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| 1 | Review of magnesium-based biomaterials and their applications显示文摘In biomedical applications,the conventionally used metallic materials,including stainless steel,Co-based alloys and Ti alloys,often times exhibit unsatisfactory results such as stress shielding and metal ion releases.Secondary surgical operation(s)usually become inevitable to prevent long term exposure of body with the toxic implant contents.The metallic biomaterials are being revolutionized with the development of biodegradable materials including several metals,alloys,and metallic glasses.As such,the nature of metallic biomaterials are transformed from the bioinert to bioactive and multi-biofunctional(anti-bacterial,anti-proliferation,anti-cancer,etc.).Magnesium-based biomaterials are candidates to be used as new generation biodegradable metals.Magnesium(Mg)can dissolve in body fluid that means the implanted Mg can degrade during healing process,and if the degradation is controlled it would leave no debris after the completion of healing.Hence,the need for secondary surgical operation(s)for the implant removal could be eliminated.Besides its biocompatibility,the inherent mechanical properties of Mg are very similar to those of human bone.Researchers have been working on synthesis and characterization of Mg-based biomaterials with a variety of composition in order to control the degradation rate of Mg since uncontrolled degradation could result in loss of mechanical integrity,metal contamination in the body and intolerable hydrogen evolution by tissue.It was observed that the applied methods of synthesis and the choice of components affect the characteristics and performance of the Mg-based biomaterials.Researchers have synthesized many Mg-based materials through several synthesis routes and investigated their mechanical properties,biocompatibility and degradation behavior through in vitro,in vivo and in silico studies.This paper is a comprehensive review that compiles,analyses and critically discusses the recent literature on the important aspects of Mg-based biomaterials. | Nurettin Sezer Zafer Evis Said Murat Kayhan Aydin Tahmasebifar Muammer Koça | 2018 | Journal of Magnesium and Alloys2018，6，1： | 38 |
| 2 | Gastrointestinal bezoars: A retrospective analysis of 34 cases显示文摘AIM: Bezoars (BZ) are the most common foreign bodies of gastrointestinal tract. Clinical manifestations vary depending on the location of BZ from no symptoms to acute abdominal syndrome. When located in small bowel, they frequently cause small bowel obstruction (SBO). We aimed to present our experience by reviewing literature.METHODS: Thirty-four patients with gastrointestinal BZ were presented. The data were collected from hospital records and analyzed retrospectively. Morbidity and mortality rates were statistically analyzed between the subgroups according to SBO and endoscopic or surgical treatment modalities.RESULTS: The 34 patients had phytobezoars (PBZ). Two patients with mental retardation and trichotillomania had trichobezoars (TBZ). More than half of them (55.88%) had previous gastric surgery. Also most of them had small bowel bezoars resulting in obstruction. Surgical and endoscopic morbidity rates were 32.14% and 14.28% respectively.The total morbidity rate of this study was 29.41%. Four patients in surgically treated group died. There was no death in endoscopically treated group. The total and surgical mortality rates were 11.76% and 14.28% respectively. The differences in morbidity and mortality rates between the subgroups were not statistically significant.CONCLUSION: BZ are commonly seen in stomach and small intestine. SBO is the most common complication.When uncomplicated, endoscopic or surgical removal can be applied easily. | Kenan Erzurumlu Zafer Malazgirt Ahmet Bektas Adem Dervisoglu Cafer Polat Gokhan Senyurek Ibrahim Yetim Kayhan Ozkan | 2005 | World Journal of Gastroenterology2005，11，12： | 33 |
