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| 1 | Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome显示文摘AIM:To investigate the correlations between selfreported symptoms of irritable bowel syndrome(IBS) and the gastrointestinal(GI) microbiota composition.METHODS:Fecal samples were collected from a total of 44 subjects diagnosed with IBS.Their symptoms were monitored with a validated inflammatory bowel disease questionnaire adjusted for IBS patients.Thirteen quantitative real-time polymerase chain reaction assays were applied to evaluate the GI microbiota composition.Eubacteria and GI bacterial genera(Bifidobacterium,Lactobacillus and Veillonella),groups(Clostridium coccoides/Eubacterium rectale,Desulfovibrio desulfuricans) and distinct bacterial phylotypes [closest 16S rDNA sequence resemblance to species Bifidobacterium catenulatum,Clostridium cocleatum,Collinsella aerofaciens(C.aerofaciens),Coprococcus eutactus(C.eutactus),Ruminococcus torques and Streptococcus bovis ] with a suspected association with IBS were quantified.Correlations between quantities or presence/absence data of selected bacterial groups or phylotypes and various IBSrelated symptoms were investigated.RESULTS:Associations were observed between subjects' self-reported symptoms and the presence or quantities of certain GI bacteria.A Ruminococcus torques(R.torques)-like(94% similarity in 16S rRNA gene sequence) phylotype was associated with severity of bowel symptoms.Furthermore,among IBS subjects with R.torques 94% detected,the amounts of C.cocleatum 88%,C.aerofaciens-like and C.eutactus 97% phylotypes were significantly reduced.Interesting observations were also made concerning the effect of a subject's weight on GI microbiota with regard to C.aerofaciens like phylotype,Bifidobacterium spp.and Lactobacillus spp.CONCLUSION:Bacteria seemingly affecting the symptom scores are unlikely to be the underlying cause or cure of IBS,but they may serve as biomarkers of the condition. | Erja Malinen Lotta Krogius-Kurikka Janne Nikkil Airi Palva Anna Lyra Anne Jskelinen Teemu Rinttil Terttu Vilpponen-Salmela Atte Johannes von Wright | 2010 | World Journal of Gastroenterology2010，16，36： | 13 |
| 2 | 脉搏波传导速度预测青年人血压进展与高血压发生显示文摘该研究旨在评估脉搏波传导速度(pulse wave velocity,PWV)是否能够预测青年人血压进展及高血压的发生,并探讨除传统心血管病危险因素外,PWV是否可改善高血压发生的风险预测。Koivistoinen等于2007年及2011年分别测量1449例芬兰成人(年龄30~45岁)的收缩压及舒张压水平。此外,于2007年还测定了其PWV及其他心血管病危险因素。 | Koivistoinen T Lyytik?inen LP Aatola H Luukkaala T Juonala M Viikari J Lehtim?ki T Raitakari OT K?h?nen M Hutri-K?h?nen N 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，1： | 12 |
