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| 1 | Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with Clostridium perfringens显示文摘Background: Necrotic enteritis caused by Clostridium perfringens infection leads to serious economic losses in the global poultry production. In the present study, we investigated the protective effects of essential oils(EO, which contained 25 % thymol and 25 % carvacrol as active components) supplementation on growth performance, gut lesions, intestinal morphology, and immune responses of the broiler chickens infected with C. perfringens. A total of448 1-day-old male broiler chicks were allocated into eight treatment groups following a 4 × 2 factorial arrangement with four dietary EO dosages(0, 60, 120, or 240 mg/kg) and two infection status(with or without C. perfringens challenge from d 14 to 20).Results: The challenge did not impair the growth performance of birds, but induced gut lesions and increased crypt depth in the ileum(P ≤ 0.05). It also down-regulated the claudin-1 and occludin m RNA expression(P ≤ 0.05),up-regulated the m RNA expression of interleukin-1β(P ≤ 0.05), tended to increase the toll-like receptor(TLR)2 m RNA expression(P < 0.10) in the ileum, and enhanced the mucosal secretory Ig A production(P ≤ 0.05). In the challenged birds, dietary EO supplementation linearly alleviated the gut lesions and improved the ratio of vil us height to crypt depth(P ≤ 0.05), and the supplementation of 120 and 240 mg/kg EO increased the serum antibody titers against Newcastle disease virus(P ≤ 0.05). Regardless of challenge, the EO supplementation showed a tendency to linearly elevate the feed conversion efficiency between 14 and 28 d of age as well as the occludin m RNA expression(P < 0.10), and linearly inhibited the m RNA expression of TLR2 and tumor necrotic factor-α in the ileum(P ≤ 0.05).Conclusions: The dietary supplementation of EO could alleviate the intestinal injury by improving intestinal integrity and modulating immune responses in the C. perfringens-challenged broiler chickens. | Encun Du Weiwei Wang Liping Gan Zhui Li Shuangshuang Guo Yuming Guo | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 43 |
| 2 | Effects of Lactobacillus acidophilus on the growth performance and intestinal health of broilers challenged with Clostridium perfringens显示文摘Background: Clostridium perfringens is the main etiological agent of necrotic enteritis. Lactobacil i show beneficial effects on intestinal health in infectious disease, but the protective functions of lactobacil i in C. perfringens-infected chickens are scarcely described. This study examined the effects of Lactobacil us acidophilus(L. acidophilus) on the growth performance and intestinal health of broiler chickens chal enged with Clostridium perfringens(C. perfringens) over a 28-day period. Using a 2 × 2 factorial arrangement of treatments, a total of 308 1-day-old male Arbor Acres broiler chicks were included to investigate the effects of Lactobacil us acidophilus(L. acidophilus) on the growth performance and intestinal health of broiler chickens chal enged with Clostridium perfringens(C. perfringens) during a 28-day trial.Results: During infection(d 14–21), C. perfringens challenge decreased the average daily gain(P < 0.05), and increased feed conversion ratio and the mortality rate(P < 0.05). However, dietary supplementation with L. acidophilus increased the body weight of C. perfringens-infected broilers on d 21(P < 0.05), and tended to decrease the mortality(P = 0.061).C. perfringens challenge decreased the villus height(P < 0.05), the ratio of villus height to crypt depth(P < 0.05) and OCLN(occludin) m RNA expression(P < 0.05), and increased the pro-inflammatory cytokine expression in the spleen and jejunum, the intestinal populations of C. perfringens and Escherichia(P < 0.05), and the serum content of endotoxin(P < 0.05), regardless of L. acidophilus supplementation. In contrast, dietary L. acidophilus reducedthe intestinal lesion score of challenged broilers(P < 0.05), the m RNA expression of pro-inflammatory cytokines, ileal populations of Escherichia and serum endotoxin content(P < 0.05), but increased the intestinal Lactobacillus populations(P < 0.05),irrespective of C. perfringens challenge.Conclusion: Dietary addition of L. acidophilus could improve the intestinal health and reduce the mortality of broilers suffering from necrotic enteritis. | Zhui Li Weiwei Wang Dan Liu Yuming Guo | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 22 |
