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| 1 | Periodicity of Holocene climatic variations in the Huguangyan Maar Lake显示文摘There exist five primary periods of 2 930, 1 140, 490, 250 and 220 a in the Holocene climatic variations in the Huguangyan Maar Lake, according to the energy-spectrum and filter analyses of high-resolution time sequences (10-15 a) of the sediment dry density. The peak values of the three temperature-decreasing periods with the 2 930 a cycle occur at about 7 300, 4 250 and 1 200 Cal. aBP. There are 7-8 temperature-decreasing periods with the 1 140 a cycle, and the climate fluctuation range is largest in the early Holocene, and reduces gradually in the middle and late Holocene. The millennial-scale climatic change in the Holocene may adjust the global water cycle and the thermohaline circulation intensity through the harmonic tones of the earth’s precession cycle, which in turn influences the global climate change. | LIU Jiaqi LÜ Houyuan JNegendank JMingram LUO Xiangjun WANG Wenyuan CHU Guoqiang | 2000 | Chinese Science Bulletin2000，45，18： | 33 |
| 2 | Experimental study on hydration damage mechanism of shale from the Longmaxi Formation in southern Sichuan Basin, China显示文摘As a serious problem in drilling operation,wellbore instability restricts efficient development of shale gas.The interaction between the drilling fluid and shale with hydration swelling property would have impact on the generation and propagation mechanism of cracks in shale formation,leading to wellbore instability.In order to investigate the influence of the hydration swelling on the crack propagation,mineral components and physicochemical properties of shale from the Lower Silurian Longmaxi Formation(LF)were investigated by using the XRD analysis,cation exchange capabilities(CEC)analysis,and SEM observation,and we researched the hydration mechanism of LF shale.Results show that quartz and clay mineral are dominated in mineral composition,and illite content averaged 67%in clay mineral.Meanwhile,CEC of the LF shale are 94.4 mmol/kg.The process of water intruding inside shale along microcracks was able to be observed through high power microscope,meanwhile,the hydration swelling stress would concentrate at the crack tip.The microcracks would propagate,bifurcate and connect with each other,with increase of water immersing time,and it would ultimately develop into macro-fracture.Moreover,the macrocracks extend and coalesce along the bedding,resulting in the rock failure into blocks.Hydration swelling is one of the major causes that lead to wellbore instability of the LF shale,and therefore improving sealing capacity and inhibition of drilling fluid system is an effective measure to stabilize a borehole. | Xiangjun Liu Wei Zeng Lixi Liang Jian Xiong | 2016 | Petroleum2016，2，1： | 14 |
| 3 | Cloning and Identification of Novel MicroRNAs from Rat Hippocampus显示文摘MicroRNAs (miRNAs ) 是小规章的分子 post-transcriptionallysuppressingmRNA 活动。在各种各样的有机体的许多 miRNAs 被克隆但是许多未知 miRNAs 遗体到我们描述从老鼠马头鱼尾的怪兽克隆六新 miRNAs 的 beidentified.Here。在他们之中,四没在老鼠米尔底被发现,但是与他们的人或老鼠相当或相同的事物相同,因此,他们被指定为 rno-miR-92b , rno-miR-146b , rno-let-7g ,和 rno-miR-551b.The 另外的二从 rno-miR-330 和 rno-miR-384 的已知的 miRNA 先锋的另外的手臂被导出,并且没在所有有机体的米尔底被发现。他们被指定为 rno-miR-330 * 并且这些 miRNAs 的 rno-miR-384 *.The 表示被跟踪 RNA 和教材扩展证实即时 reversetranscription 聚合酶链反应。这六 miRNAs 被表示在在马头鱼尾的怪兽显著地高级比在另外的纸巾包括服的外皮,心,肝,肺 andkidney.miR-384 * 是比在老鼠马头鱼尾的怪兽的 miR-384 更丰富的 10 次,但是小差别在 miR-330 之间被发现 * 并且在一样的织物的 miR-330 表示。 | Xiangjun HE Qi ZHANG Yujing LIU Xiuying PAN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 11 |
| 4 | Al-Si-P master alloy and its modification and refinement performance on Al-Si alloys显示文摘An Al-Si-P master alloy has been developed by an in-situ reaction and the electron probe microanalyzer (EPMA) results show that there are many pre-formed AlP particles contained in the master alloy. Silicon introduced into the system plays an important role in remarkably improving the distribution and content of AlP particles due to their similar crystal structure and lattice parameters. ZL109 alloys have shown fast modification response to the addition of 0.5% Al-15Si-3.5P master alloy at 720°C, with a mass of primary Si precipitating in size of about 15 μm. Also, coarse primary Si grains in Al-30Si alloy can be refined dramatically from 150 μm to 37 μm after the addition of 2.0% Al-15Si-3.5P master alloy at 850°C. The P recovery of the Al-15Si-3.5P master alloy is much higher than that of a Cu-8.5P master alloy due to the pre-formed AlP particles. | ZUO Min LIU Xiangfa DAI Hongshang LIU Xiangjun | 2009 | Rare Metals2009，28，4： | 11 |