| 3 | 帕罗西汀与达帕西汀的对比,治疗早泄的新的选择性5-羟色胺再摄取抑制剂显示文摘达帕西汀氢氯化物是一种选择性5-羟色胺再摄取抑制剂,也是第一种被批准可以按需服用治疗早泄的药物。本文目的为研究按需服用达帕西汀(30mg和H60mg)和每日服用帕罗西汀(20mg)对早泄的疗效。研究募集了150名患者进行了长达1个月的研究。患者被分成3组,每组50人。第一组按需服用达帕西汀30mg。第二组按需服用达帕西汀60mg。第三组每日服用帕罗西汀20mg。治疗结束后,我们的结果检测值相对于基准阴道内射精潜伏期(IELT)延长了。与基准IELT相比,帕罗西汀组、30mg达帕西汀组和60mg达帕西汀组的治疗后IELT分别延长了117%(P〈0.01),117%(P〈0.01)和170%(P〈0.01)。30mg达帕西汀组和帕罗西汀组的IELT增幅相同(P〉0.05),而60mg达帕西汀组的IELT增幅明显高于30mg达帕西汀组(P〈0.05和帕罗西汀组P〈0.01)。性交前1~3小时服用达帕西汀60mg是针对早泄的非常有效的治疗方法。然而,与当前普遍使用的帕罗西汀相比,达帕西汀30mg疗效并不显著。 | Abdulmuttalip Simsek Sinan Levent Kirecci Onur Kucuktopcu Faruk Ozgor Mehmet Fatih Akbulut Omer Sarilar Unsal Ozkuvanci Zafer Gokhan Gurbuz | 2014 | Asian Journal of Andrology2014，16，5： | 10 |
| 4 | Sol–gel derived Ta-containing TiO_2 films on surface roughened NiTi alloy显示文摘The surface of NiTi alloy was roughened by NaOH–HCl treatment, and the Ta-containing TiO2 films were coated on the pretreated NiTi alloy by the sol–gel method. Thermal analyses indicate that the evaporation temperature of the organics decreases with the addition of tantalum ethoxide in the TiO2 sol, but the crystallization temperature of anatase increases. The NaOH–HCl pretreatment improves the film integrity, but cracks still form in the films at high Ta contents(C20 %, molar ratio) owing to the increasing film thickness. X-ray diffraction(XRD) confirms that the addition of Ta suppresses the crystallization of anatase. X-ray photoelectron spectroscopy(XPS) reveals that Ta exists as Ta2 O5 in the film. With the increase of Ta content, the hydrophilic conversion of the films under UV illumination is impeded, but their corrosion resistance in 0.9 % NaCl solution increases, tested by the potentiodynamic polarization. The coating samples have acceptable hemolysis ratios for biomaterials(\5). The introduction of Ta improves the anti-aggregating function of the TiO2 film in the platelet adhesion test. | Bing-Hui Dong Feng Wu Zafer Alajmi Chen Zhang Tao Fu Yuan Ge | 2014 | Rare Metals2014，33，1： | 7 |
| 5 | Adipokines and ghrelin in gastric cancer cachexia显示文摘AIM:To investigate the roles of the adipocytokines,ghrelin and leptin in gastric cancer cachexia. METHODS:Resistin,ghrelin,leptin,adiponectin,insulin and insulin-like growth factor(IGF-Ⅰ),were measured in 30 healthy subjects,and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones,body mass index(BMI) loss ratio,age,gender,and Glasgow Prognostic Score(GPS) were investigated. RESULTS:Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients(P < 0.05). Ghrelin,resistin,leptin,adiponectin and IGF-Ⅰ,showed a significant correlation with BMI loss ratio and GPS(P < 0.05). A strong correlation was seen between GPS and BMI loss(R = -0.570,P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin,resistin,leptin and IGF-Ⅰ(P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION:These results showed that serum ghrelin,leptin,adiponectin,and IGF-Ⅰ play important roles in cachexia-related gastric cancers. No relationshipwas found between resistin and cancer cachexia. Also,because of the correlation between these parameters and GPS,these parameters might be used as a predictor factor. | Mustafa Kerem Zafer Ferahkose Utku Tonguc Yilmaz Hatice Pasaoglu Ebru Ofluoglu Abdulkadir Bedirli Bulent Salman Tevfik Tolga Sahin Murat Akin | 2008 | World Journal of Gastroenterology2008，14，23： | 4 |