| 3 | Neuroimaging studies of self-reflection显示文摘This paper reviews some basic findings and methodological issues in neuroimaging studies of self-referential processing.As a general rule, making judgments about one's self, inclusive of personality trait adjectives or current mental states (person's preferences, norms, aesthetic values and feeling) uniformly generates medial prefrontal activations, regardless of stimulus materials (words or pictures) and modality ( visual or auditory). Cingulate activations are also observed in association with most self-referential processing.Methodological issues include treating self-referential processing as either representing one's own personality traits or representing one'sown current mental states. Finally, self-referential processing could be considered as implement of 'I think therefore I am' approach to neuroimaging the self. | ZHUYing | 2004 | Progress in Natural Science:Materials International2004，14，4： | 16 |
| 4 | In vitro antibacterial activity of thymol and carvacrol and their effects on broiler chickens challenged with Clostridium perfringens显示文摘Background:In the post-antibiotic era,essential oils(EO) are promising alternatives to growth-promoting antibiotics.The aim of the present study was to investigate the antibacterial activities of an EO product and its components thymol and carvacrol in vitro,and the efficacy of EO to control Clostridium perfringens challenge in broiler chickens.Results:The in vitro minimum inhibitory concentration assay showed strong antibacterial activity of the EO product,thymol,and carvacrol against pathogenic Escherichia coli,C.perfringens,and Salmonella strains,and weak activity towards beneficial Lactobacillus strains.Besides,an additive effect was observed between thymol and carvacrol.The in vivo study was carried out with 448 male broiler chicks following a 4 × 2 factorial arrangement to test the effects of EO supplementation(0,60,120,or 240 mg/kg EO in wheat-based diet),pathogen challenge(with or without oral gavage of C perfringens from day 14 to day 20) and their interactions.Each treatment consisted of eight replicate pens(seven birds/pen).The challenge led to macroscopic gut lesions,and resulted in a significant increase in ileal populations of C.perfringens and Escherichia subgroup(P< 0.05) on day 21.Dietary EO supplementation did not influence C perfringens numbers,but linearly alleviated intestinal lesions on day 21 and 28(P=0.010 and 0.036,respectively),and decreased Escherichia populations in ileum with increased EO dosages(P=0.027 and 0.071 for day 21 and 28,respectively).For caecum,EO quadratically influenced Lactobacillus populations on day 21(p=0.002),and linearly decreased the numbers of total bacteria and Escherichia on day 28(P=0.026 and 0.060,respectively).Mean thymol and carvacrol concentrations in the small intestine were 0.21 and 0.20 μg/g in intestinal digesta(wet weight),respectively,for birds fed 60 mg/kg EO,and 0.80 and 0.71 μg/g,respectively,for birds fed 240 mg/kg EO.Conclusions:These results indicated that dietary EO supplementation could affect intestinal microbiota and alleviate intestinal lesions in broilers,which may contribute in controlling C.perfringens infection in broiler chickens. | Encun Du Liping Gan Zhui Li Weiwei Wang Dan Liu Yuming Guo | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 14 |
| 5 | Effect of Yiqibushenhuoxue decoction on chronic obstructive pulmonary disease measured by St. George's respiratory disease questionnaire scores and forced expiratory volume显示文摘OBJECTIVE: To investigate the effects of Yiqibushenhuoxue decoction on stable chronic obstructive pulmonary disease(COPD) by observing its influences on patients' quality of life and airway inflammation.METHODS: Seventy patients with stable COPD were randomly divided into a treatment group(n=35) treated with Yiqibushenhuoxue decoction plus Seretide and a control group(n=35) treated with Seretide only.The dosage of Yiqibushenhuoxue decoction was 100 mL each time, twice a day, and the dosage of Seretide was salmeterol 50 μg/fluticasone 250 μg twice a day. Both groups were treated for 12 weeks. Before and after the treatment, St George's respiratory disease questionnaire(SGRQ)scores,forced expiratory volume,and forced expiratory volume in 1 second/forced vital capacity(FEV1/FVC)were measured.RESULTS:The SGRQ scores in both groups were significantly lower than those before treatment(P<0.05). After treatment, the total SGRQ scores and each subscore in the treatment group were significantly lower than those in the control group(P<0.05). The percentage of the predicted FEV1% and FEV1/FVC were higher in both groups, but no statistical differences were detected from before to after the treatment or between the two groups(P>0.05).CONCLUSION: Yiqibushenhuoxue decoction could significantly decrease the SGRQ scores in patients with stable COPD, which suggests that it is able to improve patient symptoms. | Jianqiu Liu Fengli Gao Zhuying Li | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 8 |
| 6 | Computed tomography in predicting smear-negative pulmonary tuberculosis in AIDS patients显示文摘 | FENG Feng SHIYu-xin XIAGan-lin ZHUYing LU Hong-zhou ZHANG Zhi-yong | 2013 | Chinese Medical Journal2013，，17： | 7 |
