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| 1 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 2 | Global blue carbon accumulation in tidal wetlands increases with climate change显示文摘Coastal tidal wetlands produce and accumulate significant amounts of organic carbon(C)that help to mitigate climate change.However,previous data limitations have prevented a robust evaluation of the global rates and mechanisms driving C accumulation.Here,we go beyond recent soil C stock estimates to reveal global tidal wetland C accumulation and predict changes under relative sea level rise,temperature and precipitation.We use data from literature study sites and our new observations spanning wide latitudinal gradients and 20 countries.Globally,tidal wetlands accumulate 53.65(95%CI:48.52-59.01)Tg C yr^(-1),which is~30%of the organic C buried on the ocean floor.Modeling based on current climatic drivers and under projected emissions scenarios revealed a net increase in the global C accumulation by2100.This rapid increase is driven by sea level rise in tidal marshes,and higher temperature and precipitation in mangroves.Countries with large areas of coastal wetlands,like Indonesia and Mexico,are more susceptible to tidal wetland C losses under climate change,while regions such as Australia,Brazil,the USA and China will experience a significant C accumulation increase under all projected scenarios. | Faming Wang Christian J.Sanders Isaac R.Santos Jianwu Tang Mark Schuerch Matthew L.Kirwan Robert E.Kopp Kai Zhu Xiuzhen Li Jiacan Yuan Wenzhi Liu Zhian Li | 2021 | National Science Review2021，8，9： | 22 |
| 3 | New approach to training support vector machine显示文摘Support vector machine has become an increasingly popular tool for machine learning tasks involving classification, regression or novelty detection. Training a support vector machine requires the solution of a very large quadratic programming problem. Traditional optimization methods cannot be directly applied due to memory restrictions. Up to now, several approaches exist for circumventing the above shortcomings and work well. Another learning algorithm, particle swarm optimization, for training SVM is introduted. The method is tested on UCI datasets. | Tang Faming Chen Mianyun Wang Zhongdong | 2006 | Journal of Systems Engineering and Electronics2006，17，1： | 10 |
| 4 | Photoresponsive organogel and organized nanostructures of cholesterol imide derivatives with azobenzene substituent groups | Tifeng Jiao Yujin Wang Fengqing Gao Jingxin Zhou Faming Gao | 2012 | Progress in Natural Science:Materials International2012，22，1： | 9 |
| 5 | Periodontitis may induce gut microbiota dysbiosis via salivary microbiota显示文摘The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary microbes.First,faecal and salivary samples were collected from periodontally healthy participants(PH group,n=16)and patients with severe periodontitis(SP group,n=21)and analysed by 16S ribosomal RNA sequencing.Significant differences were observed in both the faecal and salivary microbiota between the PH and SP groups.Notably,more saliva-sourced microbes were observed in the faecal samples of the SP group.Then,the remaining salivary microbes were transplanted into C57BL6/J mice(the C-PH group and the C-SP group),and it was found that the composition of the gut microbiota of the C-SP group was significantly different from that of the C-PH group,with Porphyromonadaceae and Fusobacterium being significantly enriched in the C-SP group.In the colon,the C-SP group showed significantly reduced crypt depth and zonula occludens-1 expression.The m RNA expression levels of pro-inflammatory cytokines,chemokines and tight junction proteins were significantly higher in the C-SP group.To further investigate whether salivary bacteria could persist in the intestine,the salivary microbiota was stained with carboxyfluorescein diacetate succinimidyl ester and transplanted into mice.We found that salivary microbes from both the PH group and the SP group could persist in the gut for at least 24 h.Thus,our data demonstrate that periodontitis may induce gut microbiota dysbiosis through the influx of salivary microbes. | Jun Bao Lili Li Yangheng Zhang Min Wang Faming Chen Shaohua Ge Bin Chen Fuhua Yan | 2022 | International Journal of Oral Science2022，14，3： | 9 |