| 6 | An independent prognostic factor for heart failure: sympathetic hyperactivity显示文摘 | Kardesoglu, Ejder Isilak, Zafer Uz, Omer Yiginer, Omer | 2011 | Chinese Medical Journal2011，，7： | 4 |
| 7 | Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite显示文摘Hydroxyapatite(HA) co-doped with Zn2+ tand F- ions was synthesized by precipitation method for the first time in this study.FTIR spectroscopy revealed Zn2+ tand F ions incorporation into HA structure.Co-doping of Zn2+ tand F- ions decreased unit cell volume of HA and decreased grain sizes.Zn2+ tor 5 mol% F addition into HA significantly improved its density.Microhardness was increased with Zn2+ taddition and further increase was detected with F co-doping.Zn2+ tand F co-doped samples had higher fracture toughness than pure HA.Zn2+ tincorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells,and further increase was observed with 1 mol%F addition.With superior mechanical properties and biological response 2Zn1 F is a good candidate for biomedical applications. | Idil Uysal Feride Severcan Aysen Tezcaner Zafer Evis | 2014 | Progress in Natural Science:Materials International2014，24，4： | 4 |
| 8 | Etiological role of brucellosis in autoimmune hepatitis显示文摘To show that brucellosis may trigger autoimmune hepatitis(AIH), in addition to nonspecific liver involvement and toxic hepatitis, due to a class effect of tetracycline family used for treatment. We present a female patient admitted to our hospital due to partially improved fatigue and elevated liver enzymes following doxycycline and streptomycin usage for brucellosis. Brucellosis is endemic in our country, Turkey. It may involve any organ in the body. Liver is frequently involved. Doxycycline used for treatment occasionally may lead to hepatotoxicity. AIH is a necroinflammatory disease of the liver. Certain drugs (e.g. Minocycline), toxins, and viruses (hepatitis B, hepatitis C, EBV, etc.) can trigger AIH. Only one case of AIH probably caused by doxycycline and brucellosis was reported. We discuss the relationship between brucellosis, AIH, and hepatotoxicity of doxycycline. Brucellosis may trigger AIH. | Colakoglu Onder Taskiran Bengur Adnan Kirci Tunakan Mine Buyrac Zafer Unsal Belkis Aksoz Kadir Yorukoglu Gazi | 2005 | World Journal of Gastroenterology2005，11，14： | 3 |
| 9 | Investigation and modeling of water quality of Goksu River (Cleadnos) in an international pro- tected area by using GIS显示文摘Gksu Delta is an important wetland where the Gksu River reaches to sea in the eastern of the town Tasucu-Ice1. The delta is classified as a Wetland of International Impor-tance according to the Ramsar Convention on Wetlands of International Importance. The amount of fertilizers used in this area was 7200 tons in 2006. These pollutants affect the surface and groundwater quality negatively. The intensively used fertilizers and pesticides contain not only N- and P compounds but also some heavy metals. The contents of all pol-lutants in surface waters were determined for four different seasons between 2006 and 2008 and with these data a Geographic Information System (GIS) has been