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| 1 | Poly(methyl methacrylate) bone cement composited with mineralized collagen for osteoporotic vertebral compression fractures in extremely old patients显示文摘To examine the clinical effects of a new bone cement composed of poly(methyl methacrylate)(PMMA)and mineralized collagen(MC)compared with pure PMMA bone cement in treating osteoporotic vertebral compression fractures(OVCFs)in patients aged over 80.In all,32 cases using pure PMMA bone cement and 31 cases using MC-modified PMMA(MC-PMMA)bone cement for OVCFs between June 2014 and March 2016 were screened as PMMA group and MC-PMMA group,respectively,with an average age of over 80.The operation duration,intraoperative blood loss,hospital stay,oswestry disability index(ODI),visual analogue scale(VAS),anterior vertebral height(AVH),intermediate vertebral height(IVH)and posterior vertebral height(PVH)of injured vertebrae,vertebral computed tomography value,re-fracture rate of adjacent vertebrae,correction rate of spinal kyphotic angle and wedge-shaped vertebra angle and surgical complications were compared between the two groups.In the early post-operative period,the VAS,ODI,AVH and IVH in MC-PMMA group were comparable to those in the traditional PMMA group.Moreover,the MC-PMMA group showed better effects compared with the PMMA group 12months after surgery.Thus,this new bone cement has superior clinic effects in the long term. | Kefeng Luo Guoqiang Jiang Jinjin Zhu Bin Lu Jiye Lu Kai Zhang Xiumei Wang Fu-Zhai Cui | 2020 | Regenerative Biomaterials2020，7，1： | 8 |
| 2 | A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration显示文摘神经指导水管(NGC ) 是为外部神经新生的自体同源的神经的一种潜在的选择。有希望的治疗学的策略是用物理或化学的指导暗示修改神经指导水管 intraluminal 微型环境。在这研究,神经营养的 peptide-functionalized 能在 vitro 支持 PC12 细胞粘附,增长,和 neuronal 区别的自我装配的肽 nanofiber hydrogel 是在一个空 chitosan 试管(hCST ) 的腔的 prefilled 在一只老鼠加速 axonal 新生臀部的神经缺点模型。functionalized 自我装配的肽被介绍神经营养的肽开发(RGI, RGIDKRHWNSQ ) 源于导出大脑的神经营养的因素(BDNF ) 到自我装配的肽 RADA16 的 C 终点 -- 我(交流 --(RADA )4-CONH2) 。词法,组织学, electrophysiological,和功能的分析证明 RGI-functionalized,自我装配,肽 nanofiber hydrogel RAD/RGI 能生产显著地与提高的 re-myelination 和马达改进了 axonal 新生的神经营养的微型环境功能的恢复。 | Jiaju Lu Xun Sun Heyong Yin Xuezhen Shen Shuhui Yang Yu Wang Wenli Jiang Yue Sun Lingyun Zhao Xiaodan Sun Shibi Lu Antonios G. Mikos Jiang Peng Xiumei Wang | 2018 | Nano Research2018，11，9： | 6 |
| 3 | Enhanced angiogenesis by the hyaluronic acid hydrogels immobilized with a VEGF mimetic peptide in a traumatic brain injury model in rats显示文摘Angiogenesis plays an important role in brain injury repair,which contributes to the reconstruction of regenerative neurovascular niche for promoting axonal regeneration in the lesion area.As a major component of developing brain extracellular matrix,hyaluronic acid(HA)has attracted more attention as a supporting matrix for brain repair.In the present study,HA-KLT hydrogel was developed via modifying HA with a VEGF mimetic peptide of KLT(KLTWQELYQLKYKGI).The characterization of the hydrogel shows that it could provide a porous,three-dimensional scaffold structure,which has a large specific surface area available for cell adhesion and interaction.Compared with the unmodified HA hydrogel,the HA-KLT hydrogel could effectively promote the attachment,spreading and proliferation of endothelial cells in vitro.Furthermore,the pro-angiogenic ability of hydrogels in vivo was evaluated by implanting them into the lesion cavities in the injured rat brain.Our results showed that the hydrogels could form a permissive interface with the host tissues at 4 weeks after implantation.Moreover,they could efficiently inhibit the formation of glial scars at the injured sites.The HA-KLT hydrogel could significantly increase the expression of endoglin/CD105 and promote the formation of blood vessels,suggesting that HA-KLT hydrogel promoted angiogenesis in vivo.Collectively,the HA-KLT hydrogel has the potential to repair brain defects by promoting angiogenesis and inhibiting the formation of glial-derived scar tissue. | Jiaju Lu Fengyi Guan Fuzhai Cui Xiaodan Sun Lingyun Zhao Ying Wang Xiumei Wang | 2019 | Regenerative Biomaterials2019，6，6： | 5 |