| 5 | Sini powder ameliorates the inflammatory response in rats with stress-induced non-alcoholic fatty liver disease by inhibiting the nuclear factor kappa-B/pyrin domain-containing protein 3 pathway显示文摘OBJECTIVE: To evaluate the effectiveness of Sini powder for the treatment of non-alcoholic fatty liver disease(NAFLD) in rats and the molecular mechanisms involved.METHODS: A rat model of stress-induced NAFLD was established by a combination of long-term tethering and feeding of a high-fat, high-calorie diet. These rats were then intragastrically administered with either simvastatin, Sini powder, or vehicle for 1 week. The body mass and field test scores for each group were recorded weekly. Serum aspartate aminotransferase and alanine aminotransferase activities, and triglyceride, total cholesterol,and free fatty acid concentrations were measured.Liver tissue histopathology was examined on hematoxylin and eosin-stained paraffin sections and oil red O-stained frozen sections. The hepatic m RNA expression of nuclear factor kappa-B(NF-κB),NOD-, LRR-, and pyrin domain-containing protein 3(NLRP3), apoptosis-associated speck-like protein containing CARD(ASC), and caspase-1 were measured by reverse transcription-polymerase chain reaction(RT-PCR). The hepatic protein concentrations of NF-κB and NLRP3, ASC, caspase-1, interleukin-1β(IL-1β), interleukin-6(IL-6), and the serum concentrations of IL-1β and IL-6 were measured by enzyme-linked immunosorbent assay.RESULTS: Compared with the Blank group, rats in the Compound model group showed significant pathologic manifestations of NAFLD, and the expression of NF-κB, NLRP3, ASC, caspase-1, IL-1βand IL-6 were significantly higher(all P < 0.01). Both simvastatin and Sini powder significantly ameliorated the NAFLD pathology and the abnormal expression of NF-κB, NLRP3, ASC, caspase-1, IL-1β, and IL-6(all P < 0.01).CONCLUSION: Sini powder inhibits the inflamma-tory response in rats with NAFLD, which is mediated by NF-κB/NLRP3, IL-1β, and IL-6, reduces the effects of psychological stress, and improves lipid metabolism. Therefore, Sini powder may be effective for the treatment of stress-related NAFLD through multiple mechanisms. | Mu Jie Cheng Fafeng Wang Qingguo Wang Xueqian Zhu Wenxiang Ma Chongyang Yin Xiangjun Ren Beida Lian Yajun Du Xin Zhang Haixia Liu Shuling Zhang Shuang | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 6 | The Chinese carbon cycle data-assimilation system(Tan-Tracker)显示文摘In this study,the Chinese carbon cyle dataassimilation system Tan-Tracker is developed based on the atmospheric chemical transport model(GEOS-Chem)platform.Tan-Tracker is a dual-pass data-assimilation system in which both CO2concentrations and CO2fluxes are simultaneously assimilated from atmospheric observations.It has several advantages,including its advanced data-assimilation method,its highly efficient computing performance,and its simultaneous assimilation of CO2concentrations and CO2fluxes.Preliminary observing system simulation experiments demonstrate its robust performance with high assimilation precision,making full use of observations.The Tan-Tracker system can only assimilate in situ observations for the moment.In the future,we hope to extend Tan-Tracker with functions for using satellite measurements,which will form the quasioperational Chinese carbon cycle data-assimilation system. | Xiangjun Tian Zhenghui Xie Zhaonan Cai Yi Liu Yu Fu Huifang Zhang | 2014 | Chinese Science Bulletin2014，59，14： | 7 |
