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| 1 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 2 | Variations in carbon isotopic composition in the subcontinental lithospheric mantle beneath the Yangtze and North China Cratons:Evidence from in-situ analysis of diamonds using SIMS显示文摘The components and evolution of subcontinental lithospheric mantle beneath the North China Craton and the Yangtze Craton is a current topic in the geological study of China and the carbon isotopic composition of diamond is one of the most direct probes into cratonic lithospheric mantle processes.In this paper,in-situ SIMS(Secondary Ion Mass Spectrometry) techniques were used to analyze the carbon isotope compositions at different internal growth zones of diamonds from Shandong and Liaoning in the North China Craton and Hunan in the Yangtze Craton.It was found that the carbon isotopic range of diamonds from the North China Craton are rather distinct from those of the Yangtze Craton;the former has a range of 6.0‰ to 2.0‰(relative to VPDB) with an average value of 3.0‰ in their core areas,which is consistent with global peridotitic diamonds;the diamonds from the Yangtze Craton,however,have a carbon isotopic range from 8.6‰ to 3.0‰ with an average value of 7.4‰ in their core areas,being more consistent with global eclogitic diamonds.The variations of carbon isotope ratios between different internal growth zones in individual diamonds were different in the three diamond localities studied.There was a clear correlation between changes in carbon isotopic composition and phases of diamond dissolution and new growth,while no correlation was observed between δ13C and internal inclusions.The variations suggest that the carbon isotopic compositions of mantle fluids were changing during the process of diamond crystallization,and that the heterogeneity of the carbon isotopic composition in mantle carbon reservoirs was a more important factor than carbon isotope fractionation in controlling the carbon isotopic compositions and their variation in diamonds.In addition,the preliminary results of in-situ nitrogen analyses demonstrated that the variation of carbon isotopic compositions between the core and outer growth zones does not correlate with nitrogen abundances,implying either that diamonds crystallized in an open environment or that the carbon isotopic composition and nitrogen contents in mantle fluids were controlled by other,not yet understood factors.The experimental results provide hints that the isotopic composition of carbon and its original sources were different in metasomatic fluids controlling diamond formation in the mantle beneath the North China Craton and the Yangtze Craton. | CHEN Hua QIU ZhiLi LU TaiJin STERN Richard STACHEL Thomas SUN Yuan ZHANG Jian KE Jie PENG ShuYi QIN SheCai | 2013 | Chinese Science Bulletin2013，58，1： | 7 |
| 3 | Natural variations in grain length 10(GL10)regulate rice grain size显示文摘Grain size is an important determinant of grain weight and yield in rice.Although several genes related to grain size have been identified,natural variations in these genes that affect grain size are poorly characterized.Here,we describe the grain length QTL GL10,encoding MADS56,which positively regulates grain length and grain weight.A natural allelic variation of NIL-gl10,containing an~1.0-kb deletion in the first exon that abolishes its transcription,results in shorter grain length,lower grain weight and delayed flowering in gl10 plants.The knockout of GL10 in the HJX74 background leads to grain phenotypes similar to that of NIL-gl10,while overexpression of GL10 results in increased grain length and weight and earlier heading date.GL10 regulates grain length by promoting greater longitudinal cell growth in the grain glume.Additionally,GL10 participates in the regulation of gibberellic acid(GA)signaling pathway genes in young panicle tissues.Analysis of GL10 haplotypes shows obvious divergence between the japonica and indica lineages.Our findings reveal an allelic variation of GL10 that may explain differences in grain length among modern cultivars and could be used to breed rice varieties with optimized grain shape. | Penglin Zhan Shuaipeng Ma Zhili Xiao Fangping Li Xin Wei Shaojun Lin Xiaoling Wang Zhe Ji Yu Fu Jiahao Pan Mi Zhou Yue Liu Zengyuan Chang Lu Li Suhong Bu Zupei Liu Haitao Zhu Guifu Liu Guiquan Zhang Shaokui Wang | 2022 | Journal of Genetics and Genomics2022，49，5： | 3 |
| 4 | High-performance liquid chromatography–tandem mass spectrometry for the determination of pidotimod in human plasma and its application to a pharmacokinetic study显示文摘 | Yi Zhang Zhili Xiong Feng Qin Shan Lu Wei Liu Famei Li | 2009 | Journal of Chromatography B2009，，24： | 2 |
