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| 1 | 等渗性碘克沙醇与非离子型低渗性对比剂的肾毒性比较:随机对照试验的Meta分析显示文摘目的 比较随机临床试验中等渗性碘克沙醇与非离子型低渗性对比剂(LOCM)的肾毒性。方法 本Meta分析系统地检索了MEDLINE、EMBASE、BIOSIS、Web of Science、ISI知网、Medizin近期期刊报道、Cochrane图书馆(截至2007年8月)、有关试验记录、会议记录及文献列表中的研究,也向所有的对比剂制造商咨询了未能检索到的研究。 | M.C.Heinrich L.Hberle V.Müller W.Bautz M.Uder 蒋涛 | 2009 | 国际医学放射学杂志2009，32，2： | 52 |
| 2 | The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle显示文摘Carbamoyl phosphate synthetase 1(CPS1) deficiency(CPS1D) is an inborn error of the urea cycle having autosomal(2q34) recessive inheritance that can cause hyperammonemia and neonatal death or mental retardation. We analyzed the effects on CPS1 activity, kinetic parameters and enzyme stability of missense mutations reported in patients with CPS1 deficiency that map in the 20-k Da C-terminal domain of the enzyme. This domain turns on or off the enzyme depending on whether the essential allosteric activator of CPS1, N-acetylL-glutamate(NAG), is bound or is not bound to it. To carry out the present studies, we exploited a novel system that allows the expression in vitro and the purification of human CPS1, thus permitting site-directed mutagenesis. These studies have clarified disease causation by individual mutations, identifying functionally important residues, and revealing that a number of mutations decrease the affinity of the enzyme for NAG. Patients with NAG affinity-decreasing mutations might benefit from NAG site saturation therapy with N-carbamyl-Lglutamate(a registered drug, the analog of NAG). Our results, together with additional present and prior site-directed mutagenesis data for other residues mapping in this domain, suggest an NAG-triggered conformational change in the b4-a4 loop of the C-terminal domain of this enzyme. This change might be an early event in the NAG activation process. Molecular dynamics simulations that were restrained according to the observed effects of the mutations are consistent with this hypothesis, providing further backing for this structurally plausible signaling mechanism by which NAG could trigger urea cycle activation via CPS1. | Carmen Díez-Fernández José Gallego Johannes H?berle Javier Cervera Vicente Rubio | 2015 | Journal of Genetics and Genomics2015，42，5： | 7 |
| 3 | CONVERGENCE OF ADAPTIVE EDGE ELEMENT METHODS FOR THE 3D EDDY CURRENTS EQUATIONS显示文摘我们用一种剩余类型与可变系数为 3D 旋涡水流方程考虑一个适应的边有限元素方法(AEFEM ) 一个 posteriori 错误评估者。由于可变系数的出现,两个都,评估者和某些摆动术语的部件不得不在被适当体积标准照顾的适应循环以内适当地被控制。以精力的减小, discretization 错误并且摆动的标准被显示出的 AEFEM 的集中。数字结果被给说明 AEFEM 的表演。[从作者抽象] | R.H.W.Hoppe J.Schberl | 2009 | Journal of Computational Mathematics2009，27，5： | 5 |
| 4 | Adaptive changes of the rat liver cells induced by repeated intraperitoneal injections of d-galactosamine显示文摘 | Hideaki Enzan Brigitte H?berle Karin Meinhardt Christian Schuchhardt Herbert K. Koch Rainer Lesch | 1978 | Virchows Archiv B Cell Pathology1978，，1： | 2 |
| 5 | Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma显示文摘 | Verena K?berle Bernd Kronenberger Thomas Pleli J?rg Trojan Esther Imelmann Jan Peveling-Oberhag Martin-Walter Welker Mohammed Elhendawy Stefan Zeuzem Albrecht Piiper Oliver Waidmann | 2013 | European Journal of Cancer2013，，： | 2 |
| 6 | Impact of achieved blood pressure on cardiovascular outcomes in the irbesartan diabetic nephropathy trial显示文摘 | Berl T Hunsicker LG Lewis JB | 2005 | J Am Soc Nephrol2005，16，7： | 1 |
| 7 | Angiotensin-converting enzyme ihibitors versus AT1 receptor antagonist in cardiovascular and renal protection:the case for AT1 receptor antagonist显示文摘 | Berl T | 2004 | Amsoc Nephrol2004，15，1： | 1 |
| 8 | Prediction of the disposi- tion of midazolam in surgical patients by a physiologically based phar- macokinetics model显示文摘 | Bjtirkman S Wada DR Berling BM | 2001 | J Pharm Sci2001，90，： | 1 |
| 9 | An improved synthesis of the 'miracle nutrient'coenzyme Q10显示文摘 | Lipshutz BH Lower A Berl V | 2005 | Organic Letters2005，7，19： | 1 |
| 10 | Vasopressin antagonists in the treatment of waterretaining disorders显示文摘 | Kumar S Berl T | | 0，，03： | 1 |
| 11 | Corporate Powers as Powers in trust显示文摘 | Adolf Augustus Berle Jr | 1931 | Harvard Law Review1931，，： | 1 |
| 12 | 查看详情显示文摘 | Gindl W Sch(o)berl T Jeronimidis G | | 0，，04： | 1 |
| 13 | Prediction of the disposition of midazolam in surgecal patients by a physiologically based pharmacokinetics model显示文摘 | Bjorkman S Wada DR Berling BM | 2001 | J Pharm Sci2001，90，9： | 1 |
| 14 | Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer显示文摘 | Eugen Ruckh(a)berle Achim Rody | 2008 | Breast Cancer Res Treat2008，112，： | 1 |
| 15 | Narrative abilities of children with epilepsy显示文摘 | Strekas A Ratner NB Berl M | 2013 | Int J Lang Commun Disord2013，48，2： | 1 |
| 16 | Failure modes in the maritime transportation system: a functional approach to throughput vulnerability显示文摘 | ?yvind Berle JamesB. Rice Jr. Bj?rnEgil Asbj?rnslett | 2011 | Maritime Policy & Management2011，，6： | 1 |
| 17 | Response patterns in adult forest trees to chronic ozone stress:identification of variations and consistencies显示文摘 | Nunn A J Reiter I M H?berle K H | 2005 | Environmental Pollution2005，136，： | 1 |
| 18 | The Modem Corporation and Private Property显示文摘 | G Means | 1932 | Harcour Brace and World New York1932，，58： | 1 |
| 19 | Estimating “autotrophic” belowground respiration in spruce and beech forests: decreases following girdling显示文摘 | Christian P. Andersen Ivan Nikolov Petia Nikolova Rainer Matyssek Karl-Heinz H?berle | 2005 | European Journal of Forest Research2005，，3： | 1 |
| 20 | Matemal risk for newborn macrosomia,in cidence of a shoulder dystoeia and of damage of the plexus brachialis显示文摘 | Berle P Missel B Scharlau J | 2003 | Z Geburtshilfe Neonatol2003，207，4： | 1 |
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