| 7 | Experimental and DFT study on cerium inclusions in clean steels显示文摘To provide insights into deforming Ce-O-S-Al inclusions in steels and improving the mechanical properties,the evolution process of such harmful inclusions in clean steels was investigated by thermodynamic calculation,metallographic examination and first-principles calculation in this paper.For the tested IF steel,the thermodynamic analysis results are consistent with the calculated formation enthalpy.After Ce addition,the inclusions are transformed from Al_(2)O_(3)and TiN-Al_(2)TiO_(5)-Al_(2)O_(3)to Ce2O_(3),Ce_(2)O_(2)S,CeAlO_(3),TiN-Al_(2)TiO_(5)-Ce_(2)O_(3)and TiN-Al_(2)TiO_(5)-Ce_(2)O_(2)S composite inclusions,which can be confirmed by metallographic examination.The elastic constants were calculated,and the bulk modulus,Young's modulus,shear modulus and Poisson's ratio were evaluated by the Voigt-Reuss-Hill(VRH)approximation.All inclusions except Ce_(2)O_(3)show apparent brittleness.TiN,Al_(2)O_(3),Al_(2)TiO_(5)and CeAlO_(3)present much higher hardness than iron matrix,while the hardness of Ce2O_(3)or Ce_(2)O_(2)S is close to that of iron matrix.The thermal expansion coefficients of Ce_(2)O_(3)and CeAlO_(3)are close to that of iron matrix,whereas,Ce_(2)O_(2)S inclusion has largely different thermal expansion coefficient from iron matrix and may deteriorate the steel performance at higher temperatures.The relatively small differences between Ce inclusions and iron matrix in terms of hardness,toughness,brittleness,and thermal expansion coefficient can explain the improvement of the mechanical properties of the tested steel. | Xiangjun Liu Jichun Yang Fang Zhang Xiaoyang Fu Hongwei Li Changqiao Yang | 2021 | Journal of Rare Earths2021，39，4： | 6 |
| 8 | Aquatic Species Dominate Organic Matter in Qinghai Lake during the Holocene:Evidence from Eolian Deposits around the Lake显示文摘Total organic carbon(TOC) in lake sediments and its stable carbon isotope(δ^(13)C_(org)) are widely applied to investigate paleoenvironmental changes even though their implications are complicated and multi-explanatory. Organic geochemistry studies of lake sediments from Qinghai Lake have been investigated, but some interpretations are controversial. In this study, TOC of one Holocene eolian section and δ^(13)C_(org) of three eolian sections were studied around Qinghai Lake. Results indicate that the TOC content in eolian deposits was low during the Early Holocene, and gradually increased to high values during the Middle and Late Holocene. The variation in TOC content of eolian deposits is different from that in the lacustrine sequence from Qinghai Lake during the Holocene. The δ^(13)C_(org) values in the eolian sections were relatively stable, with oscillation amplitudes of ~4‰(ranging from-25.8‰ to-22.1‰), in contrast to ~10‰ variation s in δ^(13)C_(org) values(varying from-30‰ to-20‰) in lacustrine sediments. Through comparison of TOC and δ^(13)C_(org) values between eolian deposits and lacustrine sediments, we can confirm indications that the organic matter in Qinghai Lake sediments during the Holocene was primarily a contribution of the aquatic species in the lake. This is significant for understanding the origin of organic matter in lake sediments on the northeastern Qinghai-Tibetan Plateau and for paleoenvironmental inferences using such proxies. | Fangming Zeng Xiangjun Liu Xiangzhong Li Chongyi E | 2017 | Journal of Earth Science2017，28，3： | 6 |
| 9 | The influence of water-based drilling fluid on mechanical property of shale and the wellbore stability显示文摘Because of high cost and pollution of oil-based drilling fluid,the water-based drilling fluid is increasingly used now.However,bedding planes and micro-cracks are rich in shale formation.When water-based drilling fluid contacts formation rock,it causes the propagation of crack and invasion of drilling fluid,which decrease shale strength and cause wellbore instability.In this paper,we analyzed influence of water-based drilling fluid on shale strength and failure mode by mechanics experiment.Based on those experimental results,considering the effect of bedding plane and drilling time,we established modeling of wellbore stability for shale formation.The result from this model indicates that in certain azimuth of horizontal well,collapsing pressure increases dramatically due to shale failure along with bedding plane.In drilling operation,those azimuths are supposed to be avoided.This model is applicable for predication of collapsing pressure in shale formation and offers reference for choosing suitable mud weight. | Shu He Lixi Liang Yinjin Zeng Yi Ding Yongxue Lin Xiangjun Liu | 2016 | Petroleum2016，2，1： | 6 |
