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| 1 | Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules显示文摘AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)related HCC.METHODS: Thirty-eight HCC and 19 DN samples were obtained from 52 hepatitis B surface antigen-positive Korean patients. Immunohistochemical and dot immunoblot analyses of HSP27, HSP60, HSP70, HSP90, glucoseregulated protein (GRP)78, and GRP94 were performed and their expression at different stages of HCC development was statistically analyzed.RESULTS: Expression of HSP27, HSP70, HSP90, GRP78, and GRP94 increased along with the stepwise progression of hepatocarcinogenesis. Strong correlation was found only in GRP78 (Spearman's r= 0.802). There was a positive correlation between the expressions of GRP78, GRP94, HSP90, or HSP70 and prognostic factors of HCC. Specifically, the expression of GRP78, GRP94, or HSP90 was associated significantly with vascular invasion and intrahepatic metastasis.CONCLUSION: The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBVrelated hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis. | Seung Oe Lim Sung Gyoo Park Jun-Hi Yoo Young Min Park Hie-Joon Kim Kee-Taek Jang Jae Won Cho Byung Chul Yoo Gu-Hung Jung Cheol Keun Park | 2005 | World Journal of Gastroenterology2005，11，14： | 62 |
| 2 | Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms显示文摘这篇文章在开发,基因疾病和癌症考察分子的结构,表达式模式,生理的函数,病理学的角色和 Twist1 的分子的机制。Twist1 是基本 helix-loop-helix 包含域的抄写因素。以便绑 Nde1 电子盒子元素并且激活或镇压形成 homo-dimers 或 hetero-dimers 它的目标基因。在开发期间, Twist1 为中层说明和区别是必要的。人的 Twist1 基因的异质接合的 loss-of-function 变化包括 Saethre-Chotzen 症候群引起几疾病。Twist1 空的老鼠胚胎与打开的头部的神经试管和有缺点的头间充组织死,体节和手足芽。Twist1 在胸被表示,肝,前列腺,胃并且癌症的另外的类型,和它的表示通常与侵略、变形的癌症显型被联系。在癌症房间, Twist1 是由包括 SRC-1 的多重因素的 upregulated, STAT3, MSX2, HIF-1α,连接 integrin 的 kinase 和 NF-κ B。Twist1 显著地提高上皮间充质的转变(EMT ) 和癌症房间移植和侵略,因此支持癌症转移。Twist1 由直接镇压部分地支持 EMT 由招募的 E-cadherin 表示改变的 nucleosome 和为基因压抑并且由 upregulating Bmi1 的 deacetylase 建筑群, AKT2, YB-1,等等。新兴的证据也建议 Twist1 在扩大和癌症干细胞的化学疗法的抵抗起一个作用。Twist1 由支持 Twist1 功能的调节的人的转移和鉴定的机制的进一步的理解可以为开发新策略禁止 EMT 和癌症转移保持诺言。 | Qian Qin Young Xu Tao He Chunlin Qin Jianming Xu | 2012 | Cell Research2012，22，1： | 66 |
| 3 | Factors related to lymph node metastasis and surgical strategy used to treat early gastric carcinoma显示文摘AIM:The prognosis of early gastric carcinoma (EGC) is generally excellent after surgery. The presence or absence of lymph node metastasis in EGC is an important prognostic factor. The survival and recurrence rates of node-negative EGC are much better than those of node-positive EGC. This study examined the factors related to lymph node metastasis in EGC to determine the appropriate treatment for EGC.METHODS: We investigated 748 patients with EGC who underwent surgery between January 1985 and December 1999 at the Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Hospital. Several clinicopathologic factors were investigated to analyze their relationship to lymph node metastasis: age, sex, tumor location, tumor size, gross type, histologic type, depth of invasion, extent of lymph node dissection, type of operation,and DNA ploidy.RESULTS:Lymph node metastases were found in 75 patients (10.0%). Univariate analysis showed that male sex, tumor size larger than 2.0cm, submucosal invasion of tumor, histologic differentiation, and DNA ploidy pattern were risk factors for regional lymph node