraying CFFe,CFZnB,CF and KCD could significantly improve chlorophyll content of cotton leaves,and the CFFe treatment had the highest increase up to13. 30%,followed by the CFZnB treatment,which was 11. 40% higher than the CK; and photosynthetic rate,stomata conductance and transpiration rate could be improved significantly,and the CFFe treatment showed the highest photosynthetic rate,which increased by 26. 35% compared with the CK,followed by the CFZnB treatment,which increased by 17. 96% compared with CK; and intercellular CO2 concentration was significantly reduced.( 2) Spraying BDM,KCD,CF,CFFe and CFZnB can significantly increase total copper content and accumulation in various cotton organs( except the total copper content in the stem part of the CFZnB treatment; the CFZnB and CFFe treatments can significantly increase total zinc content and accumulation in various cotton organs; and spraying CFFe,CFZnB and CF can significantly increase total iron content and accumulation in various cotton organs( except the total iron content in the stem part of the CF treatment).( 3)Spraying CFFe,CFZnB,CF,KCD and BDM greatly reduced the disease index at flowering and boll-forming and boll opening stages.( 4) The CFZnB and CFFe treatments had the highest soil urease activity,which was 7. 14% higher than that of the CK,but the difference from the CK was not significant; the catalase activity of each treatment was significantly higher than that of the BDM treatment; and the sucrase activity of each treatment was significantly higher than that of the CK.( 5) Spraying CFFe,CFZnB,CF and KCD significantly improved lint yield of cotton,and the CFZnB treatment showed the highest yield increase up to 12. 34%,followed by the CFFe treatment,with an increase in the range of 8. 77%-10. 20%. [Conclusions]Copper-based nutrient foliar fertilizers have dual functions of disease control and prevention and plant nutrition and health care,and not only can significantly increase cotton yield,but also has certain disease prevention effect.It is recommended to use copper-based nutrient foliar fertilizers. | Qiang MA Wei WANG Hongjie LI Xiangjun WANG Zishuang LI Tongkai ZHAO Xianhe ZHENG Yanxiao TAN | 2019 | Agricultural Biotechnology2019，8，1： | 1 |
| 12 | Modified level set method with Canny operator for image noise removal显示文摘 | Pengcheng Wen Xiangjun Wang Hong Wei | 2010 | Chin Opt Lett2010，8，12： | 1 |
| 13 | System of Multigrid Nonlinear Least-squares Four-dimensional Variational Data Assimilation for Numerical Weather Prediction(SNAP):System Formulation and Preliminary Evaluation显示文摘A new forecasting system-the System of Multigrid Nonlinear Least-squares Four-dimensional Variational(NLS-4DVar)Data Assimilation for Numerical Weather Prediction(SNAP)-was established by building upon the multigrid NLS-4DVar data assimilation scheme,the operational Gridpoint Statistical Interpolation(GSI)−based data-processing and observation operators,and the widely used Weather Research and Forecasting numerical model.Drawing upon lessons learned from the superiority of the operational GSI analysis system,for its various observation operators and the ability to assimilate multiple-source observations,SNAP adopts GSI-based data-processing and observation operator modules to compute the observation innovations.The multigrid NLS-4DVar assimilation framework is used for the analysis,which can adequately correct errors from large to small scales and accelerate iteration solutions.The analysis variables are model state variables,rather than the control variables adopted in the conventional 4DVar system.Currently,we have achieved the assimilation of conventional observations,and we will continue to improve the assimilation of radar and satellite observations in the future.SNAP was evaluated by case evaluation experiments and one-week cycling assimilation experiments.In the case evaluation experiments,two six-hour time windows were established for assimilation experiments and precipitation forecasts were verified against hourly precipitation observations from more than 2400 national observation sites.This showed that SNAP can absorb observations and improve the initial field,thereby improving the precipitation forecast.In the one-week cycling assimilation experiments,six-hourly assimilation cycles were run in one week.SNAP produced slightly lower forecast RMSEs than the GSI 4DEnVar(Four-dimensional Ensemble Variational)as a whole and the threat scores of precipitation forecasts initialized from the analysis of SNAP were higher than those obtained from the analysis of GSI 4DEnVar. | Hongqin ZHANG Xiangjun TIAN Wei CHENG Lipeng JIANG | 2020 | Advances in Atmospheric Sciences2020，37，11： | 1 |
