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| 1 | Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy显示文摘Molecular advances support the existence of an alternative pathway of colorectal carcinogenesis that is based on the hypermethylation of specific DNA regions that silences tumor suppressor genes. This alternative pathway has been called the serrated pathway due to the serrated appearance of tumors in histological analysis. New classifications for colorectal cancer(CRC) were proposed recently based on genetic profiles that show four types of molecular alterations: BRAF gene mutations, KRAS gene mutations, microsatellite instability, and hypermethylation of Cp G islands. This review summarizes what is known about the serrated pathway of CRC, including CRC molecular and clinical features, prognosis, and response to chemotherapy. | Oscar Murcia Miriam Juárez Eva Hernández-Illán Cecilia Egoavil Mar Giner-Calabuig María Rodríguez-Soler Rodrigo Jover | 2016 | World Journal of Gastroenterology2016，22，13： | 18 |
| 2 | 结直肠锯齿状腺瘤中DNA异常甲基化状态的研究进展显示文摘锯齿状腺瘤癌变途径被认为是除了传统成瘤途径的又一重要癌变通路,结直肠癌的发生和发展是一个多基因、多阶段、多因素的复杂过程,在结直肠锯齿状病变中可以检测到多种基因的启动子异常甲基化状态,这些基因异常修饰过程可导致相应基因沉默、蛋白产物下调等,从而在某种程度上影响和促进结直肠癌的发生、发展,正确认识这些基因改变所带来的影响并很好地运用到临床实践当中去,从而早期发现癌前病变并采取有效的干预措施,对于减少结肠癌的发生有重要的指导意义。 | 崔莹 武金宝 | 2015 | 世界最新医学信息文摘2015，15，23： | 1 |
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