metastasis in EGC patients. However, a multivariate analysis showed that three risk factors were associated with lymph node metastasis:large tumor size, undifferentiated histologic type and submucosal invasion. No statistical relationship was found for age, sex, tumor location, gross type, or DNA ploidy in multivariate analysis. The 5-year survival rate was 94.2% for those without lymph node metastasis and 87.3% for those with lymph node metastasis, and the difference was significant (P<0.05).CONCLUSION: In patients with EGC, the survival rate of patients with positive lymph nodes is significantly worse than that of patients with no lymph node metastasis. Therefore,a standard D2 lymphadenectomy should be performed in patients at high risk of lymph node metastasis: large tumor size, undifferentiated histologic type and submucosal invasion. | Dong Yi Kim Jae Kyoon Joo Seong Yeob Ryu Young Jin Kim Shin Kon Kim | 2004 | World Journal of Gastroenterology2004，10，5： | 68 |
| 4 | MICROWAVE-ASSISTED EXTRACTION OF GLYCYRRHIZIC ACID FROM LICORICE ROOT-EFFECT OF THE PROPERTY OF SOLUTION ON EXTRACTION OF GA显示文摘The property of extraction solution is an important factor influencing the extraction efficiency. In the present work, the effect of the property of solution on extraction of GA was studied, which including the concentration of ethanol, ammonia and cation (M+), pH of extraction solution, different kinds of organic solvent etc. The results show that 50%-60%(v/v) ethanol can reach high percentage extraction of GA. If 1% (v/v) ammonia solution was added into 60%(v/v) ethanol, the percentage extraction can be increased from 2.0% to 2.31%. Without ammonia, 50mmol/L [M+] (M+ = K+, NH4+) was added into 60%(v/v) ethanol, percentage extraction of GA can reach about 2.26%. If pH of solution (60% ethanol) was adjust to pH=4.0, it can reach high percentage extraction. If pH of solution (60% ethanol + 50mmol [M+], pH=6.1) was adjust tO PH=4.0, especially M+ is K+ or NH4+, it can reach almost same extraction efficiency as that of 1% ammonia solution + 60% ethanol, and the operation environment can be greatly improved. | Pan Xuejun and Liu Huizhou (Young Scienctist Laboratory of Separation Science & Engineering, State Key Laboratory of Biochemical Engineering, Instigate of Chemical Metallurgy, Chinese Academy of Sciepces, Beijing 100080) | 2000 | 化工学报2000，51，S1： | 52 |
| 5 | Diagnostic value of AFP-L3 and PIVKA-Ⅱin hepatocellular carcinoma according to total-AFP显示文摘AIM:To evaluate diagnostic value ofα-fetoprotein (AFP)-L3 and prothrombin induced by vitamin K absence-Ⅱ(PIVKA-Ⅱ)in hepatocellular carcinoma(HCC). METHODS:One hundred and sixty-eight patients during routine HCC surveillance were included in this study.Of the 168 patients,90(53.6%)had HCC including newly developed HCC(n=82)or recurrent HCC after treatment(n=8).Sera were obtained during their first evaluation for HCC development and at the time of HCC diagnosis before commencing HCC treatment.HCC was diagnosed by histological examination,appropriate imaging characteristics-computed tomography or magnetic resonance imaging.Control sera were collected from 78 patients with benign liver disease(BLD),which were obtained during routine surveillance with a suspicion of HCC.AFP,AFP-L3 and PIVKA-Ⅱwere measured in the same serum by microchip capillary electrophoresis and liquid-phase binding assay on a