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| 1 | Dihydro-stilbene gigantol relieves CCl4-induced hepatic oxidative stress and inflammation in mice via inhibiting C5b-9 formation in the liver显示文摘In general,anti-inflammatory treatment is considered for multiple liver diseases despite the etiology.But current drugs for alleviating liver inflammation have defects,making it necessary to develop more potent and safer drugs for liver injury.in this study,we screened a series of(dihydro-)stillene or(dihydro-)phenanthrene derivatives extracted from Pholidota chinensis for theirpotential biological activities.Among 31 compounds,the dihydro-stlbene gigantol exerted most potent protective effects onhuman hepatocytes against lithocholic acid toxicity,and exhibited solid antioxidative and anti-inflammatory effect in vitro.In micewith CCl-induced acute liver injury,pre-administration of gigantol(10,20,40 mg kg^-1·d^-1,po,for 7 days)dose-dependentydecreased serum transaminase levels and improved pathological changes in liver tissues.The elevated lipid peroxidation andinflammatory responses in the livers were also signifhcantly alleviated by gigantol.The pharmacokinetic studies showed thatgigantol was highly concentrated in the mouse lvers,which consisted with its efficacy in preventing liver injury.Using a label-freequantitative proteomic analysis we revealed that gigantol mainly regulated the immune system process in liver tissues of CCl4-treated mice,and the complement and coagulation cascades was the predominant pathway gigantol markedly inhibited theexpression of complement component C9,which was a key component for the formation of terminal complerment complex(TCC)C5b-9.These results were validated by immunohistochemistry(IHC) or real time-PCR.Confocal microscopy analysis showed thatgigantol significantly inhibited the vascular deposition of TCC in the liver.In conclusion,we demonstrate for the first time that oral administration of gigantol potently relieves liver oxidative stress and inflammation,possibly via a novel mechanism of inhibiting the C5b-9 formation in the liver. | Ya-ru Xue Sheng Yao Qian Liu Zhao-liang Peng Qiang-qiang Deng—Bo Liu Zheng-hua Ma Le Wangf Hu Zhou Yang Ye Guo-yu Pan | 2020 | Acta Pharmacologica Sinica2020，41，11： | 3 |
| 2 | Effect of thyroxine on munc-18 and syntaxin-1 expression in dorsal hippocampus of adult-onset hypothyroid rats显示文摘 | ZhuY NingD WangF etal | 2012 | Eur J Histochem2012，56，2： | 1 |
| 3 | Comparativestudyofdifferentproce-duresfortheseparationofperipheralbloodmononuclearcellsincytokine-inducedkillercellimmunotherapyforhepatocarcinoma显示文摘 | LiuH LiJ WangF etal | 2015 | TumourBiol2015，36，4： | 1 |
| 4 | Study of the In hibition Mechanism of Imidazoline Amide on CO2 Corrosion of Armcoiron 显示文摘 | ZHANGX WANGF HE Y etal | 2011 | Corr Sci2011，43，8： | 1 |
| 5 | Thermoelectricpropertiesofgraphenenanosheets-modifiedpolyanilinehybridnanocompositesbyaninsituchemicalpolymeriztion显示文摘 | LuY SongY WangF | 2012 | MaterialsChemistryandPhysics2012，138，1： | 1 |
| 6 | Optimization of dynamic economic dispatch with valve-point effect using chaotic sequence based differential evolution algorithms显示文摘 | HeDK DongG WangF L etal | 2011 | Energy Conversion and Management2011，52，2： | 1 |
| 7 | Loquatleafdregsofadecoctionofursolicacidextractionandseparation[J]显示文摘 | LIKQ WANGF ZHAOFN | | 安徽农业科学0，，： | 1 |
| 8 | Present status and management strategies of alien invasive plants in Guangdong Province[J]显示文摘 | WangF(王芳) WangRJ(王瑞江) ZhuangPD(庄平弟)etal | | 生物学杂志0，，： | 1 |
| 9 | The prevalence of dementia in urban and rural areas of China显示文摘 | JiaJ WangF WeiC | 2014 | Alzheimers Dement2014，10，： | 1 |
| 10 | DeterminationofcarvacrolandthymolinMoslachinensisbyHPLC显示文摘 | JiL(吉力) WangF(汪芳) LiuYY(刘元艳) | | 中国新药杂志0，，： | 1 |
| 11 | AnalysisonthedevelopmentandresearchoforphandrugsinChinabylearningfromeuropeanandAmericanexperiences[J]显示文摘 | WANGF MENGR MAJJ etal | 2012 | 医药前沿2012，2，8： | 1 |
| 12 | Downregulation of receptor for activated C-kinase1(RACK1)suppresses tumor growth by inhibiting tumor cell proliferation and tumorassociated angiogenesis显示文摘 | WANGF OSAWAT TSUCHIDAR etal | 2011 | Cancer Sci2011，102，11： | 1 |
| 13 | Immunohistochemical analysis of in vivo pathiens of expression of cpp-3222(caspase-3) a death protease显示文摘 | Krajew M Wangf HG Krajewskis | 1997 | Cancer Res1997，57，18： | 1 |
| 14 | Modeling commuting patterns in Chicago in a GIS envi-ronment: A job accessibility perspective显示文摘 | WangF | 2000 | The Professional Geog-rapher2000，52，1： | 1 |
| 15 | Risk factors for mortality in patients with Acinetobacter baumannii bloodstream infection with genotypic species identification显示文摘 | WANGF D CHOW L LIU C Y | 2008 | J Microbiol Immunol Infect2008，41，： | 1 |
| 16 | Inexact alterna- ting direction method for image recovery显示文摘 | MICHAELNG WANGF YUANX | 2011 | Siam Jour- nal on Scientific Computing2011，33，4： | 1 |
| 17 | Highly luminescent organosilane-functionalized carbon dots 显示文摘 | WangF XieZ ZhangH LiuCY ZhangYG | 2011 | Advanced Functional Materials2011，21，21： | 1 |
| 18 | Immunohistochemical analysis of in vivo pathiens of expression of cpp-3222(caspase-3) a death protease显示文摘 | Wangf HG Krajewskis | 1997 | Cancer Res1997，57，18： | 1 |
| 19 | Isolation and identification of fatty acid amides from Sheng!i coal显示文摘 | DINGMJ ZONGZM ZONGY OU-YANGXD HUANGYG ZHOUL WANGF CAOJP WEIXY | 2008 | Energy Fuels2008，22，4： | 1 |
| 20 | Investigation onbraking tribological properties of metro brake shoe materials 显示文摘 | W ANGW J WANGF GU K K | 2015 | W ear2015，，2015： | 1 |
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