| 7 | Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)显示文摘The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the world.Diagnosis and treatment guidelines for clinicians caring for patients are needed.In the early stage,we have issued'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)';now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline.We formed a working group of clinical experts and methodologists.The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge management.We searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,Development and Evaluation(GRADE)approach.Recommendations were either strong or weak,or in the form of ungraded consensus-based statement.Finally,we issued 34 statements.Among them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based statement.They covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung transplantation,invasive or noninvasive ventilation,and extracorporeal membrane oxygenation(ECMO)),and discharge management(including discharge criteria and management plan in patients whose RT-PCR retesting shows SARS-CoV-2 positive after discharge).We also created two figures of these recommendations for the implementation purpose.We hope these recommendations can help support healthcare workers caring for COVID-19 patients. | Ying-Hui Jin Qing-Yuan Zhan Zhi-Yong Peng Xue-Qun Ren Xun-Tao Yin Lin Cai Yu-Feng Yuan Ji-Rong Yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-Rong Li Fu-Xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng Yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-Gang Zhang Wei Li Wen Chen Yue-Xian Shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang Yun-Yun Wang Shao-Fu Yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying Ren Li-Sha Luo Man-Ru Fan Di Huang Hong-Yang Xue Lin-Xin Yu Jin-Ping Gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang | 2020 | Military Medical Research2020，7，3： | 6 |
| 8 | Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough显示文摘Pediatric cough is a heterogeneous condition in terms of symptoms and the underlying disease mechanisms.Symptom phenotypes hold complicated interactions between each other to form an intricate network structure.This study aims to investigate whether the network structure of pediatric cough symptoms is associated with the prognosis and outcome of patients.A total of 384 cases were derived from the electronic medical records of a highly experienced traditional Chinese medicine (TCM) physician.The data were divided into two groups according to the therapeutic effect,namely,an invalid group (group A with 40 cases of poor efficacy) and a valid group (group B with 344 cases of good efficacy).Several well-established analysis methods,namely,statistical test,correlation analysis,and complex network analysis,were used to analyze the data.This study reports that symptom networks of patients with pediatric cough are related to the effectiveness of treatment: a dense network of symptoms is associated with great difficulty in treatment.Interventions with the most different symptoms in the symptom network may have improved therapeutic effects. | Mengxue Huang Jingjing Wang Runshun Zhang Zhuying Ni Xiaoying Liu Wenwen Liu Weilian Kong Yao Chen Tiantian Huang Guihua Li Dan Wei Jianzhong Liu Xuezhong Zhou | 2020 | Frontiers of Medicine2020，14，3： | 4 |
| 9 | Distribution and sources of polycyclic aromatic hydrocarbons in Wuhan section of the Yangtze River, China显示文摘 | Chenglian Feng Xinghui Xia Zhenyao Shen Zhui Zhou | 2007 | Environmental Monitoring and Assessment (-)2007，，1： | 2 |
| 10 | Laser micro-area analysis of^(40) Ar- ^(39) Ar isochron age for Fanshan superlarge alunite deposit, Zhejiang Province, China显示文摘Laser micro area analysis 40 Ar 39 Ar isochron dating for pure alunite is first reported. Micro area 40 Ar 39 Ar isochron dating results revealed that the metallogenetic epoch of Fanshan superlarge alunite deposit is 74.50 Ma, and this age is 10-20 Ma later than that of regional volcanic activity. Moreover, the potential application of micro area analysis 40 Ar 39 Ar isochron dating method in metallogenetic epoch studies for nonmetal deposits is also discussed. | REN Shengli 1, ZHOU Xinhua 1* , DAI Tongmo 2 and CHU Zhuying 1 1. Institute of Geology, Chinese Academy of Sciences, Beijing 100029, China 2. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China. * Correspo | 1998 | Chinese Science Bulletin1998，43，23： | 2 |