constructed by using Map Info. From the photometric heavy metal analysis, it is inferred that the excess concen-tration of Fe, Ni, Mn, Mo and Cu at some locations is the cause of undesirable quality for drinking purposes. The source of excess concentration of various heavy metals is the agri-cultural activities and fertilizers. It is determined that in all periods between 2006 and 2008 the heavy metals and other pollutants in the fertilizers and pesticides transported easily to river water with irrigation return flow. The organic pollutants, including COD, BOD, NH3 and NO3 followed the sharply increasing trends from Silifke city to Mediterranean Sea. The water quality of Gksu River is modeled and determined that the waste water discharge of 10,700 m3/day from Silifke city does not create a serious problem because of the high amount of flow rate of Gksu River. | Zeynel DEMIREL Zafer OZER Olcay OZER | 2011 | Journal of Geographical Sciences2011，21，3： | 3 |
| 10 | 钽、铌、钛的表面特性与生物相容性显示文摘目的:筛选心血管支架材料。方法:考察Ta、Nb、Ti的表面特性、血液相容性和内皮化能力。结果:Ta表面平整,Nb、Ti表面较为粗糙;三者均表现出弱的疏水性和良好的耐蚀性。三种试样的溶血率均低于5%,Ta表面粘附的血小板较少。内皮细胞培养3天时,Ta表面的细胞增殖活性较好,而Nb表面的细胞生长较差。结论:Ta是一种良好的心血管支架材料。 | 吴锋 董兵辉 ALAJMI Zafer 付涛 | 2013 | 中国口腔种植学杂志2013，18，4： | 3 |
| 11 | 2D materials for conducting holes from grain boundaries in perovskite solar cells显示文摘Grain boundaries in organic-inorganic halide perovskite solar cells(PSCs)have been found to be detrimental to the photovoltaic performance of devices.Here,we develop a unique approach to overcome this problem by modifying the edges of perovskite grain boundaries with flakes of high-mobility two-dimensional(2D)materials via a convenient solution process.A synergistic effect between the 2D flakes and perovskite grain boundaries is observed for the first time,which can significantly enhance the performance of PSCs.We find that the 2D flakes can conduct holes from the grain boundaries to the hole transport layers in PSCs,thereby making hole channels in the grain boundaries of the devices.Hence,2D flakes with high carrier mobilities and short distances to grain boundaries can induce a more pronounced performance enhancement of the devices.This work presents a cost-effective strategy for improving the performance of PSCs by using high-mobility 2D materials. | Peng You Guanqi Tang Jiupeng Cao Dong Shen Tsz-Wai Ng Zafer Hawash Naixiang Wang Chun-Ki Liu Wei Lu Qidong Tai Yabing Qi Chun-Sing Lee Feng Yan | 2021 | Light(Science & Applications)2021，10，4： | 3 |
| 12 | 高超音速双楔形升力面的主动热气动弹性控制问题的研究(英文)显示文摘非线性热弹性和气动不稳定性问题在再入大气层运载工具和高超音速飞行器上都是极为重要的问题,应该在飞行器的设计阶段给予特别的重视。尤其是热力学问题更为重要,因为温度环境的变化可对高超音速飞行器结构的静力学与动力学特性产生显著影响,进而导致动力学不稳定乃至于灾难性的结构疲劳破坏。为了深入理解这类'热'结构的动力学行为,本文分析一种双楔形升力面,该升力面在沉浮和俯仰两个自由度方向都有自由间隙与三次非线性结构刚度。三阶空气动力学活塞理论被用来计算施加于升力面上的非线性非定常气动载荷。还考虑了由于升力面气动加热产生的轴向应力所导致的扭转刚度的损失。根据高速气流产生的隔热层温度可以预估气动加热的影响。主动控制是今年来兴起的主要用于航空宇航结构系统的新技术,为了抑制颤振边界上和颤振后的动力响应,我们采用了线性和非线性主动控制策略,给出了建模方法及其仿真结果。值得强调的是,当扭转刚度损失较大时有可能引发升力面的动力学不稳定状态。此外,主动控制策略还可以拓展颤振边界,并且能将不稳定极限环振动转变为稳定极限环振动,或者可以将这两种状态的转捩点推向更高的马赫数。 | Laith K Abbas 陈前 Piergiovanni Marzocca Gürdal Zafer Abdalla Mostafa | 2008 | Chinese Journal of Aeronautics2008，21，1： | 3 |
