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| 1 | Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity显示文摘AIM:To assess whether glutamate plays a similar role to glutamine in preserving gut wall integrity.METHODS:The effects of glutamine and glutamate on induced hyperpermeability in intestinal cell lines were studied.Paracellular hyperpermeability was induced in Caco2.BBE and HT-29CL.19A cell lines by adding phorbol-12,13-dibutyrate(PDB) apically,after which the effects of glutamine and glutamate on horseradish peroxidase(HRP) diffusion were studied.An inhibitor of glutamate transport(L-trans-pyrrolidine-2,4-dicarboxylic acid:trans-PDC) and an irreversible blocker(acivicin) of the extracellular glutamine to glutamate converting enzyme,γ-glutamyltransferase,were used.RESULTS:Apical to basolateral HRP flux increased significantly compared to controls not exposed to PDB (n=30,P<0.001).Glutamine application reduced hyperpermeability by 19%and 39%in the respective cell lines.Glutamate application reduced hyperpermeability by 30%and 20%,respectively.Incubation of HT29CL.19A cells with acivicin and subsequent PDB and glutamine addition increased permeability levels.Incubation of Caco2.BBE cells with trans-PDC followed by PDB and glutamate addition also resulted in high permeability levels.CONCLUSION:Apical glutamate-similar to glutaminecan decrease induced paracellular hyperpermeability.Extracellular conversion of glutamine to glutamate and subsequent uptake of glutamate could be a pivotal step in the mechanism underlying the protective effect of glutamine. | Mechteld AR Vermeulen Jeffrey de Jong Mathijs J Vaessen Paul AM van Leeuwen Alexander PJ Houdijk | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 2 | 膳食中钠(盐)与血压的关系及其他膳食因素可能的调节作用显示文摘现有资料表明,膳食钠(盐)与血压直接相关。以往大多数研究结果来自缺乏膳食数据的研究;因此,这种钠-血压关系是否受其他膳食因素调节尚不清楚。国际宏量/微量营养素和血压研究(international study on macro/micronutrients and blood pressure,INTERMAP)结果显示,在控制多种非膳食因素情况下,年龄40~59岁的男性和女性4680人(中国、日本、英国和美国的17个人口样本)的血压与24h尿钠排泄和尿钠/钾直接相关。 | 刘莉 叶鹏 Stamler J Chan Q Daviglus ML Dyer AR Van Horn L Garside DB Miura K Wu Y Ueshima H Zhao L Elliott P INTERMAP Research Group | 2018 | 中华高血压杂志2018，26，4： | 8 |
| 3 | Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury显示文摘 | Yumiko Imai Keiji Kuba G. Greg Neely Rubina Yaghubian-Malhami Thomas Perkmann Geert van Loo Maria Ermolaeva Ruud Veldhuizen Y.H. Connie Leung Hongliang Wang Haolin Liu Yang Sun Manolis Pasparakis Manfred Kopf Christin Mech Sina Bavari J.S. Malik Peiris Ar | 2008 | Cell2008，，2： | 4 |
| 4 | Gap junctions containing alpha8-connexin (MP70) in the adult mammalian lens epithelium suggests a re-evaluation of its role in the lens显示文摘 | Dahm R van Marie J Prescott AR | 1999 | Exp Eye Res1999，69，： | 1 |
| 5 | Flavonoid genes in pentunia:addition of a limited number of gene copies may lead to a suppression of gene expression显示文摘 | Mur LA Beld M | 1990 | Plant Cell1990，2，： | 1 |
| 6 | Sealing ability of a new polydimethylsiloxane-baesd root canal filling material显示文摘 | Ozok AR van der Sluis LW Wu MK | 2008 | J Endod2008，34，2： | 1 |
| 7 | Long-term follow-up of a randomized clinical trial of non-mesh versus mesh repair of primary inguinal hernia 显示文摘 | van Veen RN Wijsmuller AR Vrijland WW | 2007 | Br J Surg2007，94，： | 1 |
| 8 | Molecular mimicry of human cytochrome P450 by hepattitis C virus at the level of cytotoxic T cell recognition显示文摘 | Kammer AR van der Burg SH Grabscheid B | 1999 | J Exp Med1999，190，2： | 1 |
| 9 | Clinical validation of the non-invasive cardiac outputmonitor USC0M-1A in critically ill patients 显示文摘 | van Lelyvele-Haas LE van Zanten AR Bonn GF | 2008 | Eur JAnaesthesiol2008，25，11： | 1 |
| 10 | Simulation of HMA compaction by u-sing FEM 显示文摘 | Ter Huerne H L Van Maarseveen M F A M Molena- ar A A A | 2008 | International Journal of Pavement Engi- neering2008，9，3： | 1 |
| 11 | Angiotensin receptor nepri- ysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction tfter myocardial infarction by reducing cardiac fibrosis and hypertrophy显示文摘 | van Lueder TG Wang BH Kompa AR | 2015 | 3irc Heart Fail2015，8，1： | 1 |
| 12 | Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish显示文摘 | Timme -Laragy AR Van Tiem LA Linney EA | 2009 | Toxicol Sci2009，109，2： | 1 |
| 13 | The value of routinely performing a bone biopsy during percutaneous vertebroplasty in treatment of osteoporotic vertebral compression fractures显示文摘 | Muijs SP Akkermans PA van Erkel AR | 2009 | Spine (Phila Pa 1976)2009，34，： | 1 |
| 14 | Strategies for global prevention of hepatitis B virus infection 显示文摘 | Van Damme P Zanetti AR Shouval D | 2010 | Adv Exp MedBiol2010，659，： | 1 |
| 15 | Maternal X chromosome,visceral adiposity, and lipid profile 显示文摘 | Van PL Bakalov VK Zinn AR | 2006 | JAMA2006，295，： | 1 |
| 16 | Protein translocation by the Sec61/SecY channel 显示文摘 | Osborne AR Rapoport TA van den Berg B | 2005 | Annu Rev Cell Dev Biol2005，21，： | 1 |
| 17 | Spiral CT angiography for suspected pulmonary embolism: a cost-effective analysis显示文摘 | van Rossum AB Bloem JL | 1996 | Radiology1996，201，1： | 1 |
| 18 | Familial oligoasthenoteratozoospermia:evidence of autosomal dominant inheritance with sex-limited expression显示文摘 | Tuerlings JH van Golde R J Oudakker AR | 2002 | Fertil Steril2002，77，2： | 1 |
| 19 | KIR in type 1 diabetes:disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control sub- jects显示文摘 | Van der Slik AR Koeleman BP Verduijin W | 2003 | Diabetes2003，52，10： | 1 |
| 20 | The global impact of vaccination against hepatitis B : a historical overview 显示文摘 | Zanetti AR Van Damme P Shouval D | 2008 | Vaccine2008，26，49： | 1 |
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