micro-total analysis system Wako i30 auto analyzer.The performance characteristics of three tests and combined tests for the diagnosis of HCC were obtained using receiver operating characteristic curves in all populations and subgroups with AFP<20 ng/mL. RESULTS:Of 90 HCC patients,38(42.2%)patients had AFP<20 ng/mL,20(22.2%)patients had AFP 20-200 ng/mL and 32(35.6%)patients had AFP>200 ng/mL.Of the 78 BLD patients,74(94.9%)patients had AFP<20 ng/mL.After adjustment for age and HBV infection status,AFP-L3 levels were higher in HCC than in BLD among patients with low AFP levels(<20 ng/mL)(P<0.001).In a total of 168 patients,areas under the curve(AUC)for HCC were 0.879,0.887,0.801 and 0.939 for AFP,AFP-L3,PIVKA-Ⅱand the combined markers,respectively.The combined AUC for three markers showed higher value than the AUCs of individual marker(P<0.05).AFP-L3 had higher AUC value than PIVKA-Ⅱfor HCC detection in entire patients(P =0.043).With combination of AFP-L3(cut-off>5%) and PIVKA-Ⅱ(cut-off>40 AU/L),the sensitivity were 94.4%and specificity were 75.6%in all patients.In 112 patients with low AFP levels(<20 ng/mL),AUCs of AFP-L3,PIVKA-Ⅱand combine AFP-L3 and PIVKA-Ⅱtests were 0.824,0.774 and 0.939,respectively. AFP-L3 with a cut-off value of 5%showed sensitivity of 71.1%and specificity of 83.8%,and PIVKA-Ⅱwith a cut-off value of 40 AU/L had sensitivity of 57.9%and specificity of 95.9%in patients with low AFP levels. The combination of AFP-L3 and PIVKA-Ⅱincreased the sensitivity and specificity up to 92.1%and 79.7%, respectively,in low AFP group.Combined markers detected 81.8%of early stage HCC(Union for Inter-national Cancer Control stageⅠ),86.7%of small sized tumor(<2 cm)and 91.7%of single tumor of HCC in the low AFP group.In multivariate analysis,AFP-L3 was correlated with AFP and tumor size,and PIVKA-Ⅱwas correlated with laboratory tests including serum aspartate aminotransferase,total bilirubin,platelets and albumin levels.PIVKA-Ⅱhad no correlation with AFP,AFP-L3 or tumor characteristics. CONCLUSION:Combined determination of AFP-L3 and PIVKA-Ⅱcould improve the diagnostic value for HCC detection in patients with or without increased AFP levels. | Jong Young Choi Seung Won Jung Hee Yeon Kim Myungshin Kim Yonggoo Kim Dong Goo Kim Eun-Jee Oh | 2013 | World Journal of Gastroenterology2013，19，3： | 55 |
| 6 | Long-term result of endoscopic Histoacryl (N-butyl-2-cyanoacrylate)injection for treatment of gastric varices显示文摘AIM:To evaluate the long-term efficacy and safety of endoscopic obliteration with Histoacryl for treatment of gastric variceal bleeding and prophylaxis.METHODS:Between January 1994 and March 2010 at SoonChunHyang University Hospital,a total of 127 patients with gastric varices received Histoacryl injections endoscopically.One hundred patients underwent endoscopic Histoacryl injections because of variceal bleeding,the other 27 patients received such injections as a prophylactic procedure.RESULTS:According to Sarin classification,56 patients were GOV1,61 patients were GOV2 and 10 patients were IGV.Most of the varices were large(F2 or F3,111 patients).The average volume of Histoacryl per each session was 1.7±1.3 cc and mean number of sessions was 1.3±0.6.