| 10 | Experimental research on reasonable lubricant quantity for transmission gears used in high-speed train显示文摘The transmission efficiency, bulk temperature, integrate temperature, and scuffing load of test gears were investigated by a modified FZG rig. These values were measured in four different oil immersion depths with one kind of potential oil that may be used to replace the current synthetic oil in order to find the reasonable lubricant quantity that meets not only the need of transmission performance but also the need of scuffing resistance for high-speed train gears. For the purpose of evaluating the efficiency of the test gears, there were two sensors added to measure the output torque of testing gears and the compensation torque of motor. The minimum lubrication film thickness at the pitch point was gained through an EHL model. The ratio of the film thickness was used to identify the friction status when scuffing occurred at different oil levels. The results demonstrated that no matter what kind of the immersion depth was, the minimum film thickness on the pitch point was about 0.1 m and the ratio of film thickness was about 1.5 when scuffing occurred. According to the relationship of contact pressure and ratio of film thickness at the pitch point, it was found that the immersion depth of pinion should not be less than one module of the gear when the contact pressure of high-speed train gear at pitch point was about 580 MPa, which was the actual pressure at start-up stage. | LIU Ying ZHANG XiangJun ZHANG YiMing MENG YongGang | 2012 | Science China(Technological Sciences)2012，55，12： | 4 |
| 11 | Petrophysical evaluation and its application to AVO based on conventional and CMR-MDT logs显示文摘常规 loggings 在岩石物理为 AVO (Amplitude-Versus-Offset ) 分析提供必要数据,它能造连接 petrophysics 和地震数据的一座桥。不管多么一些复杂液体系统例如到形成的严肃的液体侵略,低抵抗力反应或复杂的水咸度等等在水库存在,常规日志可以没能提供优秀数据,导致为有弹性的性质计算了错误那么更坏 AVO 结果不能匹配地震数据。在中国在 Bohai 海湾的第三级的水库克服如此的困难,我们利用了常规木头和 CMR-MDT 工具(可结合的磁性的回声和模块化的形成动力学测试者) 执行形成评估和水库描述。我们的研究求婚,它允许 petrophysicists 获得水库参数(例如孔,渗透,水浸透,界限液体和毛孔迫使等等),然后基于实验室的大小与核心分析结合执行一个进一步的岩石物理的这些结果学习并且在地震领域的 AVO 分析。 | Yan Jun Liu Tangyan Liu Xiangjun | 2007 | Applied Geophysics2007，4，3： | 4 |
| 12 | Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry显示文摘Because many therapeutic agents are contaminated by epimeric impurities or form epimers as a result of metabolism, analytical tools capable of determining epimers are increasingly in demand. This article is a proof-of-principle report of a novel DMS–MS/MS method to separate and simultaneously quantify epimers, taking PGF2α and its 8-epimer, 8-iso-PGF2α, as an example. Good accuracy and precision were achieved in the range of 10–500 ng/m L with a run time of only 1.5 min. Isopropanol as organic modifier facilitated a good combination of sensitivity and separation. The method is the first example of the quantitation of epimers without chromatographic separation. | Chunsu Liang Hui Sun Xiangjun Meng Lei Yina J.Paul Fawcett Huaidong Yu Ting Liu Jingkai Gu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 3 |
| 13 | Controllable and switchable capillary adhesion mechanism for bio-adhesive pads: Effect of micro patterns显示文摘Some insects and animals, such as bugs, grasshoppers and tree frogs, realize their efficient adhesion mechanism to glass surface, wall and ceiling by injecting a wetting liquid thin film into the pad-substrate contact area. Their ability to control adhesion (attaching or detaching from a surface) is in many cases connected to the contact geometry and surface patterns of their attachment pads. This paper focuses on the dependence of the capillary adhesion (wet adhesion) on the micro patterns of the bio-adhesive pads. The objective is to reveal the possible mechanism for a bio-adhesive pad to control capillary force through adjusting its micro-scale surface pattern and topography. A capillary adhesion force model is built up taking account of the combined role of micro-dimple geometry as well as the wetting behavior of the confined liquid thin film. Calculated results of the apparent contact angle on the regularly micro-dimpled surfaces are compared with and in good agreement with the experimental measurements. Simulation of the capillary adhesion force reveals that it is controllable in a large mag- nitude by adjusting a dimensionless surface pattern parameter k defined as a/(a+b), where a is the dia- meter of micro dimple, and (a+b) is the side length of one pattern cell. When adjusting the parameter k more than 0.75, the capillary adhesion force could be switchable from attractive to repulsive. This effect of micro patterns on the interfacial capillary force is proved to be dominant when the pad-substrate clearance decreases to the nano/micrometer scale. These results indicate that a controllable and switchable capillary adhesive mechanism might be utilized by a living insect or animal to realize its stable adhesion and quick releasing movement through adjusting the micro-pattern topography of its bio-adhesive pad. | ZHANG XiangJun LIU Yuan LIU YongHe AHMED S.I.-U. | 2009 | Chinese Science Bulletin2009，54，10： | 3 |