| 6 | Coastal blue carbon: Concept, study method, and the application to ecological restoration显示文摘Coastal blue carbon refers to the carbon taken from atmospheric CO2; fixed by advanced plants(including salt marsh,mangrove, and seagrass), phytoplankton, macroalgae, and marine calcifiers via the interaction of plants and microbes; and stored in nearshore sediments and soils; as well as the carbon transported from the coast to the ocean and ocean floor. The carbon sequestration capacity per unit area of coastal blue carbon is far greater than that of the terrestrial carbon pool. The mechanisms and controls of the carbon sink from salt marshes, mangroves, seagrasses, the aquaculture of shellfish and macroalgae, and the microbial carbon pump need to be further studied. The methods to quantify coastal blue carbon include carbon flux measurements, carbon pool measurements, manipulative experiments, and modeling. Restoring, conserving, and enhancing blue carbon will increase carbon sinks and produce carbon credits, which could be traded on the carbon market. The need to tackle climate change and implement China's commitment to cut carbon emissions requires us to improve studies on coastal blue carbon science and policy. The knowledge learned from coastal blue carbon improves the conservation and restoration of salt marshes,mangroves, and seagrasses; enhances the function of the microbial carbon pump; and promotes sustainable aquaculture, such as ocean ranching. | Jianwu TANG Shufeng YE Xuechu CHEN Hualei YANG Xiaohong SUN Faming WANG Quan WEN Shaobo CHEN | 2018 | Science China Earth Sciences2018，61，6： | 8 |
| 7 | Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases显示文摘Fecal microbiota transplantation(FMT)has been used as a core therapy for treating dysbiosis-related diseases by remodeling gut microbiota.The methodology and technology for improving FMT are stepping forward,mainly including washed microbiota transplantation(WMT),colonic transendoscopic enteral tubing(TET)for microbiota delivery,and purified Firmicutes spores from fecal matter.To improve the understanding of the clinical applications of FMT,we performed a systematic literature review on FMT published from 2011 to 2021.Here,we provided an overview of the reported clinical benefits of FMT,the methodology of processing FMT,the strategy of using FMT,and the regulations on FMT from a global perspective.A total of 782 studies were included for the final analysis.The present review profiled the effectiveness from all clinical FMT uses in 85 specific diseases as eight categories,including infections,gut diseases,microbiotagut-liver axis,microbiotagut-brain axis,metabolic diseases,oncology,hematological diseases,and other diseases.Although many further controlled trials will be needed,the dramatic increasing reports have shown the promising future of FMT for dysbiosis-related diseases in the gut or beyond the gut. | Yun Wang Sheng Zhang Thomas JBorody Faming Zhang | 2022 | Chinese Medical Journal2022，135，16： | 6 |
| 8 | A novel CCCH-type zinc finger protein SAW1 activates OsGA20ox3 to regulate gibberellin homeostasis and anther development in rice显示文摘Male sterility is a prerequisite for hybrid seed production.The phytohormone gibberellin(GA)is in-volved in regulating male reproductive development,but the mechanism underlying GA homeostasis in anther development remains less understood.Here,we report the isolation and characterization of a new positive regulator of GA homeostasis,swollen anther wall 1(SAW1),for anther development in rice(Oryza sativa L.).Rice plants carrying the recessive mutant allele saw1 produces abnormal anthers with swollen anther wall and aborted pollen.Clustered regularly interspaced short palindromic repeats(CRISPR)/CRIPSR-associated protein 9-mediated knockout of SAW1 in rice generated similar male sterile plants.SAW1 encodes a novel nucleus-localizing CCCH-tandem zinc finger protein,and this protein could directly bind to the promoter region of the GA synthesis gene OsGA20ox3 to induce its anther-specific expression.In the saw1 anther,the significantly decreased OsGA20ox3 expression resulted in lower bio-active GA content,which in turn caused the lower expression of the GA-inducible anther-regulator gene OsGAMYB.Thus,our results disclose the mechanism of the SAW1-GA20ox3-GAMYB pathway in controlling rice anther development,and provide a new target gene for the rapid generation of male sterile lines by genome editing for hybrid breeding. | Bin Wang Ruiqiu Fang Faming Chen Jingluan Han Yao-Guang Liu Letian Chen Qinlong Zhu | 2020 | Journal of Integrative Plant Biology2020，62，10： | 5 |
| 9 | Fecal microbiota transplantation through mid‐gut for refractory C rohn’s disease: Safety, feasibility, and efficacy trial results显示文摘 | Bota Cui Qiang Feng Honggang Wang Min Wang Zhaoyuan Peng Pan Li Guangming Huang Zheng Liu Ping Wu Zhining Fan Guozhong Ji Xin Wang Kaichun Wu Daiming Fan Faming Zhang | 2015 | J Gastroenterol Hepatol2015，，1： | 3 |