| 3 | Impact of preoperative chemoradiotherapy on survival in patients with resectable pancreatic cancer显示文摘AIM:To explore whether preoperative chemoradiation therapy improves survival of patients with pancreatic cancer undergoing resectional surgery. METHODS:Forty-seven patients with a malignant pancreatic tumor localized in the head or uncinate process of the pancreas underwent radical pancreaticoduodenectomy. Twenty-two received chemoradiation therapy (gemcitabine and radiation dose 50.4 Gy) before surgery (CRR) and 25 patients underwent surgery only (RO). The study was non-randomised. Patients were identified from a prospective database. RESULTS:The median survival time was 30.2 mo in the CRR group and 35.9 mo in the RO group. No statistically significant differences were found in subclasses according to lymph node involvement,TNM stages,tumor size,or perineural invasion. The one,three and five year survival rates were 81%,33% and 33%,respectively,in the CRR group and 72%,47% and 23%,respectively,in the RO group. In ductal adenocarcinoma,the median survival time was 27 mo in the CRR group and 20 mo in the RO group. No statistically significant differences were found in the above subclasses. The one,three and five year survival rates were 79%,21% and 21%,respectively,in the CRR group and 64%,50% and 14%,respectively,in the RO group. The overall hospital mortality rate was 2%. The morbidity rate was 45% in the CRR group and 32% (NS) in the RO group. CONCLUSION:Major multicenter randomized studies are needed to conclusively assess the impact of neoadjuvant treatment in the management of pancreatic cancer. | Plvi Vento Harri Mustonen Timo Joensuu Pivi Krkkinen Eero Kivilaakso Tuula Kiviluoto | 2007 | World Journal of Gastroenterology2007，13，21： | 8 |
| 4 | Low circulating levels of gastrin-17 in patients with Barrett's esophagus显示文摘AIM: To examine whether the fasting levels of serum gastrin-17 (G-17) are lower in Barrett's esophagus (BE)patients than in non-Barrett controls.METHODS: Nineteen patients with BE (presenting with a tubular segment ≥2 cm long in lower esophagus and intestinal metaplasia of incomplete type ('specialized columnar epithelium') in endoscopic biopsies from the tubular segment below the squamocolumnar junction were collected prospectively from outpatients referred to diagnostic gastroscopy. The controls comprised 199 prospectively collected dyspeptic outpatients without BE or any endoscopically visible lesions in the upper GI tract.Fasting levels of serum G-17 (G-17fast) were assayed with an EIA test using a Mab highly specific to amidated G-17. None of the patients and controls received therapy with PPIs or other antisecretory agents.RESULTS: The mean and median levels of G-17fast in serum were significantly lower (P = 0.001) in BE patients than in controls. The positive likelihood ratios (LR+) of low G-17fast to predict BE in the whole study population at G-17fast levels <0.5, <1, or <1.5 pmol/L were 3.5, 3.0,and 2.8, respectively. Among patients and controls with healthy stomach mucosa, the LR+ were 5.6, 3.8, and 2.6,respectively. In the whole study population, serum G-17 was below 2 pmol/L in 15 of 19 BE patients (79%). The corresponding prevalence was 66 of 199 (33%) in controls (P<0.001). The G-17fast was 5 pmol/L or more in only one of the 19 BE patients (5%). In controls, 76 of the 199 patients (38%) had such high serum G-17fast levels (P<0.01).CONCLUSION: Serum levels of G-17fast tend to be lower in native patients with BE than in healthy controls. | Pentti Sipponen Matti Vauhkonen Timo Helske Ilpo Kriinen Matti Hrknen | 2005 | World Journal of Gastroenterology2005，11，38： | 6 |