(1 session-98 patients,2 sessions-25 patients,≥3 sessions-4 patients).Twenty-seven patients with high risk of bleeding(large or fundal or RCS+or Child C) received Histoacryl injection as a primary prophylactic procedure.In these patients,hepatitis B virus was the major etiology of cirrhosis,25 patients showed GOV1 or 2(92.6%)and F2 or F3 accounted for 88.9%(n=24).The rate of initial hemostasis was 98.4%and recurrent bleeding within one year occurred in 18.1%of patients.Successful hemostasis during episodes of rebleeding was achieved in 73.9%of cases.Median survival was 50 mo (95%CI 30.5-69.5).Major complications occurred in 4 patients(3.1%).The rebleeding rate in patients with hepatocellular carcinoma or GOV2 was higher than in those with other conditions.None of the 27 subjects who were treated prophylactically experienced treatment-related complications.Cumulative survival rates of the 127 patients at 6 mo,1,3,and 5 years were 92.1%,84.2%,64.2%,and 45.3%,respectively.The 6 mo cumulative survival rate of the 27 patients treated prophylactically was 75%.CONCLUSION:Histoacryl injection therapy is an effective treatment for gastric varices and also an effective prophylactic treatment of gastric varices which carry high risk of bleeding. | Eun Jung Kang Soung Won Jeong Jae Young Jang Joo Young Cho Sae Hwan Lee Hyun Gun Kim Sang Gyune Kim Young Seok Kim Young Koog Cheon Young Deok Cho Hong Soo Kim Boo Sung Kim | 2011 | World Journal of Gastroenterology2011，17，11： | 41 |
| 7 | Comparison of RECIST version 1.0 and 1.1 in assessment of tumor response by computed tomography in advanced gastric cancer显示文摘Objective:Response Evaluation Criteria in Solid Tumors(RECIST)guideline version 1.0(RECIST 1.0)was proposed as a new guideline for evaluating tumor response and has been widely accepted as a standardized measure.With a number of issues being raised on RECIST 1.0,however,a revised RECIST guideline version 1.1(RECIST 1.1)was proposed by the RECIST Working Group in 2009.This study was conducted to compare CT tumor response based on RECIST 1.1 vs.RECIST 1.0 in patients with advanced gastric cancer(AGC).Methods:We reviewed 61 AGC patients with measurable diseases by RECIST 1.0 who were enrolled in other clinical trials between 2008 and 2010.These patients were retrospectively re-analyzed to determine the concordance between the two response criteria using theκstatistic.Results:The number and sum of tumor diameters of the target lesions by RECIST 1.1 were significantly lower than those by RECIST 1.0(P<0.0001).However,there was excellent agreement in tumor response between RECIST 1.1 and RECIST 1.0(κ=0.844).The overall response rates(ORRs)according to RECIST1.0 and RECIST 1.1 were 32.7%(20/61)and 34.5%(20/58),respectively.One patient with partial response(PR)based on RECIST 1.0 was reclassified as stable disease(SD)by RECIST 1.1.Of two patients with SD by RECIST 1.0,one was downgraded to progressive disease and the other was upgraded to PR by RECIST 1.1.Conclusions:RECIST 1.1 provided almost perfect agreement with RECIST 1.0 in the CT assessment of tumor response of AGC. | Gil-Su Jang Min-Jeong Kim Hong-Il Ha Jung Han Kim Hyeong Su Kim Sung Bae Ju Dae Young Zang | 2013 | Chinese Journal of Cancer Research2013，25，6： | 42 |
| 8 | Gene expression profiling:Canonical molecular changes and clinicopathological features in sporadic colorectal cancers显示文摘瞄准:为了调查其他或辅助的小径,在颜色包含了表面的肿瘤发生和肿瘤生长,可能决定在风险人口并且预言回答到治疗。方法:用微数组基因表示分析,我们在 84 分散的颜色相对正规分子的变化和 clinicopathological 特征分析了基因表示的模式表面的癌症病人,由肿瘤地点标准化了。差别的子集表示了基因被即时反向抄本的聚合酶链反应(RT-PCR ) 证实。结果:作为差别正在被表示识别的基因的最大的数字由 lymphovascular 或肿瘤房间并且由失配修理(MMR ) 的神经侵略由肿瘤地点,和下一个最大的数字缺点。在生物过程之中,有免疫力的反应显著地在在颜色期间观察的全部分子的变化被含有表面的肿瘤发生(P <