| 10 | Student Performance Prediction Based on Behavior Process Similarity显示文摘Student performance prediction plays an important role in improving education quality.Noticing that students'exercise-answering processes exhibit different characteristics according to their different performance levels,this paper aims to mine the performance-related information from students'exercising logs and to explore the possibility of predicting students'performance using such process-characteristic information.A formal model of student-shared exercising processes and its discovery method from students'exercising logs are presented.Several similarity measures between students'individual exercising behavior and student-shared exercising processes are presented.A prediction method of students'performance level considering these similarity measures is explored based on classification algorithms.An experiment on real-life exercise-answering event logs shows the effectiveness of the proposed prediction method. | BAO Yunxia LU Faming WANG Yanxiao ZENG Qingtian LIU Cong | 2020 | Chinese Journal of Electronics2020，29，6： | 3 |
| 11 | Ecological Environment Conservation and Restoration and Sustainable Development of Minqin Oasis显示文摘Minqin oasis in the lower reaches of the Shiyang River is a main natural barrier for the Wuwei Basin. Due to the combined influence of human activities and natural factors in the past half a century, water quality in the lower reaches of the Shiyang River decreased and ecological environment deteriorated, which influenced sustainable development of this area and surrounding area seriously. This paper analyzed current situation and reasons of the deteriorated ecological environment in the lower reaches of the Shiyang River, and proposed that water environment regulation was the primary task in the eco-environment control of Minqin area, specifically,(a) By using existing policies, accelerating the construction of water-saving agriculture in the middle reaches of the Shiyang River, water quantity in the lower reaches would be guanranted, water shortage for agricultural production and ecological use in Minqin oasis would be relieved;(b) Unreasonable human activities such as overexploitation of underground water should be controlled strictly;(c) Water conservancy project should be developed vigorously to ensure rate of flow. It was expected that the above schemes would contribute to the benign circulation of ecological environment in Minqin oasis. | WANG Lide YAO Tuo XU Feng HAN Fugui GUO Chunxiu WANG Fangling Li Faming | 2016 | Journal of Landscape Research2016，8，1： | 2 |
| 12 | Experimental and numerical study on instability structure of the supersonic mixing layer(M_c = 0.5)显示文摘The parameters of instability wave of supersonic mixing layer(Mc=0.5,M1=3.5/M2=1.4) are measured by flow visualization and calculated by means of two-dimensional direct numerical simulaitons of the compressible Navier-Stokes equations.In both cases of the mixing layer with harmonic disturbance or not,the comparative results indicate that the wavelength of the two-dimensional wave is equal to the vortex spacing in the streamwise direction because the difference between them is less than 1%.However,the measured convective velocity of the large-scale structure deviates from the theoretical isentropic prediction about 10%.Here the measured value confirms that Mc,2 | YANG WuBing ZHUANG FengGan SHEN Qing GUAN FaMing WANG Qiang YI ShiHe ZHAO YuXin HE Lin TIAN LiFeng | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，10： | 2 |
| 13 | Establishment and Characterization of a High Metastatic Potential in the Peritoneum for Human Gastric Cancer by Orthotopic Tumor Cell Implantation显示文摘 | Feihu Bai Xinning Guo Li Yang Jun Wang Yongquan Shi Faming Zhang Huihong Zhai Yuanyuan Lu Huahong Xie Kaichun Wu Daiming Fan | 2007 | Digestive Diseases and Sciences2007，，6： | 1 |
| 14 | Variability of Tropical Cyclone in High Frequent Occurrence Regions over the Western North Pacific显示文摘In this study, three high frequent occurrence regions of tropical cyclones(TCs), i.e., the northern South China Sea(the region S), the south Philippine Sea(the region P) and the region east of Taiwan Island(the region E), are defined with frequency of TC's occurrence at each grid for a 45-year period(1965–2009), where the frequency of occurrence(FO) of TCs is triple the mean value of the whole western North Pacific. Over the region S, there are decreasing trends in the FO of TCs, the number of TCs' tracks going though this region and the number of TCs' genesis in this region. Over the region P, the FO and tracks demonstrate decadal