| 5 | 时间分辨荧光免疫分析方法检测烟草中菌核净残留显示文摘建立了简便、灵敏地检测烟草中菌核净残留的时间分辨荧光免疫分析方法(TRFIA),及配套的无净化的快速前处理技术。采用镧系元素螯合物Eu-N1标记亲和纯化后的羊抗兔IgG示踪抗体。采用间接竞争TRFIA法建立了菌核净标准抑制曲线,方法的检出限I10为2.0μg/L;抑制终浓度I50为32.00μg/L;检测线性范围为4~128μg/L。考察了丙酮提取后33%,10%和1%的烟草基质对菌核净-TRFIA分析方法的影响,表明在1%烟叶基质条件下,建立的菌核净的抑制曲线的线性范围与标准抑制曲线趋于平行,确定烟草样品的前处理稀释倍数为100倍,计算得到基质影响因子(Im)为17.1。对烟叶样品中添加1,7和24mg/L的菌核净标样,连续3d的添加回收实验表明,方法的回收率为73%~128%,相对标准标准偏差(RSD)在4.3%~13.2%之间;烟草中菌核净的实际最低检出限为1mg/L。本方法可望用于烟草中菌核净残留的快速筛选检测。 | 刘媛 刘蓉蓉 刘贤金 方敦煌 宋春满 Huovinen Tuomas Vehniinen Markus Lvgren Timo | 2012 | 分析化学2012，40，7： | 6 |
| 6 | A comparative study of texture measures with classification based on featured distributions显示文摘 | Timo Ojala Matti Pietik?inen David Harwood | 1996 | Pattern Recognition1996，，1： | 4 |
| 7 | Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist显示文摘 | Sama I. Sayin Annika Wahlstr?m Jenny Felin Sirkku J?ntti Hanns-Ulrich Marschall Krister Bamberg Bo Angelin Tuulia Hy?tyl?inen Matej Ore?i? Fredrik B?ckhed | 2013 | Cell Metabolism2013，，2： | 3 |
| 8 | 为满足芬兰暴雨管控需要进行的缝隙透水路面水文模拟实验显示文摘芬兰开始对透水路面进行水文性能研究,是因为政府市政管理者对城市暴雨管理有一个分项计划——需要提出城市雨水的全新技术解决方案,故在2012~2014年度"全天候路面"研究项目中,对透水路面开展了专门的水文模拟试验研究。该项目由TEKES(针对技术和创新领域的芬兰国家投资机构)资助,具体合作承担该研究项目的 16家单位,含盖了市政管理者、建筑材料生产商、暴雨管控设计师、行业协会和芬兰国家技术研究中心(VTT)有限公司等,基本覆盖了与城市雨水管理相关的部门(和单位)。本研究项目还与瑞典由CBI(编辑注:应是瑞典水泥与混凝土研究院的瑞典文缩写)和24家合作伙伴承担的"绿色—灰色"研究项目(英文"Green-Grey",应是水泥混凝土生产二氧化碳减排技术方面的研究)进行了协作。气象报告显示,芬兰会遭受较大体量的降雨和较大强度的暴雨。人类社会正致力于拥有更好的环境保护和产生更少污染物的地表径流水,这两个问题都是开展本项目研究工作出发点。混凝土路面砖和路基材料层结合形成的透水路面(PBP),在芬兰还没有得到应用,是由于缺乏成熟的技术。本项目是在VTT实验室内进行雨水过滤仿真模拟(FS-装置)试验,对路面结构的各层材料进行单独或叠合组成层状系统,进行雨水过滤性能的评估,以模拟路面结构设计方案。实验室试验的优点是能够在保持所有其它参数不变的情况下,对各个关键因素的影响进行评价。通过本项目的研究,期望获得关于不同块型路面砖和路基结构的渗透性能的基础数据,例如一些典型变量(路面砖接缝和开孔面积的比例、填缝砂子的颗粒级配、粘结型复合材料接缝)的影响;还包含对地表雨水含堵塞物及后期清理程度的影响研究。另外,或在今后的项目中,这些基础数据可被用作未来缝隙透水路面设计的参照数据,包括新型路面砖,路基的垫层、基层和底基层材料,填缝砂子粘合剂,一些再生材料的应用,路面坡度,等等对路面雨水径流的影响。 | Kalle Loimula Emma Niemelinen Hannele Kuosa 崔玉忠 | 2015 | 建筑砌块与砌块建筑2015，，6： | 3 |
| 9 | Infliximab in pediatric inflammatory bowel disease rapidly decreases fecal calprotectin levels显示文摘AIM: To study the response to infliximab in pediatric inflammatory bowel disease (IBD), as reflected in fecal calprotectin levels. METHODS: Thirty-six pediatric patients with IBD [23 Crohn's disease (CD), 13 ulcerative colitis (UC); median age 14 years] were treated with infliximab. Fecal calprotectin was measured at baseline, and 2 and 6 wk after therapy, and compared to blood inflammatory markers. Maintenance medication was unaltered until the third infusion but glucocorticoids were tapered off if the patient was doing well. RESULTS: At introduction of infliximab, median fecal calprotectin level was 1150 μg/g (range 54-6032 μg/g). By week 2, the fecal calprotectin level had declined to amedian 261 μg/g (P < 0.001). In 37% of the patients, fecal calprotectin was normal (< 100 μg/g) at 2 wk. By week 6, there was no additional improvement in the fecal calprotectin level (median 345 μg/g). In 22% of the patients, fecal calprotectin levels increased by week 6 to pretreatment levels or above, suggesting no response (or a loss of early response). Thus, in CD, the proportion of non-responsive patients by week 6 seemed lower, because only 9% showed no improvement in their fecal calprotectin level when compared to the respective figure of 46% of the UC patients (P < 0.05). CONCLUSION: When treated with infliximab, fecal calprotectin levels reflecting intestinal inflammation normalized rapidly in one third of pediatric patients suggesting complete mucosal healing. | Anssi Hmlinen Taina Sipponen Kaija-Leena Kolho | 2011 | World Journal of Gastroenterology2011，17，47： | 3 |
| 10 | Overlap Syndrome of Asthma and COPD Predicts Low Quality of Life显示文摘 | Paula Kauppi Henna Kupiainen Ari Lindqvist Lauri Tammilehto Maritta Kilpel? inen Vuokko L. Kinnula Tari Haahtela Tarja Laitinen | 2011 | Journal of Asthma2011，，3： | 2 |
| 11 | DNAemico-造纸厂不同生产条件下的经济分析报告系统显示文摘该系统是专门为纸厂研究的全厂范围内的经济指导软件系统。它定位于满足不同阶层管理人员在日常工作中对所需资料的准确提供 ,并确保能相互参考引用。在实际工作中 ,这些不同的原料消耗 (包括预计和和具体到单一批次产品生产 ) ,能够通过不同的组合方式和组成 ,以金融货币的方式表现出来。 | John Fogelholm 文向丰 Esa Hmlinen | 2003 | 黑龙江造纸2003，31，1： | 2 |
| 12 | 美卓C160系列颚式破碎机 确保Zinkgruvan锌矿平稳运行显示文摘Zinkgruvan锌矿,坐落于瑞典斯德哥尔摩西南约200km处,是北欧历史最悠久的地下矿山之一,于1857年投入运行。采矿方法为盘区回采和阶梯式开采。 | Eero Hmlinen | 2012 | 矿业装备2012，，2： | 2 |
| 13 | The Economic Value of Urban Forest Amenities:An Application of the Contingent Valuation Method显示文摘 | Tyrv(a)inen Liisa V(a)(a)n(a)nen Hannu | 1998 | Landscape and Urban Planning1998，43，： | 1 |
| 14 | Xylo-oligosaccharides enhance the growth of bifidobacteria and Bifidobacterium lactis in a simulated colon model显示文摘 | H. M?kel?inen S. Forssten M. Saarinen J. Stowell N. Rautonen A. C. Ouwehand | 2009 | Beneficial Microbes2009，，1： | 1 |
| 15 | Face description with local binary patterns:Application to face recognition显示文摘 | AHONEN T HADID A PIETIK(A)INEN M | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，12： | 1 |
| 16 | Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis 显示文摘 | Penttil M J skel inen E Hirvonen N | 2014 | The British Journal of Psychiatry2014，205，2： | 1 |
| 17 | 多囊卵巢综合征患者雄激素受体CAG基因长度多态性 | Jskelinen J Korhonen S Voutilainen R 李跃萍 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，10： | 1 |
| 18 | The Amenity Value of the Urban Forest:An Application of the Hedonic Pricing Method显示文摘 | Tyrv(a)inen Liisa | 1997 | Landscape and Urban Planning1997，37，： | 1 |
| 19 | A comparative study of texture measures with classification based on featured distributions显示文摘 | Ojala T Pietik?inen M Harwood D | 1996 | Pattern Recognition1996，29，1： | 1 |
| 20 | Multiresolution gray-scale and rotation invariant texture classification with local binary patterns显示文摘 | Ojala T Pietik?inen M M?enp??T | 2002 | IEEE Transactions on Pattern Analysis&Machine Intelligence2002，24，7： | 1 |
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