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| 1 | Clostridium perfringens bacteremia caused by choledocholithiasis in the absence of gallbladder stones显示文摘A 67-years-old male presented with periumbilical abdominal pain, fever and jaundice. His anaerobic blood culture was positive for clostridium perfringens. Computed tomogram scan of the abdomen and abdominal ultrasound showed normal gallbladder and common bile duct (CBD). Subsequently magnetic resonance cholangiopancreaticogram showed choledocholithiasis. Endoscopic retrograde cholangiopancreaticogram-with sphincterotomy and CBD stone extraction was performed. The patient progressively improved with antibiotic therapy Choledocholithiasis should be considered as a source of clostridium perfringens bacteremia especially in the setting of elevated liver enzymes with cholestatic pattern. | Antwan Atia Tejas Raiyani Pranav Patel Robert Patton Mark Young | 2012 | World Journal of Gastroenterology2012，18，39： | 11 |
| 2 | 人类免疫缺陷病毒感染者抑郁障碍、自杀风险和日常生活能力的研究显示文摘目的研究人类免疫缺陷病毒(H IV)感染者抑郁症和自杀观念的流行情况及其与日常生活能力改变的关联。方法对28例H IV阳性者及23例H IV阴性者,用复合性国际诊断用检查提纲中文版调查抑郁症的总发生率和自杀史,用贝克抑郁问卷(BD I)评估当前抑郁障碍及自杀风险的严重程度,用日常生活能力问卷(ADL)评估H IV感染对日常生活能力的影响。结果(1)H IV阳性组和H IV阴性组中分别有22例(79%)和1例(4%)符合抑郁症的诊断标准(P<0.001);H IV阳性组BD I总分[(22.4±12.7)分]高于H IV阴性组[(6.6±7.8)分;P<0.001]。(2)H IV阳性组和H IV阴性组中分别有18例(64%)和2例(9%)有过自杀观念。(3)H IV阳性组ADL总分[(17.1±5.2)分]高于H IV阴性组[(14.0±0.0)分;P<0.001]。(4)BD I与H IV状况的交互作用是有显著贡献(F=23.95,P<0.001)的自变量,抑郁障碍与H IV状况的相互作用是有意义(F=13.29,P=0.001)的预测因子。结论H IV感染的人群中抑郁症的发生率及自杀风险均较高,抑郁的严重程度和日常生活能力受损有显著相关性。 | 于欣 石川 金华 J.Hampton Atkinson Robert Heaton Thomas Marcotte Corinna Young Joseph Sadek 吴尊友 Igor Grant | 2006 | 中华精神科杂志2006，39，2： | 8 |
| 3 | Dementia and osteoporosis in a geriatric population: Is there a common link?显示文摘AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords 'osteoporosis', 'osteoporotic fracture', 'dementia' and 'Alzheimer's disease'(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet independent aetiology lies in the APOE4 allele, which is a well-established risk for AD but also carries an independent association with fracture risk. The mechanism behind this is thought to be the reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele which may be amplified by the nutritional deficiencies associated with dementia, which are known to include vitamins K and D. The vitamin theory postulates that malnutrition and reduced exposure to sunlight in patients with AD leads to vitamin deficiencies. CONCLUSION Robust evidence remains to be produced regarding potential links and regarding the exact aetiology of these diseases and remains relevant given the burden of dementia and osteoporosis in our ageing population. Future research into amyloid beta, APOE4 and vitamins K and D as the most promising aetiological links should be welcomed. | Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis | 2017 | World Journal of Orthopedics2017，8，5： | 6 |
| 4 | Phoenix phylogeny, and analysis of genetic variation in a diverse collection of date palm(Phoenix dactylifera) and related species显示文摘Date palm(Phoenix dactylifera),one of the most ancient crops,is grown commercially in>30 countries.Using whole plastome assemblies,phylogenetic analyses revealed that cultivated date palm accessions share the same clade with Phoenix sylvestris,Phoenix pusilla and Phoenix acaulis,which are native to the Indian subcontinent,and Phoenix caespitosa that is native to the Arabian Peninsula and the deserts of Somalia.Analysis of genetic diversity and genetic relationships among date palm accessions from 13 producing countries involved 195 date palm accessions that were genotyped at 19 microsatellite loci.Extensive genetic diversity was observed,with many accessions heterozygous for most markers in this clonally propagated crop.The average number of alleles per locus(42.1),expected heterozygosity(0.8),observed heterozygosity(0.47)and fixation indices(FST=0.42)demonstrated substantial genetic diversity and population structure.Iraqi accessions were found to have the richest allelic diversity,and the most private alleles.The model-based Bayesian method indicated that these accessions could be broadly divided into two structure groups,one group with predominantly African accessions and another predominantly Asian.Some germplasm,especially from Tunisia and Iraq,deviated from this generalization.Many accessions in the STRUCTURE-derived groups were found to be genetic admixtures,with gene flow between Asian and African groups.Indian and Pakistani date palms were found to be most closely related to North African germplasm. | Srinivasa R.Chaluvadi Porter Young Kentrez Thompson Bochra Amina Bahri Bhavesh Gajera Subhash Narayanan Robert Krueger Jeffrey L.Bennetzen | 2019 | Plant Diversity2019，41，5： | 3 |