variation with periods of 10–12 year, while over the region E, a significant 4–5 years' oscillation appears in both FO and tracks. It is demonstrated that the differences of TCs' variation in these three different regions are mainly caused by the variation of the Western Pacific Subtropical High(WPSH) at different time scales. The westward shift of WPSH is responsible for the northwesterly anomaly over the region S which inhibits westward TC movement into the region S. On the decadal timescale, the WPSH stretches northwestward because of the anomalous anticyclone over the northwestern part of the region P, and steers more TCs reaching the region P in the greater FO years of the region P. The retreating of the WPSH on the interannual time scale is the main reason for the FO's oscillation over the region E. | YANG Yuxing HUANG Fei WANG Faming | 2014 | Journal of Ocean University of China2014，13，3： | 1 |
| 15 | Evaluation of an electrically heated vest (EHV) using a thermal manikin in cold environments 显示文摘 | WANG Faming LEE Hansup | 2010 | Ann Occup Hyg2010，，54： | 1 |
| 16 | A review of technology of personal heating garments 显示文摘 | WANG Faming GAO Chuansi KUKLANE Kalev | 2010 | Int J Occup Saf Ergon2010，，16： | 1 |
| 17 | Seven facts and five initiatives for gut microbiome research显示文摘The gut microbiome has attracted increasing attention over the past 15 years.Along with the fast-growing body of research literature and media reports,the public's opinions on the gut microbiome have begun to appear polarized.Some believe that the gut microbiome is at the core of human health and is related to every single disease.To the opposite,some people question the scientific basis of gut microbiome studies and criticize that many of them are farfetched;there is even a joke spreading in the biomedical research field—'keeping gut microbiome in mind,no mechanism is hard to find'. | Danyi Li Chunhui Gao Faming Zhang Ruifu Yang Canhui Lan Yonghui Ma Jun Wang | 2020 | Protein & Cell2020，11，6： | 1 |
| 18 | Gut microbisal methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract显示文摘Dear Editor,Circadian rhythms are the periodic turmover of biological behaviors and physiological functions of many organisms(Allada and Bass,2021).In mammals,circadian rhythms are maintained by the clock system,involving central clock in suprachiasmatic nucleus and peripheral clock in organs like intestine;and at cellular level a cell-autonomous transcriptional and translational feedback loop involving clock genes like BMAL1(brain and muscle ARNT-Like 1,also known as ARNTL),CLOCK(clock circadian regulator),PER1/2/3(period circadian regulator 1/2/3)and CRY1/2(cryptochrome circadian regulator 1/2)(Allada and Bass,2021). | Xiaolin Liu Yue Ma Ying Yu Wenhui Zhang ingjing Shi Xuan Zhang Min Dai Yuhan Wang Hao Zhang Jiahe Zhang Jianghua Shen Faming Zhang Moshi Song Jun Wang | 2023 | Protein & Cell2023，14，4： | 1 |
| 19 | Identifying the Zn-Co binary as a robust bifunctional electrocatalyst in oxygen reduction and evolution reactions via shifting the apexes of the volcano plot显示文摘The performance of an electrocatalyst is closely correlated with the binding strength of key oxygencontaining intermediates,i.e.,*OOH,*O and*OH,in the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).Facile strategies to achieve favorable binding strength of these oxygen-containing species are urgently demanded,yet it still remains great challenges.Herein,the Zn-Co bimetallic isolation,which serves as an ideal model,is studied systematically by the density functional theory(DFT).Reaction activity volcano plots are built from 48 models,among them the ZnCoN6-gra(I)configuration is confirmed to be the most stable,featured of the strongest interaction with the oxygen-containing species.Optimal △G*O(free energy change of an atomic oxygen containing intermediate)is facilitated,which effectively drifts the volcano peaks of ORR and OER closer to each other,enabling promising bifunctional catalyst.Moreover,the small overpotential in the simulation of protonation and oxidation by hydroxy groups rationalizes the durability of the catalyst in both acid and alkaline media. | Jing Wang Rui Xu Yuling Sun Qian Liu Meirong Xia Yan Li Faming Gao Yufeng Zhao John S.Tse | 2021 | Journal of Energy Chemistry2021，30，4： | 1 |
| 20 | Selective removal of phosphate in waters using a novel of cation adsorbent: Zirconium phosphate (ZrP) behavior and mechanism显示文摘 | Qingrui Zhang Qing Du Tifeng Jiao Bingcai Pan Zhaoxiang Zhang Qina Sun Sufeng Wang Ting Wang Faming Gao | 2013 | Chemical Engineering Journal2013，，： | 1 |
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