0.001 ) 。在 47 之中,差别表示了基因,(PISD, NIBP, BAI2, STOML1, MRPL21, MRPL16,和 MKKS ) 七最新被发现与肿瘤发生和肿瘤生长相关。最联系地点的分子的变化在基因表示上有不同效果,但是后者的效果有时是矛盾的。结论:我们证明几差别表示了基因在分散的颜色与正规分子的变化被联系表面的癌症,可能组成肿瘤发生的其他或辅助的小径。因为肿瘤地点是影响微分基因表示的主导的因素,地点特定的分析可以识别联系地点的小径并且提高班预言的精确性。 | Jin Cheon Kim Seon Young Kim Seon Ae Roh Dong-Hyung Cho Dae Dong Kim Jeong Hyun Kim Yong Sung Kim | 2008 | World Journal of Gastroenterology2008，14，43： | 36 |
| 9 | Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome显示文摘AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and sonography.Fatty pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on sonography.In a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid profile.The incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal pancreases.Fatty pancreas also showed a strong correlation with metabolic syndrome. | Jun Seok Lee Sang Heum Kim Dae Won Jun Jee Hye Han Eun Chul Jang Ji Young Park Byung Kwan Son Seong Hwan Kim Yoon Ju Jo Young Sook Park Yong Soo Kim | 2009 | World Journal of Gastroenterology2009，15，15： | 40 |
| 10 | WHO(2014)卵巢肿瘤组织学分类显示文摘上皮性肿瘤 浆液性肿瘤 良性 浆液性囊腺瘤 8441/0 浆液性腺纤维瘤 9014/0 浆液性表面乳头状瘤 8461/0 交界性 浆液性交界性肿瘤/不典型增生性浆 液性肿瘤 8442/1 浆液性交界性肿瘤-微乳头亚型/非浸润性低级别浆液性癌 | 马亚琪 王昀 刘爱军 Kurman RJ Carcangiu ML Herrington CS Young RH Eds | 2014 | 诊断病理学杂志2014，21，8： | 36 |
| 11 | Intestinal microbiota in pathophysiology and management of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is a functional bowel disorder without any structural or metabolic abnormalities that sufficiently explain the symptoms, which include abdominal pain and discomfort, and bowel habit changes such as diarrhea and constipation. Its pathogenesis is multifactorial: visceral hypersensitivity, dysmotility, psychosocial factors, genetic or environmental factors, dysregulation of the brain-gut axis, and altered intestinal microbiota have all been proposed as possible causes. The human intestinal microbiota are composed of more than 1000 different bacterial species and 1014 cells, and are essential for the development, function, and homeostasis of the intestine, and for individual health. The putative mechanisms that explain the role of microbiota in the development of IBS include altered composition or metabolic activity of the microbiota, mucosal immune activation and inflammation, increased intestinal permeability and impaired mucosal barrier function, sensory-motor disturbances provoked by the microbiota, and a disturbed gut-microbiota-brain axis. Therefore, modulation of the intestinal microbiota through dietary changes, and use of antibiotics, probiotics, and anti-inflammatory agents has been suggested as strategies for managing IBS symptoms. This review summarizes and discusses the accumulating evidence that intestinal microbiota play a role in the pathophysiology and management of IBS. | Kang Nyeong Lee Oh Young Lee | 2014 | World Journal of Gastroenterology2014，20，27： | 35 |
