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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland显示文摘Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland. | Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen | 2021 | Virologica Sinica2021，36，6： | 7 |
| 3 | A novel surface molecularly imprinted polymer as the solid-phase extraction adsorbent for the selective determination of ampicillin sodium in milk and blood samples显示文摘Surface molecularly imprinted polymers(SMIPs) for selective adsorption of ampicillin sodium were synthesized using surface molecular imprinting technique with silica gel as a support.The physical and morphological characteristics of the polymers were investigated by scanning electron microscope(SEM),Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),elemental analysis and nitrogen adsorption–desorption test.The obtained results showed that the SMIPs displayed great adsorption capacity(13.5 μg/mg),high recognition ability(the imprinted factor is 3.2) and good binding kinetics for ampicillin sodium.Finally,as solid phase extraction adsorbents,the SMIPs coupled with HPLC method were validated and applied for the enrichment,purification and determination of ampicillin sodium in real milk and blood samples.The averages of spiked accuracy ranged from 92.1% to 107.6%.The relative standard deviations of intra- and inter-day precisions were less than 4.6%.This study provides a new and promising method for enriching,extracting and determining ampicillin sodium in complex biological samples. | Ningli Wu Zhimin Luo Yanhui Ge Pengqi Guo Kangli Du Weili Tang Wei Du Aiguo Zeng Chun Chang Qiang Fu | 2016 | Journal of Pharmaceutical Analysis2016，6，3： | 6 |
| 4 | Sulfur deposition in sour gas reservoirs:laboratory and simulation study显示文摘Sulfur deposition in the formation,induced by a reduction in the solubility of the sulfur in the gas phase,may significantly reduce the in flow performance of sour gas wells and some wells in sour gas reservoirs have even become completely plugged with deposited sulfur within several months.Accurate prediction and effective management of sulfur deposition are crucial to the economic viability of sour gas reservoirs.In this paper,a dynamic flow experiment was carried out to investigate formation damage resulting from sulfur deposition using an improved experimental method.The core sample was extracted from the producing interval of the LG2 well,LG gas field in the Sichuan Basin.The experimental temperature was 26 oC and the initial pressure was 19 MPa.The displacement pressure continuously decreased from 19 to 10 MPa,and the depletion process lasted 15 days.Then the core was removed and dried.The core mass and core permeability were measured before and after experiments.Experimental results indicated that the core mass increased from 48.372 g before experiment to 48.386 g afterwards,while the core permeability reduced from 0.726 to 0.608 md during the experiment.Then the core was analyzed with a scanning electron microscope(SEM) and energy-dispersive X-ray mapping.The deposition pattern and micro-distribution of elemental sulfur was observed and the deposited elemental sulfur distributed as a film around the pore surface.In addition,a preliminary three-dimensional,multi-component model was developed to evaluate the effect of sulfur deposition on production performance,and the effect of production rate on sulfur deposition was also investigated.Simulation results indicated that the stable production time would be shortened and the gas production rate would be decreased once sulfur deposited in the formation.The increase in deposited sulfur at high flow rates may be attributed to a bigger pressure drop than that at low gas flow rates.Gas production rate has a severe effect on sulfur saturation in the grid of producing well located in sour gas reservoir.The work suggests sulfur deposition should be considered to correctly predict production performance and gas production rate should be optimized in order to control or retard sulfur deposition during the development of sour gas reservoir. | Xiao Guo Zhimin Du Xuefeng Yang Yong Zhang Dekui Fu | 2009 | Petroleum Science2009，6，4： | 4 |
| 5 | Start-up of the Anammox process from the conventional activated sludge in a membrane bioreactor显示文摘 | Tao Wang Hanmin Zhang Fenglin Yang Sitong Liu Zhimin Fu Huihui Chen | 2008 | Bioresource Technology2008，，9： | 2 |