| 14 | Graphene-based thermal modulators显示文摘为能够控制热流动的材料和设备的探索继续在热控制设备上造成研究。在这封信,用分子的动力学模拟,我们证明部分夹钳的单个层的 graphene 能用作一个热调节的人。在在在声子接口散布的 unclamped 和夹钳的 graphene 节结果之间的声子分散的失配,和接口散布的力量由经由使用外部压力控制 clamp-graphene 距离是悦耳的。由于到外部物理相互作用的 graphene 和它的高度敏感的声子分散的极端薄的结构,调整 efficiencywhich 被定义为比率对在 50 GPa 的一个中等压力象 150% 一样高的最低的热 fluxcan 活动范围最高。这调整效率能被沿着热流动的方向在系列安排很多 clamps 进一步提高。 | Xiangjun Liu Gang Zhang Yong-Wei Zhang | 2015 | Nano Research2015，8，8： | 3 |
| 15 | Review of Coded Modulation Free Space Optical Communication System显示文摘This paper presents a constructive discussion and inclusive review on advancements in the coded modulation free-space optical(FSO) communication system and corresponding techniques. These techniques mainly include channel model,forward error correction(FEC) and modulation schemes. Firstly,a complete view of FSO system is presented which contains the description,the current research situation along with the advantages over the traditional radio frequency(RF) wireless communication and fiber optical communications. Then,the channel model,FEC,modulation schemes and complete system of coded modulation FSO are analyzed successively. At last,the review work of coded modulation FSO system is summarized and further improvements are prospected. | WANG Kaimin LIU Bo ZHANG Lijia ZHANG Qi TIAN Qinghua XIN Xiangjun | 2015 | China Communications2015，12，11： | 3 |
| 16 | Research on fabric characteristics and borehole instability mechanisms of fractured igneous rocks显示文摘There are favorable exploration prospects in igneous rock reservoirs.However,problems of borehole instability occur frequently during drilling igneous formations,which is a serious impediment to oil and gas exploration and production.The lack of systematic understanding of the inherent instability mechanisms is an important problem.A series of experiments were conducted on several igneous rock samples taken from the sloughing formations in the Tuha area in an attempt to reveal the inherent mechanisms of wellbore instability when drilling in fractured igneous rocks.Research methods involved slurry chemistry,analysis of micro-geological features(Micro-CT imaging,SEM),and rock mechanics testing.The experimental results indicated that clay minerals were widely distributed in the intergranular space of the diagenetic minerals,crystal defects,and microcracks.Drilling fluid filtrate would invade the rock along the microcracks.The invasion amount gradually increased over time,which constantly intensified the hydration and swelling of clay minerals,leading to changes in the microscopic structure of igneous rocks.Primary and secondary microcracks can propagate and merge into single cracks and thus reducing rock cohesion and the binding force along cleavage planes.Based on this result the authors propose that a key towards solving wellbore instability in igneous formations is that specific micro-geological characteristics of the igneous rocks should be taken into consideration in the design of antisloughing drilling muds. | Liu Xiangjun Zhu Honglin Liang Lixi | 2013 | Petroleum Science2013，10，2： | 2 |