| 4 | Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery显示文摘Nerve guidance conduits with hollow lumen fail to regenerate critical-sized peripheral nerve defects(15 mm in rats and 25 mm in humans),which can be improved by a beneficial intraluminal microenvironment.However,individual cues provided by intraluminal filling materials are inadequate to eliminate the functional gap between regenerated nerves and normal nerves.Herein,an aligned fibrin/functionalized self-assembling peptide(AFG/fSAP)interpenetrating nanofiber hydrogel that exerting synergistic topographical and biochemical cues for peripheral nerve regeneration is constructed via electrospinning and molecular self-assembly.The hydrogel possesses an aligned structure,high water content,appropriate mechanical properties and suitable biodegradation capabilities for nerve repair,which enhances the alignment and neurotrophin secretion of primary Schwann cells(SCs)in vitro,and successfully bridges a 15-mm sciatic nerve gap in rats in vivo.The rats transplanted with the AFG/fSAP hydrogel exhibit satisfactory morphological and functional recovery in myelinated nerve fibers and innervated muscles.The motor function recovery facilitated by the AFG/fSAP hydrogel is comparable with that of autografts.Moreover,the AFG/fSAP hydrogel upregulates the regeneration-associated gene expression and activates the PI3K/Akt and MAPK signaling pathways in the regenerated nerve.Altogether,the AFG/fSAP hydrogel represents a promising approach for peripheral nerve repair through an integration of structural guidance and biochemical stimulation. | Shuhui Yang Jinjin Zhu Changfeng Lu Yi Chai Zheng Cao Jiaju Lu Zhe Zhang He Zhao Yin-Yuan Huang Shenglian Yao Xiangdong Kong Peixun Zhang Xiumei Wang | 2022 | Bioactive Materials2022，7，2： | 3 |
| 5 | Laves phase hydrogen storage alloys for super-high-pressure metal hydride hydrogen compressors显示文摘Ti-Cr- and Ti-Mn-based alloys were prepared to be low- and high-pressure stage metals for a double-stage super-high-pressure metal hydride hydrogen compressor. Their crystallographic characteristics and hydrogen storage properties were investigated. The alloy pair Ti0.9Zr0.1Mn1.4- Cr0.35V0.2Fe0.05/TiCr1.55Mn0.2Fe0.2 was optimized based on the comprehensive performance of the studied alloys. The product hydrogen with a pressure of 100 MPa could be produced from 4 MPa feed gas when hot oil was used as a heat reservoir. | GUO Xiumei WANG Shumao LIU Xiaopeng LI Zhinian LU Fang MI Jing HAO Lei JIANG Lijun | 2011 | Rare Metals2011，30，3： | 3 |
| 6 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 7 | Halteriomantispa grimaldii gen.et sp.nov.:A new genus and species of the family Dipteromantispidae(Insecta:Neuroptera)from the mid-Cretaceous amber of Myanmar显示文摘The family Dipteromantispidae, previously with only two genera and three species, is one of the enigmatic groups of the Cretaceous Neuroptera by the mantispid-like appearance combined with strongly reduced hind wings specialized into a haltere-like structure. A new genus and species of Dipteromantispidae, namely Halteriomantispa grimaldii gen. et sp. nov., is herein described based on an exquisitely preserved specimen from the mid-Cretaceous amber of northern Myanmar. It represents the first record of Dipteromantispidae from the amber deposit of mid-Cretaceous(Albian-Cenomanian) of Myanmar. A brief discussion on the homology of forewing venations and female genital sclerites of Dipteromantispidae is given. | Xingyue Liu Xiumei Lu Weiwei Zhang | 2016 | Zoological Systematics2016，41，2： | 2 |