| 12 | Clinical significance of the neutrophil-lymphocyte ratio as an early predictive marker for adverse outcomes in patients with acute pancreatitis显示文摘AIM To investigated the prognostic value of the neutrophillymphocyte ratio(NLR) in patients with acute pancreatitis and determined an optimal cut-off value for the prediction of adverse outcomes in these patients.METHODS We retrospectively analyzed 490 patients with acute pancreatitis diagnosed between March 2007 and December 2012. NLRs were calculated at admission and 24, 48, and 72 h after admission. Patients were grouped according to acute pancreatitis severity and organ failure occurrence, and a comparative analysis was performed to compare the NLR between groups. RESULTS Among the 490 patients, 70 had severe acute pancreatitis with 31 experiencing organ failure. The severe acute pancreatitis group had a significantly higher NLR than the mild acute pancreatitis group on all 4 d(median, 6.14, 6.71, 5.70, and 4.00 vs 4.74, 4.47, 3.20, and 3.30, respectively, P < 0.05). The organ failure group had a significantly higher NLR than the group without organ failure on all 4 d(median, 7.09, 6.72, 6.27, and 6.24 vs 4.85, 4.49, 3.35, and 2.34, respectively, P < 0.05). The optimal cut-off value for baseline NLR was 4.76 in predicting severity and 4.88in predicting organ failure in acute pancreatitis. CONCLUSION Elevated baseline NLR correlates with severe acute pancreatitis and organ failure. | Tae Joo Jeon Ji Young Park | 2017 | World Journal of Gastroenterology2017，23，21： | 37 |
| 13 | Bedside index for severity in acute pancreatitis:comparison with other scoring systems in predicting severity and organ failure显示文摘BACKGROUND:The early identification of severe acute pancreatitis is important for the management and for improving outcomes.The bedside index for severity in acute pancreatitis(BISAP)has been considered as an accurate method for risk stratification in patients with acute pancreatitis.This study aimed to evaluate the comparative usefulness of the BISAP.METHODS:We retrospectively analyzed 303 patients with acute pancreatitis diagnosed at our hospital from March 2007to December 2010.BISAP,APACHE-II,Ranson criteria,and CT severity index(CTSI)of all patients were calculated.We stratified the number of patiants with severe pancreatitis,pancreatic necrosis,and organ failure as well as the number of deaths by BISAP score.We used the area under the receiveroperating curve(AUC)to compare BISAP with other scoring systems,C-reactive protein(CRP),hematocrit,and body mass index(BMI)with regard to prediction of severe acute pancreatitis,necrosis,organ failure,and death.RESULTS:Of the 303 patiants,31(10.2%)were classified as having severe acute pancreatitis.Organ failure occurred in 23(7.6%)patients,pancreatic necrosis in 40(13.2%),and death in6(2.0%).A BISAP score of 2 was a statistically significant cutoff value for the diagnosis of severe acute pancreatitis,organ failure,and mortality.AUCs for BISAP predicting severe pancreatitis and death were 0.80 and 0.86,respectively,which were similar to those for APACHE-II(0.80,0.87)and Ranson criteria(0.74,0.74)and greater than AUCs for CTSI(0.67,0.42).The AUC for organ failure predicted by BISAP,APACHE-II,Ranson criteria,and CTSI was 0.93,0.95,0.84 and 0.57,respectively.AUCs for BISAP predicting severity,organ failure,and death were greater than those for CRP(0.69,0.80,0.72),hematocrit(0.45,0.35,0.14),and BMI(0.41,0.47,0.17).CONCLUSION:The BISAP predicts severity,death,and especially organ failure in acute pancreatitis as well as APACHE-II does and better than Ranson criteria,CTSI,CRP,hematocrit,and BMI. | Ji Young Park Tae Joo Jeon Tae Hwan Ha Jin Tae Hwang Dong Hyun Sinn Tae-Hoon Oh Won Chang Shin Won-Choong | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 33 |