| 13 | Reaching proficiency in laparoscopic splenectomy显示文摘AIM:To investigate the proficiency level reached in laparoscopic splenectomy using the learning curve method.METHODS:All patients in need of splenectomy for benign causes in whom laparoscopic splenectomy was attempted by a single surgeon during a time period of 6 years were included in the study (n=33). Besides demographics, operation-related variables and the response to surgery were recorded. The patients were allocated to groups of five, ranked according to the date of the operation. Operation duration, complications, postoperative length of stay, conversion to laparotomy and splenic weight were then compared between these groups.RESULTS: There was a significant difference regarding operation times between the groups (P = 0.001). An improvement was observed after the first 5 cases. The learning curve was flat up to the 25th case. Following the 25th case the operation times decreased still further. There was no difference between the groups regarding the other parameters.CONCLUSION: Unlike the widely accepted 'L' shape, the learning curve for laparoscopic splenectomy is a horizontal lazy 'S' with two distinct slopes. Privileges may be granted after the first 5 cases. However proficiency seems to require 25 cases. | Tarik Zafer Nursal Ali Ezer Sedat Belli Alper Parlakgumus Kenan Caliskan Turgut Noyan | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 14 | Characteristics of sildenafil erections in healthy young men显示文摘瞄准:在夜的阴茎勃起以后决定 sildenafil 柠檬酸盐的效果(即发作,勃起的持续时间,和在第一和第二勃起之间的间隔的时间) 健康年轻男人。方法:22 个有势力男人, 23-29 岁,为学习被招募。所有题目用监视设备的 RigiScan 在连续夜里完成了三个会议(Dacomed,明尼阿波利斯,美国) 。在改编的第一夜里以后,夜里 2 记录是他们的基线价值,并且在夜里 3 上,他们收到了 sildenafil 柠檬酸盐的 100 mg。统计比较在第二和第三个夜里数据之间被做。结果:有 sildenafil 柠檬酸盐的第一勃起的发作的吝啬的时间是(34+/-18 ) min,而它是(74+/-24 ) 没有 sildenafil 的 min (P 0.0001 ) 柠檬酸盐。在 sildenafil 柠檬酸盐药以后在开始的 5 h 期间观察的勃起的数字是与没有药(P=0.001 ) 的 2.4+/-0.5 相对照的 3.6+/-0.5。在第一和第二勃起之间的间隔与 sildenafil 柠檬酸盐是更短的:(52+/-26 ) min 对(85+/-34 ) min (P = 0.01 ) 。最后勃起的持续时间是统计上与 sildenafil 柠檬酸盐显著地更长:(64 +/-33 ) min 对(42 +/-28 ) min (P 0.001 ) 。结论:健康年轻男人比 1 h 间隔由制造商求婚在 sildenafil 柠檬酸盐管理以后在 34 min 以内完成了勃起,它短。在第一和第二勃起之间的间隔更短,最后夜的勃起的持续时间更长。 | Onder Yaman Zafer Tokatli Murat Akand Atilla H. Elhan Kadri Anafarta | 2005 | Asian Journal of Andrology2005，7，4： | 2 |
| 15 | Effect of 1%brinzolamide and 0.5%timolol fixed combination on intraocular pressure after cataract surgery with phacoemulsification显示文摘AIM:To evaluate the effect of brinzolamide-timolol fixed combination on intraocular pressure(IOP)after cataract surgery.METHODS:The study included 92 eyes of 87 patients who underwent cataract surgery and intraocular lens implantation.Patients scheduled for phacoemulsification were assigned to 1 of 2 groups.The treatment group received 1 drop of brinzolamide-timolol fixed combination immediately after surgery,and the control group received no treatment.The IOP was measured preoperatively and at 2h and 24h postoperatively.RESULTS:The mean IOP change was lower in the treatment group than in the control group at 2h postoperatively.The difference between the mean IOP values of the two groups at 2h postoperatively was found to be statistically significant.Twenty-four hours after the surgery,the mean IOP change was still higher in the control group when compared to the treatment group.CONCLUSION:The fixed combination brinzolamidetimolol can effectively reduce IOP after cataract surgery. | Kemal rnek Nesrin Byktortop Nurgl rnek Reyhan Ogurel Inci Elif Erbahceci Zafer Onaran | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 2 |
| 16 | 结构非线性屈曲分析的有限元降阶方法显示文摘基于Koiter的初始后屈曲理论以及Newton法的增量迭代技术,提出了一种能够自动跟踪非线性平衡路径的降阶方法.降阶模型中摄动载荷以及主路径上变形位移的引入使摄动展开能够在平衡路径上的任意一点处进行;在每个摄动步中将求解降阶模型得到的非线性解作为结构响应的初始预测,然后采用有限元模型计算的残余力对解进行修正,最后以修正后的解作为下一个摄动步的已知展开点,并通过更新降阶模型来反映当前结构刚度的变化.算例分析表明,该方法不仅具有很高的非线性分析精度,而且需要计算的线性方程组(阶数与有限元全模型阶数相当)的数目远小于常规的非线性有限单元法. | 梁珂 孙秦 Zafer Gurdal | 2013 | 华南理工大学学报(自然科学版)2013，41，2： | 2 |