| 8 | In situ TEM revealing the effects of dislocations on lithium-ion migration in transition metal dichalcogenides显示文摘The two-dimensional (2D) structure of layered transition metal dichalcogenides (TMDs) provides unusual physical properties [1,2]and chemical reactivity [3,4], which can be influenced by defects such as dislocations [5,6]. For example, dislocations can act as nucleation sites for the onset of deformation when subjected to stress [7]. | Ruiwen Shao Chengkai Yang Chen Yang Shulin Chen Weikang Dong Bairong Li Xiumei Ma Jing Lu Lixin Dong Peng Gao Dapeng Yu | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 9 | Simultaneous determination of icariin, icariside 1I and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS显示文摘 | Man Liu Huiping Liu Xiumei Lu | 2007 | J Chromatogr B2007，860，2： | 1 |
| 10 | Plasma and urinarytanshinol from Salvia miltiorrhiza ( Danshen) can be used aspharmacokinetic markers for cardiotonic pills, a cardiovascularherbal medicine显示文摘 | Lu Tong Yang Junling Gao Xiumei | 2008 | Drug Metab Dispos2008，36，8： | 1 |
| 11 | Determination of vitexin-2'-O-rhamnoside in rat plasma by ultra-performance liquid chromatography clectrospray ionization tandem mass spectrometry and its application to pharmacokinetic study显示文摘 | Ying Xixiang Lu Xiumei Sun Xiaohong | 2007 | Talanta2007，72，4： | 1 |
| 12 | Modulating effects of Astragalus polysaccharide on immune disorders via gut microbiota and the TLR4/NF-κB pathway in rats with syndrome of dampness stagnancy due to spleen deficiency显示文摘The syndrome of dampness stagnancy due to spleen deficiency(DSSD)is relatively common globally.Although the pathogenesis of DSSD remains unclear,evidence has suggested that the gut microbiota might play a significant role.Radix Astragali,used as both medicine and food,exerts the effects of tonifying spleen and qi.Astragalus polysaccharide(APS)comprises a macromolecule substance extracted from the dried root of Radix Astragali,which has many pharmacological functions.However,whether APS mitigates the immune disorders underlying the DSSD syndrome via regulating gut microbiota and the relevant mechanism remains unknown.Here,we used DSSD rats induced by high-fat and low-protein(HFLP)diet plus exhaustive swimming,and found that APS of moderate molecular weight increased the body weight gain and immune organ indexes,decreased the levels of interleukin-1β(IL-1β),IL-6,and endotoxin,and suppressed the Toll-like receptor 4/nuclear factor-κB(TLR4/NF-κB)pathway.Moreover,a total of 27 critical genera were significantly enriched according to the linear discriminant analysis effect size(LEfSe).APS increased the diversity of the gut microbiota and changed its composition,such as reducing the relative abundance of Pseudoflavonifractor and Paraprevotella,and increasing that of Parasutterella,Parabacteroides,Clostridium XIVb,Oscillibacter,Butyricicoccus,and Dorea.APS also elevated the contents of short-chain fatty acids(SCFAs).Furthermore,the correlation analysis indicated that 12 critical bacteria were related to the body weight gain and immune organ indexes.In general,our study demonstrated that APS ameliorated the immune disorders in DSSD rats via modulating their gut microbiota,especially for some bacteria involving immune and inflammatory response and SCFA production,as well as the TLR4/NF-κB pathway.This study provides an insight into the function of APS as a unique potential prebiotic through exerting systemic activities in treating DSSD. | Wenxiao ZHAO Chenchen DUAN Yanli LIU Guangying LU Qin LYU Xiumei LIU Jun ZHENG Xuelian ZHAO Shijun WANG Haijun ZHAO | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，7： | 1 |
| 13 | Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride显示文摘 | Taoguang Huo Shuang Cai Xiumei Lu Yi Sha Mingyang Yu Famei Li | 2009 | Journal of Pharmaceutical and Biomedical Analysis2009，，4： | 1 |
| 14 | Stress effects on ferroelectric and fatigue properties of Nd-and La-doped Bi4Ti3O12 thin films显示文摘 | WU XIUMEI LU XIAOMEI CHEN AIPING | 2005 | Appl Phys Lett2005，86，09： | 1 |