| 5 | Advances in the development of molecular genetic tools for Mycobacterium tuberculosis显示文摘Mycobacterium tuberculosis, a Gram-positive bacterium of great clinical relevance, is a lethal pathogen owing to its complex physiological characteristics and development of drug resistance. Several molecular genetic tools have been developed in the past few decades to study this microorganism. These tools have been instrumental in understanding how M. tuberculosis became a successful pathogen. Advanced molecular genetic tools have played a significant role in exploring the complex pathways involved in M. tuberculosis pathogenesis. Here, we review various molecular genetic tools used in the study of M. tuberculosis. Further, we discuss the applications of clustered regularly interspaced short palindromic repeat interference(CRISPRi), a novel technology recently applied in M. tuberculosis research to study target gene functions. Finally, prospective outcomes of the applications of molecular techniques in the field of M. tuberculosis genetic research are also discussed. | Chiranjibi Chhotaray Yaoju Tan Julius Mugweru Md Mahmudul Islam H.M.Adnan Hameed Shuai Wang Zhili Lu Changwei Wang Xinjie Li Shouyong Tan Jianxiong Liu Tianyu Zhang | 2018 | Journal of Genetics and Genomics2018，45，6： | 2 |
| 6 | Self-assembly of semiconductor nanoparticles toward emergent behaviors on fluorescence显示文摘Due to the unique fluorescence characteristics,superstructures from self-assembly of semiconductor nanoparticles have become essential components of material and chemical science,and thus it has broad application potential in displays,single-photon source,sensing,biological tagging and emerging quantum technologies.Superstructure refers to an artificial functional architecture whose length scale is between the quantum scale and the macroscale.When solely treating this complicated stage fitted from less complicated pieces together(basic nanoparticles)and pile speculation on speculation,we must understand the fundamental questions,that is,what the hierarchy or specialization of function is at the stage.The uniqueness of this stage is not the collection of basic nanoparticles,but the behavior that emerges on fluorescence-basically a new type of behavior.Under the angle of view,this study reviews the advances in the fluorescence of individual semiconductor nanoparticles,inter-nanoparticles coupling and thus emergent fluorescence behaviors of assemblies.We also try to present the methodology for seeking emergent behaviors on fluorescence. | Xiao Li Zhili Lu Tie Wang | 2021 | Nano Research2021，14，5： | 2 |
| 7 | Copper nanowire with enriched high‐index facets for highly selective CO_(2) reduction显示文摘Electroreduction of carbon dioxide into fuels and feedstocks with renewable energy is an attractive route to mitigate carbon emission and solve energy crisis.However,how to improve the selectivity of high‐value multicarbon products is still challenging.Here,we demonstrate that the high‐index crystalline surface of copper could be designed and obtained through a simple square‐wave potential treatment on copper nanowires,which is beneficial to improve the selectivity of multi‐carbon products,especially the reaction route towards ethylene.The Faradaic efficiency of C_(2+)products can reach nearly 60%,and hydrogen can be suppressed to below 20%.Density functional theory(DFT)calculations reveal that(311)high‐index facet can activate CO_(2) effectively and promote adsorption of the*COCOH intermediate on copper for ethylene formation,therefore improves the selectivity of ethylene and inhibits the competing hydrogen evolution reaction.This method can be extended to the design of other catalytic systems and has inspirations for other electrochemical catalytic reactions. | Lu Han Benqiang Tian Xiangxiang Gao Yang Zhong Shengnan Wang Shuchang Song Zhili Wang Ying Zhang Yun Kuang Xiaoming Sun | 2022 | SmartMat2022，3，1： | 2 |
| 8 | Shaking table testing of a U-shaped plan building model显示文摘 | Xilin Lu Huiyun Zhang Hu Zhili | 1999 | Canadian Journal of Civil Engineering1999，26，： | 1 |
| 9 | OSMRβmutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients显示文摘Dear Editor,Primary localized cutaneous amyloidosis(PLCA)is a skinlimited disorder characterized by deposition of amyloid material in the superficial dermis.According to clinical characteristics,PLCA is divided into lichen,macular,and nodular amyloidosis.PLCA is found worldwide but has a higher incidence in South America and Southeast Asia,such as in Brazil and China(Chang et al.,2014;Tey et al.,2016). | Jun Liu Junchen ChenYadan Zhong Xiaoling Yu Ping Lu Jianqi Feng Xin Zhang Shufeng Ma Chao Yang Bin Yang Zhili Rong | 2021 | Protein & Cell2021，12，8： | 1 |
| 10 | Shake-table testing of a U-shaped plan building model 显示文摘 | Lu Xilin Zhang Huiyun Hu Zhili | 1999 | Canadian Journal of Civil Engineering1999，26，： | 1 |
| 11 | Metabonomic study on ' Kidney-Yang deficiency syndrome' and intervention effects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry 显示文摘 | LU Xiumei XIONG Zhili LI Jingjing | 2001 | Talanta2001，83，3： | 1 |