| 14 | Risk factors affecting pancreatic fistulas after pancreaticoduodenectomy显示文摘AIM: To analyze the risk factors of pancreatic leakage after pancreaticoduodenectomy.METHODS: We retrospectively reviewed 172 consecutive patients who had undergone pancreatico-duodenectomy at Inha University Hospital between April 1996 and March 2006. We analyzed the pancreatic fistula rate according to the clinical characteristics, the pathologic and laboratory findings, and the anastomotic methods.RESULTS: The incidence of developing pancreatic fistulas in patients older than 60 years of age was 21.7% (25/115), while the incidence was 8.8% (5/57) for younger patients; the difference was significant (P = 0.03). Patients with a dilated pancreatic duct had a lower rate of post-operative pancreatic fistulas than patients with a non-dilated duct (P = 0.001). Other factors, including clinical features, anastomotic methods, and pathologic diagnosis, did not show any statistical difference. CONCLUSION: Our study demonstrated that pancreatic fistulas are related to age and a dilated pancreatic duct. The surgeon must take these risk factors into consideration when performing a pancre-aticoduodenectomy. | Yun-Mee Choe Keon-Young Lee Cheong-Ah Oh Joung-Bum Lee Sun Keun Choi Yoon-Seok Hur Sei-Joong Kim Young Up Cho Seung-Ik Ahn Kee-Chun Hong Seok-Hwan Shin Kyung-Rae Kim | 2008 | World Journal of Gastroenterology2008，14，45： | 32 |
| 15 | Small sphincterotomy combined with endoscopic papillary large balloon dilation versus sphincterotomy显示文摘AIM:To compare small sphincterotomy combined with endoscopic papillary large balloon dilation(SES+ ELBD)and endoscopic sphincterotomy(EST)for large bile duct stones. METHODS:We compared prospectively SES+ELBD (group A,n=27)with conventional EST(group B, n=28)for the treatment of large bile duct stones(≥ 15 mm).When the stone could not be removed with a normal basket,mechanical lithotripsy was performed. We compared the rates of complete stone removal with one session and application of mechanical lithotripsy. RESULTS:No significant differences were observed in the mean largest stone size(A:20.8 mm,B:21.3 mm), bile duct diameter(A:21.4 mm,B:20.5 mm),number of stones(A:2.2,B:2.3),or procedure time(A:18 min, B:19 min)between the two groups.The rates of complete stone removal with one session was 85%in group A and 86%in group B(P=0.473).Mechanical lithotripsy was required for stone removal in nine of 27 patients(33%)in group A and nine of 28 patients (32%,P=0.527)in group B.CONCLUSION:SES+ELBD did not show significant benefits compared to conventional EST,especially for the removal of large(≥15 mm)bile duct stones. | Hyun Gun Kim Young Koog Cheon Young Deok Cho Jong Ho Moon Do Hyun Park Tae Hoon Lee Hyun Jong Choi Sang-Heum Park Joon Seong Lee Moon Sung Lee | 2009 | World Journal of Gastroenterology2009，15，34： | 34 |
| 16 | Early neurosurgical intervention of spinal cord contusion: an analysis of 30 cases显示文摘背景有针的绳索殴打的脊柱受伤的发生在发达国家高并且现在在中国正在成长。而且,针的绳索损害主要在有长寿期待的年轻人发生。很多病人因此是为他们的生活的其余部分的轮椅界限。因此,针的绳索损害引起了世界范围的大担心。尽管有大努力,从针的绳索损害的恢复仍然保持不能令人满意。基于针的绳索殴打的病理,早 neurosurgical 干预的一个想法在这研究被提出了。有“完全”的针的绳索损害的 30 个病人全部或象美国脊柱受伤协会(亚洲) A 分类的方法 A 被学习。受伤椎骨(e) ,脊椎的列的内部固定,和为硬膜上的解压缩的双边的 laminectomy 的矫形治疗被 neurosurgical 管理直接跟随,包括恢复脑髓的液体流动和针的绳索的清创术的蛛网状的粘附的分离有伴随物 intramedullary 解压缩的坏死的织物。康复在操作以后开始了 17 天。最后的结果在 3 月康复以后被评估。皮尔森 chi 平方分析被用于统计分析。所有病人恢复了的结果走的某能力。最少的恢复病人能在稳定忍受膝关节的重量与 wheeled 重量支持和帮助走(12 个盒子, 40%) 。13 个病人(43%) 能与一双丁字拐走,一根棍子或没有任何支持。在损害以后预定操作是重要的。一扇最佳的操作时间窗户在损害以后在 4-14 天被识别。康复跟随的针的绳索殴打的结论早 neurosurgical 干预能显著地改进病人的运动。它是为针的绳索殴打的一条治疗学的途径的一个新想法并且被证明了很成功。 | ZHU Hui FENG Ya-ping Young Wise YOU Si-wei SHEN Xue-feng LIU Yan-sheng JU Gong | 2008 | Chinese Medical Journal2008，，24： | 30 |