| 14 | Purification of four strains of endophytic fungi from Astragalus and their optimized liquid fermentations显示文摘This study was designed to isolate endophytic fungi from A. mongholicus(growing in northeast China) to determine whether they can produce bioactive metabolites. Four strains of endophytic fungi(strains 16, 17, 23 and 75) were successfully isolated from A. mongholicus using the surface disinfection method. According to ITS-rDNA sequences analysis, strains 16 and 75 were identified as Fusarium oxysporum, and strains 17 and 23 were identified as Bionectria ochroleuca. We applied the Box-Behnken design(BBD) to optimize the liquid fermentation conditions and obtain the maximum cell dry weight(CDW) yield. Optimal parameters were obtained under the following experimental conditions: temperature of 28°C, potato dextrose agar(PDA) liquid medium of 80 mL and rotation speed of 150 rpm. The four isolated endophytic fungi did not produce astragalosides I–IV, flavonoids or polysaccharides. Isolation of additional species of endophytic fungi from A. mongholicus and determination of their capacity to produce biologically active substances are subjects in need of further research. | Wei Ma Xiubo Liu Jiao Jiao Leiming Zhang Weichao Ren Ling Ma Xiangjun Kong Ning Zhang Xiwu Zhang | 2014 | Journal of Forestry Research2014，25，3： | 1 |
| 15 | PSO-LSSVM-based Online SOC Estimation for Simulation Substation Battery显示文摘As the emergency power supply for a simulation substation,lead-acid batteries have a work pattern featuring noncontinuous operation,which leads to capacity regeneration.However,the accurate estimation of battery state of charge(SOC),a measurement of the amount of energy available in a battery,remains a hard nut to crack because of the non-stationarity and randomness of battery capacity change.This paper has proposed a comprehensive method for lead-acid battery SOC estimation,which may aid in maintaining a reasonable charging schedule in a simulation substation and improving battery’s durability.Based on the battery work pattern,an improved Ampere-hour method is used to calculate the SOC during constant current and constant voltage(CC/CV)charging and discharging.In addition,the combined Particle Swarm Optimization(PSO)and Least Squares Support Vector Machine(LSSVM)model is used to estimate the SOC during non-CC discharging.Experimental results show that this method is workable in online SOC estimation of working batteries in a simulation substaion,with the maximum relative error standing at only 2.1%during the non-training period,indicating a high precision and wide applicability. | Qiang Zhang Xianguang Zha Jun Wu Liang Zhang Wei Dai Gang Ren Shiqian Li Ning Ji Xiangjun Zhu Fengwei Tian | 2022 | Structural Durability & Health Monitoring2022，16，1： | 0 |
| 16 | A binary logistic regression model for discriminating real protein-protein interface显示文摘The selection and study of descriptive variables of protein-protein complex interface is a major question that many biologists come across when the research of protein-protein recognition is concerned. Several variables have been proposed to understand the structural or energetic features of complex interfaces. Here a systematic study of some of these 'traditional' variables, as well as a few new ones, is introduced. With the values of these variables extracted from 42 PDB samples with real or false complex interfaces, a binary logistic regression analysis is performed, which results in an effective empirical model for the evaluation of binding probabilities of protein-protein interfaces. The model is validated with 12 samples, and satisfactory results are obtained for both the training and validation sets. Meanwhile, three potential dimeric interfaces of staphylokinase have been investigated and one with the best suitability to our model is proposed. | LIN Wei, SUN Ping and LIU Xiangjun(Bioinformatics Laboratory, School of Medicine, Tsinghua University, Beijing 100084, China) | 2003 | Progress in Natural Science:Materials International2003，13，6： | 0 |
| 17 | The source of heavy metals and its indication to the sediment transfer in the Hangzhou Bay显示文摘-Suspended matters are important carriers of heavy metals in the hydrocycle.In this paper, the field investigation , lab. experiment and 'corresponding analysis' were made to study sources of the heavy metals and the transfer of suspended matters from the Hangzhou Bay.This conclusion shows that the contents of heavy metals in this area are the natural background values ; the distributions of heavy metals are controlled by the plume front. | Liao Xiangui, Zhang Xiangjun Ying Shili, Wei Linying and Zhu Linfan Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012, China | 1993 | Acta Oceanologica Sinica1993，12，1： | 0 |