| 6 | Fabrication of Cu/rGO/MoS2 nanohybrid with energetic visible-light response for degradation of rhodamine B显示文摘A novel visible-light-driven Cu/rGO/MoS2(CRM) ternary nanostructure as a photocatalyst with high catalytic activity towards environmental purification using solar energy was successfully synthesized through a facile solvothermal method.It was found that the nanoflower structure of MoS2 increased the number of its exposed edges.Meanwhile rGO as a catalytic substrate played a role of charge-carrier channel to improve the separation of holes and electrons,which originated from the band gap absorption of MoS2.The content of Cu in photocatalyst affected photocatalytic performance obviously.And the optimal 30% Cu/rGO/MoS2 possessed the highest photocatalytic performance,which could be attributed to the improved separation of charges and synergistic effects among Cu,rGO and MoS2.The removal efficiency of Rhodamine B(RhB) over CRM was up to 100% in 5 min.CRM as a photocatalyst maintained good reproducibility and stability during 3 times of the recycle experiments.These results indicate CRM is a promising photocatalyst for degrading organic pollutants in wastewater. | Huanjing Liang Peng Hua Yufei Zhou Zhimin Fu Jiaoning Tang Junfeng Niu | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 7 | Start-up of the Anammox process from the conventional activated sludge in a membrane bioreactor显示文摘 | Tao Wang Hanmin Zhang Fenglin Yang Sitong Liu Zhimin Fu Huihui Chen | 2008 | Bioresource Technology2008，，9： | 2 |
| 8 | miR-145 Inhibits Migration and Invasion of Glioma Stem Cells by Targeting ABCG2显示文摘 | Lei Shi Zhimin Wang Guan Sun Yi Wan Jun Guo Xingli Fu | 2014 | NeuroMolecular Medicine2014，，2： | 1 |
| 9 | Evaluation on thermal hazard of methyl ethyl ketone peroxide by using adiabatic method 显示文摘 | Fu Zhimin Li Xinrui Koseki Hiroshi | 2003 | Journal of Loss Prevention in the Process Industries2003，16，5： | 1 |
| 10 | Simultaneous nitro- gen and phosphorus removel by a novel sequencing batch moving bed membrane bioreactor for wastewater treatment 显示文摘 | Shuai Yang Fenglin Yang Zhimin Fu | 2010 | Journal of Hazardous Materials2010，175，13： | 1 |
| 11 | Simultaneous nitrogen and phosphorus removal by a novel sequencing batch moving bed membrane bioreactor for wastewater treatment显示文摘 | Shuai Yang Fenglin Yang Zhimin Fu Tao Wang Ruibo Lei | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 12 | Characteristics of nitrite and nitrate in situ denitrification in landfill bioreactors显示文摘 | Zhimin Fu Fenglin Yang Yingyu An Yuan Xue | 2008 | Bioresource Technology2008，，12： | 1 |
| 13 | Comparison between a moving bed membrane bioreactor and a conventional membrane bioreactor on organic carbon and nitrogen removal显示文摘 | Shuai Yang Fenglin Yang Zhimin Fu Ruibo Lei | 2008 | Bioresource Technology2008，，8： | 1 |
| 14 | Control of COD/N ratio for nutrient removal in a modified membrane bioreaetor (MBR) treating high strength wastewater 显示文摘 | Zhimin Fu Fenglin Yang Feifei Zhou | 2009 | Bioresource Technology2009，，100： | 1 |
| 15 | Simultaneous nitrification and denitrifieation coupled with phosphorus removal in an modified anoxic/oxic-membrane bioreaetor (A/O-MBR) 显示文摘 | FU Zhimin YANG Fenglin AN Yingyu | 2009 | Biochemical Engineering Journal2009，43，2： | 1 |
| 16 | Simultaneous nitrification and denitrifieation coupled with phosphorus removal in an modified anoxic/oxie-membrane bioreaetor (A/O-MBR) 显示文摘 | Zhimin Fu Fenglin Yang Yingyu An | 2009 | Biochemical Engineering Journal2009，，43： | 1 |
| 17 | Comparison between a moving bed membrane bioreactor and a conventional membrane bioreactor on organic carbon and nitrogen removal 显示文摘 | Yang Shuai Yang Fenglin Fu Zhimin | 2009 | BioresourceTechnology2009，100，8： | 1 |
| 18 | Simultaneous nitrification and denitrification coupled with phosphorus removal in an modified anoxic/oxic-membrane bioreactor (A/O-MBR) 显示文摘 | Zhimin Fu Fenglin Yang Yingyu An | 2009 | Biochemical Engineering Journal2009，43，2： | 1 |
| 19 | Start-up of the Anammox process from the conventional activated sludge in a membrane bioreactor显示文摘 | Tao Wang Hanmin Zhang Fenglin Yang Sitong Liu Zhimin Fu Huihui Chen | 2008 | Bioresource Technology2008，，9： | 1 |
| 20 | Comparison between a moving bed membrane bioreactor and conventional membrane bioreactor on organic carbon and nitrogen removal 显示文摘 | Yang Shuai Yang Fenglin Fu Zhimin | 2009 | Bioresource Technology2009，100，8： | 1 |
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