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| 1 | Evodiamine induces extrinsic and intrinsic apoptosis of ovarian cancer cells via the mitogen-activated protein kinase/phosphatidylinositol-3-kinase/protein kinase B signaling pathways显示文摘OBJECTIVE: To explore the effects of evodiamine on ovarian cancer cells and the mechanisms underlying such effects.METHODS: Human ovarian cancer cells HO-8910 PM were treated with evodiamine at 0, 1.25,2.5, and 5 μM for 1-4 d. 3-(4,5-Dimethiylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was used to detect the growth inhibition rate of evodiamine-treated HO-8910 PM cells. The cell cycle was observed via propidium iodide(PI) staining. Apoptosis induction was assessed via Annexin V-fluorescein isothiocyanate/propidium iodide(Annexin V-FITC/PI) double staining assay. To verify the mechanism of apoptosis, caspase-dependent apoptotic pathway-related protein was detected by Western blot analysis. The expression levels of mitogen-activated protein kinase(MAPK)and/or phosphatidylinositol-3-kinase(PI3K)/pro-tein kinase B(Akt) pathway-related proteins were also investigated.RESULTS: Evodiamine significantly inhibited the proliferation of HO-8910 PM cells in a dose- and time-dependent manner. Evodiamine induced G2/M arrest with an increase of cyclin B1 level, and promoted cell apoptosis with a decrease of B cell lymphoma/lewkmia-2(Bcl-2) and an increase of Bcl-2-associated X protein(Bax) level. In addition,evodiamine treatment led to the activation of caspase-8, caspase-9, and caspase-3 and the cleavage of poly(ADP-ribose)-polymerase(PARP). Evodiamine targeted the MAPK and/or PI3K/Akt pathways by reducing the expression and activity of PI3 K, Akt, and extracellular signal-regulated kinase mitogen-activated protein kinase(ERK1/2 MAPK)and the activity of p38 MAPK.CONCLUSION: Evodiamine can inhibit the growth of ovarian cancer cells by G2/M arrest and intrinsic and extrinsic apoptosis. In addition, evodiamine-induced PI3K/Akt, ERK1/2 MAPK, and p38 MAPK signaling may be involved in cell death. | Wei Lijuan Jin Xiaoying Cao Zipei Li Wenlu | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 5 |
| 2 | Organogelators based on p-alkoxylbenzamide and their self-assembling properties显示文摘展示长烷基链的一系列 p-alkoxylbenzamides 被综合了并且是乐意地在许多器官的溶剂形成稳定的胶化。他们的自己组装性质和结构性质关系被扫描电子显微镜学调查, X 光检查衍射, 1 H 原子磁性的回声,和 Fourier 变换红外线的光谱学。形成的胶化对象温度和氟化物阴离子那样的环境刺激多应答。结果显示出那结合的氢的联合, - 叠并且在 p-alkoxylbenzamides 到的聚集的货车 der Waals 相互作用结果形成三尺寸的网络,取决于长烷基链的长度。 | Yan Zhai Wei Chai Wenwen Cao Zipei Sun Yaodong Huang | 2015 | Frontiers of Chemical Science and Engineering2015，9，4： | 3 |
| 3 | Preparation of an amphoteric flocculant having both high polymer content and low viscosity and its polymerization kinetics显示文摘It is not easy for liquid cationic flocculant diallyldimethyl-ammonium chloride(DM) homopolymer to simultaneously exhibit both low viscosity and high polymer content, which limited its application in offshore oilfield.In this paper, sodium allylsulfonate(XS) and sodium formate were used in the aqueous solution polymerization of DM.An amphoteric flocculant(PDMXS) with the properties of high polymer content(about 55 wt%) and low viscosity(efflux time measured by an Apply 4 viscometer was less than 100 s) was prepared.The optimum reaction conditions were identified as follows: the mass ratio of XS/DM was 10 wt%, the concentration of sodium formate was 2000 mg·L^(-1), reaction temperature was 55 ℃, the concentration of KPS was 0.5 wt% and the reaction time was 4 h.The polymerization kinetics was discussed.The results showed that R_p∝ [M]^(1.97)[I]^(0.68)[CTA]^(0.71) and the apparent activation energy was 72.55 kJ·mol^(-1). | Shenwen Fang Manlin Wang Zipei Xu Lei Zhai Xiujun Wang Yan Xiong | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 3 |
| 4 | 2,5-Dialkoxylphenyl-l,3,4-oxadiazoles as efficient organogelators and their self-assembling property显示文摘 | Zipei SUN Xuelin DONG Yan ZHAI Ziyan Li Yaodong HUANG | 2014 | Frontiers of Chemical Science and Engineering2014，8，2： | 2 |
| 5 | Characterization of stipe and cap powders of mushroom ( Lentinus edodes ) prepared by different grinding methods显示文摘 | Zipei Zhang Huige Song Zhen Peng Qingnan Luo Jian Ming Guahua Zhao | 2011 | Journal of Food Engineering2011，，3： | 2 |
| 6 | The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis显示文摘 | Xiaobin F Zipei L Shugno Z et a1 | 2009 | Med Hypotheses2009，72，4： | 1 |