| 5 | A Comparison of Clinical Outcomes with Retrievable and Permanent Inferior Vena Cava Filters显示文摘 | Hyun S. Kim Mark J. Young Anand K. Narayan Kelvin Hong Robert P. Liddell Michael B. Streiff | 2008 | Journal of Vascular and Interventional Radiology2008，，3： | 2 |
| 6 | Molecular Features of Colorectal Hyperplastic Polyps and Sessile Serrated Adenoma/Polyps From Korea显示文摘 | Kyoung-Mee Kim Eui Jin Lee Sangyun Ha So Young Kang Kee-Taek Jang Cheol Keun Park Jin Yong Kim Young Ho Kim Dong Kyung Chang Robert Daniel Odze | 2011 | The American Journal of Surgical Pathology2011，，： | 2 |
| 7 | Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease显示文摘 | Alexandra K. Leamy Robert A. Egnatchik Jamey D. Young | 2012 | Progress in Lipid Research2012，，： | 2 |
| 8 | Coronary Artery Disease in Peripheral Vascular Patients: A Classification of 1000 Coronary Angiograms and Results of Surgical Management显示文摘 | NORMAN R. HERTZER EDWIN G. BEVEN JESS R. YOUNG PATRICK J. O?HARA WILLIAM F. RUSCHHAUPT ROBERT A. GRAOR VICTOR G. DEWOLFE LINDA C. MALJOVEC | 1984 | Annals of Surgery1984，，2： | 2 |
| 9 | Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficle显示文摘 | Robert A. Britton Vincent B. Young | 2014 | Gastroenterology2014，，： | 2 |
| 10 | G Protein-Coupled Estrogen Receptor (GPER) Expression in Normal and Abnormal Endometrium显示文摘 | Beth J. Plante Bruce A. Lessey Robert N. Taylor Wei Wang Milan K. Bagchi Lingwen Yuan Jessica Scotchie Marc A. Fritz Steven L. Young | 2012 | Reproductive Sciences2012，，7： | 1 |
| 11 | AMPK activation is fibertype specific in human skeletal muscle: effects of exercise andshort-term exercise training显示文摘 | Robert S Young L Canny B J | 2009 | J Appl Physiol2009，107，1： | 1 |
| 12 | Adenoma Malignum (Minimal Deviation Adenocarcinoma) of the Uterine Cervix: A Clinicopathological and Immunohistochemical Analysis of 26 Cases显示文摘 | C. Blake Gilks Robert H. Young Pascasio Aguirre Ronald A. DeLellis Robert E. Scully | 1989 | The American Journal of Surgical Pathology1989，，： | 1 |
| 13 | Relationship between admission hyperglycemia and neurologic outcone of severely brain-injured patients显示文摘 | Young B Ott L Robert MS | 1989 | Ann Surg1989，210，4： | 1 |
| 14 | Transient release of lipid peroxides after coronary artery balloon angioplaety 显示文摘 | Roberts M J Young I S Trouton T G | 1990 | Lancet1990，336，8708： | 1 |
| 15 | How Does Residents' Satisfaction with Community Services Influence Quality of Life (QOL) Outcomes? 显示文摘 | Sirgy M J Gao Tao Young Robert F | 2008 | Applied Research Quality Life2008，，3： | 1 |
| 16 | Implementing multivariate statistical process control using hotelling's T2 statistic显示文摘 | ROBERT L M YOUNG J C | 2001 | Quality Progress2001，，： | 1 |
| 17 | Relationships between Psychological Climate Perceptions and Work Outcomes:A Meta-analytic Review显示文摘 | Parker C P Baltes B B Young S A Huff J W Altmann R A LaCost H A Roberts J E | 2003 | Journal of Organizational Behavior Chichester2003，24，4： | 1 |
| 18 | Interfacial micromechanics oftechnora fibre/epoxy composites显示文摘 | Warawan Prasithphol Robert J Young | 2005 | Journal of materials science2005，40，： | 1 |
| 19 | Knowledge reuse in manufacturability analysis显示文摘 | Sean Cochrane Robert Young Keith Case Jennifer Harding James Gao Shilpa Dani David Baxter | 2007 | Robotics and Computer Integrated Manufacturing2007，，4： | 1 |
| 20 | Manage-ment factors associated with farrowing rate in commercial sowherds in Ontario显示文摘 | Beth Young Catherine E Dewey Robert M Friendship | 2010 | Can Yet J2010，，51： | 1 |
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