| 18 | Co-NC as adsorbent and matrix providing the ability of MALDI MS to analyze volatile compounds显示文摘Traditional matrix does not allow matrix-assisted laser desorption/ionization mass spectrometry(MALDI MS) to analyze volatile compounds,because volatile analytes may vaporize during the sample preparation process or in the high vacuum circumstance of ion source.Herein,we reported a Co and N doped porous carbon material(Co-NC) which were synthesized by pyrolysis of a Schiff base coordination compound.Co-NC could simultaneously act as adsorbent of volatile compounds and as matrix of MALDI MS,to provide the capability of MALDI MS to analyze volatile compounds.As adsorbent,Co-NC could stro ngly adsorb and enrich the volatile compounds in perfume and herbs,and hold them even in the high vacuum circumstance.On the other hand,Co-NC could absorb the energy of the laser,and then transfer the energy to the analyte for desorption and ionization of analyte in both negative and positive ionization modes.Additionally,the background interferences were avoided in the low-mass region(<500 Da) when using Co-NC as matrix,overcoming the challenges of MALDI MS analysis of small molecule compounds.In summary,Co-NC as matrix tremendously extended the application of MALDI MS. | Shumu Li Jian’an Liu Jiping Sun Zhenpeng Wang Kai Wang Lei Guo Shuliang Yang Jinchao Wei Xiangjun Zheng Zhenwen Zhao | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
| 19 | Efficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3D culture显示文摘Although widely applied in treating hematopoietic malignancies,transplantation of hematopoietic stem/progenitor cells(HSPCs)is impeded by HSPC shortage.Whether circulating HSPCs(cHSPCs)in steady-state blood could be used as an alternative source remains largely elusive.Here we develop a three-dimensional culture system(3DCS)including arginine,glycine,aspartate,and a series of factors.Fourteen-day culture of peripheral blood mononuclear cells(PBMNCs)in 3DCS led to 125-and 70-fold increase of the frequency and number of CD34+cells.Further,3DCS-expanded cHSPCs exhibited the similar reconstitution rate com-pared to CD34+HSPCs in bone marrow.Mechanistically,3DCS fabricated an immunomodulatory niche,secreting cytokines as TNF to support cHSPC survival and proliferation.Finally,3DCS could also promote the expansion of cHSPCs in patients who failed in HSPC mobilization.Our 3DCS successfully expands rare cHSPCs,providing an alternative source for the HSPC therapy,particularly for the patients/donors who have failed in HSPC mobilization. | Yulin Xu Xiangjun Zeng Mingming Zhang Binsheng Wang Xin Guo Wei Shan Shuyang Cai Qian Luo Honghu Li Xia Li Xue Li Hao Zhang Limengmeng Wang Yu Lin Lizhen Liu Yanwei Li Meng Zhang Xiaohong Yu Pengxu Qian He Huang | 2022 | Protein & Cell2022，13，11： | 0 |
| 20 | Probability Distribution of Edge in Adjacent Matrix of Aviation Network of China and Algorithm of Searching Non-overlap Community Structure Based on Complex Network显示文摘In order to discover the probability distribution feature of edge in aviation network adjacent matrix of China and on the basis of this feature to establish an algorithm of searching non-overlap community structure in network to reveal the inner principle of complex network with the feature of small world in aspect of adjacent matrix and community structure,aviation network adjacent matrix of China was transformed according to the node rank and the matrix was arranged on the basis of ascending node rank with the center point as original point.Adjacent probability from the original point to extension around in approximate area was calculated.Through fitting probability distribution curve,power function of probability distribution of edge in adjacent matrix arranged by ascending node rank was found.According to the feature of adjacent probability distribution,deleting step by step with node rank ascending algorithm was set up to search non-overlap community structure in network and the flow chart of algorithm was given.A non-overlap community structure with 10 different scale communities in aviation network of China was found by the computer program written on the basis of this algorithm. | Cheng Xiangjun Yang Fang Wei Chong | 2021 | Journal of Traffic and Transportation Engineering2021，9，1： | 0 |
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