| 12 | Shaking table testing of a U-shaped plan building model 显示文摘 | Lu Xilin Zhang Huiyun Hu Zhili | 1999 | Canadian Journal of Civil Engineering1999，26，： | 1 |
| 13 | Distribution,Seismic Characteristics and Controlling Factors of Carbonate Platforms on the Northwestern Margin of the South China Sea显示文摘Newly-acquired seismic data reveal widespread carbonate deposits covering a large part of the northwestern South China Sea margin.Three carbonate platforms are identified to have developed on the topographic highs inherited from tectonic deformation and volcanic accretion.Across the carbonate platforms,the Miocene strata are characterized by high-amplitude seismic reflections and distinct platform architecture that overlaps older strata.The Guangle and Xisha carbonate platforms grew on faulted blocks due to South China Sea continental rifting,while the Zhongjian carbonate platform developed on a structural high induced by early Miocene volcanism.During the late Miocene,partial drowning resulted in the inhibition of platform growth,eventual platform drowning and termination of most carbonate deposition.The drowning of the Guangle and Zhongjian carbonate platforms is shown by the supply of siliciclastic sediments during the late Miocene and seems to be closely linked to late Neogene volcanic activity,whilst the drowning of the Xisha carbonate platform is primarily related to relative eustatic changes.Our results imply that tectonic activity,volcanism and eustasy are the dominant controls on the evolution of carbonate platforms on the northwestern margin of the South China Sea. | LI Lin WANG Bin YANG Taotao YANG Zhili LI Li LU Yintao WANG Xuefeng WU Jingwu SUN Guozhong | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 14 | Improved method for synthesis of low molecular weight protamine–siRNA conjugate显示文摘RNAi technology has aroused wide public interest due to its high efficiency and specificity to treat multiple types of diseases. However, the effective delivery of siRNA remains a challenge due to its large molecular weight and strong anionic charge. Considering their remarkable functions in vivo and features that are often desired in drug delivery carriers, biomimetic systems for siRNA delivery become an effective and promising strategy. Based on this, covalent attachment of synthetic cell penetrating peptides(CPP) to siRNA has become of great interest. We developed a monomeric covalent conjugate of low molecular weight protamine(LMWP, a well-established CPP) and siRNA via a cytosol-cleavable disulfide linkage using PEG as a crosslinker. Results showed that the conjugates didn't generate coagulation, and exhibited much better RNAi potency and intracellular delivery compared with the conventional charge-complexed CPP/siRNA aggregates. Three different synthetic and purification methods were compared in order to optimize synthesis efficiency and product yield. The methodology using hetero-bifunctional NHS–PEG–OPSS as a crosslinker to synthesize LMWP–siRNA simplified the synthesis and purification process and produced the highest yield. These results pave the way towards siRNA biomimetic delivery and future clinical translation. | Zhili Yu Junxiao Ye Xing Pei Lu Sun Ergang Liu Jianxin Wang Yongzhuo Huang Seung Jin Lee Huining He | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 1 |
| 15 | Biomedical Event Extraction Using a New Error Detection Learning Approach Based on Neural Network显示文摘Supervised machine learning approaches are effective in text mining,but their success relies heavily on manually annotated corpora.However,there are limited numbers of annotated biomedical event corpora,and the available datasets contain insufficient examples for training classifiers;the common cure is to seek large amounts of training samples from unlabeled data,but such data sets often contain many mislabeled samples,which will degrade the performance of classifiers.Therefore,this study proposes a novel error data detection approach suitable for reducing noise in unlabeled biomedical event data.First,we construct the mislabeled dataset through error data analysis with the development dataset.The sample pairs’vector representations are then obtained by the means of sequence patterns and the joint model of convolutional neural network and long short-term memory recurrent neural network.Following this,the sample identification strategy is proposed,using error detection based on pair representation for unlabeled data.With the latter,the selected samples are added to enrich the training dataset and improve the classification performance.In the BioNLP Shared Task GENIA,the experiments results indicate that the proposed approach is competent in extract the biomedical event from biomedical literature.Our approach can effectively filter some noisy examples and build a satisfactory prediction model. | Xiaolei Ma Yang Lu Yinan Lu Zhili Pei Jichao Liu | 2020 | Computers, Materials & Continua2020，，5： | 1 |