| 17 | Synthesis and characterization of salt-impregnated anodic aluminum oxide composites for low-grade heat storage显示文摘Thermochemical heat storage(THS)systems have recently attracted a lot of attention in research and development.In this study,an anodic aluminum oxide(AAO)template,fabricated by a two-step anodization method,was used for the first time as the matrix material for a THS system.Different salts were studied as thermochemical materials for their suitability in low-grade heat storage application driven by solar energy for an open system.Compositions were prepared by absorbing CaCl2,MgCl2,LiCl,LiNO3 and mixtures of these salts under a vacuum in an AAO matrix.Field Emission Scanning Electron Microscopy was used to examine the morphology of the produced AAO composites.Thermal energy storage capacities of the composites were characterized using a differential scanning calorimeter.Characterization analysis showed that anodized Al plates were suitable matrix materials for THS systems,and composite sorbent prepared with a 1:1 ratio LiCl/LiNO3 salt mixture had the highest energy value among all composites,with an energy density of 468.1 k J·kg-1. | Bengisu Yilmaz Behiye Yüksel Gökhan Orhan Devrim Aydin Zafer Utlu | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，1： | 2 |
| 18 | Effects of chronic ethanol consumption on rat upper gastrointestinal system: Functional and histologic findings显示文摘 | Yusufhan Yazir Melih Tugay Zafer Utkan Tijen Utkan | 2012 | Alcohol2012，，7： | 2 |
| 19 | The effect of metoclopramide on gastric emptying in traumatic brain injury显示文摘 | Tarik Zafer Nursal Bulent Erdogan Turgut Noyan Melih Cekinmez Betul Atalay Nevzat Bilgin | 2005 | Journal of Clinical Neuroscience2005，，4： | 2 |
| 20 | Safety of hydroimplantation in cataract surgery in patients with pseudoexfoliation syndrome显示文摘AIM:To evaluate the safety of hydroimplantation in cataract surgery in patients with pseudoexfoliation syndrome.METHODS:This prospective randomized study comprised 100 eyes of 100 consecutive patients who underwent cataract surgery and implantation of foldable intraocular lens(IOL). Each eye was assigned to group 1 or group 2. Hydroimplantation without using viscoelastic agent as group 1(n=50), and hydroxypropylmethylcellulose(Eyevisc, Biotech, India) was used in group 2(n=50). RESULTS:There were no statistically significant differences in central corneal thickness(CCT) and corneal endothelial cell count(ECC) between both groups at each visit and percentage change in CCT and ECC(P>0.05). The mean intraocular pressure(IOP) at postoperative 5h increased statistically significantly in group 2(P<0.001). There was no statistically significant difference in IOP between two groups, before and after surgery excluding the 24 h postoperative IOP, but patients in group 2 had higher IOP than that in the group 1 at 24 h after surgery(P=0.035). No case in either group experienced posterior capsular rupture, or zonular dialysis. Fixation of the globe during IOL implantation was better in group 1 than that in group 2.CONCLUSION:Hydroimplantation has advantages in terms of IOP changes and duration of the surgery and seems to be safe in patients with pseudoexfoliation syndrome. | Tevfik Ogurel Reyhan Ogurel Zafer Onaran Kemal Ornek | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 2 |
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