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| 1 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis显示文摘AIM:To investigate the significance of Thrombospondin-1 (TSP-1) expression and its relationship with angiogenesis during experimental fibrosis. METHODS:Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN). The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS:Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis (GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P < 0.05). Moreover, TSP-1 expression was found to be correlated with angiogenesis (P < 0.05). CONCLUSION:The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 (TGF-β1), TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver. | Gülsüm zlem Elpek Güzide Ayse Gkhan Sevgi Bozova | 2008 | World Journal of Gastroenterology2008，14，14： | 7 |
| 2 | α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma显示文摘 | Jorge A. Marrero Ziding Feng Yinghui Wang Mindie H. Nguyen Alex S. Befeler Lewis R. Roberts K. Rajender Reddy Denise Harnois Josep M. Llovet Daniel Normolle Jackie Dalhgren David Chia Anna S. Lok Paul D. Wagner Sudhir Srivastava Myron Schwartz | 2009 | Gastroenterology2009，，1： | 3 |
| 3 | PlaD: A Transcriptomics Database for Plant Defense Responses to Pathogens, Providing New Insights into Plant Immune System显示文摘High-throughput transcriptomics technologies have been widely used to study plant transcriptional reprogramming during the process of plant defense responses, and a large quantity of gene expression data have been accumulated in public repositories. However, utilization of these data is often hampered by the lack of standard metadata annotation. In this study, we curated2444 public pathogenesis-related gene expression samples from the model plant Arabidopsis and three major crops(maize, rice, and wheat). We organized the data into a user-friendly database termed as PlaD. Currently, PlaD contains three key features. First, it provides large-scale curated data related to plant defense responses, including gene expression and gene functional annotation data.Second, it provides the visualization of condition-specific expression profiles. Third, it allows users to search co-regulated genes under the infections of various pathogens. Using PlaD, we conducted a large-scale transcriptome analysis to explore the global landscape of gene expression in the curated data. We found that only a small fraction of genes were differentially expressed under multipleconditions, which might be explained by their tendency of having more network connections and shorter network distances in gene networks. Collectively, we hope that PlaD can serve as an important and comprehensive knowledgebase to the community of plant sciences, providing insightful clues to better understand the molecular mechanisms underlying plant immune responses. PlaD is freely available at http://gffzzed113f2916314452hcn9uw09pf0vp69c0.ffgz.tsg.suse.edu.cn/plad/index.php or http://gffzz5f8709884ffc4e15hcn9uw09pf0vp69c0.ffgz.tsg.suse.edu.cn/plad/index.php. | Huan Qi Zhenhong Jiang Kang Zhang Shiping Yang Fei He Ziding Zhang | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 2 |
| 4 | Identification of osteopontin as a novel marker for early hepatocellular carcinoma显示文摘 | Sufen Shang Amelie Plymoth Shaokui Ge Ziding Feng Hugo R. Rosen Suleeporn Sangrajrang Pierre Hainaut Jorge A. Marrero Laura Beretta | 2012 | Hepatology2012，，2： | 2 |
| 5 | Active terahertz metamaterial devices显示文摘 | Chen Houtong Padilla W J Zide J M O | 2006 | Nature2006，444，11： | 1 |
| 6 | Reconstruction of superficial skin cancer defects of the nose显示文摘 | ZIDE M F | 2001 | J Oral Maxillofacial Surg2001，59，7： | 1 |
| 7 | Effect of pre-treatment of Luffa fibres on the structural porperties显示文摘 | GHALI L MSAHLI S ZIDE M | 2009 | Materials Letter2009，63，： | 1 |
| 8 | Active terahertz metamaterial devices 显示文摘 | Chan H T Padilla W J Zide J M O | 2006 | Nature2006，444，30： | 1 |
| 9 | Indications for open reduction of mandibular condyle fraeture显示文摘 | Zide MF Kent JN | 1983 | J Oral MaxiUofur surg1983，41，1： | 1 |
| 10 | Kinetic Study of Thermal inactivation for native and methoxypolyethylene glycol modified trypsin显示文摘 | Zhimin He Ziding Zhang Mingxia He | 2000 | Process Chemistry2000，35，10： | 1 |
| 11 | Active terahertz metamaterial devices显示文摘 | Chen H T Padilla W J Zide J M | 2006 | Nature2006，444，7119： | 1 |
| 12 | Active terahertz metamaterial devices 显示文摘 | Chen H T Padilla W J Zide J M O | 2006 | Nature2006，44，11： | 1 |
| 13 | Statin Use in Relation to Prostate Cancer Outcomes in a Population‐based Patient Cohort Study显示文摘 | Milan S. Geybels Jonathan L. Wright Sarah K. Holt Suzanne Kolb Ziding Feng Janet L. Stanford | 2013 | Prostate2013，，11： | 1 |
| 14 | Natural history of subclavian steal syndrome显示文摘 | Moran KT Zide RS Persson AV | 1998 | Am Surg1998，54，11： | 1 |
| 15 | A surgical system for thecorrection of bony chin deformity 显示文摘 | Mccarthy J G Ruff GL Zide MB | 1991 | Clin Plast Surg1991，18，： | 1 |
| 16 | Indications for open reduction of mandibular con- dyle fractures显示文摘 | Zide MF Kent JN | 1983 | J Oral Maxillofae Surg1983，41，2： | 1 |
| 17 | Optimal wound closure after tethered cord correction technical note 显示文摘 | Zide BM Epstein FJ Wisoff J | 1991 | J Neurosurg1991，74，4： | 1 |
| 18 | Oral the partial-thickness cross-lip flap for correction of postoncologic surgical defects显示文摘 | Zide MF Fuselier C | 2001 | Maxillofac Surg2001，59，： | 1 |
| 19 | Indications for open reduction of mandibular condylar fractures显示文摘 | ZIDE W F KENT J N | 1993 | J Oral Maxillofac Surg1993，41，： | 1 |
| 20 | Active terahertz metamaterial devices显示文摘 | Chen H T Padilla W J Zide J M O | 2006 | Nature2006，440，7119： | 1 |
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