| 17 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 18 | Machine learning-based estimates of aboveground biomass of subalpine forests using Landsat 8 OLI and Sentinel-2B images in the Jiuzhaigou National Nature Reserve,Eastern Tibet Plateau显示文摘Accurate estimates of forest aboveground biomass(AGB)are critical for supporting strategies of ecosystem conservation and climate change mitigation.The Jiuzhaigou National Nature Reserve,located in Eastern Tibet Plateau,has rich forest resources on steep slopes and is very sensitive to climate change but plays an important role in the regulation of regional carbon cycles.However,an estimation of AGB of subalpine forests in the Nature Reserve has not been carried out and whether a global biomass model is available has not been determined.To provide this information,Landsat 8 OLI and Sentinel-2B data were combined to estimate subalpine forest AGB using linear regression,and two machine learning approaches–random forest and extreme gradient boosting,with 54 inventory plots.Regardless of forest type,Observed AGB of the Reserve varied from 61.7 to 475.1 Mg hawith an average of 180.6 Mg ha.Results indicate that integrating the Landsat 8 OLI and Sentinel-2B imagery significantly improved model efficiency regardless of modelling approaches.The results highlight a potential way to improve the prediction of forest AGB in mountainous regions.Modelled AGB indicated a strong spatial variability.However,the modelled biomass varied greatly with global biomass products,indicating that global biomass products should be evaluated in regional AGB estimates and more field observations are required,particularly for areas with complex terrain to improve model accuracy. | Ke Luo Yufeng Wei Jie Du Liang Liu Xinrui Luo Yuehong Shi Xiangjun Pei Ningfei Lei Ci Song Jingji Li Xiaolu Tang | 2022 | Journal of Forestry Research2022，33，4： | 2 |
| 19 | DNA damage stress induces the dissociation of Smurf1/2 from MDM2 in a slow manner显示文摘The tumor suppressor p53 locates at the key point of cell growth or apoptosis balance, and the expression level of p53 is tightly controlled by ubiquitin ligases including MDM2. Upon DNA damage stresses, p53 was accumulated and activated, leading to cell cycle arrest or apoptosis. We previously showed that Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by interacting with and stabilizing MDM2, and consequently enhancing MDM2-mediated ubiquitylation of p53. However, it is unclear how the Smurf1-MDM2 interaction is regulated in response to DNA damage stress. Here, we show that in response to etoposide treatment Smurf1 dissociates from MDM2, resulting in MDM2 destabilization and p53 accumulation. The negative regulation of Smurf1 on apoptosis is released. Notably, this dissociation is a slow process rather than a rapid response, implicating high expression of Smurf1 might confer the resistance against p53 activation. Consistent with this notion, we observed that Smurf1/2 ligases are highly expressed in colon cancer, esophageal squamous cell carcinoma and pancreatic cancer tissues, suggesting the oncogenic tendency of Smurf1/2. | NIE Jing LIU Lin ZHAO XiaoHang XIE Ping ZHOU PingKun XING GuiChun LIU XiangJun HE FuChu HAN WeiDong ZHANG LingQiang | 2011 | Chinese Science Bulletin2011，56，30： | 2 |
| 20 | Myristica fragrans promotes ABCA1 expression and cholesterol efflux in THP-1-derived macrophages显示文摘Myristica fragrans is a traditional herbal medicine and has been shown to alleviate the development of atherosclerosis.However,the anti-atherogenic mechanisms of M.fragrans are still to be addressed.In this study,we explored the effect of M.fragrans on lipid metabolism and inflammation and its mechanisms in THP-1-derived macrophages.The quantitative polymerase chain reaction and western blot analysis results showed that M.fragrans promotes cholesterol efflux from THP-1-derived macrophages and reduces intracellular total cholesterol,cholesterol ester,and free cholesterol contents in a dose-and a time-dependent manner.Further study found that liver X receptor alpha(LXRα)antagonist GGPP significantly blocked the upregulation of ABCA1 expression with M.fragrans treatment.In addition,chromatin immunoprecipitation assay confirmed that GATA binding protein 3(GATA3)can bind to the LXRαpromoter,and inhibition of GATA3 led to the downregulation of LXRαand ATP-binding cassette subfamily A member 1 expression.Furthermore,M.fragrans reduced lipid accumulation,followed by decreasing tumor necrosis factor-α,interleukin(IL)-6,and IL-1βand increasing IL-10 produced by THP-1-derived macrophages.Therefore,M.fragrans is identified as a valuable therapeutic medicine for atherosclerotic cardiovascular disease. | Shangming Liu Jiahui Gao Linhao He Zhenwang Zhao Gang Wang Jin Zou Li Zhou Xiangjun Wan Shilin Tang Chaoke Tang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 2 |
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