| 17 | 嗅鞘细胞促使脊髓挫裂伤后神经再生和功能恢复的研究显示文摘目的 :研究嗅鞘细胞在脊髓挫裂损伤后不同时期植入能否帮助轴突再生、穿过瘢痕和神经功能恢复。方法 :用 NYU打击器制造 Log Evans Hooded大鼠的脊髓挫裂损伤模型 ,在伤后即刻和二周后植入嗅鞘细胞 ,采用 BBB方法做行为学观察三个月 ,经运动皮层注入神经示踪剂 (BDA)后行组织化学研究。结果 :部分大鼠嗅鞘细胞植入后比对照组的神经功能恢复好 ,组织学发现这些神经功能恢复好 (BBB分数 >10 )的大鼠 ,再生神经轴突能穿过损伤瘢痕区到达损伤下段。结论 :嗅鞘细胞在脊髓挫裂损伤后即刻和二周后植入均能帮助轴突再生、穿过瘢痕和神经功能恢复。 | 黄红云 刘凯 黄文成 刘宗惠 Wise Young | 2001 | 海军总医院学报2001，14，2： | 30 |
| 18 | Non-invasive diagnosis of hepatitis B virus-related cirrhosis显示文摘Chronic hepatitis B(CHB)infection is a major public health problem associated with significant morbidity and mortality worldwide.Twenty-three percent of patients with CHB progress naturally to liver cirrhosis,which was earlier thought to be irreversible.However,it is now known that cirrhosis can in fact be reversed by treatment with oral anti-nucleotide drugs.Thus,early and accurate diagnosis of cirrhosis is important to allow an appropriate treatment strategy to be chosen and to predict the prognosis of patients with CHB.Liver biopsy is the reference standard for assessment of liver fibrosis.However,the method is invasive,and is associated with pain and complications that can be fatal.In addition,intra-and inter-observer variability compromises the accuracy of liver biopsy data.Only small tissue samples are obtained and fibrosis is heterogeneous in such samples.This confounds the two types of observer variability mentioned above.Such limitations have encouraged development of non-invasive methods for assessment of fibrosis.These include measurements of serum biomarkers of fibrosis;and assessment of liver stiffness via transient elastography,acoustic radiation force impulse imaging,real-time elastography,or magnetic resonance elastography.Although significant advances have been made,most work to date has addressed the diagnostic utility of these techniques in the context of cirrhosis caused by chronic hepatitis C infection.In the present review,we examine the advantages afforded by use of non-invasive methods to diagnose cirrhosis in patients with CHB infections and the utility of such methods in clinical practice. | Sangheun Lee Do Young Kim | 2014 | World Journal of Gastroenterology2014，20，2： | 29 |
| 19 | Establishment and characterization of four human hepatocellular carcinoma cell lines containing hepatitis B virus DNA显示文摘INTRODUCTIONHepatocelularcarcinoma(HCC)isoneofthemostprevalentmalignantdiseasesencounteredintheworld,kilingupto1milionpeoplea... | Jae Ho Lee 1, Ja Lok Ku 1, Young Jin Park 1,2 , Kuhn Uk Lee 2, Woo Ho Kim 3 and Jae Gahb Park 1,2 | 1999 | World Journal of Gastroenterology1999，5，4： | 28 |
| 20 | 关于BL-代数的模糊滤子与模糊理想(英文)显示文摘在BL-代数中引入模糊超滤子和模糊固执滤子的概念,证明了如下条件对于BL-代数的非常数模糊滤子f来说是等价的:(1)f是布尔的和素的,(2)f是蕴涵的和素的,(3)f是超的,(4)f是固执的。应用模糊正蕴涵滤子给出G-代数的若干特征性质。提出BL-代数模糊理想的概念,给出一些重要例子,并通过例子说明在BL-代数中模糊理想一般不能由模糊滤子导出。同时,从模糊理想出发构造了商BL-代数,并建立了相应的同态基本定理。最后,研究了BL-代数的几类模糊理想及其相互关系,给出模糊布尔理想、模糊素理想、模糊超理想的特征性质。 | 张小红 Jun Young Bae Doh Myung Im | 2006 | 模糊系统与数学2006，20，3： | 27 |
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