| 7 | The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis显示文摘 | Xiaobin F Zipei L Shugno Z et a1 | 2009 | Med Hypotheses2009，72，4： | 1 |
| 8 | The pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis 显示文摘 | XIAOBIN F ZIPEI L SHUGUO Z | 2009 | Med Hypotheses2009，72，4： | 1 |
| 9 | The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis显示文摘 | Xiaobin F Zipei L Shuguo Z | 2009 | Med Hypotheses2009，72，4： | 1 |
| 10 | The Pringle manoeu-vre should be avoided in hepatectomy for cancer patientsdue to its side effects on tumor recurrence and worseprognosis显示文摘 | Xiaobin F Zipei L Shuguo Z | 2009 | Med Hypotheses2009，72，4： | 1 |
| 11 | The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis 显示文摘 | Xiaobin F Zipei L Shuguo Z | 2009 | Med Hypotheses2009，72，4： | 1 |
| 12 | The Pringle manoeuvre Should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis 显示文摘 | Xiaobin F Zipei L Shugno Z | 2009 | Med Hypotheses2009，72，4： | 1 |
| 13 | Achieving high thermoelectric performance through carrier concentration optimization and energy filtering in Cu_(3)SbSe_(4)-based materials显示文摘The previous works commonly adjust the carrier concentration through acceptor doping,but at the same time,the decrease of the Seebeck coefficient limits the further improvement of electrical properties in Cu_(3)SbSe_(4)-based materials.In this work,a microwave-assisted hydrothermal synthesis method was used to synthesize Cu_(3)SbSe_(4)/TiO_(2) hollow microspheres.Part of TiO_(2) participates in the reaction,replaces the Sb site of Cu_(3)SbSe_(4) to form holes,and the rest is dispersed in the matrix in the form of the second phase.The first-principles calculations reveal that the doping of Ti significantly changes the band structure and phonon spectrum,thereby regulating carrier concentration while increasing phonon scattering.In addition,experimental results show that the energy filtering effect generated by the extra-mixed TiO_(2) nano particles,which suppresses the decrease of Seebeck coefficient by acceptor doping.Consequently,the highest average power factor 897.5 mW m^(-1) K^(-2) and the zT peak value of 0.70 can be obtained in Cu_(3)SbSe_(4)/6%TiO_(2) sample at 298e623 K.This work provides a new sight to improve the thermoelectric properties in Cu_(3)SbSe_(4) through carrier concentration regulation and nano-phase composition. | Sitong Wei Boyi Wang Zipei Zhang Wenhao Li Lu Yu Shikai Wei Zhen Ji Weiyu Song Shuqi Zheng | 2022 | Journal of Materiomics2022，8，5： | 1 |
| 14 | Characterization of stipe and cap powders of mushroom (Lentinus edodes) prepared by different grinding methods 显示文摘 | Zhang Zipei Song Huige Peng Zhen | 2012 | Journal of Food Engineering2012，109，： | 1 |
| 15 | Characterization of stipe and cap powders of mushroom (Lentinus edodes) prepared by different grinding methods显示文摘 | ZHANG Zipei SONG Huige PENG Zhen | 2012 | Journal of Food Engineering2012，109，3： | 1 |
| 16 | Novel 1,2,3-triazole-based compounds: Iodo effect on their gelation behavior and cation response显示文摘有或没有 iodo 替换, 1,2,3-triazole 衍生物的二个新系列被综合,他们的冻结性质被测量。在 5 triazole 包围的位置的 iodo 替换能极大地提高冻结能力,这被发现。扫描电子显微镜学和 X 光检查衍射表明从 iodo 和氢的 gelators 的 organogels 的结构完全是不同的。而氢的胶化能对 Hg 2+ 和 Cu 2+ 作出回应, Iodo 胶化对 Hg 2+, 的刺激有选择地应答。而且,氢的胶化的可逆胶化大音阶的第五音转变能被氧化还原作用反应控制或与合适的化学药品调节了。参考化合物(C2 ) 的单个水晶分析建议有分子间并且 intramolecular 非古典的氢结合相互作用但是没有 - 在氢的 gelator 的相互作用。混合物的二个系列之间的大差别源于 iodo 效果并且在 iodo 混合物暗示卤素结合相互作用的存在。 | Yaodong Huang Shuxue Liu Zhuofeng Xie Zipei Sun Wei Chai Wei Jiang | 2018 | Frontiers of Chemical Science and Engineering2018，12，2： | 1 |
| 17 | LPS Increases MUC5AC by TACE/TGF- α /EGFR Pathway in Human Intrahepatic Biliary Epithelial Cell显示文摘 | Zipei Liu Feng Tian Xiaobin Feng Yu He Peng Jiang Jianwei Li Fei Guo Xin Zhao Hong Chang Shuguang Wang Dimitrios P. Bogdanos | 2013 | BioMed Research International2013，，： | 1 |
| 18 | The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis显示文摘 | Feng Xiaobin Liu Zipei Zheng Shuguo Dong Jiahong Li Xiaowu | 2009 | Medical Hypotheses2009，，4： | 1 |
| 19 | The Pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its side effects on tumor recurrence and worse prognosis 显示文摘 | Xiaobin F Zipei L Shuguo Z | 2009 | Med Hypotheses2009，72，4： | 1 |
| 20 | The pringle manoeuvre should be avoided in hepatectomy for cancer patients due to its aide effects on tumor recurrence and worse prognosis显示文摘 | Xiaobin F Zipei L Shuguo Z | 2009 | Med Hypotheses2009，72，4： | 1 |
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