| 11 | Hierarchical mesoporous S,N-codoped carbon nanostructures composed of Co/Co-Cu-S/carbon nanoplate arrays on carbon nanofibers as a self-supported air cathode for long-lasting rechargeable Zn-air batteries显示文摘One of the primary roadblocks to widespread applications of rechargeable Zn-air batteries is the durability issue with oxygen reduction and evolution processes(ORR/OER)bifunctional electrocatalysts.We herein report the construction of a selfsupported air cathode for Zn-air batteries made of S,N-codoped porous complex carbon nanostructures of Co/Co-Cu-S/carbon nanoplate arrays and carbon nanofibers(denoted as Co/Co-Cu-S@SNPCP-CFs).The hierarchical heteroatom-doped mesoporous carbon nanohybrids with multiple active species not only provide a high surface-to-volume ratio,exposing more catalytic sites and accelerating the charge and mass transfer,but also boost the activity and durability.The Co/Co-Cu-S@SNPCP-CFs catalyst reveals a small potential gap(ΔE=0.67 V)between the half-wave potential of ORR and OER potential at 10 m A ccm^(-2),demonstrating outstanding bifunctional performance.Furthermore,the rechargeable Zn-air battery made with the as-obtained electrocatalyst exhibits a high-power density of 220 m W cm^(-2)and a long cycling time of over 800 h at 10 m A ccm^(-2),and the flexible solid-state rechargeable Zn-air battery based on Co/Co-Cu-S@SNPCP-CFs self-supporting air cathode also displays a long duration time of over 60 h. | XU ZhuYing YAN Lei SHEN JunLing YANG XiaoJing NING JiQiang ZHONG YiJun HU Yong | 2022 | Science China(Technological Sciences)2022，65，3： | 2 |
| 12 | Chinese expert consensus on the diagnosis and treatment of severely and critically ill patients with coronavirus disease 2019显示文摘The coronavirus disease 2019(COVID-19)threatens the health of humans worldwide,and at the time of this writing,there is no specifically targeted effective drug for COVID-19.The major initial symptoms of patients with COVID-19 are fever,dry cough,and fatigue,although some patients mainly experience vomiting,diarrhea,and other gastrointestinal symptoms.Other severe symptoms,namely chest tightness,dyspnea,and respiratory distress,usually appear one week later,with some patients rapidly developing acute respiratory distress syndrome(ARDS),septic shock,and possibly even death.A retrospective study of critically ill patients with COVID-19 has recently reported that 67.3%of patients presented with ARDS,28.9%with acute kidney injury,23.1%with heart injury,and 28.9%with abnormality in liver function.In addition,the 28-day mortality rate was up to 61.5%.[1] | Tong-Wen Sun Xi-Jing Zhang Zhui Yu You Shang | 2020 | Chinese Medical Journal2020，，24： | 2 |
| 13 | Isolation and Characterization of Recombinant Variable Domain of Heavy Chain Anti-idiotypic Antibodies Specific to Aflatoxin B_1显示文摘Some unique subclasses of Camelidae antibodies are devoid of the light chain,and the antigen binding site is comprised exclusively of the variable domain of the heavy chain(VHH).The recombinant VHHs have a high potential as alternative reagents for the next generation of immunoassay.In particular,they might be very useful for molecular mimicry.The present study demonstrated an alpaca immunized with the F(ab’)2fragment of anti-aflatoxin B1 mAb and developed an important anti-idiotypic(anti-Id)responses.Antigen-specific elution method was used for panning private anti-Id VHHs from the constructed alpaca VHH library.The selected VHHs were expressed,renatured,purified,and then identified by a competitive enzyme-linked immunosorbent assay(ELISA).Our findings indicated that the VHH would be an alternative tool for haptens mimicry studies. | WANG Dan XU Yang TU Zhui FU Jin Heng XIONG Yong Hua FENG Fan TAO Yong LEI Da | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 14 | MicroRNAs and their roles in osteoclast differentiation显示文摘Osteoclasts,which are derived from monocyte-macrophage precursors,are exclusive bone resorption cells.Limited evidence indicates that a class of small non-coding single-stranded RNAs known as“microRNAs”(miRNAs)is also involved in bone resorption.Although various miRNAs regulate cell proliferation and differentiation,few miRNAs have been reported to play a key role in the regulation of osteoclast differentiation.In this short review,the biology and functional mechanisms of miRNAs in osteoclastogenesis are summarized.The profiling,function,and target prediction of miRNAs are discussed as well. | Zhuying Xia Chao Chen Peng Chen Hui Xie Xianghang Luo | 2011 | Frontiers of Medicine2011，5，4： | 2 |
| 15 | Effect of thyroxine on munc-18 and syntaxin-1 expression in dorsal hippocampus of adult-onset hypothyroid rats显示文摘 | ZhuY NingD WangF etal | 2012 | Eur J Histochem2012，56，2： | 1 |
| 16 | FluorinemediatedphotocatalyticactivityofBiPO4显示文摘 | LiuY LvY ZhuY etal | 2014 | AppliedCatalysisB2014，147，5： | 1 |
| 17 | MelEnA cytes are patentialammunocompetant cells :evidence from recognition of immunalogical characteristics of cultured human melano-cyts显示文摘 | Lu Y Zhui WaY Ian G | 2002 | Pigment Cell Res2002，，15： | 1 |
| 18 | Permian volcanisml in the Mongo-lian orgenic zone, northeast China:geochemistry, magma sourcesand petrogenesis显示文摘 | ZhuY F Sun S H Gu L B | 2001 | Geological Magazine2001，138，： | 1 |
| 19 | DegradationandmineralizationmechanismofphenolbyBiPO4 photocatalysisassistedwithH2O2显示文摘 | LiuY ZhuY XuJ etal | 2013 | AppliedCatalysisB2013，，： | 1 |
| 20 | Graphene and graphene oxide : synthesis, properties, and applications 显示文摘 | ZhuY Murali S Cai W | 2010 | Advanced materials2010，22，35： | 1 |
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