| 15 | A Kinase-Phosphatase-Transcription Factor Module Regulates Adventitious Root Emergence in Arabidopsis Root-Hypocotyl Junctions显示文摘Adventitious roots form from non-root tissues as part of normal development or in response to stress or wounding.The root primordia form in the source tissue,and during emergence the adventitious roots penetrate the inner cell layers and the epidermis;however,the mechanisms underlying this emergence remain largely unexplored.Here,we report that a regulatory module composed of the AP2/ERF transcription factor ABSCISIC ACID INSENSITIVE 4(ABI4),the MAP kinases MPK3 and MPK6,and the phosphatase PP2C12 plays an important role in the emergence of junction adventitious roots(J-ARs)from the root-hypocotyl junctions in Arabidopsis thaliana.ABI4 negatively regulates J-AR emergence,preventing the accumulation of reactive oxygen species and death of epidermal cells,which would otherwise facilitate J-AR emergence.Phosphorylation by MPK3/MPK6 activates ABI4 and dephosphorylation by PP2C12 inactivates ABI4.MPK3/MPK6 also directly phosphorylate and inactivate PP2C12 during J-AR emergence.We propose that this'double-check'mechanism increases the robustness of MAP kinase signaling and finely regulates the local programmed cell death required for J-AR emergence. | Zechen Bai Jing Zhang Xin Ning Hailong Guo Xiumei Xu Xiahe Huang Yingchun Wang Zhubing Hu Congming Lu Lixin Zhang Wei Chi | 2020 | Molecular Plant2020，13，8： | 1 |
| 16 | Stress effects on ferroelectric and fatigue properties of Nd-and La-doped Bi4Ti3O12 thin films显示文摘 | Xiumei Wu Xiaomei Lu | 2005 | AppI Phys Lett2005，86，09： | 1 |
| 17 | Metabonomic study on ' Kidney-Yang deficiency syndrome' and intervention effects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry 显示文摘 | LU Xiumei XIONG Zhili LI Jingjing | 2001 | Talanta2001，83，3： | 1 |
| 18 | Rapid and sensitive analysis of melatonin by LC-MS/MS and its application to pharmacokinetic study in dogs显示文摘A rapid and sensitive liquid chromatography tandem mass spectrometry method was established and validated for determination of melatonin in dog plasma using desvenlafaxine as an internal standard (IS). Plasma samples were pretreated by liquid–liquid extraction with ethyl acetate. Chromatographic separation was carried out on a C18 column at a flow rate of 0.2 ml/min by an isocratic mobile phase of methanol : 5 m M ammonium acetate : formic acid (40:60:0.1, v/v/v). Positive ion mode detection was performed using multiple reaction monitoring (MRM) at m/z 233.2→174.2 for melatonin and m/z 264.2→58.2 for desvenlafaxine.The method was linear in the concentration range of 0.020–10 ng/ml with a correlation coefficient ≥0.996. The intra-and inter-assay precision (%RSD) values were within 12.6% (LLOQ15.2%), and accuracy (%RE) ranged from -1.8% to 5.0% (LLOQ ±16.5%). The total analysis time was 3.0 min. The method was fully validated and successfully applied to a pharmacokinetic study of melatonin prolonged-release tablet in Beagle dogs. The values of half-life and Tmax were similar to the corresponding data reported before. | Huimin Zhao Yifei Wang Yi Jin Shu Liu Haiyan Xu Xiumei Lu | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，2： | 1 |
| 19 | Determination of trace glucose and forecast of human diseases by affinity adsorption solid substrate room temperature phosphorimetry based on Triticum valgaris lectin labeled with 4.0-generation dendrimers显示文摘 | Zhiming Li Guohui Zhu Jiaming Liu Qiaomei Lu Minlan Yang Hong Wu Xiumei Shi Xinhua Chen | 2007 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2007，，5： | 1 |
| 20 | Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after thetreatment of metformin hydrochloride 显示文摘 | HUO Taoguang CAI Shuang LU Xiumei | 2009 | J Pharm Biomed Anal2009，49，4： | 1 |
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