| 16 | Synergetic roadmap of carbon neutrality and clean air for China显示文摘It is well recognized that carbon dioxide and air pollutants share similar emission sources so that synergetic policies on climate change mitigation and air pollution control can lead to remarkable co-benefits on greenhouse gas reduction,air quality improvement,and improved health.In the context of carbon peak,carbon neutrality,and clean air policies,this perspective tracks and analyzes the process of the synergetic governance of air pollution and climate change in China by developing and monitoring 18 indicators.The 18 indicators cover the following five aspects:air pollution and associated weather-climate conditions,progress in structural transition,sources,inks,and mitigation pathway of atmospheric composition,health impacts and benefits of coordinated control,and synergetic governance system and practices.By tracking the progress in each indicator,this perspective presents the major accomplishment of coordinated control,identifies the emerging challenges toward the synergetic governance,and provides policy recommendations for designing a synergetic roadmap of Carbon Neutrality and Clean Air for China. | Qiang Zhang Zhicong Yin Xi Lu Jicheng Gong Yu Lei Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Hancheng Dai Zhanfeng Dong Guannan Geng Dabo Guan Jianlin Hu Cunrui Huang Jianing Kang Tiantian Li Wei Li Yongsheng Lin Jun Liu Xin Liu Zhu Liu Jinghui Ma Guofeng Shen Dan Tong Xuhui Wang Xuying Wang Zhili Wang Yang Xie Honglei Xu Tao Xue Bing Zhang Da Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Bo Zheng Yixuan Zheng Tong Zhu Jinnan Wang Kebin He | 2023 | Environmental Science and Ecotechnology2023，，4： | 0 |
| 17 | Graphene binding on black phosphorus enables high on/off ratios and mobility显示文摘Graphene is one of the most promising candidates for integrated circuits due to its robustness against short-channel effects,inherent high carrier mobility and desired gapless nature for Ohmic contact,but it is difficult to achieve satisfactory on/off ratios even at the expense of its carrier mobility,limiting its device applications.Here,we present a strategy to realize high back-gate switching ratios in a graphene monolayer with well-maintained high mobility by forming a vertical heterostructure with a black phosphorus multi-layer.By local current annealing,strain is introduced within an established area of the graphene,which forms a reflective interface with the rest of the strain-free area and thus generates a robust off-state via local current depletion.Applying a positive back-gate voltage to the heterostructure can keep the black phosphorus insulating,while a negative back-gate voltage changes the black phosphorus to be conductive because of hole accumulation.Then,a parallel channel is activated within the strain-free graphene area by edge-contacted electrodes,thereby largely inheriting the intrinsic carrier mobility of graphene in the on-state.As a result,the device can provide an on/off voltage ratio of>10^(3)as well as a mobility of∼8000 cm^(2)V^(−1)s^(−1)at room temperature,meeting the low-power criterion suggested by the International Roadmap for Devices and Systems. | Fanrong Lin Zhonghan Cao Feiping Xiao Jiawei Liu Jiabin Qiao Minmin Xue Zhili Hu Ying Liu Huan Lu Zhuhua Zhang Jens Martin Qingjun Tong Wanlin Guo Yanpeng Liu | 2024 | National Science Review2024，11，2： | 0 |
| 18 | Environmental selection and evolutionary process jointly shape genomic and functional profiles of mangrove rhizosphere microbiomes显示文摘Mangrove reforestation with introduced species has been an important strategy to restore mangrove ecosystem functioning.However,how such activities affect microbially driven methane(CH4),nitrogen(N),and sulfur(S)cycling of rhizosphere microbiomes remains unclear.To understand the effect of environmental selection and the evolutionary process on microbially driven biogeochemical cycles in native and introduced mangrove rhizospheres,we analyzed key genomic and functional profiles of rhizosphere microbiomes from native and introduced mangrove species by metagenome sequencing technologies.Compared with the native mangrove(Kandelia obovata,KO),the introduced mangrove(Sonneratia apetala,SA)rhizosphere microbiome had significantly(p<0.05)higher average genome size(AGS)(5.8 vs.5.5 Mb),average 16S ribosomal RNA gene copy number(3.5 vs.3.1),relative abundances of mobile genetic elements,and functional diversity in terms of the Shannon index(7.88 vs.7.84)but lower functional potentials involved in CH4 cycling(e.g.,mcrABCDG and pmoABC),N2 fixation(nifHDK),and inorganic S cycling(dsrAB,dsrC,dsrMKJOP,soxB,sqr,and fccAB).Similar results were also observed from the recovered Proteobacterial metagenome-assembled genomes with a higher AGS and distinct functions in the introduced mangrove rhizosphere.Additionally,salinity and ammonium were identified as the main environmental drivers of functional profiles of mangrove rhizosphere microbiomes through deterministic processes.This study advances our understanding of microbially mediated biogeochemical cycling of CH_(4),N,and S in the mangrove rhizosphere and provides novel insights into the influence of environmental selection and evolutionary processes on ecosystem functions,which has important implications for future mangrove reforestation. | Xiaoli Yu Qichao Tu Jihua Liu Yisheng Peng Cheng Wang Fanshu Xiao Yingli Lian Xueqin Yang Ruiwen Hu Huang Yu Lu Qian Daoming Wu Ziying He Longfei Shu Qiang He Yun Tian Faming Wang Shanquan Wang Bo Wu Zhijian Huang Jianguo He Qingyun Yan Zhili He | 2023 | mLife2023，2，3： | 0 |
| 19 | A Trusted Edge Resource Allocation Framework for Internet of Vehicles显示文摘With the continuous progress of information technique,assisted driving technology has become an effective technique to avoid traffic accidents.Due to the complex road conditions and the threat of vehicle information being attacked and tampered with,it is difficult to ensure information security.This paper uses blockchain to ensure the safety of driving information and introduces mobile edge computing technology to monitor vehicle information and road condition information in real time,calculate the appropriate speed,and plan a reasonable driving route for the driver.To solve these problems,this paper proposes a trusted edge resource allocation framework for assisted driving service,which includes two stages:the blockchain generation stage(the first stage)and assisted driving service stage(the second stage).Furthermore,in the first stage,a delay-and-throughput-oriented block generation model for the mobile terminal is designed.In the second stage,a balanced offloading algorithm for assisted driving service based on edge collaboration is proposed to solve the problems of unbalanced load of cluster mobile edge computing(MEC)servers and low resource utilization of the system.And this paper optimizes the throughput of blockchain and delay of the transportation network through deep reinforcement learning(DRL)algorithm.Finally,compared with joint computation and communication resources’allocation(JCCR)and resource allocation method based on binary offloading(RAB),our proposed scheme can optimize the delay by 7.4%and 26.7%,and support various application services of the vehicular networks more effectively. | Yuxuan Zhong Siya Xu Boxian Liao Jizhao Lu Huiping Meng Zhili Wang Xingyu Chen Qinghan Li | 2023 | Computers, Materials & Continua2023，77，11： | 0 |
| 20 | The morphodynamic responses to deposition-promoting projects in island and reef coasts of the Zhoushan Archipelago, China显示文摘China's island and reef coasts are mainly distributed along the coasts of Zhejiang and Fujian provinces.These areas have favorable deep-water conditions and great development potential. The Zhoushan Archipelago is a typical island and reef coast. In the midst of the islands, there are many tidal channels with high water depth and high current velocity. Daishan Island is located on the northern part of the Zhoushan Archipelago. The sea north of Daishan Island can be characterized as having great water depth(generally between 10 and 20 m), high current velocity(the maximum measured value is about 2 m/s),and hyperconcentrated suspended sediment(annual average concentration under normal weather conditions is about 0.6 kg/m^3). Sediment transport is influenced by the co-action of waves and currents.Land reclamation can ease the contradiction between the desire for development and the land resource shortage on island and reef coasts. Land reclamation generally starts from deposition-promoting projects on island and reef coasts with hyperconcentration of suspended sediment with the aim of reducing the reclamation cost. Based on the morphodynamic characteristics of the sea area near north of Daishan Island, a two-dimensional mathematical model was developed to analyze the co-action of current and waves and the model was verified for spring as well as neap tides in 2007 and 2012. The simulated values of tidal stages, tidal current velocities, tidal current directions, and suspended sediment concentration at15 stations in 2007 and 9 stations in 2012 were in good agreement with the in-situ measured values.Furthermore, the simulated magnitude and pattern of erosion and sedimentation agreed well with the observations. This model was used to evaluate the effects of a proposed siltation scheme on the hydrodynamic environment and morphological change of the study area. The results of this study can inform the protection, development, and utilization of shoal-channels on island and reef coasts, as well provide a scientific basis for comprehensive maritime protection and development. | Qingzhi Hou Zhili Wang Yongjun Lu Siping Mo | 2017 | International Journal of Sediment Research2017，32，3： | 0 |
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